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JPH0339505B2 |
Novel derivatives of vitamin D2 and more specifically 1alpha,25-dihydroxylated compounds of the vitamin D series. A process for the preparation of such derivatives is also provided as are certain intermediates in such process. The invent...
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JPH0339058B2 |
The invention relates to a method of preparing 1 alpha -hydroxyvitamin D or 1 alpha -hydroxy-previtamin D compounds by hydroxylating the 1 alpha -position of an adduct of a previtamin D compound with a suitable dienophile, in which adduc...
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JPH0339059B2 |
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JPH0329372B2 |
1α, 3β-dihydroxysteroid-5-ene, an intermediate of 1α-hydroxy vitamin D2 and D3, was prepd. Thus, 1α-hydroxy or 1α, 2α-epoxysteroid-4,6-diene-3-one having immediately removable 6-substitute radical was reduced with alk. metal/liq. N...
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JPH0321159B2 |
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JPH03501259A |
This invention provides novel 1 alpha -hydroxyvitamin D compounds, methods for their preparation, and pharmaceutical compositions of these compounds. The new compounds, which are characterized structurally by having a cyclopentane ring a...
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JPH0319240B2 |
The invention provides new vitamin D derivatives as well as new intermediate compounds derived during the processes for preparing such new derivatives. The new derivatives have been identified as 1 alpha -hydroxy-25-keto-27-nor-vitamin D...
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JPH0314304B2 |
Prostaglandin D analogues of the formula: (wherein [A] represents a group of the formula: X represents ethylene or cis-vinylene, C13-C14-C15 represents (i) a group of the formula: when [A] represents a group of the formula (II) or (III),...
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JPH0314303B2 |
The invention provides new derivatives of vitamin D3, specifically, 1 alpha ,25-dihydroxy-2 beta -fluorocholecalciferol. The compound is characterized by vitamin D-like activity as measured by its ability to stimulate intestinal calcium ...
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JPH0314017B2 |
alpha diene 16-hydroxy prostanoic acid derivatives displaying valuable pharmacological properties, e.g., gastric antisecretory, are described herein.
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JPH039887B2 |
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JPH039906B2 |
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JPH039889B2 |
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JPH039907B2 |
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JPH039904B2 |
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JPH039888B2 |
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JPH039903B2 |
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JPH039905B2 |
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JPH039093B2 |
4,5-unsaturated 16-hydroxy prostanoic acid derivatives displaying valuable pharmacological properties, e.g. gastric antisecretory, are described herein.
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JPH039104B2 |
5-Thiaprostagliandins E1 having the general formula (I): wherein R<1> represents a hydrogen atom, a C1-C10 alkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted C3-C10 cycloalkyl group, a substituted or...
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JPH039105B2 |
15-acetyloxy-11,16,16,-trimethyl-9-oxo-prosta-5,13-dien-1-oi
c acid and lower alkyl esters thereof useful as anti-secretory agents for preventing hyperacidity in the stomach and as an anti-ulcer agent, and compositions and methods for us...
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JPH038337B2 |
Prostaglandin D derivatives of the general formula: wherein [A] represents a group of the formula: C13-C14-C15 represents (i) a group of the formula: when [A] represents a group of the formula (II), or (ii) a group of the formula: when [...
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JPH038338B2 |
Prostaglandin D derivatives of the formula: wherein R<1> is hydrogen or alkyl, R<2> is a group of the formula: or (ii) -R<6>-R<7> wherein R<3> is alkyl, R<4> is hydrogen or alkyl, R<5> is alkyl R<6> is a single bond or alkylene, R<7> is ...
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JPH038339B2 |
Trans-Δ2-prostaglandin D derivatives of the formula:wherein [A] is a group of the formula:X is ethylene or cis-vinylene, C13-C14-C15 is:(i) a group of the formula:when [A] is a group of the formula (II) or (III), or(ii) a group of the f...
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JPH037665B2 |
1. A process for the manufacture of 4-oxo-beta-ionone of the formula see diagramm : EP0101811,P5,F2 characterized by oxidizing retroionone of the formula see diagramm : EP0101811,P5,F3 with oxygen or an oxygen-containing gas.
