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JPH07149731A |
PURPOSE: To obtain a compound of high purity which is useful as a synthetic intermediate for semisynthetic penicillin by allowing an inexpensive, readily available hydantoin unsubstituted in the 5-position to be chlorinated, then reactin...
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JPH07149732A |
PURPOSE: To easily obtain compound of high purity which is useful as a synthetic intermediate for semisynthetic penicillin by allowing an inexpensive, readily available hydantoin substituted with a halogen in the 5-position to react with...
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JPH0745411B2 |
Amines (I) are acylated with carboxylic acid 2-benzothiazolylthio esters (A) by using (I) in the form of an acid addition salt. Pref. (I) is a 7-aminocephalosporin or 6-aminopenicillin deriv. (I) and (A) are of formulae: R1 = H or standa...
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JPH0737462B2 |
A process for the synthesis of penems from azetidinones via 1-aza-4,5-dithiabicyclo[4.2.0]oct-2-en-8-one-2-carboxylate esters.
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JPH0737463B2 |
Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(1S-oxo-3R-thiolanylthio )-2-penem-3-carboxylic acid and 5R,6S-6-(1R-hydroxyethyl)-2-(1R-oxo-3S-thiolanylthio )-2-penem-3-carboxylic acid, and pharmaceutically-acceptable salts and in vivo hydro...
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JPH0735383B2 |
New antibacterial agents are compounds of formula wherein R is hydrogen atom or C1-C4 alkyl group optionally substituted from halogen atom or hydroxy group optionally protected, A is Z, ZOCO or ZCO residue, wherein Z is phenylene, naphth...
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JPH0735384B2 |
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JPH0730082B2 |
alpha -Bromo diethylcarbonate is used to prepare ethylcarbonyloxyethyl esters of penicillins and caphalosporins. The amino group in ampicillin can first be protected by reaction with an acetoacetate derivative and the protecting group re...
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JPH0730057B2 |
There is described a process for the manufacture of a compound of the formula IV wherein R1 is lower alkyl, lower alkanoyl, lower alkenyl or the group -CH2COOR2 or -C(CH3)2COOR2 and R2 is a readily cleavable group, by reacting a compound...
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JPH0720971B2 |
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JPH0714944B2 |
PURPOSE:To effect high-efficient concentration of beta-lactam solution useful as a medicine with increased leakage and permeation rate by utilizing a specific loose reverse osmosis membrane to remove low-molecular-weight compounds from a...
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JPH0710868B2 |
Carbapenem derivatives useful as antibacterial agents have the formulawherein:X represents a hydrogen atom or a methyl group: andY represents a group of the formula:in which:Z represents an oxygen atom or two hydrogen atoms;R' represents...
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JPH0733719A |
PURPOSE: To provide a novel compound which, when administered to warm- blooded animals, induces a bio-affecting response characteristic of the original acid from which the compound is derived and is less irritating and more excellent in ...
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JPH075463B2 |
Penem compounds represented by the general formula: (wherein R denotes hydrogen or allyl group, A denotes oxygen atom or methylene group and B denotes methylene, ethylene or carbonyl group) and pharmacologically acceptable salts thereof ...
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JPH075605B2 |
There are provided compounds of formula wherein R is hydrogen atom or C1-C3 alkyl group optionally substituted from halogen atom or hydroxy group optionally protected, and Q(+) represents a group wherein R1, R2 and R3 are each either: (i...
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JPH072750B2 |
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JPH072869A |
PURPOSE: To prepare a sterile sodium amoxycillin in an industrial scale without the precipitate. CONSTITUTION: A process for the preparation of sterile sodium amoxycillin characterized in that a solution of amoxycillin trihydrate in a mi...
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JPH06104671B2 |
PCT No. PCT/US91/01765 Sec. 371 Date Sep. 28, 1992 Sec. 102(e) Date Sep. 28, 1992 PCT Filed Mar. 15, 1991.A simplified method for making the chloromethyl ester of sulbactam in which the tetraalkylammonium sulbactam salt is not dried and ...
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JPH06104672B2 |
An efficient, multistep process for the synthesis of certain 6-(1-hydroxyethyl) 2-substituted penem antibiotics from 2-[4R-(triphenylmethylthio)-3S-(1R-(dimethyl-t-butyl silyloxy)ethyl)-2-azetidon-1-yl]acetic acid esters.
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JPH06104670B2 |
PCT No. PCT/DK86/00090 Sec. 371 Date Apr. 28, 1987 Sec. 102(e) Date Apr. 28, 1987 PCT Filed Aug. 18, 1986 PCT Pub. No. WO87/01371 PCT Pub. Date Mar. 12, 1987.The present invention relates to a new and improved method for the preparation ...
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JPH06345773A |
PURPOSE: To obtain the subject compound useful as a synthetic intermediate for penem compounds known as agents for the treatment of microbism by reacting a penem allyl derivative with an allyl receptor in the presence of a bivalent palla...
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JPH06102649B2 |
A new process involving novel intermediates for the synthesis of antibiotics comprises: 1. acylation of a dianion followed by reduction to introduce an arylhydroxymethyl or alkylhydroxymethyl group; alternatively, alkylation followed by ...
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JPH0699387B2 |
Compounds of formula I wherein R1 and R2 is each H, halo or an organic group, R3 is H or organic group, n=1 or 2, M is a heavy mono- or divalent metal, or M2A wherein M2 is a heavy divalent metal and A is an organic or inorganic group, a...
