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JPH02275885A |
NEW MATERIAL: A compds. being an aminocarboxylic acid deriv. containing a (cyclo)alkylideneammonio group as N-terminal group represented by the formula (wherein X- is an anion from an acid HX, and R1 and R2 are a 1-16C alkyl or form a cy...
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JPH02273683A |
NEW MATERIAL: A compd. represented by formula I {wherein R1 is hydroxymethyl or (1R)-1-hydroxyethyl, R2 is (esterified) carboxyl, A is lower alkylene, R3 is groups represented by formulae II, III [R4 is H or lower alkyl and R5 and R6 are...
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JPH02273682A |
NEW MATERIAL: A compd. represented by formula I [wherein R1 is a (substd.) phenyl and R is cycloalkyl having an alkyl substituent at a 1-position, R1 is F or phenyl substd. by trifluoromethyl and R is H or an org. group]. EXAMPLE: 6β-[Z...
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JPH0251436B2 |
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JPH02270881A |
NEW MATERIAL: Compd. (their salts) of formula I [wherein A is a 1-12C alkylene, a 1-12C alkylidene, phenylene, etc.; R is formula II (wherein R2 is H, a group of formula III, etc.), formula IV, etc.; R3 is H or a 1-3C alkyl; R1 is H, a 1...
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JPH0250116B2 |
A new process is described for the preparation of penicillanic acid 1,1-dioxide by dehalogenation of 6,6-dibromopenicillanic acid 1,1-dioxide with magnesium in association with an acid.
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JPH0250117B2 |
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JPH0248525B2 |
A novel formulation of bacampicillin for oral administration is disclosed. Microcapsules comprising an acid addition salt of bacampicillin coated with a mixture of ethyl cellulose:water-soluble or water-permeable filler material are susp...
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JPH0246594B2 |
The present invention relates to a novel process for the preparation of 7 beta -amino-3- or -2-cephem-3-ol-4-carboxylic acid compound of the formula IA or the formula IB in which R@ denotes hydrogen or an amino protective group R@, R@ re...
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JPH0246198B2 |
The present invention relates to a method for concentrating a dilute aqueous solution of a β-lactam antibiotic which is readily susceptible to heat, by subjecting a dilute aqueous solution of a β-lactam antibiotic, said solution contai...
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JPH02247181A |
NEW MATERIAL:A compound expressed by formula I (R1 is H, 1-hydroxyethyl, etc.; R2 is H or protecting group; R3 and R4 are H, lower alkyl, protecting group of guanidino group, etc., or mutually linked to represent alkylene chain; R5 is H ...
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JPH02200686A |
NEW MATERIAL: The compound of formula I [R1 is 3-6C oxocycloalkyl, 3-6C (1,1-bis-1-3C alkoxy)cycloalkyl, etc.; R2 is H, 1-5C alkanoyloxy-1-3C alkyl, 1-5C alkoxycarbonyloxy-1-3C alkyl, etc.; the stereochemistry at 5-position is R, the ste...
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JPH0234953B2 |
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JPH02191283A |
NEW MATERIAL: A compd. represented by formula I [R is H, ester, etc.; R1 is H; R2 is H or acyl, R1 and R2 are combined to form a group represented by formula II (n is 5-7), X is fluoro, thiocyanate or azide but, when R is a protective gr...
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JPH0229678B2 |
Preparation of penicillanic acid 1,1-dioxide-and derivatives thereof by debromination of 6-alpha-bromo- and/or 6,6-dibromopenicillanic acid 1,1-dioxides. The debromination is effected in a water-containing medium by reduction with zinc i...
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JPH0225914B2 |
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JPH0224833B2 |
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JPH0224832B2 |
NEW MATERIAL:Compounds of formula 1 (R<1> is H, lower alkyl; lower alkoxy, lower hydroxyalkyl; R<2> is H, lower alkyl; R<3> is H, amino-protecting group; A is lower alkyl with branched chains; R<4> is H, carboxyl-protecting group) and th...
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JPH0224834B2 |
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JPH0223558B2 |
In a process for the total synthesis of thienamycin from L-aspartic acid via intermediate III: R = H, blocking group or salt cation there is disclosed a process for preparing III via wherein R is a protecting group.
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JPH0222759B2 |
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JPH0222077B2 |
A cephalosporin derivative having an antibacterial activity similar to a cephalosporin antibiotic in living bodies without affecting the intestinal bacterial colonies, a method for preparing the derivative and a pharmaceutical compositio...
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JPH0219804B2 |
Preparation of a pharmaceutical parenteral dosage unit of a lyophilized penicillin derivative in which the penicillin derivative is dissolved in water to a concentration of 100-135 mg/ml, as compared to the standard concentration of 200 ...
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JPH0219119B2 |
A process for the production of solid sodium amoxicillin comprises spray-drying a solution of sodium amoxicillin in aqueous t-butanol.
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JPH0217557B2 |
Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcephem. The 6- or 7-side-c...
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JPH02501043A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPH0296582A |
NEW MATERIAL:A compound expressed by formula I [R1 represents H or methyl; R2 represents H, (protected) OH or (protected) hydroxymethyl; R3 represents H or forms single bond together with R1; R4 represents -CH2-CH2- or -CH=CH-; R5 repres...
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JPH0253497A |
PURPOSE: To efficiently obtain mandelic acid having high optical purity by reacting a specific compound with a cultured product of a microorganism, etc., having an ability capable of asymmetrically hydrolyzing an ester bond of the compou...
