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JP2000053639A |
To obtain the subject compound in high yield by coupling between a phenylsulfonic acid and a specific steroid derivative followed by halogenation, dehydrohalogenation, epoxidation, hydrolysis, esterification, ultraviolet irradiation, the...
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JP2000053640A |
To obtain the subject compound in high yield by with column chromatography from a mixture of dehydrocholesterol and/or lumisterol and/or tachysterol and other component(s). The subject compound is obtained according to the following proc...
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JP2000502063A |
PCT No. PCT/DK96/00502 Sec. 371 Date Jan. 8, 1998 Sec. 102(e) Date Jan. 8, 1998 PCT Filed Dec. 2, 1996 PCT Pub. No. WO97/20811 PCT Pub. Date Jun. 12, 1997The present invention relates to compounds of formula (I) in which formula X is hyd...
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JP3008195B2 |
Compounds having anti-inflammatory and other activities. The compounds are derived from diterpenes, indol alkaloids, polyacetates, diaminobenzyl alcohols, diacylglycerol and bryostatins.
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JP2000026443A |
To efficiently obtain in high purity and yield a compound useful for producing epivitamin D3 analogs by reaction of a specific epoxide under specified conditions. This compound of formula VII is obtained according to the following steps:...
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JP2000026405A |
To provide a process for the photolytic production of previtamin D3 from 7-dehydrocholesterol. The production of previtamin D3 from 7-dehydrocholesterol is carried out in a reactor furnished with a UV radiation source. The radiation sour...
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JP2000015090A |
To cause photochemical reaction efficiently by a method in which when a photo-reaction solution of an organic compound solution is irradiated with ultraviolet light of a specified wavelength to generate the aimed photochemical reaction, ...
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JP2000016987A |
To obtain an activated vitamin D derivative having an excellent bone quantity-improving action, an excellent differentiation inducing action, an excellent cell proliferation-inhibiting action, an excellent immunoregulatory action, etc., ...
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JP2988253B2 |
PURPOSE: To obtain a new compound having low hypercalcemic action and high differentiating-inducing action of tumor cells and useful as a carcinostatic agent. CONSTITUTION: A compound of formula I (R3, R4 and R5 are each a protecting gro...
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JPH11310569A |
To obtain a new compound having excellent improving actions on bone mass, inducing actions on differentiation and immunomodulating actions in spite of weak actions on a rise in calcium level in blood. This compound is represented by form...
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JPH11302296A |
To provide a method for more efficiently producing 1α,24(R)- dihydroxycholesterol. This method for producing the objective 1α,24(R)- dihydroxycholesterol of formula III comprises a process for affording a compound of formula II (A and ...
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JP2945505B2 |
Isomerisation esp. tachysterol cpds. into previtamin D cpds. and trans-vitamin D cpds. into cis-vitamin D cpds., under the influence of radiation, is by exposing a soln. of the organic cpd. to be converted in the presence of a non-polyme...
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JP2927368B2 |
1 alpha -Hydroxy-24-epi-vitamin D4 and novel intermediates formed in a novel method of preparing this compound. The method includes campesterol as a starting material which is converted to 24-epi-vitamin D4 which is in turn hydroxylated ...
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JP2926008B2 |
A convergent synthesis of 19-nor-vitamin D compounds, specifically 19-nor-1 alpha ,25-dihydroxyvitamin D3, is disclosed. The synthesis can also readily be utilized for preparing other 1 alpha -hydroxylated 19-nor-vitamin D compounds. The...
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JP2925382B2 |
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JPH11507649A |
A method of preparing a pharmaceutical composition, comprising combining a pharmaceutically compatible vehicle with a compound according to formula (I)
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JP2914690B2 |
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JPH11171859A |
To obtain the subject new compound estimated to have a differentiation-inducing action and a proliferation-inhibiting action and capable of being expected to be used as an antitumor agent, and antirheumatic agent, a psoriasis-treating ag...
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JP2908566B2 |
PCT No. PCT/EP96/00176 Sec. 371 Date Jul. 21, 1997 Sec. 102(e) Date Jul. 21, 1997 PCT Filed Jan. 17, 1996 PCT Pub. No. WO96/22776 PCT Pub. Date Aug. 1, 1996A method of using vitamin D derivatives of the formula I wherein X is =CH2 or H,H...
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JPH11506791A |
1 alpha -hydroxy vitamin D4 and analogues, preferably 1,24 dihydroxy vitamin D4, which are useful as active compounds of pharmaceutical compositions for the inhibition of hyperproliferative activity of malignant cells.
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JPH11506792A |
The disclosure is of methods of treating various skin disorders, including skin cancer, with compounds of novel 1 alpha -hydroxy vitamin D4 and novel analogues, thereof, including 1,25 dihydroxy vitamin D4 and 1,24 dihydroxy vitamin D4. ...