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JPH0696579B2 |
Compounds of the general formula I:and their pharmaceutically acceptable salts and in vivo hydrolysable esters. in whichone of R1 and R2 denotes hydrogen,the other of R' and R2 denotes an unsubstituted or substituted five-membered hetero...
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JPH0696580B2 |
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JPH0692417B2 |
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JPH0689005B2 |
beta-Lactamase inhibitors which are 6-alpha- and 6-beta-(aminomethyl) and (1-aminoethyl)pencillanic acid 1,1-dioxides, said aminomethyl compounds optionally substituted on amino nitrogen with benzyl, hydroxybenzyl, picolyl or phenethyl; ...
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JPH0689004B2 |
Compounds of formula (II) …… having antibacterial and beta-lactamase inhibitory properties and in which R<1> and R<2> represent hydrogen or an optionally substituted hydrocarbon or heterocyclic group, and R<3> represents hydrogen or ...
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JPH06509818A |
There is provided a process for preparing a compound of formula (I) wherein R is H or a hydroxy protecting group, R2 is an organic residue and R3 is H or a nitrogen protecting group, which process comprises reacting together a compound o...
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JPH06298769A |
PURPOSE: To obtain the subject composition useful for preventing and treating streptococcal of fish, having a specific structure. CONSTITUTION: The objective ester of formula I (R is H, alkyl, lower alkoxy, benzylcyxy, alkanoyloxyalkyl, ...
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JPH06509119A |
The present invention relates the removal of t-butyldimethylsilyl protecting groups in the preparation of penems which are useful antibiotics. The invention provides a process for preparing a compound of the formula I: I wherein R is a f...
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JPH0670059B2 |
Compounds of formula I I wherein, R1 represents hydrogen or methyl, R2 represents hydrogen or lower alkyl, lower alkenyl, lower alkynyl or cycloalkyl each of which may be unsubstituted or mono- or poly-substituted by amino, mono- or di(l...
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JPH06234676A |
PURPOSE: To enable efficient and inexpensive removal of silyl groups by reaction of a specific silyl ether compound with an acidic ammonium fluoride in an organic solvent whereby an alcohol of high optical purity is obtained. CONSTITUTIO...
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JPH0662634B2 |
Therapeutically active organic compound exhibiting at least one group comprising a structure -S min -S sec -R, wherein the group -S sec -R is defined by R being an organic group comprised in a physiologically acceptable compound H-S sec ...
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JPH0662631B2 |
beta -Lactam antibiotics of the formula in which A is a hydrogen atom, an optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl group, a substituted or unsubstituted phenyl ring, a polycyclic aromatic ring or an optionally substit...
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JPH06220058A |
PURPOSE: To obtain the subject compound useful as an antimicrobial agent by reacting specific two compounds in the presence of a metal salt. CONSTITUTION: A compound of formula I [R1 is H or carboxyl-protecting group; R2 and R3 are H, lo...
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JPH06211871A |
PURPOSE: To provide the novel compounds useful in the treatment of bacterial infection in mammal including human. CONSTITUTION: By removing protection of a compound of formula V [wherein R10 is R2 or an amino protecting group; R13 is R1 ...
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JPH0655676B2 |
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JPH0649705B2 |
Kinetically controlled triaryl phosphite halogen compounds of the formula wherein X is Cl or Br, and Z is hydrogen, halo, C1-C4 alkyl or C1-C4 alkoxy, are used to effect a) halogenation of a C-6 or C-7 accylamine penicillin or cephalospo...
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JPH0649706B2 |
Kinetically controlled triaryl phosphite halogen compounds of the formula wherein X is Cl or Br, and Z is hydrogen, halo, C1-C4 alkyl or C1-C4 alkoxy, are used to effect a) halogenation of a C-6 or C-7 accylamine penicillin or cephalospo...
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JPH0649708B2 |
Antibacterially active and animal growth-promoting novel beta -lactam compounds of the formula in which R1 represents the radical Y representing N or CR9, or Y-R7 representing >C=O or >C=N-R7, Z representing O, S, or NR10, and R2 represe...
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JPH0645624B2 |
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JPH0637459B2 |
Intermediates and a stepwise process for the conversion of D-methionine or certain of its derivatives to optically active compounds of the formula wherein R is (C1-C3)alkyl, phenyl or tolyl. The latter compounds are in turn useful as an ...
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JPH0637496B2 |
A process is disclosed for the deprotection of allylic esters and ethers. The process comprises reacting an allyl ester of a carboxylic acid or an allyl ether of a phenol with pyrrolidine or piperidine and a catalytic amount of an organi...
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JPH0635463B1 |
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JPH0631254B2 |
Penems of the formula I in which R is hydrogen or an organic radical, G is hydroxyloweralkyl and X is hydrogen, a pharmaceutically acceptable salt forming group or a metabolisable ester group, or a protecting group are disclosed. Process...
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JPH0631256B2 |
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JPH0631253B2 |
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JPH0631255B2 |
Improved processes for the production of 6-hydroxyethyl-2-substituted thio penem-3-carboxylates which eliminate the step of using a silver reagent are disclosed.
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JPH0613525B2 |
Anhydrous crystalline (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(2-carboxyprop-2-ox
imino)acet amido]-3-(1-pyridiniummethyl)-3-cephem-4-carboxylate and a process for its preparation, a pharmaceutical formulation which is active against ba...
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