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JP4801335B2 |
Pyrimidine derivatives of formula (I) wherein Q1, Q2, G and R1 are as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes for their manufacture, pharmaceutical compositio...
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JP4798815B2 |
Compounds of the formula I wherein R 1 , R 2 , R 3 and R 4 , independently of each other, are C 1 -C 8 alkyl or C 1 -C 5 hydroxyalkyl, or R 1 and R 2 together with the carbon atom they are attached to are C 5 -C 12 cycloalkyl, or R 3 and...
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JP4794793B2 |
Compounds that selectively inhibit inappropriate kinase activities and methods for their preparation are disclosed. In one embodiment, the compounds are represented by Formula (I). As selective inhibitors of inappropriate kinase activiti...
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JP2011201879A |
To provide a new stable compound that has valuable characteristics and can be used as an ionic liquid, and a method for producing the same.The compound is represented by formula (1), [wherein X is N, P, O or S; n is an integer of 0, 1 or...
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JP4790270B2 |
Salts (A) of saturated or (partly) unsaturated (di)heterocyles (C) with the bis(trifluoromethyl)amide anion are new. Salts (A) of saturated or (partly) unsaturated (di)heterocyles (C) with the bis(trifluoromethyl)amide anion, of formulae...
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JP4785169B2 |
The present invention generally relates to methods of inhibiting ethylene responses in plants and plant materials, and particularly relates to methods of inhibiting various ethylene responses including plant maturation and degradation, b...
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JP4782344B2 |
The present invention is related to benzazole derivatives according to formula I wherein X is O, S or NR<0>, G is selected from the group comprising or consisting of unsubstituted or substituted aryl or heteroaryl substituents, unsubstit...
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JP4782903B2 |
Ionic compound with low melting point has cation of the onium type with at least one heteroatom such as N, O, S or P; and anion which includes, wholly or partially, at least one imide ion. Independent claims are also included for: (1) el...
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JP4771660B2 |
There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of whic...
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JP4755602B2 |
The invention relates to a process for the distillation of ionic liquids, in which a pressure not higher than ambient pressure is set in a first step and the ionic liquid is heated to a temperature in the range from 60° C. to 350° C. i...
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JP4754693B2 |
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mamma...
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JP4757188B2 |
Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
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JP4754145B2 |
According to a novel process, microbicidally active 2-(1,2,4-triazol-1-yl)-ethanols of the formula in which A1, A2, R1, R2, R3 and R4 are as defined in the description, can be prepared by reacting hydrazine derivatives of the formula wit...
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JP4751567B2 |
The present invention relates to an amide derivative of the formula (1), having a C5a receptor antagonistic action wherein each symbol is as defined in the specification. The above-mentioned amide derivative, an optically active form the...
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JP4744050B2 |
Compounds of the formula A - Q - D - E - G - J - X in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphthyl group or a hete...
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JP4739678B2 |
The present invention relates to a process for the preparation of mono-hydroperfluoroalkanes, bis(perfluoroalkyl)phosphinates and perfluoroalkyl-phosphonates which comprises at least the treatment of at least one perfluoroalkylphosphoran...
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JP4739625B2 |
N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inh...
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JP4726175B2 |
The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
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JP4729259B2 |
Novel heterocyclo compounds useful as inhibitor of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating del...
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JP2011126888A |
To provide a method for treating disease states associated with angiogenesis and/or exacerbated vascular permeability.A quinazoline derivative is represented by formula (I) (wherein ring C is a 5-6-membered heterocyclic moiety; Z is -O-,...
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JP4707321B2 |
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JP4709148B2 |
An azole derivative of formula (I) having a fluorovinyl moiety or a pharmaceutically acceptable salt thereof is superior to the conventional antifungal drugs in antifungal activity against a wide spectrum of pathogenic fungi, and has adv...
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JP4703607B2 |
This invention provides a compound of the following formula: or salts thereof, and a compound of the following formula: or salts thereof, wherein Y 1 , Y 2 , Y 3 and Y 4 are independently selected from N, CH, etc.; R 1 is H, C 1-8 alkyl,...
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JP4699358B2 |
The invention relates to benzenesulphonamide derivatives of formula (I), methods and intermediate products for production thereof and use of said compounds, or means comprising said compounds for the control of undesired plants and for t...
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JP4698945B2 |
Low melting ionic compounds of the general formula (cation) (R'SO4) in which R' is a branched or linear, saturated or unsaturated, aliphatic or alicyclic functionalized or non-functionalized hydrocarbon chain with 3-36 carbon atoms are p...
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JP4694490B2 |
A series of compounds represented by the structural formulas and pharmaceutically acceptable isomers, salts, solvates and polymorphs thereof are disclosed. Also disclosed are pharmaceutical compositions containing said compounds and thei...