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JPH037666B2 |
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JPH037664B2 |
The invention relates to a method of preparing 1 alpha -hydroxyvitamin D or 1 alpha -hydroxy-previtamin D compounds by hydroxylating the 1 alpha -position of an adduct of a previtamin D compound with a suitable dienophile, in which adduc...
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JPH036139B2 |
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JPH036137B2 |
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JPH036138B2 |
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JPH036159B2 |
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JPH036127B2 |
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JPH034558B2 |
PURPOSE:To deprotect selectively only a protecting group of acetal type, by heat-treating a compound containing a protecting group of acetal type and a protecting group of silyl ether type in the molecule. CONSTITUTION:A compound (e.g., ...
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JPH034066B2 |
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JPH0251886B2 |
A pharmaceutical composition for use in inducing cytoprotection in mammals comprises the prostaglandin derivative 16-methyl-1,11 alpha , 16RS- trihydroxyprost-13E-en-9-one in a pharmaceutically acceptable carrier.
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JPH0251559B2 |
PCT No. PCT/JP85/00636 Sec. 371 Date Jul. 16, 1986 Sec. 102(e) Date Jul. 16, 1986 PCT Filed Nov. 14, 1985 PCT Pub. No. WO86/02923 PCT Pub. Date May 22, 1986.This invention provides a process for producing bicyclo[3.3.0]octanes expressed ...
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JPH02262555A |
NEW MATERIAL: Compd. of formula I [wherein R1 is a 1-15C substd. alkyl, in particular a side chain of vitamin D2 (20-28C) or vitamin D3 (20-27C); Y is H, OH, etc.; X is a 1-6C alkyl, an arom. or a heterocyclic ring, etc.; R2 and R3 are H...
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JPH0244458B2 |
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JPH0244312B2 |
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JPH0244311B2 |
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JPH0243751B2 |
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JPH02235861A |
NEW MATERIAL:26,27-Dipropyl-1α,25-dihydroxyvitamin D3. USE: Remedy for chronic renal failure, hypoparathyroidism, osteoporosis, psoriasis and cancer. PREPARATION: The objective 26,27-dipropyl-1α,25-dihydroxyvitamin D3 can be produced b...
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JPH02231449A |
NEW MATERIAL: A compound of formula VI [wherein R1 is H, an acyl, an alkylsilyl or tetrahydropyranyl; X is formula VII (wherein R2=R1) or formula VIII (wherein R3=R1; and R4 are each H or an alkyl), provided that when X is formula VII, a...
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JPH02502824A |
PCT No. PCT/US88/00817 Sec. 371 Date Sep. 19, 1989 Sec. 102(e) Date Sep. 19, 1989 PCT Filed Mar. 18, 1988 PCT Pub. No. WO88/07527 PCT Pub. Date Oct. 6, 1988.The amino-9,10-secosteroids (I) of the present invention contain an amino group ...
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JPH02218642A |
NEW MATERIAL: A compd. represented by formula I (a group represented by formula II is divalent cyclic groups represented by formulae III-VII, R1 is 6- carboxyhexa-2-enyl or a modified group modified by the reduction of a double bond volu...
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JPH0237355B2 |
The invention provides methods for preparing the various isomeric forms of 25-hydroxyvitamin D3-26,23-lactone utilizing cyanohydrin formation with readily prepared steroid materials followed by actinic radiation of the products and recov...
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JPH0236593B2 |
The present invention relates to intermediates of the general formula:(wherein Y and Z, which may be the same or different, each represents a trans-vinylene group or an ethylene group, R2 represents a hydrogen atom or a methyl or ethyl g...
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JPH0236586B2 |
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JPH02202870A |
PURPOSE: To photochemically convert a tachysterol compound and a trans-vitamin D compound into a previtamin D compound and a cis-vitamin D compound, respectively, by the use of a specific polymeric photosensitizer such as a photosensitiz...
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JPH0234331B2 |
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