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Matches 401 - 450 out of 2,204

Document Document Title
JP2000514054A
(57) [Summary] The present invention relates to a compound of formula (I) (in the formula, R).1, R2, R3, R4And R5Is defined herein, the functional groups may be protected if desired) and a method for producing salts thereof, obtained by ...  
JP2000512297A
A new crystalline form of potassium clavulanate is disclosed. Also disclosed are a process for producing the new crystalline form of potassium clavulanate, pharmaceutical compositions containing it and methods of treating bacterial infec...  
JP2000229986A
To efficiently obtain 6-aminoacyl-penicillin or the like useful as an antimicrobial agent or the like in high purity and high yield by acylating silylated 6-amino-penicillanic acid or the like obtained under a specified condition. 7-Amin...  
JP3072857B2
PCT No. PCT/EP95/04562 Sec. 371 Date Jul. 25, 1997 Sec. 102(e) Date Jul. 25, 1997 PCT Filed Nov. 2, 1995 PCT Pub. No. WO96/16067 PCT Pub. Date May 30, 1996A process for the silylation of 6-aminopenicillanic acid or 7-amino-desacetoxy-cep...  
JP3066110B2
Dicarboxylic acid imides of the formulae Ia, Ib and Ic in which the substituents have the following meaning: X is oxygen or sulphur; R<1> is hydrogen; halogen; cyano; alkyl; cycloalkyl; alkenyl; alkynyl; alkoxy; alkenyloxy; alkynyloxy; a...  
JP3046068B2
Antimicrobial quinolone thiourea compounds of the general formula: wherein (1) A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial ...  
JP3044175B2
PURPOSE: To remove an allyl group, etc., in high selectivity and high yield without exercising bad influence on other functional group by reacting a specific compound containing an allyl group, etc., with a sulfinic acid compound in the ...  
JP3038715B2
Inclusion complexes of hydroxypropyl, hydroxyethyl, glucosyl, maltosyl or maltotriosyl derivatives of beta - or gamma -cyclodextrin with the reduced, biooxidizable, blood-brain barrier penetrating, lipoidal forms of dihydropyridine -><- ...  
JP3025910B2
PURPOSE: To provide a new compound having excellent antibacterial activity to Gram-positive bacteria and Gram-negative bacteria, stable to β-lactamase, exhibiting excellent activity to resistant bacteria and useful as a penam-type antib...  
JP3025911B2  
JP3025788B2  
JP2992314B2
A process for removing an allyl group from a penem compound of formula (I), wherein R<1> is an allyl group which may have a substituent and m denotes 0 or 1, is disclosed. The process comprises reacting said penem compound of formula (I)...  
JP2993576B2
The present invention provides an allenyl beta -lactam compound represented by the formula (1) wherein R<1> is a hydrogen atom, halogen atom, amino or protected amino, R<2> is a hydrogen atom, halogen atom, lower alkoxyl, lower acyl, low...  
JP2977212B2
Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked, by a non-ester linking moiety, to the 3-carboxy group of a quinolone moiety. These compounds are of the formula: wherein (1) R<3>, R<4>, and R<5>, to...  
JP2973126B2
NEW MATERIAL:A compound expressed by formula I{R<1> is H, amino protecting group or acyl; R<2> is H or lower alkyl; R<3> is H, lower alkoxy, lower alkylthio or formamide; R<4> is (protected) carboxyl or carboxylate; R is -NHR<5>, formula...  
JPH11512730A
PCT No. PCT/EP96/04291 Sec. 371 Date Mar. 26, 1998 Sec. 102(e) Date Mar. 26, 1998 PCT Filed Sep. 27, 1996 PCT Pub. No. WO97/12889 PCT Pub. Date Apr. 10, 1997New solvates of penicillin, in particular amoxycillin glycolate has been provide...  
JPH11512397A
Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vi...  
JP2965752B2
The invention relates to novel optically active N- alpha -fluoroacrylolyamino acid derivatives of the general formula (I) in which R1, R2, R3 and X have the meaning given in the description, to a process for the preparation, to their pol...  
JP2954956B2
A crystalline form of (5R,6S)-2-carbamoyloxymethyl-6-((1R)-hydroxyethyl)-2-penem-3 -carboxylic acid incorporates two molecules of water per molecule of the acid and is useful as an antibacterial agent.  
JPH11255767A
To obtain the subject new compound useful as a stable intermediate for chemically synthesizing physiologically active β-lactam compounds. A compound of formula I [R1, R3 and R4 are each H or a halogen; R2 is H, a halogen or phthalimide;...  
JP2952015B2  
JP2949363B2  
JP2936404B2  
JP2922220B2
Antibacterial penems of formula (I): wherein R represents a) alkanoyloxymethyl or 1-(alkanoyloxy)ethyl wherein the alkanoyl moiety is a C2-C10 alkanoyl or C4-C8 cycloalkanoyl group; b) benzoyloxymethyl or 1-(benzoyloxy)ethyl; c) alkoxyca...  
JP2909145B2
A process for producing the compound [2S-(2 alpha ,3 beta ,5 alpha )]-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-aza bicyclo[3 2 0]-heptane-2-carboxylic acid, (4-nitrophenyl)methyl ester, 4,4-dioxide, which comprises reacting...  