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JP2898882B2 |
The 2 alpha and 2 beta -hydroxy as well as the 2 alpha (3'-hydroxypropoxy)- and 2 beta (3'-hydroxypropoxy)- and 2 alpha (benzyloxy)- analogs of 19-nor-1 alpha ,25-dihydroxyvitamin D3 are disclosed. The two 2-hydroxy analogs showed in viv...
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JP2900607B2 |
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JP2889864B2 |
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JPH11116551A |
To obtain the subject new derivative bearing methyl group on the 2 site, and useful as a therapeutic agent for osteoporosis. This new derivative is a 1,25-dihydroxy-2-methyl vitamin D3 derivative of formula I [R1 and R2 are each H or a t...
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JP2879776B2 |
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JP2879777B2 |
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JPH1160535A |
To obtain the subject new vitamin D3 analogue or derivative having a biologically calcium-controlling action and a tumor cell differentiation-inducing action. An vitamin D3 analogue of formula I (R1 is H and R2 is OH, or R1 is OH and R2 ...
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JP2859961B2 |
New antitumoral biotenside ester and phosphatide with vitamin D and vitamin E compounds are disclosed, as well as a process for preparing the same and for producing spontaneously dispersible concentrates therefrom, and processes for deve...
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JPH1149747A |
To obtain a new compound useful as a medicine excellent in improving action on bone quantity, differentiation-inducing action, inhibitory action on cell proliferation without causing hypercalcemia. This active type vitamin D derivative i...
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JP2859247B2 |
Compounds of the formula wherein R is hydrogen, fluorine, or hydroxy, R2 is hydrogen, lower alkyl or halogen, X is =CH2 or when R is hydroxy, X is (H,H) or =CH2, are useful in the treatment of hyperproliferative skin disorders, neoplasti...
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JP2858571B2 |
To obtain the subject new compound useful for treating hypertrophic diseases, neoplastic diseases and sebaceous gland diseases by inducing the differentiation and suppression of proliferation of various ski cell systems and cancer cell s...
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JP2859248B2 |
The novel fluorinated Vitamin D3 analogs of formula wherein: X is (H,H) or =CH2; R1 and R2 are, independently of each other, hydrogen, (C1-C4) alkyl or fluoroalkyl, or R1 and R2 together with C-20 form a (C3-C6) cycloalkyl or cyclofluoro...
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JPH1135553A |
To obtain the subject new compound manifesting excellent bone quantity-improving activities, differentiation-inducing activities and cell growth- inhibiting activities without causing hypercalcemia. The objective compound is an activated...
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JPH1135469A |
To obtain a prophylactic or treating agent for chronic cardiac failure on the basis of the inhibition of hypercardia by formulating a specific vitamin compound as an active ingredient. This prophylactic or treating agent contains a thera...
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JP2850751B2 |
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JP2850716B2 |
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JP2850628B2 |
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JP2850687B2 |
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JP2835195B2 |
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JPH10316652A |
To obtain the subject compound having biological activity and useful for the treatment of skin and bone diseases, the application to beauty care and the treatment of celldifferentiation, cell-proliferation or immunological diseases inclu...
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JPH10512297A |
The invention relates to a compound of formula (I) wherein A is a carbon double bond having the stereochemical configuration E or Z, i.e. of formula (a) or (b), respectively, R is hydroxy and R<1> is hydrogen or =CH2 or R is hydrogen or ...
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JP2818493B2 |
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JP2818494B2 |
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JPH10265453A |
To obtain the subject derivative having high activity and safety and useful as a therapeutic agent for diseases by which calcium metabolism, etc., is abnormalized by reacting a specific exomethylene derivative with a specific ene-yne der...
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JP2807087B2 |
PCT No. PCT/DK90/00168 Sec. 371 Date Nov. 19, 1991 Sec. 102(e) Date Nov. 19, 1991 PCT Filed Jul. 4, 1990 PCT Pub. No. WO91/00855 PCT Pub. Date Jan. 24, 1991. (I) The present invention relates to compounds of formula (I), in which formula...
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JP2807086B2 |
The present invention relates to compounds of formula (I), in which formula, n is 0 or 1, m is 0 or an integer from 1-7, R<1> and R<2> (which may be the same or different) stand for hydrogen or C1-C8-hydrocarbyl, or, taken together with ...
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JP2804606B2 |
An adduct-aldehyde of formula (I) is new. In (I), R = H or opt. etherified or esterified OH; R1 = opt. etherified or esterified OH; Z = sulphonyl or a gp. of formula A and B independently = 1-4C alkoxy; or A and B together form phenylimi...
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JP2807083B2 |
The present invention relates to compounds of formula (I), in which formula R stands for an alkyl group containing from 7 to 12 carbon atoms optionally substituted with a hydroxy group; and derivatives of the compounds of formula (I) in ...
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JP2807084B2 |
The present invention relates to compounds of formula (I), in which formula R stands for an alkyl group containing from 7 to 12 carbon atoms optionally substituted with a hydroxy group; and derivatives of the compounds of formula (I) in ...
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