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Matches 151 - 200 out of 2,204

Document Document Title
WO/1999/003859A1
A compound of formula (I) wherein n is 0 or 1; m is 0 or 1; p is 0 or 1; X is oxygen or sulfur; Y is CH, N or NO; W is oxygen, H¿2? or F¿2?; A is N or C(R?2¿); G is N or C(R?3¿); D is N or C(R?4¿); with the proviso that no more than...  
WO/1998/058931A1
A process for producing $g(b)-lactam derivatives, characterized by treating a $g(b)-lactam derivative having a protected carboxyl group and represented by the general formula (1): A-COO-X (wherein A is a $g(b)-lactam derivative residue; ...  
WO/1998/048037A1
The invention relates to a method for controlling the solubility of a $g(b)-lactam nucleus having general formula (I) wherein R�0? is hydrogen or C�1-3? alkoxy; Y is CH�2?, oxygen, sulfur, or an oxidized form of sulfur; and Z is (a...  
WO/1998/046566A1
The present invention relates to novel $g(b)-lactam compounds, their pharmacologically acceptable salts and prodrugs, which exhibit antibiotic activity against a broad spectrum of organisms, especially bacteria which are resistant to con...  
WO/1998/039336A1
A process for producing exo-methylenepenam compounds of general formula (2), wherein R?1� represents a hydrogen atom, an amino group or a protected amino group; R?2� represents a hydrogen atom, a halogen atom or the like; and R?3� ...  
WO/1998/032766A1
The present invention provides substituted amino bicyclic-$g(b)-lactam penam derivatives and substituted amino bicyclic-$g(b)-lactam cepham derivatives and their diastereoisomers of general formula (I) as well as compositions containing ...  
WO/1998/032718A1
The properties of biologically active compounds, for example drugs and agrochemicals, which contain in their molecular structure one or more functional groups selected from alcohol, ether, phenyl, amino, amido, thiol, carboxylic acid and...  
WO/1998/024775A1
The invention relates to a method for producing metal complex carboxylic acid amides characterized in that a metal complex carboxylic acid mixture consisting of metal complex carboxylic acid and at least one solubilizing substance is pre...  
WO/1998/004732A1
Disclosed is a process for the synthesis of $g(b)-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.  
WO/1998/000429A1
The invention provides a process for the preparation of compounds of formula (I) wherein R?1�, R?2�, R?3�, R?4� and R?5� are as defined in the specification; and wherein any functional groups are optionally protected; and salts...  
WO/1997/049670A1
The invention concerns new catechol derivatives of the general formula (I), in which azomethine-carboxylic acid rests, azobenzene-carboxylic acid rests, benzhydrazon rests, aminobenzoic acid rests and amino acid rests or dipeptides, pyrr...  
WO/1997/047301A1
A new crystalline form of potassium clavulanate is disclosed. Also disclosed are a process for producing the new crystalline form of potassium clavulanate, pharmaceutical compositions containing it and methods of treating bacterial infec...  
WO/1997/042177A1
A new process is described for the synthesis of ureide derivatives having formula (I) where the P ring is a saturated or unsaturated nitrogen heterocycle with 5 or 6 members, possibly containing, in addition, one or more hetero-atoms cho...  
WO/1997/035029A1
Alternative process to obtain 6-amino-penicillanic acid. The process comprises the substitution of the steps of extraction with organic solvents and isolation and separation as solid material of the intermediary penicillin salt, by a cul...  
WO/1997/031922A1
It is described a process for the preparation of 2-halomethyl-penems (in particular 2-chloromethyl-penems) comprising, as intermediate step, the formation of the corresponding 2-haloacetylthio-azetidone.  
WO/1997/030984A1
Compounds that possess selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs, derivatives, or mimics of these groups, such that sialic acid and fucose or their...  
WO/1997/031006A1
Compounds that possess selection binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs, derivatives, or mimics of these groups, such that sialic acid and fucose or thei...  
WO/1997/017352A1
An efficient process for de-esterification has been provided for by application of special tetrahalogenides. By applying this process a new compound, viz. cefesone, and especially the E-isomer thereof, has been prepared.  
WO/1997/015579A1
A process for the production of a crystalline salt, e.g. sodium, of amoxicillin, in ethanol as solvent, the use of ethanol as solvent in the crystallization of a salt, e.g. sodium, of amoxicillin and a crystalline salt of amoxicillin con...  
WO/1997/012889A1
New solvates of penicillin, in particular amoxycillin glycolate has been provided for together with a simple one-step process to prepare the same.  
WO/1997/009052A1
Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vi...  
WO/1997/006172A1
Novel 3-(substituted)-3-methyl-4-thia-1-azabicyclo[3.2.0]heptane-2 -carboxylate, 4,4-dioxides of formula (I) wherein R2 is OR3 or NR4R5, which are of value for use in combination with 'beta'-lactam antibiotics to increase the effectivene...  
WO/1997/000259A1
A novel process for producing penicillin G phenyl esters represented by formula (I), or salts thereof by the reaction between a compound represented by formula (II), or a salt thereof and the compound represented by formula (IV) or a sal...  
WO/1996/040978A1
The present invention provides detectable compounds comprising a chemically-transformable first compound covalently linked to an electrochemiluminescent compound. These compounds are useful in processes and kits that monitor the status o...  
WO/1996/040156A1
Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are obtained by combining chemically a diphosph...  
WO/1996/040190A1
Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are obtained by combining chemically a diphosph...  
WO/1996/038450A1
The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which...  
WO/1996/038448A1
The compounds of formulae A-D, wherein: X is selected from the group consisting of CH2, S, and O; T is selected from the group consisting of CH2 and O; U is selected from the group consisiting of CH2, S, O, and CH(alkyl), where alkyl is ...  
