Heterocyclic Compounds

Matches 651 - 700 out of 8,728	< 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 >

Document	Document Title
WO/2017/049245A2	COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions fu...
WO/2017/044314A1	MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...
WO/2017/041230A1	HERBICIDAL CHLOROMETHYL TRIAZOLINONES A new type of herbicidal chloromethyl triazolinones of general formula (III), compositions of them, methods of preparing them, and methods for preventing or destroying undesired plant growth by preemergence or postemergence application o...
WO/2017/036404A1	CARBOXY SUBSTITUTED (HETERO) AROMATIC RING DERIVATIVES AND PREPARATION METHOD AND USES THEREOF Carboxy-substituted (hetero)aryl derivatives, pharmaceutical compositions comprising these compounds, and methods of preparing such compounds and compositions are provided. The compounds or compositions are useful in inhibiting xanthine ...
WO/2017/040060A1	MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...
WO/2017/037146A1	PHENOXYMETHYL DERIVATIVES The invention provides novel compounds having the general formula (I), wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.
WO/2017/036884A1	A LESINURAD, FREE FORM / LESINURAD ETHYL ESTER CO-CRYSTAL The present disclosure relates to a co-crystal comprising 2-[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol -3-ylsulfanyl]acetic acid (lesinurad, free form) and ethyl-2-[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-t riaz...
WO/2017/032728A1	SUBSTITUTED KETOXIME BENZOYLAMIDES The invention relates to substituted ketoxime benzoylamides of general formula (I) as herbicides. In said formula (I), R1', R2', X, Y and W represent groups such as hydrogen, organic groups such as alkyl, and other groups such as halogen...
WO/2017/027309A1	GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I), as follows: wherein R1, R2, R4, W, X, Y, and G, are def...
WO/2017/027870A1	TRIAZOLE CONJUGATED UREAS, THIOUREAS, CARBAMATES, AND "REVERSED" CARBAMATES FOR PSMA-TARGETED IMAGING AGENTS AND USES THEREOF Triazole conjugated urea-based and thiourea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used to image cells and tumors that express PSMA. Methods of synthesizing radioflu...
WO/2017/027312A1	GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (III); wherein R1c, R2C, R4C, Wc, Yc, Zc and Gc, are defined...
WO/2017/027310A1	GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula II.
WO/2017/023739A1	DERIVATIVES OF RUFINAMIDE AND THEIR USE IN INHIBTION OF THE ACTIVATION OF HUMAN VOLTAGE-GATED SODIUM CHANNELS The present invention provides compounds of formula I which are capable of inhibition of the activation of hNav1.1 or hNavl.6 sodium channels in neurons. Pharmaceutical compositions comprising these compounds are also provided. Methods f...
WO/2017/012922A1	SUBSTITUTED CYCLIC ARYL AND HETEROARYL CARBOXYLIC ACID HYDRAZIDES OR SALTS THEREOF AND USE THEREOF TO INCREASE STRESS TOLERANCE IN PLANTS The invention relates to substituted cyclic aryl and heteroaryl carboxylic acid hydrazides of general formula (I) or salts thereof, wherein the groups of formula (I) have the definitions stated in the description, for increasing the stre...
WO/2017/013206A1	PROCESS FOR PREPARING 3,3'-DINITRO-5,5'-BIS(1H-1,2,4-TRIAZOLE) The invention relates to a process for preparing 3,3'-dinitro-5,5'-bis(1H-1,2,4-triazole) (DNBT) from 3,3'-diamino-5,5'-bis(1H-1,2,4-triazole) (DABT), wherein in the presence of nitrite H2SO4 is added to a suspension of DABT in H2O.
WO/2017/013265A1	METABOLICALLY ROBUST ANALOGS OF CYP-EICOSANOIDS FOR THE TREATMENT OF CARDIAC DISEASE The present invention relates to compounds according to general formula (I) which are metabolically robust analogues of bioactive lipid mediators derived from omega-3 polyunsaturated fatty acids (n-3 PUFAs).The present invention further ...
WO/2017/009344A1	PSEUDOMONAS AERUGINOSA INHIBITOR COMPOUNDS The invention relates to a method of identifying molecules which inhibit the virulence machinery of Pseudomonas aeruginosa, to a device for identifying a molecule which inhibits the virulence machinery of Pseudomonas aeruginosa, to novel...
