Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 30,693

Document Document Title
WO/2024/039689A1
Provided herein are compounds of formula (I) that modulate RMB39 and methods of using the compounds in RMB39-associated disorders, such as cancer (e.g., renal cell carcinoma).  
WO/2024/037608A1
Provided is a PRMT5 inhibitor represented by formula (I), or a pharmaceutically acceptable salt, an isotopic variant, a tautomer, a stereoisomer, a prodrug, a polymorph, a hydrate or a solvate thereof. Also provided is a method for prepa...  
WO/2024/037212A1
A preparation method for isavuconazonium sulfate, comprising the following steps: dissolving an iodized salt of isavuconazolium in a reaction solvent, adding sulfuric acid to remove tert-butoxycarbonyl, removing the solvent and collectin...  
WO/2024/040259A2
Provided are thiazole derivative compounds that can reduce CD4+ IFNγ+ T cells and inhibit or reduce inflammation. Also provided are methods of treating diseases characterized by gastrointestinal tract inflammation using the compounds.  
WO/2024/039250A1
The present invention relates to a new class of methanogen inhibitors for ruminants. The invention also extends to the use of such compounds in ruminants to reduce methane production in the rumen and/or to enhance productivity in the rum...  
WO/2024/033458A1
The present invention provides new bicyclic tetrahydroazepine derivatives having the general formula (I) wherein R1, R2 and R4 are as defined herein, compositions including the compounds, processes of manufacturing the compounds and meth...  
WO/2024/034657A1
The present invention addresses the problem of providing a pharmaceutical composition for cancer treatment of colorectal cancer and/or lung cancer. The present inventors have studied compounds useful as an active ingredient for a pharm...  
WO/2024/036270A1
The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.  
WO/2024/035618A1
The invention relates to crystalline forms and processes for preparing a compound of Formula I (I) and pharmaceutically acceptable salts thereof which are useful for the treatment of bacterial infections, particularly mycobacterial infec...  
WO/2024/032529A1
Provided are a protein degradation agent and a preparation method therefor and a pharmaceutical use thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method therefor, a ...  
WO/2024/033388A1
The present invention provides new bicyclic tetrahydrothiazepine derivatives having the general formula (I) wherein Y, R1, R2 and R4 are as defined herein, compositions including the compounds, processes of manufacturing the componds and...  
WO/2024/033293A1
The present invention relates to acylhydrazides obtained in situ by enzymatic hydrolysis of the parent prodrug 2-(difluoromethyl)- or 2-(trifluoromethyl)-1,3,4- oxadiazole, in histone deacetylase 6 (HDAC6).  
WO/2024/032501A1
Provided are a compound of formula 0, a stereoisomer thereof, a tautomer thereof, a geometric isomer thereof, an enantiomer thereof, a diastereomer thereof, a racemate thereof, a polymorph thereof, a solvate thereof, a hydrate thereof, a...  
WO/2024/033479A1
The application relates to compounds of formula (B1A), (B1B), (B1C) or a salt, a solvate, a hydrate, a polymorph, a tautomer, a racemate or a stereoisomer thereof, to pharmaceutical compositions comprising such a compound, and to the com...  
WO/2024/032530A1
Provided are an aromatic heterocyclic cyclohexyl aminoalkyl piperidine derivative, a preparation method and a use thereof. Specifically, provided are a compound of formula (I), a stereoisomer thereof, a tautomer thereof or a pharmaceutic...  
WO/2024/032584A1
The present invention relates to a protein tyrosine kinase inhibitor for treating protein tyrosine kinase-mediated proliferative diseases or symptoms, such as ocular diseases and malignant tumors accompanied by pathological neoangiogenes...  
WO/2024/033389A1
The present invention provides new bicyclic tetrahydrothiazepine derivatives having the general formula (I) wherein R1, R2 and R4 are as defined herein, compositions including the compounds, processes of manufacturing the compounds and m...  
WO/2024/034565A1
Provided is a compound represented by formula (I-1a) or the like, or a salt thereof. [In formula (I-1a), R1 represents a substituted or unsubstituted C1-6 alkyl group, a substituted or unsubstituted C2-6 alkenyl group, or the like; R2 re...  
WO/2024/033457A1
The present invention provides new bicyclic tetrahydrothiazepine derivatives having the general formula (I) wherein R1, R2 and R4 are as defined herein, compositions including the compounds, processes of manufacturing the componds and me...  
WO/2024/029489A1
Provided herein are compounds and compositions useful in inhibiting a receptor tyrosine kinase, KIT. The compounds and compositions provided herein are useful for the prevention or treatment of one or more KIT mediated diseases or cond...  
WO/2024/031089A1
The present disclosure relates to compounds of Formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, useful in the treatment of treating viral infections, for example, coronaviridae infections.  
WO/2024/028533A1
The present invention relates to compounds containing a 2-(pyrrolidin-1-yl)thiazole carbon backbone with a structure described in general formula (5). (5) Wherein R1 = H, methyl, ethyl; R2 = benzyl, (3-indolyl)methyl; R3 = 3-indolyl, ary...  
WO/2024/028243A1
The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description, Formula...  
WO/2023/235305A3
The invention provides novel sulfonyl cyclic derivatives, and compositions and methods of preparation and use thereof, that are useful in treating various diseases and disorders related to TRPML activities such as lysosome storage diseas...  