WO/1996/036627A1
The present invention relates to the field of combinatorial carbohydrate chemistry and involves the modification of organic molecules and/or the synthesis of large numbers of products comprising carbohydrate and/or glycominetic entities....  
WO/1996/034846A1
Compounds of 1,3-propane diol linked structure (I), when for use in therapy, where R1 is an acyl or fatty alcohol group derived from a C12-30 preferably C16-30 fatty acid desirably with two or more cis or trans double bonds, and R2 is hy...  
WO/1996/034855A1
Compounds of structure (I), and when for use in therapy: where R1 is an acyl group derived from a C16-30 fatty acid with two or more cis or trans double bonds and particularly an n-6 or n-3 series EFA or conjugated linoleic acid, or colu...  
WO/1996/034858A1
Niacin as a compound, per se or for use in therapy, of structure (I), where B is -C(=O)- (nicotinic acid) or -CH2-O- (niacin alcohol), the "link" C which is optional is a diol or hydroxy carboxylic acid or dicarboxylic acid residue, and ...  
WO/1996/030376A1
Process for the recovery of ampicillin from a mixture containing ampicillin and 6-aminopenicillic acid (6-APA), in which a mixture of ampicillin and 6-APA, with a pH higher than 7, which apart from any solid ampicillin being present is h...  
WO/1996/028422A1
A process for the production of a halogenated 'beta'-lactam compound represented by general formula (2) which comprises replacing the hydroxyl group of a halogenated 'beta'-lactam compound represented by general formula (1) with a haloge...  
WO/1996/025417A1
A penem derivative represented by general formula (I), or a pharmacologically acceptable salt thereof, wherein R1 represents optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aralkyl, optionally substit...  
WO/1996/023797A1
Process for the recovery of a 'beta'-lactam antibiotic from a mixture containing the ammonium salt of the 'beta'-lactam antibiotic and the ammonium salt of the corresponding 'beta'-lactam core by subjecting the mixture to a physical trea...  
WO/1996/022296A1
A back extraction process in which beta-lactam antibiotics or clavulanic acid is extracted from an organic solvent phase into an aqeous medium phase, using a mixing region in which the phases are mixed rapidly under high turbulence and s...  
WO/1996/016067A1
A process for the silylation of 6-aminopenicillanic acid or 7-amino-desacetoxy-cephalosporanic acid by silylation in certain carboxylic acid esters and its use in the production of 6-alpha-aminoacyl-penicillins and 7-alpha-aminoacyl-desa...  
WO/1996/004247A1
The present invention provides a process for making a compound having a structure according to formula (I) wherein A1, A2 and A3 are independently carbon or nitrogen and R1, R3, R4 and R6 are known quinolone substituents; and wherein one...  
WO/1996/004285A1
A 6'beta'-substituted penicillanic acid of formula (XII) or a pharmaceutically acceptable salt or ester thereof, wherein A and B are each hydrogen wherein the carbon atoms to which A and B are attached are linked by a single bond, or A a...  
WO/1996/004286A1
The present invention provides processes for making compounds of the structure (Q-L1)-L-(L2-B), wherein (I) Q is a quinolone moiety; (II) B is a lactam moiety; and (III) L, L1, and L2 together comprise a linking moiety; comprising the st...  
WO/1995/034566A1
The present invention is related to compounds which inhibit pancreatic cholesterol esterase. The compounds have formula (I), wherein R1 is H or C1-6 alkyl; R2 is H or C1-6 alkyl; R3 is H or C1-6 alkyl; X is CHR6, S or O; R6 is H or C1-6 ...  
WO/1995/029182A1
Intermediates in the production of cephalosporins of formula (IA) wherein either 'alpha') Ra denotes hydrogen or a silyl group; Rb denotes a group of formula -ORe, wherein Re denotes hydrogen or alkyl; and Rc and Rd together denote a bon...  
WO/1995/026966A1
The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which...  
WO/1995/012601A1
Crystalline sodium 2'alpha'-methyl-2'beta'-(1,2,3-triazol-1-yl)-methylpenam-3'a lpha'-carboxylate-1,1-dioxide monohydrate (crystalline tazobactam sodium monohydrate) obtainable by adding to a concentrated aqueous solution of sodium 2'alp...  
WO/1995/000477A1
The invention concerns nitrates containing a disulphide group and having for instance formula (I) in which R, R', R1, R1', R2, R2', R3, R3', R4, R4', R5, R5', m, m', n, n', o, o', p, p', q and q' are as defined in claim 1, plus methods o...  
WO/1994/022819A1
A process for the preparation of a compound of formula (IVA) which process comprises subjecting a compound of formula (V), where R is an ester-forming group or carboxy-protecting group, and X and Y are hydrogen or halogen provided that a...  
WO/1994/010178A1
Compounds of formula (I) in which: R1 is hydrogen or an organic substituent group; R2 is a fused bicyclic heterocyclic ring system of general formula (a) wherein R4 and R5 are independently hydrogen or one or more substituents replacing ...  
WO/1994/006803A1
Described are penems derivatives of general formula (I) wherein R1 is chosen in the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, C3-C7 cycloalkyl, optionally protected C1-C6 hydroxyalkyle; R2 is chosen in the group consisting of car...  
WO/1994/003168A1
The use of a 5S penem compound of general formula (I) wherein n is 0 or 1, R2 is hydrogen or a substituent group, R3 is an ester- or amide-forming group, and R1 is hydrogen or an organic group linked via carbon and wherein the group -COR...  

Matches 151 - 200 out of 2,204