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WO/1987/003591A1 |
Novel imidazole derivatives represented by general formula (I), (wherein R1 represents a hydrogen atom or a lower alkyl group, R2 represents a lower alkyl group, R3 represents an akenyl group, a cycloalkyl group, an alkoxyalkyl group or ...
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WO/1987/002587A1 |
Compounds of formula (I), wherein Het is imidazol-1-yl or 1,2,4-triazol-1-yl; py is 2-, 3- or 4-pyridyl; R and R2 are H or alkyl; R1 is H, alkyl or vicinal R1 groups from a C-C double bond; and x is 0 or 1; or a pharmaceutically acceptab...
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WO/1987/002664A1 |
Novel 3'-pyridinylalkenylindol-2-carboxylic acids and derivatives thereof of the formulas (I) and (II) which are useful as thromboxane A2 (TXA2) synthetase inhibitors and as such represent potent pharmacological agents.
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WO/1987/002358A1 |
Novel thiadiazole compounds and lubricant compositions thereof prepared from the derivatives of dimercaptothiadiazole and maleic anhydride or a halosuccinate. Lubricating compositions containing the compound, or their metal salts, provid...
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WO/1987/000836A1 |
Compounds of formula (I), wherein R1 is an alkoxycarbonyl group, acetyl, benzoyl, cyano, nitro or aminocarbonyl; R2 is an optionally substituted aryl or hetaryl group; R3 is an alkoxycarbonyl group; O/ is a thio residue such as alkylthio...
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WO/1987/000178A1 |
Compounds represented by formula (I), (wherein R1 represents amino or an organic residue bound via nitrogen, R2 represents carboxy or its derivative, and X represents hydrogen, methoxy or formylamino, provided that, when R1 represents ac...
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WO/1986/006721A1 |
New triazolyl quinoline derivatives and acid addition salts thereof (wherein R1 stands for hydrogen, methyl, trihalogenomethyl or carboxy; R2 is hydrogen, halogen, C1-4 alkyl, hydroxy, C1-4 alkoxy, phenoxy, amino, acetamino, C1-4 dialkyl...
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WO/1986/006064A1 |
Compound having the formula (I) wherein R1 to R4 represent independently H, OH, C1-C6 alkyl or C1-C6 alkoxy; and A represents -COR5, R5 being H when at least one of the substituants R1 to R4 is different from H; C1-C6 alkyl; amino; (C1-C...
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WO/1986/004894A1 |
Lipid derivatives represented by formula (I), wherein R1 represents alkyl or alkylcarbamoyl, R2 represents hydrogen, optionally substituted hydroxy, optionally substituted amino or cyclic amino, R3 represents a bond or optionally substit...
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WO/1986/004581A1 |
Dihydropyridines of formula (I) wherein R1 is alkyl or alkoxyalkyl, wherein R2 and R3 each is alkyl, wherein benzene ring A bears one or more substituents selected from halogeno, cyano, nitro, trifluoromethyl and alkyl or bears the subst...
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WO/1986/004058A1 |
Quinone derivatives represented by general formula (I), wherein R1 and R2 may be the same or different and each represents hydrogen, methyl or methoxy or, when taken together, R1 and R2 represent -CH=CH-CH=CH-, R3 represents hydrogen or ...
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WO/1986/003752A1 |
Compounds represented by formula (I), (wherein R1 represents amino or an organic residue bound via a nitrogen atom, R2 represents carboxy or a group derived therefrom and X represents hydrogen, methoxy or formylamino, provided that, R2 d...
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WO/1986/003199A1 |
(5-Acylamino-2-hydroxy)benzoic acid and salts thereof with imidazole, substituted imidazole, lysine or methyl-glucamine are endowed with remarkable antiinflammatory, antiaggregating and antithrombotic properties.
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WO/1986/002349A1 |
Lipid derivatives represented by formula (I), (wherein R1 represents alkyl or alkylcarbamoyl, R2 represents H, optionally substituted hydroxy, optionally substituted amino or cyclic amino, R3 represents alkylene, R4 represents H, alkyl o...
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WO/1986/001202A1 |
Compounds of formula (I) wherein R is hydrogen, lower alkyl, halo, cyano, hydroxy, amino, lower alkylamino, -CH2NH2, -CH2OH or -COOR''; R' is hydrogen, lower cycloalkyl or lower alkyl; R'' is lower alkenyl, lower alkynyl, lower cycloalky...