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JPH027956B2 |
Crystalline 1,1-dioxopenicillanoyloxymethyl 6-(D- alpha -amino- alpha -phenylacetamido)penicillanate napsylate. The product may be prepared by reacting 1,1-dioxopenicillanoyloxymethyl 6-(D- alpha -amino- alpha -phenylacetamido)penicillan...
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JPH027957B2 |
The present invention relates to a crystalline hydrate of a salt of the antimicrobial agent 1,1-dioxopenicillanoyloxymethyl 6-(D- alpha -amino- alpha -phenylacetamido)penicillanate with p-toluenesulfonic acid, more particularly the mono-...
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JPH026758B2 |
6-Halo- and 6,6-dihalo-1,1-dioxopenicillanoyloxymethyl 6-[D-2-(2-alkoxycarbonyl-1-methylvinylamino- and 1-methyl-3-oxo-1-butenylamino)-2-phenylacetamido]-penicillan
ates and analogs; process for their conversion to sultamicillin and anal...
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JPH0236186A |
PURPOSE: To industrially and advantageously obtain the subject compound by reacting an aminopenicillanic acid with an hexamethylleniminecarboxaldhydedimethylacetal in a solvent, followed by reaction with a halomethyl pivalate in the pres...
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JPH0232082A |
PURPOSE: To stably provide the subject compound having excellent antibacterial activity against gram positive and negative bacteria by reacting a 2,3- dioxopiperazine derivative with a penicillin derivative obtained by reacting a penicil...
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JPH029884A |
NEW MATERIAL: A compound of the formula {wherein R1 is H or an amino protective group; and R is CHRaOCORb [wherein Ra is H, a 1-6C alkyl, a 3-7C cycloalkyl or phenyl; and Rb is a 1-6C alkyl, a 1-6C alkoxyl, (substituted) phenyl, benzyl o...
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JPH02357B2 |
Sodium amoxycillin is obtained by spray drying a solution of sodium amoxycillin in aqueous isopropyl alcohol, wherein the initial ratio of isopropyl alcohol to sodium amoxycillin present in the solution to be spray dried is from 5:3 to 3...
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JPH02288A |
NEW MATERIAL: Compounds of formula I [formula II is a (substituted) nitrogen- containing heterocycle bonded to the remainder of the molecule through a ring nitrogen atom which is charged positively; a vary line is position of E- or Z- is...
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JPH02287A |
NEW MATERIAL: Compounds of formula I (R is acyl, corrugated line is position of E- or Z-isomer). EXAMPLE: (5R)-(Z)-6-[1-(2-Acetoxyethyl)-1,2,3-triazol-4-yl methylene] penem-3- carboxylic acid. USE: β-Lactamase inhibitors, antibacterial ...
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JPH0160476B2 |
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JPH0160010B2 |
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JPH01305093A |
NEW MATERIAL: A compound of formula I [X is H, NHR1 (R1 is H, amino protecting group; R is (substituted) 5-9 cycloalkyl, cycloalkenyl], its salt and ester which can be hydrolyzed in organisms. EXAMPLE: 6β-[Z-2(2-aminothiazol-4-yl)3-cycl...
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JPH01304896A |
PURPOSE: To convert a β-lactam compound to other compound by protecting the carboxy group at 2nd position as the corresponding phenylacetyloxymethylester form, enzymatically hydrolyzing the compound and removing a protecting group. CONS...
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JPH0154356B2 |
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JPH0154354B2 |
NEW MATERIAL:A compound shown by the formulaI[R<1> is H, alkyl, alkoxy, or group shown by the formula R<3>A-(R<3> is OH, alkoxy, acyloxy, trialkylsilyloxy, SH, alkylthio, NH2, acylamino, etc.; A is alkylene which may contain CF3 or pheny...
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JPH0153674B2 |
NEW MATERIAL:The compound of formula I [R<1> is H, lower alkanoyl, or lower alkoxycarbonyl; R<2> is (halogen-substituted) lower alkyl, cycloalkyl, etc.; R<3> is group of formula II (R<4> is H, lower akyl or aryl; R<5> is H or R<5> and R<...
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JPH01503297A |
A composition comprising an aqueous preparation on the basis of keratin softening, which contains as a swelling and penetration agent, an N-alkyl pyrrolidone wherein the alkyl group contains between 8 and 22 carbon atoms.
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JPH0149718B2 |
This invention relates to 2- substituted and 2,6-disubstituted penem compounds of the formula: wherein Y is a hydrogen or halogen atom or certain specified groups and X represents certain specified groups. Also included in the invention ...
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JPH01503064A |
A permanent hair color altering composition comprising an aqueous preparation on the basis of melanin dissolution and/or oxidation of a hair colorant dye intermediate, which contains as a swelling and penetration agent, an N-alkyl pyrrol...
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JPH01503037A |
The extraction of water soluble antibiotics containing a phenolic or carboxylic group from an aqueous solution or fermentation broth using a N-C8-C14 alkyl pyrrolidone extractant and the process involving the extraction of said antibiotic.
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JPH0146516B2 |
Processes for the preparation of a penem derivative of formula I I wherein n=0 or 1; R is a carboxy protecting group or H; R1 is hydrogen, a hydrocarbon group substituted or unsubstituted, or lower alkoxy; and R2 is hydrogen, C1-C5 alkyl...
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JPH0142946B2 |
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