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Matches 651 - 700 out of 8,693

Document Document Title
WO/2016/202253A1
Provided are aryl analogs,pharmaceutical compositions containing them and their use as NRF2 regulators.  
WO/2016/204270A1
The present invention provides a compound represented by formula (I) (in the formula, A1 and A2 each independently indicate a carbon atom or nitrogen atom; X1 indicates a substituted or unsubstituted C1-6 alkyl group or the like; n is an...  
WO/2016/200283A1
1,2,3-triazolyl cyclohexanol derivatives have been disclosed and their use as ligands accelerating the copper(I)-catalyzed azide-alkyne cycloaddition and the zinc(II)-catalyzed azide-nitrile cycloaddition.  
WO/2016/198507A1
Compound of formula (I) wherein A is selected from (i), where RF1 is H or F; (ii); (iii) a N-containing C6 heteroaryl group; and B is (B), where X1 is either CRF2 or N, where RF2 is H or F; X2 is either CR3 or N, where R3 is selected fro...  
WO/2016/199104A1
The present application relates to solid state forms of a triazolone compound which exhibit mPGES-1 enzyme inhibition activity, specifically N-(4-chloro-3-(5-oxo-1-(4-(trifluoromethyl)phenyl)-4,5-dihyd ro-1H-1,2,4-triazol-3-yl)benzyl) pi...  
WO/2016/198374A1
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...  
WO/2016/193470A1
The present invention relates to compounds according to Formula (I): or a pharmaceutically acceptable salt thereof. The compounds can be used as inhibitors of RORy and are useful for the treatment of RORy mediated diseases.  
WO/2016/196492A1
Described herein are a method, a column matrix, and a column utilizing heterogeneous metal catalysts for the preparation of cycloaddition compounds, such as triazoles and biomolecules. The heterogeneous metal catalysts is generated from ...  
WO/2016/196280A1
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, (I) wherein Z is Z1, Z2, Z3, Z4, Z5. A is phenyl or a 5- or 6-membered heteroaromatic ring, each unsubstituted or substituted w...  
WO/2016/197009A1
The invention relates to triazole compounds of formula I and I' or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising...  
WO/2016/189877A1
The present invention provides a urea compound or a pharmacologically acceptable salt thereof that has a formyl peptide receptor like 1 (hereinafter may be abbreviated as FPRL1) agonist effect, a pharmaceutical composition containing the...  
WO/2016/191667A2
Disclosed are novel compounds and methods useful in applications relating to industrial water systems. The compounds of the present invention are nitrogen-containing heterocyclic compounds comprising a benzotriazole covalently bonded to ...  
WO/2016/188835A1
The invention relates to branched soluble polymeric supports for membrane enhanced peptides synthesis (MEPS), and their use in MEPS.  
WO/2016/173503A1
The present invention relates to the field of drugs for hyperuricemia and gout. In particular, the present invention relates to a carboxylic acid uric acid transporter 1 (URAT1) inhibitor of general formula (I) containing a diarylmethane...  
WO/2016/170009A1
The present invention relates to novel aminoindazolyl derivative compounds of Formula(I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav1.7 AND to compositions con...  
WO/2016/172424A1
Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth: (I)  
WO/2016/168059A1
This disclosure relates to the field of moiecuies having pesticida i utility against pests in Phyla Arthropoda, Moliusca, and hJematoda, processes to produce such moiecuies, intermediates used In such processes, pesticidai compositions c...  
WO/2016/168058A1
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...  
WO/2016/168769A1
Disclosed herein are switches for regulating the activity of a chimeric antigen receptor effector cells (CAR-ECs). The switches generally comprise a chimeric antigen receptor-interacting domain (CAR-ID) and a target interacting domain TI...  
WO/2016/157087A1
A compound of general Formula (1) : (Cat+)(An-) · xL, wherein: Cat+ is a lithium or sodium cation having a constant coordination number of the cation CNLi5-6 or CNNA=6-7, L is a ligand selected from the group consisting of molecules of ...  
WO/2016/156076A1
Compounds of formula (I), wherein the substituents are as defined in claim 1, and agrochemically acceptable salts thereof, can be used as insecticides.  
WO/2016/155653A1
Disclosed are two axially chiral isomers and pharmaceutically available salts thereof, preparation methods therefor, and pharmaceutical uses of the two axially chiral isomers or pharmaceutical compositions thereof.  
WO/2016/156314A1
The present invention relates to novel triazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmf...  
WO/2016/156311A1
The present invention relates to novel triazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmf...  
WO/2016/151300A1
Compounds of Formula (I), which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes, are provided. Methods and uses of these compounds for the treatment or prevention of disorders requiring a reduction of sec...  
WO/2016/146605A1
The invention relates to substituted phenylalanine derivatives and to a method for the production thereof and to the use thereof for producing medicaments for treating and/or prophylaxis of diseases, in particular blood loss in hyperfibr...  