WO/2017/007672A1	SUBSTITUTED BENZOTRIAZOLE PHENOLS Benzotriazole phenols with substituents either ortho to the phenol hydroxyl group and/or para to the phenol hydroxyl group can be prepared from the unsubstitued benzotriazole phenol by coupling reactions. The ortho substituent group can ...
WO/2017/006929A1	PRODUCTION METHOD FOR OPTICALLY ACTIVE COMPOUND, AND TRIAZOLIUM SALT USED AS CATALYST IN SAME The present invention makes it easy to obtain, with good yield and stereoselectivity, an optically active α-tetrasubstituted α-amino nitrile derivative, or an intermediate for the synthesis of said derivative, by reacting a cyanometala...
WO/2017/003685A1	PHOTOSTABILIZING COMPOUNDS AND METHODS OF MAKING AND USING THE SAME Compounds that stabilize ultraviolet (UV) light are generally disclosed herein. Methods of making and using such compounds are also generally disclosed. Compositions, such as sunscreen compositions, containing such UV-stabilizing compoun...
WO/2017/003894A1	SUBSTITUTED TRIAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS The present invention is directed to substituted triazolo bicyclic compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The presen...
WO/2016/203400A1	NRF2 REGULATORS The present invention relates to aryl analogs Formula (I), pharmaceutical compositions containing them and their use as Nrf2 regulators.
WO/2016/203436A1	AMORPHOUS AND AMORPHOUS SOLID DISPERSION OF LESINURAD AND THEIR PREPARATION The present invention provides amorphous form of lesinurad, amorphous solid dispersion of lesinurad and processes for preparation thereof. The present invention also provides a pharmaceutical composition comprising amorphous or amorphous...
WO/2016/202935A1	GLUCOSE TRANSPORT INHIBITORS The present invention relates to quinoline-4-carboxamide derivatives of Formula (I) that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprisin...
WO/2016/202807A1	PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYL KETONES The present invention relates to a process for providing substituted phenyl ketones wherein a Grignard reagent which is obtained from a substituted phenyl bromide is reacted with an acyl chloride at a temperature of -20 to 10 °C. Furthe...
WO/2016/202253A1	NRF2 REGULATORS Provided are aryl analogs，pharmaceutical compositions containing them and their use as NRF2 regulators.
WO/2016/204270A1	DIARYL AZOLE COMPOUND AND PESTICIDE The present invention provides a compound represented by formula (I) (in the formula, A1 and A2 each independently indicate a carbon atom or nitrogen atom; X1 indicates a substituted or unsubstituted C1-6 alkyl group or the like; n is an...
WO/2016/200283A1	DERIVATIVES OF 1,2,3-TRIAZOLYL CYCLOHEXAN-1-OL AND ITS USE 1,2,3-triazolyl cyclohexanol derivatives have been disclosed and their use as ligands accelerating the copper(I)-catalyzed azide-alkyne cycloaddition and the zinc(II)-catalyzed azide-nitrile cycloaddition.
WO/2016/198507A1	ARYL SULFONOHYDRAZIDES Compound of formula (I) wherein A is selected from (i), where RF1 is H or F; (ii); (iii) a N-containing C6 heteroaryl group; and B is (B), where X1 is either CRF2 or N, where RF2 is H or F; X2 is either CR3 or N, where R3 is selected fro...
WO/2016/199104A1	POLYMORPHS OF A PGES-1 INHIBITING TRIAZOLONE COMPOUND The present application relates to solid state forms of a triazolone compound which exhibit mPGES-1 enzyme inhibition activity, specifically N-(4-chloro-3-(5-oxo-1-(4-(trifluoromethyl)phenyl)-4,5-dihyd ro-1H-1,2,4-triazol-3-yl)benzyl) pi...
WO/2016/198374A1	AROMATIC SULFONAMIDE DERIVATIVES Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...
WO/2016/193470A1	ROR GAMMA (RORY) MODULATORS The present invention relates to compounds according to Formula (I): or a pharmaceutically acceptable salt thereof. The compounds can be used as inhibitors of RORy and are useful for the treatment of RORy mediated diseases.
