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JPS5817195B2 |
Novel pteridines of formula (I), wherein R is a lower alkyl group, substituted with one or more halogen atoms, and R1 and R2 are the same or different and each is a lower alkyl group or R1 and R2, together with the carbon atom in the pte...
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JPS5838285A |
PURPOSE: To prepare the titled compound which is a methyl-transfer coenzyme, in high purity, by reacting (6RS)-5,6,7,8-tetrahydro-L-folic acid with formaldehyde, followed by reduction and precipitation. CONSTITUTION: (6RS)-5,6,7,8-Tetrah...
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JPS5829785A |
Diglycidyl-substituted pteridine compounds of the general formula: I wherein n is the whole number 1 or 2, R2 and R2 are the same or different, and are either hydrogen, a hydrocarbon radical, or together form a 5- or 6-membered carbocycl...
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JPS58436B2 |
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JPS5738597B2 |
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JPS57106647A |
Derivatives of known bio-affecting carboxylic acids, their non-toxic pharmaceuticaily acceptable acid addition salts and N-oxides as well as processes for preparing those novel derivatives are disclosed. Those derivatives having the stru...
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JPS5727087B2 |
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JPS5770850A |
A process for the preparation of N-(D)-ribityl-2-phenylazo-4,5-dimethylaniline (I), wherein 1. in the case of pure or virtually pure (D)-ribose (III) (a) the latter is reacted with 3,4-dimethylnitrobenzene (IVa) or 3,4-dimethylaniline (I...
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JPS5767512A |
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JPS5716996B2 |
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JPS577638B2 |
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JPS574990A |
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JPS5652897B2 |
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JPS56152482A |
PURPOSE: Vitamin B2, after dissolved in an alkaline aqueous system, is neutralized with an acidic substance in the presence of a gummy substance and a dispersing agent to make the aqueous system neutral to acidic, whereby vitamin B2 read...
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JPS56133661A |
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JPS56110689A |
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JPS5541234B2 |
The preparation of N5-methyltetrahydrohomofolic acid and alkali metal salts thereof is from homofolic acid starting material (HFA) by catalytic reduction with platinum oxide in the dark under hydrogen at a slight overpressure to produce ...
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JPS5541207B2 |
A method of inhibiting methotrexate sensitive leukemia L1210 and methotrexate resistant leukemias derived from L1210, such as variants L1210/FR-8, L1210/M-46-R, L1210/C-95, and L1210/M-66-3A in mice. This method produces optimum results ...
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JPS5589748A |
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JPS555517B2 |
Trioxopteridine derivatives of the formula , WHEREIN R1 is a normal alkyl group having 0 to 6 hydroxyl groups and R2 is hydrogen or a normal lower alkyl group having 0 to 5 hydroxyl groups, are prepared by catalytically hydrogenating a 6...
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JPS5439398B2 |
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JPS5439399B2 |
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JPS5439397B1 |
1363064 Pyrimidines and pteridines WELLCOME FOUNDATION Ltd 13 July 1971 [27 July 1970] 36289/70 Heading C2C Novel compounds of the Formula IV wherein Z is C 1-4 alkyl optionally having a methylene group attached to the ring system or hyd...
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JPS54115337A |
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JPS54100394A |
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JPS5414120B1 |
1303919 Pyrimido-quinoxalines BAYER AG 9 July 1971 [11 July 1970] 32356/71 Heading C2C Novel compounds I: (in which R is H or a substituted or unsubstituted aliphatic or cycloaliphatic hydrocarbon radical) are prepared by reacting compou...
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JPS5462318A |
The use of specific known 4-alkylaminopyrimido-(4,5-b)quinoxaline- 5,10-dioxides for combating bacteria which damage plants. The compounds of the general formula in which R represents methyl or ethyl, have strong bactericidal effects. Th...
