Heterocyclic Compounds

Matches 151 - 200 out of 30,910	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2024/017897A1	1,3,4-OXADIAZOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS The present invention relates to selective oxadiazole-based inhibitors of histone deacetylase 6 (HDAC6) and uses thereof in treating various diseases and disorders.
WO/2024/019916A2	CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS The present invention relates to monobactam compounds of Formula (I):(Formula (I)) and pharmaceutically acceptable salts thereof. The present invention also relates to compositions which comprise a monobactam compound of structural formu...
WO/2024/018290A1	STABLE SYNERGISTIC PESTICIDAL COMPOSITION The present invention relates to a stable synergistic pesticidal composition capable of protecting plant propagation materials such seeds, seedlings; and plants/crops from harmful effects of seed-borne, soil borne pathogenic fungi and/or...
WO/2024/017855A1	NOVEL ISOTHIAZOL-3-YL AND ISOXAZOL-3-YL SULFONAMIDE COMPOUNDS The invention relates to novel compounds having the general formula (I) wherein R1, R2, R3, X and Y are as described herein, composition including the compounds and methods of using the compounds.
WO/2024/015569A2	SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with abnormal levels of amino acids by modulation of SLC6A19 transport.
WO/2024/015497A1	TYROSINE KINASE 2 INHIBITORS AND USES THEREOF This disclosure relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, in which all of the variables in Formula (I) are as defined in the application. The compounds of this disclosure are capable of inhibiting ...
WO/2024/015425A1	HERBICIDAL BENZOXAZINES Disclosed are compounds of Formula (I), including all stereoisomers, N-oxides, and salts thereof, agricultural compositions containing them and their use as herbicides A is a 5- or 6-membered heterocyclic ring, containing ring members se...
WO/2024/013209A1	PCSK9 INHIBITORS AND METHODS OF USE THEREOF Disclosed herein are PCSK9 inhibitors. Also disclosed herein are methods of using PCSK9 inhibitors to treat certain diseases and disorders.
WO/2024/015637A1	GLUTATHIONE PEROXIDASE 4 (GPX4) INHIBITORS FOR THE TREATMENT OF CANCER The application relates to relates to glutathione peroxidase 4 (GPX4) inhibitors of the general Formulae I and II which induce ferroptosis in a cell and are useful for the treatment of cancer.
WO/2024/009215A1	NOVEL COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF Provided herein are novel compounds, e.g., those of Formula (I), as GCN2 inhibitors. Also provided are pharmaceutical compositions including one or more of the novel compounds, and pharmaceutical uses thereof. Compounds provided herein c...
WO/2024/008941A1	NEW SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS Compounds of Formula (I): wherein R1, R2, R3, R4 and are as defined in the description. Medicaments.
WO/2024/010050A1	AMINE COMPOUND, AND ORGANIC ELECTROLUMINESCENCE ELEMENT, ELECTRONIC EQUIPMENT, AND ELECTRONIC ELEMENT CONTAINING SAME [Problem] The purpose of the present invention is to provide a compound that prevents internal elemental deterioration of an organic EL element, that, in order to significantly improve light-extraction efficiency, does not affect materia...
WO/2024/009283A1	AT2 ANTAGONISTS FOR NON-ADDICTIVE PAIN RELIEF Angiotensin AT2 receptor antagonists have been clinically validated for the treatment of chronic neuropathic pain. We discovered a series of lead compounds comprising a trisubstituted heterocyclic core that show high in vitro (sub-nanomo...
WO/2024/009120A1	TRIAZINE DERIVATIVES AND METHODS OF USE THEREOF Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.
WO/2024/008805A1	HETEROAROMATIC KETONES AND THEIR USE IN RADICAL AND CATIONIC POLYMERIZATION The invention relates to heteroaromatic ketones of formula (I) for radical and cationic polymerization (I), wherein the substituents A, B, C and D can be the same or different and are nitrogen or carbon, while R1 and R2, independently of...
WO/2024/007511A1	ARYLAMINE COMPOUND, ORGANIC ELECTROLUMINESCENT DEVICE, AND ELECTRONIC APPARATUS The present application provides an arylamine compound, an organic electroluminescent device comprising same, and an electronic apparatus. The arylamine compound of the present application contains benzocarbazole and benzoxazole groups a...
WO/2024/008166A1	α,β-UNSATURATED AMIDE COMPOUND, AND PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF Provided in the present invention are an α,β-unsaturated amide compound, and a preparation method therefor, and a pharmaceutical composition and the use thereof. Specifically, provided in the present invention is a compound as represen...