WO/2024/028169A1
The present invention relates to novel thiophenolic compounds (I) which are useful in the treatment of proliferative and/or hyper-proliferative diseases. Preferably, the compounds of the present invention are endowed with inhibitory acti...  
WO/2024/030633A1
Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulat...  
WO/2023/129564A9
Provided herein are compounds (e.g., compounds of Formulae (I)), and pharmaceutically acceptable salts, stereoisomers, tautomers, isotopically labeled derivatives, solvates, hydrates, polymorphs, co-crystals, and prodrugs thereof, pharma...  
WO/2024/028711A1
The present invention concerns a process for the preparation of isavuconazonium monosulfate, the process allowing to obtain isavuconazonium monosulfate as a isolated powder in good yield, with high HPLC purity (> 95%) and the proper amou...  
WO/2024/029613A1
Provided is a compound useful as an active ingredient in a pharmaceutical composition for treating pancreatic cancer. The present inventors carried out investigations with regard to compounds useful as an active ingredient in a pharmac...  
WO/2024/030651A1
The present disclosure provides a compound of Formula (I'), or a pharmaceutically acceptable salt thereof and its use in, e.g. treating a condition, disease, or disorder in which inhibiting GPX4 in a subject is of therapeutic benefit, sp...  
WO/2024/026262A1
Provided herein are compounds and compositions thereof for modulating IRAK3. In some embodiments, the compounds and compositions are provided for treatment of cancer.  
WO/2024/022519A1
Provided are a compound of formula (I) or a pharmaceutically acceptable salt thereof as a USP1 inhibitor and a pharmaceutical composition comprising the compound or the pharmaceutically acceptable salt thereof. The compound and the pharm...  
WO/2024/023330A1
The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof; wherein X1 is CR7 or N, X2 is CR8 or N, X3 is CR9 or N and wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the claims, as well...  
WO/2024/020517A1
Provided herein are compounds of formula (II) and formula (I) that are inhibitors of QPCTL and QPCT: (II) & (I) Also provided are pharmaceutical compositions comprising the compounds, as well as the compounds for use in methods for the t...  
WO/2024/017306A1
Disclosed are a sulfur-containing heteroaromatic ring compound, a pharmaceutical composition thereof, and a use thereof. Specifically disclosed are a compound as represented by formula (I), a pharmaceutically acceptable salt thereof, a s...  
WO/2024/020084A1
Provided herein are compounds and compositions thereof for modulating IRAK4. In some embodiments, the compounds and compositions are provided for treatment of inflammatory or autoimmune diseases.  
WO/2024/017247A1
The present application relates to a fluorescent dye, and in particular, to a cyanine dye, and a preparation method therefor and a use thereof. Specifically, provided is a compound having a structure as represented by general formula I, ...  
WO/2024/017897A1
The present invention relates to selective oxadiazole-based inhibitors of histone deacetylase 6 (HDAC6) and uses thereof in treating various diseases and disorders.  
WO/2024/019916A2
The present invention relates to monobactam compounds of Formula (I):(Formula (I)) and pharmaceutically acceptable salts thereof. The present invention also relates to compositions which comprise a monobactam compound of structural formu...  
WO/2024/018290A1
The present invention relates to a stable synergistic pesticidal composition capable of protecting plant propagation materials such seeds, seedlings; and plants/crops from harmful effects of seed-borne, soil borne pathogenic fungi and/or...  
WO/2024/017855A1
The invention relates to novel compounds having the general formula (I) wherein R1, R2, R3, X and Y are as described herein, composition including the compounds and methods of using the compounds.  
WO/2024/015569A2
Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with abnormal levels of amino acids by modulation of SLC6A19 transport.  
WO/2024/015497A1
This disclosure relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, in which all of the variables in Formula (I) are as defined in the application. The compounds of this disclosure are capable of inhibiting ...  
WO/2024/015425A1
Disclosed are compounds of Formula (I), including all stereoisomers, N-oxides, and salts thereof, agricultural compositions containing them and their use as herbicides A is a 5- or 6-membered heterocyclic ring, containing ring members se...  
WO/2024/013209A1
Disclosed herein are PCSK9 inhibitors. Also disclosed herein are methods of using PCSK9 inhibitors to treat certain diseases and disorders.  
WO/2024/015637A1
The application relates to relates to glutathione peroxidase 4 (GPX4) inhibitors of the general Formulae I and II which induce ferroptosis in a cell and are useful for the treatment of cancer.  
WO/2024/009215A1
Provided herein are novel compounds, e.g., those of Formula (I), as GCN2 inhibitors. Also provided are pharmaceutical compositions including one or more of the novel compounds, and pharmaceutical uses thereof. Compounds provided herein c...  
WO/2024/008941A1
Compounds of Formula (I): wherein R1, R2, R3, R4 and are as defined in the description. Medicaments.  
WO/2024/010050A1
[Problem] The purpose of the present invention is to provide a compound that prevents internal elemental deterioration of an organic EL element, that, in order to significantly improve light-extraction efficiency, does not affect materia...  
WO/2024/009283A1
Angiotensin AT2 receptor antagonists have been clinically validated for the treatment of chronic neuropathic pain. We discovered a series of lead compounds comprising a trisubstituted heterocyclic core that show high in vitro (sub-nanomo...  

Matches 1 - 50 out of 30,693