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JPS53124296A |
PURPOSE: Penicillin derivatives 2 (R is C1-4 alkyl; X1 and X2 are H, OH, amino, halogen) and their salts, e.g. potassium 6-[D-2-(2-ethylamino-8-ethyl-7(8H)pteridinone-6-carboxamido)
-2-phenylacetamido] penicillanate.
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JPS5337879B2 |
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JPS53115814A |
The invention relates to a process for the determination of an immunologically active material in a sample. The process is characterised in that the sample is brought together with a receptor which is able to bind the immunologically act...
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JPS5398996A |
The present invention consists of three process improvements in the so-called multi-step Piper-Montgomery process designed especially to produce the antifolate methotrexate which is closely related to both aminopterin and folic acid. 2,4...
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JPS5382800A |
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JPS5377097A |
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JPS5353696A |
Derivatives of folic acid wherein the alpha -carboxyl group of the glutamyl moiety is substituted with a radical which is capable of being radioiodinated, such as, substituted and unsubstituted tyrosyl and histidyl. The radioiodinated de...
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JPS5310155B2 |
1434299 Riboflavine AJINOMOTO CO Inc 26 Oct 1973 [26 Oct 1972] 49952/73 Heading C2V Riboflavine is obtained by culturing riboflavine-producing, artificially induced mutants of Bacillus subtilis, the parent strains of which are unable to ...
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JPS5295698A |
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JPS5291892A |
New, N, N-dioxide derivs. are cpds. of formula (I). In this formula, R1 and R2 are H, lower alkyl, phenyl, -CHO, -CN, -CH=N(right arrow O) -CH3 or -CHR3R4; R3 is OH, lower alkoxy, lower alkylthio, -COCH3, -cOOR5 or -CONR6R7; R4 is H, low...
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JPS5283800A |
PURPOSE: Pteridine derivatives of formula I(R1 is H, lower alkyl, dialkylaminoalkyl, chloroalkyl, hydroxyalkyl; R2, R3 are H, halogen, lower alkyl, lower alkoxy, CF3), such as 1-(m-chlorophenyl)-3-ethyl-2,4-(1H, 3H)-pteridinedione.
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JPS5283699A |
PURPOSE: Pteridine derivative I(R1 and R2 are H, halogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfonyl, nitro, trifluoromethyl; R is H or lower alkyl), e.g. 2-oxo-4-phenyl-1H-pteridine.
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JPS5283339A |
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JPS5281086A |
A selective adsorbent for the separation of organic material from solution comprises adsorbent particles and magnetic particles embedded in a porous matrix of organic polymeric material, the porosity of the matrix being selected so as to...
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JPS5271495A |
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JPS5220999B2 |
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JPS5259188A |
PURPOSE: Alkoxy-substituted puteridine derivatives of formula I (one of R3 and R4 is H, and the other ia H or R; R is alkoxy); for example, 6-methoxy-1methyl-2-oxo-4-phenylputeridine.
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JPS5251395A |
PURPOSE: Pteridine derivatives of formula I (R1 is H, lower alkyl, dialkylaminoalkyl, chloroalkyl, hydroxyalkyl; R2, R3 are H, halogen, lower alkyl, lower alkoxy, CF3);for example, 1-(m-chlorophenyl)-3-Et-2,4 (1H, 3H) pteridinedione.
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JPS51138700A |
PURPOSE: Pteridine derivatives of formula I where R1 and R2 are H, halogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsufonyl, nitro or trifluoromethyl; R is H or lower alkyl.
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JPS5143994A |
Novel folic acid derivatives useful for radioassaying folic acid and its metabolites in biological liquids are prepared from pteroyl- gamma -glutamyl-tyrosines by iodination with I125 or I131.
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JPS519760B2 |
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JPS50126700A |
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JPS50101385A |
A N6-substituted-9-[3-(4-phenyl-piperazino)-propyl]-adenine of the formula (I) wherein R1 is hydrogen or a lower alkyl radical, and R2 is a lower alkyl radical, a lower alkyl radical substituted by at least one of phenyl and hydroxyl, a ...
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