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JP4693247B2 |
Compounds or salts thereof represented by the formula (I) wherein R<1> represents hydrogen atom, a C1-6 alkyl group, a C1-6 alkenyl group, or an acyl group, R<2> and R<3> represent hydrogen atom or a C1-6 alkyl group, or adjacent R<2> an...
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JP4685331B2 |
The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated...
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JP2011079867A |
To provide acyl derivatives which treat VLA-4 related disorders.There are disclosed compounds such as Ia and Ib which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated ...
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JP4664673B2 |
The present invention provides novel amino benzothiazole compounds, compositions comprising these compounds and methods of using these compounds as neuroprotectants. In particular, the compounds described in the present invention are use...
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JP4662764B2 |
An azole derivative of formula (I) a medicament that contains the azole derivative of formula (I), a method of treating a disease with the azole derivative of formula (I), and a method of preparing the azole derivative of formula (I).
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JP4657201B2 |
Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields,...
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JP4652223B2 |
The present invention relates to new orally active azole derivatives with antifungal activity of formula I wherein: X is CH or N; Ar represents phenyl substituted with halogen and/or trifluoromethyl; Z is -C(=O)- or -SO2-; R1 is CN, CO2H...
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JP4652342B2 |
The present invention refers to a crystalline polymorph Form 1 of Compound 2 of the formula: that exhibits a powder x-ray diffraction pattern having characteristic peak locations of 11.2, 16.4, 19.2 and 21.0 degrees 2¸.
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JP4651576B2 |
The invention relates to the use of compounds of the formula I: wherein ring C is an 8, 9, 10, 12 or 13-membered bicyclic or tricyclic moiety which optionally may contain 1-3 heteroatoms selected independently from O, N and S; Z is -O-, ...
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JP4648626B2 |
Novel compounds of formulae (I), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonam...
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JP2011042665A |
To provide a new pharmaceutically active azole derivative.The azole derivative is represented by formula (1) (wherein, X is O, S or NR0; R0 and R1 are each hydrogen atom or unsubstituted or substituted 1-6C alkyl or the like; and A is 2-...
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JP4641795B2 |
The present invention relates to a process for the preparation of 1,2,4-triazol-1-ylmethyloxiranes of the formula I in which A and B are identical or different and, independently of one another, are C1-C4-alkyl, phenyl-C1-C2-alkyl, C3-C6...
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JP4642318B2 |
Heterocyclic-substituted compounds of formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein: Z is - (CH2)n-; (a); (b), wherein R 10 is absent; or, (c) wherein R 3 is absent; the single dotted line represents a...
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JP4637365B2 |
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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JP4638664B2 |
Haloalkenyl dithiocarbamate esters (I) are new. Haloalkenyl dithiocarbamate esters of formula (I) are new: R = haloalkenyl; Z' = N(A)(B); A, B = H or optionally substituted alkyl, alkenyl, alkoxy, acyl, aroyl, aryl, heteroaryl, alkylsulf...
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JP2011026326A |
To provide the compounds and medicinal compositions useful in treating disorders induced or deteriorated by vanilloid receptor subtype 1 (VR1) activity.There are provided the compounds represented by formula (I). The compounds are new VR...
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JP4627944B2 |
Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R<1> is -CH(OH)-CH(R<4>)-(A)n -Y, -CH2 -CH(R<4>)-(A)n-Y, -CO-B<1>-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which...
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JP4630063B2 |
Compounds of formula (I) or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a variety of conditions and diseases.
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JP4625969B2 |
This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by general formula (I):wherein R1 is aryl optionally substituted with lower alkoxy, etc.,R2 is lower alkyl, etc.,R3 is h...
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JP2011016803A |
To provide a new compound with characteristics improved in, especially, herbicidal action.What are provided are a substituted 2-benzoylcyclohexane-1,3-dione represented by formula I [wherein Het is a 3-6-membered partially saturated or f...
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JP4619371B2 |
4-[(Heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinone hypocholesterolemic agents of the formula I or a pharmaceutically acceptable salt thereof, wherein: A is optionally substituted heterocycloalkyl, heteroaryl, benzo...
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JP4614662B2 |
Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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JP2011006443A |
To provide a new method for producing a sterically hindered amine ether compound, a method for using the compound as a stabilizer to stabilize organic materials against oxidation and/or heat, and a corresponding composition.The compound ...
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JP4610744B2 |
The present invention concerns compounds of formulathe N-oxide forms, the salts, the quaternary amines and stereochemically isomeric forms thereof, whereinD represents a tetrahydrofuran or dioxolane ring substituted with aryl and azolmet...
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