WO/2024/006916A1	AZETIDINYL PYRIMIDINES AND USES THEREOF AS JAK INHIBITORS Provided herein are compounds useful as inhibitors of Janus kinase (JAK) proteins and in treating JAK-related diseases.
WO/2024/003408A1	SMALL-MOLECULE INHIBITORS OF THE FRS2-FGFR INTERACTION The invention relates to a compound of the general formula (100) wherein Y is O or S, X is N or CH, L is a linker selected from formula (I), a C1-C4 alkyl, a C1-C3 amine, a C1-C3 amide, and a C1-C3 amide-ether, wherein Q is N or CH, and ...
WO/2024/002328A1	NITROGEN-CONTAINING COMPOUND AND USE THEREOF Provided are a nitrogen-containing compound and use thereof. Specifically, provided is a nitrogen-containing compound represented by formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof, a met...
WO/2024/002377A1	CLASS OF PRMT5 INHIBITORS AND USE THEREOF Provided is a class of compounds with methyltransferase inhibitory activity. Specifically, provided is a class of compounds with PRMT5 inhibitory activity. The compounds can be used for preparing a pharmaceutical composition for treating...
WO/2024/000067A1	PYRAZOLE DERIVATIVES FOR THE INHIBITION OF PHAGOCYTOSIS There is provided a method of treating an immune cytopenia in a subject in need thereof, the method comprising administering a therapeutically effective amount of a compound of formula (I) wherein R1, R2, R3 and R4 are as defined herein.
WO/2024/005548A1	ISOXAZOLINE DERIVATIVE COMPOUND AND INSECTICIDAL COMPOSITION COMPRISING SAME The present invention relates to a novel isoxazoline derivative compound and an insecticidal composition comprising same as an active ingredient, wherein the insecticidal composition can exhibit excellent insecticidal effects against var...
WO/2024/006881A1	WEE1 DEGRADING COMPOUNDS AND USES THEREOF Provided herein are compounds and compositions thereof that reduce WEE1 kinase protein levels. In some embodiments, the compounds and compositions are provided for treatment WEE1 associated diseases such as cancer.
WO/2024/003259A1	TEAD INHIBITORS The present invention covers heterocyclic compounds of general formula (I): Formula (I), wherein (I'), Formula (I') represents a heterocyclic ring, said compound of general formula (I) being selected from the group consisting of: Formula...
WO/2024/005578A1	NOVEL INDENONE DERIVATIVES AND USES THEREOF The present invention relates to novel indenone derivatives, isomers thereof or pharmaceutically acceptable salts thereof, and uses thereof. The indenone derivatives according to the present invention may be advantageously used for (i) t...
WO/2024/006742A2	NRF2 PROTEIN DEGRADERS The present disclosure provides compounds represented by Formula A-I: and the salts or solvates thereof, wherein R1, R2a, R2b, R2c,R3, R4a, R4b, >R4c, R4d, L, X, Y, and B1 are as defined in the specification. Compounds having Formula I a...
WO/2024/002223A1	HETEROCYCLIC DERIVATIVE AS INHIBITOR, METHOD FOR PREPARING SAME, AND USE THEREOF The present invention relates to a heterocyclic derivative as an inhibitor, a method for preparing same, and use thereof. In particular, the present invention relates to a compound represented by general formula (I), a method for prepari...
WO/2024/001839A1	HETEROAROMATIC RING COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF The present invention relates to a heteroaromatic ring compound, a method for preparing same, and use thereof. Specifically, the present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, a stereoisomer...
WO/2023/246873A1	AMINO-SUBSTITUTED HETEROARYL DERIVATIVES AND USE THEREOF Disclosed in the present application are a series of amino-substituted heteroaryl derivatives and a use thereof. In particular, disclosed are a compound represented by formula (P) and a pharmaceutically acceptable salt thereof.
WO/2023/246656A1	SOS1 PROTEOLYSIS TARGETING CHIMERA, AND COMPOSITION, PREPARATION AND USE THEREOF The present invention belongs to the technical field of medicinal chemistry, and relates to an SOS1 proteolysis targeting chimera and a composition, a preparation and the use thereof. Specifically, the general formula structure of the ch...
WO/2023/246677A1	INDOLE-PHENYLPIPERIDINE COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF The present application relates to the technical field of chemical drugs, and particularly, to a compound represented by general formula (I), a racemate thereof, an isomer thereof or a pharmaceutically acceptable salt thereof as a comple...
WO/2023/250399A1	TREX1 INHIBITORS AND USES THEREOF Described herein are compounds of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds for inhibiting three prime repair exonuclease 1 (...