JPH11507020A
(57) [Summary] The present invention relates to the field of combined carbohydrate chemistry and involves denaturation of organic molecules and the synthesis of numerous products consisting of / or carbohydrates and / or glycominetic ind...  
JPH11505425A
Alternative process for obtaining 6-aminopenicillanic acid. The process comprises replacing the stages of extraction with organic solvents and isolation and separation of the intermediate penicillin salt as a solid by a process of ultraf...  
JP2875015B2
Antimicrobial dithiocarbamoyl quinolone compounds of the general formula: wherein (1) A<1>, A<2>, A<3>, R<1>, R<3>, R<4>, and R<6> form any of a variety of quinolone and related heterocyclic structures similar to those known in the art t...  
JPH11502832A
Process for the recovery of ampicillin from a mixture containing ampicillin and 6-aminopenicillic acid (6-APA), in which a mixture of ampicillin and 6-APA, with a pH higher than 7, which apart from any solid ampicillin being present is h...  
JPH1156258A
To obtain the subject agent effective also against penicillin-resistant strain by formulating a β-lactam-based antibiotic or salt thereof with a β- lactamase inhibitor in specific proportions. This agent is obtained by formulating (A) ...  
JP2860421B2  
JP2840286B2
There are provided compounds of the formula Ia and Ib wherein A is hydrogen atom or an organic residue, R<1> is halogen atom, or an organic group, R<2> is hydrogen or halogen atom, C1-C4 alkyl or alkoxy group R<3> is hydrogen atom, C1-C4...  
JP2831808B2  
JPH10316666A
To obtain a new compound capable of acting as siderophore or a biological chelate and suitable for introducing an active ingredient, e.g. an antibiotic, into microbial cells through the microbial iron-transporting route. This compound is...  
JPH10511076A
A 6 beta -substituted penicillanic acid of the formula XII: or a pharmaceutically acceptable salt or ester thereof, wherein A and B are each hydrogen wherein the carbon atoms to which A and B are attached are linked by a single bond, or ...  
JP2814286B2  
JPH10245386A
To obtain the subject compound for synthetic raw materials, etc., of β-lactamase inhibitors in high yield by reducing a specific cephem compound with a metal having a specific standard oxidation-reduction potential and a metal compound ...  
JP2787683B2  
JPH10130272A
To obtain the subject derivative useful as an antimicrobial agent in a high yield by reacting a specific compound with a specific carboxyamidine. (A) A compound of formula I [R1 is a (substituted) phenyl; R2 is a (protected) sulfo or sul...  
JPH10504815A
The present invention provides a process for making a compound having a structure according to Formula (I) (I) wherein A1, A2 and A3 are independently carbon or nitrogen and R1, R3, R4 and R6 are known quinolone substituents; and wherein...  
JPH10504283A
The present invention is related to compounds which inhibit pancreatic cholesterol esterase. The compounds have the formula: wherein R1 is H or C1-6 alkyl; R2 is H or C1-6 alkyl; R3 is H or C1-6 alkyl; X is CHR6, S or O; R6 is H or C1-6 ...  
JPH10503521A
The present invention provides processes for making compounds of the structure(Q-L1)-L-(L2-B)wherein (I) Q is a quinolone moiety; (II) B is a lactam moiety; and (III) L, L1, and L2 together comprise a linking moiety; comprising the steps...  
JPH1053533A
To provide a method useful for treatment and prevention of sepsis and acute respiratory disease syndrome of adult by independently administrating a specific chemokine or its fragment and simultaneously administrating it together with an ...  
JP2711244B2
To obtain the subject compound useful as an intermediate for synthesizing a starting substance for producing a β-lactam antibiotic such as a penem or carbapenem derivative. An acetoacetic acid ester represented by formula I is cyclized ...  
JPH107678A
To obtain the subject new compound of β-lactam analog useful as an intermediate for producing antibiotics, etc., by reacting a penicillanic acid amidosulfoxide with a phosphorus compound and subsequently subjecting the obtained ring-ope...  
JP2693189B2
A new compound called N,N min -carbonyl-bis-(4-ethyl-2,3-dioxo)-piperazine of Formula I A process for the preparation thereof based on the reaction of 4-ethyl-2,3-dioxo-piperazine or a trimethylsilyl derivative thereof with carbonyl chlo...  
JP2695137B2
PURPOSE: To obtain a new compound useful as an intermediate of 6-(substituted methylene)-penems having an antibacterial activity. CONSTITUTION: The object 6-substituted penems are expressed by formula I (X is a halogen; Y1 is H or a halo...  
JP2691678B2
New derivatives of penem and pharmaceutically acceptable salt thereof are herein disclosed; the compouinds being useful as an antibacterial agent which has a high sensibility to  
JP2689412B2
PURPOSE: To provide a method for removing a protecting group in which a tri-substituted silyl group can efficiently be removed under mild conditions and the objective compound can be obtained in high yield at a low cost. CONSTITUTION: Th...  
JP2688065B2
Compounds of the formula I: wherein R is a carboxy group or a carboxylate anion, R2 represents a hydroxy protecting group or hydrogen atom, R1 represents one of certain defined organic groups, useful as antibiotics, are prepared by hydro...  

Matches 401 - 450 out of 2,204