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WO/1986/000887A1 |
Quinone derivatives represented by general formula (I) wherein R1 and R2 may be the same or different, and each represents hydrogen, methyl or methoxy or, when taken together, R1 and R2 represent -CH=CH-CH=CH-, R3 represents hydrogen or ...
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WO/1986/000066A1 |
New butyramide derivatives corresponding to formula (I), wherein X and Y independently represent hydroxymethyl; cyano; carboxy; functionally modified carboxy selected from esterified carboxy, carbamoyl, and N-substituted carbamoyl; 5-tet...
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WO/1985/005358A1 |
Compounds having the general formula (I), wherein X is H, a phenyl, phenylalkyl, phenylcarbonyl, phenyloxy group, optionally substituted with a halogen; Y is N or CH; R1 is H or a phenyl group; R2 and R3, equal or different, are H, an al...
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WO/1985/004652A1 |
The object of the present invention are compounds of formula (I). Said compounds can be used therapeutically for the treatment of acne, psoriasis, keratinization disorders, in certain types of cancer and as healing agents, in particular ...
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WO/1985/004656A1 |
9-halogen-prostane having the formula (I) wherein Hal represents a chlorine or fluorine atom in position alpha or beta; R1 represents the rest CH2OH or the formula (A) with R2 representing a hydrogen atom, an alkyl, cycloalkyl, aryl or h...
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WO/1985/004401A1 |
A process for preparing an optically active alcohol derivative of formula (I) (wherein R1 represents a substituted or unsubstituted hydrocarbyl group, and R2 represents an imidazol-l-yl group or a 1, 2, 4-triazol-l-yl group), which compr...
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WO/1985/004398A1 |
Novel compounds of formula (I), wherein R1 represents C10-30 alkyl or alkylcarbonyl, R2 represents hydrogen, hydroxy, alkoxy, aralkyloxy, acyloxy, acylamino or a group represented by formula (II), (wherein W represents oxygen or sulfur, ...
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WO/1985/003937A1 |
The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are compounds of the formula (I), and the non-toxic pharmaceutically acceptable salts thereof, wherein D is ...
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WO/1985/002185A1 |
A process for the preparation of an aromatic cyanate which comprises (a) preparing in situ a cyanogen chloride by contacting a solution of chlorine in a chlorinated hydrocarbon with an aqueous solution of an alkali metal cyanide at a tem...
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WO/1985/001940A1 |
Compounds having the formula (I), wherein R1 is hydrogen, cycloalkyl with 3 to 7 atoms of carbon, optionally substituted alkyl with 1 to 6 atoms of carbon; R2 and R4, independently from each other, represent hydrogen or alkyl with 1 to 6...
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WO/1984/004918A1 |
Novel triazolyl-substituted propane compounds of general formula (I), and the pharmaceutically acceptable salts thereof, wherein n is 1,2 or 3 and X independently represents halogen, lower alkoxy, lower alkyl or phenyl. The novel compoun...
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WO/1984/004919A1 |
N- AD3-morpholinyl-(4)-1-methylpropyl BD-amines and N- AD3-azolyl-(4)-1-methylpropyl BD-N-alkylamines having the general formula (I), wherein R1 represents separated linear alkyl rests containing from 8 to 14 atoms of carbon or mixtures ...
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WO/1984/003885A1 |
Asymmetrically modified boron hydride compounds to be used for preparing optically active alcohol derivatives by asymmetrical reduction of ketone compounds are prepared by reacting an acid salt of an optically active amino alcohol of for...
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WO/1984/003091A1 |
Dihydrobenzofuran derivatives represented by the general formula (I), (wherein R1 represents hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy, and R2 represents hydrogen or lower alkyl) and the acid addition salts thereof. These a...
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WO/1984/003092A1 |
A compound of formula (I), or a salt or ester thereof wherein X is an optionally substituted 1,2,4 triazolyl group attached via a nitrogen atom thereof. Processes for the production of these compounds and compositions containing them are...
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WO/1984/000007A1 |
Therapeutic compositions containing as an active principle N-substituted hydrazones having the formula (I) wherein Z is a radical thiazolyl-2 or phenyl. These compositions have an anti-inflammatory activity particularly in the ocular field.
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WO/1983/003605A1 |
Ethenylimidazoles of the formula (I), in which n is 0, 1 or 2, R1 represents a halogen atom, a trifluoromethyl group or an alkyl or alkoxy group with at most 6 carbon atoms, the two substituents being the same or different when n is 2, R...