WO/2016/146599A1
The invention relates to a method for producing substituted phenylalanine derivatives of formula (Ia), particularly a method for producing 3-[5-(4-{[(2S)-2 ({[trans-4-(Aminomethyl)cyclohexyl]carbonyl}amino)-3-{4'-[(t rans-4-hydroxycycloh...  
WO/2016/145614A1
The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present inven...  
WO/2016/141747A1
The present invention relates to a triazole alcohol derivative and a preparation method and use thereof. The triazole alcohol derivative is a 2-(2,4-difluorophenyl )-3-(1-substituted-1H-1,2,3-triazol-4-yl)-1-(1H-1,2,4-triazo l-1-yl)butyl...  
WO/2016/141548A1
A method for preparing a high-purity sulfonamide compound, and an intermediate of the sulfonamide compound. The method comprises the following steps: a first step: using a sulfonamide compound (I) crude product as a starting material, al...  
WO/2016/138821A1
The present invention provides compounds of the Formula (1), wherein R, R1-R3 are as described herein; methods of treating patients for diabetes using the compounds, and processes for preparing the compounds.  
WO/2016/138631A1
Compounds of formula I and the pharmaceutically acceptable salt thereof are disclosed, wherein R is selected from the group consisting of O and NH, R 1 is selected from the group consisting of CF 3, OCF 3 and Cl.  
WO/2016/135062A1
The present invention discloses the efficient preparation of 2-substituted-4-amido-1,2,3-triazoles.  
WO/2016/131098A1
ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in ...  
WO/2016/133217A1
The present invention is able to provide a method for stereoselectively introducing an amino group having various substituents into the α-position of an oxindole compound by a single step by having a specific compound (a carbonyl compou...  
WO/2016/128541A1
The present invention refers to compounds endowed with RNA helicase DDX3 inhibitory activity of formula I and II and their therapeutic use, in particular for the treatment of viral diseases.  
WO/2016/123533A1
Substituted 1,2,3-triazole compounds are disclosed which have utility in the treatment of a variety of neurological disorders. The compounds provided herein have the general structure wherein R1, R2, R3 and n are as defined herein, inclu...  
WO/2016/112455A1
Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds...  
WO/2016/107603A1
The present invention relates to a compound of formula (V), preparation method therefor and pharmaceutical applications thereof. Specifically, the present invention relates to derivatives represented by the general formula (V), preparati...  
WO/2016/108249A1
Disclosed herein are novel five membered heterocyclic compounds of Formula (I) wherein, X is S or SO2; n is 0, 1; m is1 or 2; Y is N, O or S; R2 independently represents H or alkyl or halo selected from -CI, -F; or -CF3, or -OH or-NH2 or...  
WO/2016/104317A1
The present invention addresses the problems of providing a polymerizable compound which, when added to a polymerizable composition, has high storage stability without causing any crystal precipitation, etc. and of providing a polymeriza...  
WO/2016/101118A1
An amidoethyl azole compounds are provided as antagonists of orexin receptors. The compounds may be used for treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.  
WO/2016/097626A1
The invention relates to novel compounds, to the synthesis method thereof and to the use of same in medicine and in cosmetics. The invention relates to novel compounds, ligands that modulate RAR receptors.  
WO/2016/090491A1
Described herein is a contrast agent for administration to a subject. The contrast agent includes a targeting portion that includes a hydrazide functional group; a metal ion bound to a metal-complexable portion; and a linker joining the ...  
WO/2016/092573A1
The present invention relates to a new process for the preparation of Tetraconazole or one of its optically active isomers by means of the fluorination of 2- (2,4- dichlorophenyl) -3- (1H-1, 2, 4-triazol-1-yl) propan-1-ol.  
WO/2016/090495A1
The present invention is related to a compound that includes (a) α-L-iduronidase (IDUA), a fragment, or analog thereof and (b) a dendrimeric targeting moiety, for example, a dendrimeric targeting moiety including Angiopep-2. In certain ...  
WO/2016/094659A1
A compound of Formula II, or a salt, ester, solvate, hydrate or prodrug thereof: where: X1 is a branched or unbranched C1-10 alkyl, (CH2)s-NH-(CH2)t, (CH2)s-0-(CH2)t, or (CH2)S-C(NH2)- (CH2)v-NH-(CH2)t,where s, t and v are each, independ...  
WO/2015/164411A9
This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.  
WO/2016/065145A2
"Reversed" carbamate based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can ...  
WO/2016/062175A1
Provided is a preparation method for 1-substituted-1H-1,2,3-triazole-4-carboxylic acid. 1-Substituted-4,5-dibromo-1H-1,2,3-triazole is added to an isopropylmagnesium chloride to obtain 1-substituted-4-bromo-1H-1,2,3-triazole by a reactio...  

Matches 651 - 700 out of 8,693