WO/2016/196492A1	METHODS, COMPOSITIONS, AND KITS USING HETEROGENEOUS CATALYSTS Described herein are a method, a column matrix, and a column utilizing heterogeneous metal catalysts for the preparation of cycloaddition compounds, such as triazoles and biomolecules. The heterogeneous metal catalysts is generated from ...
WO/2016/196280A1	HETEROCYCLE-SUBSTITUTED BICYCLIC PESTICIDES Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, (I) wherein Z is Z1, Z2, Z3, Z4, Z5. A is phenyl or a 5- or 6-membered heteroaromatic ring, each unsubstituted or substituted w...
WO/2016/197009A1	TRIAZOLES FOR THE TREATMENT OF DEMYELINATING DISEASES The invention relates to triazole compounds of formula I and I' or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising...
WO/2016/189877A1	UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF The present invention provides a urea compound or a pharmacologically acceptable salt thereof that has a formyl peptide receptor like 1 (hereinafter may be abbreviated as FPRL1) agonist effect, a pharmaceutical composition containing the...
WO/2016/191667A2	NOVEL CORROSION INHIBITORS Disclosed are novel compounds and methods useful in applications relating to industrial water systems. The compounds of the present invention are nitrogen-containing heterocyclic compounds comprising a benzotriazole covalently bonded to ...
WO/2016/188835A1	SUPPORTS FOR MEMBRANE ENHANCED PEPTIDE SYNTHESIS The invention relates to branched soluble polymeric supports for membrane enhanced peptides synthesis (MEPS), and their use in MEPS.
WO/2016/173503A1	CARBOXYLIC ACID URAT1 INHIBITOR CONTAINING DIARYLMETHANE STRUCTURE, PREPARATION METHOD AND USE THEREOF The present invention relates to the field of drugs for hyperuricemia and gout. In particular, the present invention relates to a carboxylic acid uric acid transporter 1 (URAT1) inhibitor of general formula (I) containing a diarylmethane...
WO/2016/170009A1	AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS The present invention relates to novel aminoindazolyl derivative compounds of Formula(I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav1.7 AND to compositions con...
WO/2016/172424A1	INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth: (I)
WO/2016/168059A1	MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO This disclosure relates to the field of moiecuies having pesticida i utility against pests in Phyla Arthropoda, Moliusca, and hJematoda, processes to produce such moiecuies, intermediates used In such processes, pesticidai compositions c...
WO/2016/168058A1	MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...
WO/2016/168769A1	CHIMERIC RECEPTOR T CELL SWITCHES FOR HER2 Disclosed herein are switches for regulating the activity of a chimeric antigen receptor effector cells (CAR-ECs). The switches generally comprise a chimeric antigen receptor-interacting domain (CAR-ID) and a target interacting domain TI...
WO/2016/157087A1	COMPOUND OF GENEREAL FORMULA (KAT+)(AN -)·XL A compound of general Formula (1) : (Cat+)(An-) · xL, wherein: Cat+ is a lithium or sodium cation having a constant coordination number of the cation CNLi5-6 or CNNA=6-7, L is a ligand selected from the group consisting of molecules of ...
WO/2016/156076A1	PESTICIDALLY ACTIVE CARBAMOYLATED AND THIOCARBAMOYLATED OXIME DERIVATIVES Compounds of formula (I), wherein the substituents are as defined in claim 1, and agrochemically acceptable salts thereof, can be used as insecticides.
WO/2016/155653A1	AXIALLY CHIRAL ISOMERS, AND PREPARATION METHODS THEREFOR AND PHARMACEUTICAL USES THEREOF Disclosed are two axially chiral isomers and pharmaceutically available salts thereof, preparation methods therefor, and pharmaceutical uses of the two axially chiral isomers or pharmaceutical compositions thereof.
WO/2016/156314A1	TRIAZOLE DERIVATIVES AS PESTICIDES AND PLANT GROWTH REGULATORS The present invention relates to novel triazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmf...
WO/2016/156311A1	TRIAZOLE DERIVATIVES AS PESTICIDES AND PLANT GROWTH REGULATORS The present invention relates to novel triazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmf...
WO/2016/151300A1	TRIAZOLE DERIVATIVES AND THEIR USE AS PDE4 ACTIVATORS Compounds of Formula (I), which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes, are provided. Methods and uses of these compounds for the treatment or prevention of disorders requiring a reduction of sec...

Matches 651 - 700 out of 8,728	< 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 >