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WO/1983/003096A1 |
Imidazole derivatives represented by the general formula (I), wherein R1 and R4 each represents a hydrogen atom or a lower alkyl group, R2 and R3 each represents a hydrogen atom, a halogen atom, a hydroxy group, a lower alkyl group, a lo...
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WO/1983/002279A1 |
Procedure for precipitating cellulose carbamate from an aqueous alkali solution. The solution is brought into contact with an aqueous solution of sulphuric acid containing one or several cations selected from the group consisting of Na, ...
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WO/1983/001446A1 |
Method for the preparation of cyano-heterocycles having the general formula I$(5,)$wherein W, X, Y and Z represent a nitrogen atom, the CH rest or CR1 rest, with R1 representing a hydrogen atom, an alkyl rest with a straight or branched ...
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WO/1982/004048A1 |
Novel class of amidinourea and amidinothiourea compounds wherein the urea nitrogen atom is substituted by a heretocyclic alkylene group, and their use in pharmaceutical preparations which are useful for producing anti-ulcerogenic, antise...
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WO/1982/004050A1 |
Heterocyclic alkyl s-triazine compounds are prepared from the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give respectively substituted s-triazinones and thiones of the f...
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WO/1982/004047A1 |
Novel class of heterocyclic amidinourea and heterocyclic amidinothiourea compounds wherein the heterocyclic substitution is at the 1-N urea nitrogen atom. These compounds exhibit pharmaceutical activity and may be incorporated into pharm...
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WO/1982/002552A1 |
Preparation of imidazolyl-vinyl-ethers having the formula: (FORMULA) wherein the residue Im is a substituted or non substituted 1-H- imidazol-l-yl group, Ar representing phenyl, naphthyl, thienyl or pyridyl, R representing hydrogen, alky...
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WO/1982/002045A1 |
Pyridine derivatives represented by the following general formula (FORMULA) wherein R1, R2, R3, and R4, which may the same or different, each represents a hydrogen atom or a lower alkyl group, or R1 and R2, or R3 and R4, are taken togeth...
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WO/1981/003490A1 |
New tricyclic compounds of the formula: (FORMULA) having valuable CNS and cardiovascular properties.
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WO/1981/000109A1 |
A novel process for preparing imidazole derivatives represented by the following general formula: (FORMULA) (wherein R1 and R4 each represents a lower alkyl group, and R2 and R3 each represents a lower alkylene group) and the salts there...
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WO/1980/002286A1 |
The compounds have the following formula (I): (FORMULA) wherein n represents an integer between O and 4, R1 a C1-C6 halogenated alkyle group a C3-C6 cyclo alkyle group cycloalkyl in C3-C6 optionally halogenated and R2 represents a number...
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WO/1980/001914A1 |
Cyano-ureas of formula: (FORMULA) and cyano-thioureas of formula (FORMULA) wherein R is (a) the remainder HF-CH2-CH2- (b) the remainder (FORMULA) and several methods for the respective preparation thereof, as well as the preparation of c...
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WO/1980/000701A1 |
Acetanilides of formula (FORMULA) wherein: R and R1, being identical or different, represent each an alkyl rest having 1 to 4 atoms carbon , Z is a methylene group or an ethylenic group which may have one or two rests of methyle as subst...
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JP2024518530A |
Bicyclic heterocyclic compounds and derivatives thereof having antiviral properties are disclosed. Disclosed are pharmaceutical compositions and formulations in unit dosage form suitable for the delivery of a compound to a subject in nee...
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JP6843889B2 |
Disclosed are electrically conductive polymer compositions, and their use in organic electronic devices. The electrically conductive polymer compositions include an intrinsically electrically conductive polymer having Formula II:where Q,...
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JP6821558B2 |
This invention relates new radiopharmaceutical conjugates for use in improved methods of diagnosis and treatment of cancer. The radiopharmaceutical conjugate comprises, in sequence: a metabolite that targets tumour cells, bound to a chel...
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JP5710931B2 |
The invention relates to the use of compounds of the formula I: wherein ring C is an 8, 9, 10, 12 or 13-membered bicyclic or tricyclic moiety which optionally may contain 1-3 heteroatoms selected independently from O, N and S; Z is -O-, ...
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JP5709688B2 |
Compounds I-III wherein U is CH, O, or S; Z is mono- or di-substituted carbon; R is (CH2)nCO2H, (CH2)nSO3H, (CH2)nPO3H2, (CH2)nNO2, CH(SCH3)3, esters; R1 is H, hydroxyalkyl, aminoalkyl, alkoxyalkyl; RR1 is O; n is 0-4; R2, R3 is H, hydro...
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