WO/2023/247563A1	CATALYST A compound of formula (I-A), R1 in each occurrence is selected from H, optionally substituted C1-12 alkyl and optionally substituted C6-20 aryl; R2 in each occurrence is selected from optionally substituted C1-12 alkyl and optionally sub...
WO/2023/250083A1	SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecule compounds having a 6,6-heterocyclic structure (e.g., compounds having a naphthyridine, pyrido-pyridazine, pyrido...
WO/2023/247670A1	NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS The present invention provides compounds of formula (I) CB (I) or pharmaceutically acceptable salts thereof, wherein R3 to R5, R4a, B and C are as described herein, compositions including the compounds, processes of manufacturing the com...
WO/2023/248871A1	HETEROARYL COMPOUND AND PEST CONTROL AGENT Provided are a compound represented by formula (I), etc. (wherein: Z represents an oxygen atom, etc.; R1, R2, R3 and R4 each independently represent a hydrogen atom or a substituted or unsubstituted C1-6 alkyl group; Y1 and Y2 each indep...
WO/2023/247293A1	ISOXALIDINE DERIVATIVES AS HERICIDAL COMPOUNDS The present invention relates to compounds of Formula (I), or an agronomically acceptable salt of said compounds wherein A1, A2, A3, X1, R3, R4, R5, R6 are as defined herein. The invention further relates to herbicidal compositions which...
WO/2023/247489A1	N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)- QUINOLINE-4-CARBOXAMIDES Compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, wherein X1, R1, R2, R3, R4, R5, and R6 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use...
WO/2023/246944A1	SUBSTITUTED 4-AMINOISOINDOLINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF The present invention relates to a substituted 4-aminoisoindoline compound, a preparation method therefor, a pharmaceutical composition thereof, and use thereof. The compound has a structure represented by formula (I). Specifically, the ...
WO/2023/246924A1	BENZOTHIAZOLE COMPOUND AND USE THEREOF The present invention relates to a benzothiazole compound represented by formula (I), or a pharmaceutically acceptable salt, solvate, hydrate, polymorph, eutectic, tautomer, stereoisomer, or prodrug thereof. The present invention further...
WO/2023/246872A1	HETEROCYCLIC COMPOUND AS TAAR1 LIGAND AGONIST Provided are a heterocyclic compound used as a TAAR1 agonist, a preparation method of the compound, a pharmaceutical composition containing the compound, and a use of the compound as a TAAR1 agonist in preventing and/or treating various ...
WO/2023/250181A1	TRIAZOLE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR D Provided is a compound having the structure of Formula (1) or a pharmaceutically acceptable salt, hydrate, solvate or isotope thereof, wherein A, B, Ri, R2, R3, R4, R5, R6, R7, m, 11, p, and y are as defined herein, for use in methods fo...
WO/2023/247301A1	HERBICIDAL COMPOUNDS The present invention relates to compounds of Formula (I), or an agronomically acceptable salt of said compounds wherein A1, A2, A3, X1, R3, R4, are as defined herein. The invention further relates to herbicidal compositions which compri...
WO/2023/249228A1	NOVEL COMPOUND AND USE THEREOF FOR TREATMENT OF AUTOIMMUNE DISEASES The present invention relates to a novel compound and use thereof for the treatment of autoimmune diseases. A pharmaceutical composition, for the treatment or prevention of an autoimmune disease, comprising the novel compound of the pres...
WO/2023/250439A1	TREX1 INHIBITORS AND USES THEREOF Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds for inhibiting three prime repair exonuclease 1 ("TREX1").
WO/2023/247487A1	SOLID-STATE FORMS OF N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)- 6-MORPHOLINOQUINOLINE-4-CARBOXAMIDE Solid-state forms of N-(2-(4-cyanothiazolidin-3-yl)-2-oxoethyl)-6- morpholinoquinoline-4-carboxamide; corresponding pharmaceutical compositions; uses to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated c...
WO/2023/247358A1	HERBICIDAL IMIDAZOLE-CONTAINING COMPOUNDS The present invention relates to compounds of Formula (I) or an agronomically acceptable salt of said compounds wherein A, Q, R1, R2, R4 and m are as defined herein. The invention further relates to herbicidal compositions which comprise...
WO/2023/247360A1	PESTICIDALLY ACTIVE FUSED BICYCLIC HETEROAROMATIC COMPOUNDS Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.
WO/2023/246925A1	ESTER COMPOUNDS AND USE THEREOF Disclosed in the present invention are compounds or pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers or isotope labeled compounds thereof. The compounds are as shown in formula (I)....

Matches 151 - 200 out of 30,910	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >