| Document |
Document Title |
|
JPS5835520B2 |
The cortisol compound of the formula (E) (E) wherein R represents a hydroxy group, a tyrosine lower alkyl ester residue, a tyramine residue, a histamine residue, a 7-aminoheptanoyl-tyrosine lower alkyl ester residue, a radioiodinated tyr...
|
|
JPS58113200A |
New steroidal chiral phosphines of formula (I) wherein R represents a phosphorated group selected between methods for their preparation; catalytic systems comprising metal complexes and the above steroidal chiral phosphines; asymmetrical...
|
|
JPS5829320B2 |
The present invention relates to a process for the preparation of steroidal spirolactones having the formula WHEREIN R1 is a linear alkyl having 1 to 4 carbon atoms and R2 is hydrogen or methyl comprising the steps reacting a compound of...
|
|
JPS5821639B2 |
1,3-Dihydroxy-1,3,5(10)-8alpha-oestratrienes or their ethers or esters of the following formula in which the substituents are defined in Claim 1 are prepared. The said compounds are obtained by hydrogenating the 8(9) and, if present, the...
|
|
JPS5852268A |
1. Claims for the contracting states : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE A cholecalciferol derivative of the formula see diagramm : EP0073465,P14,F3 1. Claims for the contracting state : AT A process for the manufacture of a choleca...
|
|
JPS5829800A |
PURPOSE: A clathrate compound of spironolatone with cyclodextrin, prepared by including the spironolatone in cyclodextrin, and having improved solubility in water without deteriorating the diuretic and hypotensive action of the spironola...
|
|
JPS5826898A |
This invention relates to novel isomers of naturally occurring cardiotonic compounds, specifically novel isobufalins and novel isoresibufogenins. This invention also relates to a novel method of preparing the novel isomers.
|
|
JPS57193499A |
A process for the preparation of corticoids (IX) which comprises reacting a 17-keto steroid (I) with a metallated halogenated acetylene (II) followed by reaction with a sulfenylating agent (IV) and C17 side chain rearrangement.
|
|
JPS57193500A |
A process for the preparation of corticoids (XI) which comprises reacting a protected 17-keto steroid (II) with a metallated 1,2-dihaloethene (III).
|
|
JPS57183783A |
The invention is concerned with a process for the preparation of 1 hydrogen or hydroxy cholesterol derivatives and intermediates therefor. The compounds of the present invention are useful as intermediates in the preparation of 24,25-dih...
|
|
JPS57181095A |
Cell-specific ligands comprising conjugates of saccharides and amino acids or peptides are synthesized from amino acids such as ornithine, lysine, peptides such as dilysine, diornithine or oligolysine and selected saccharides having reac...
|
|
JPS5751840B2 |
The synthesis of 25-hydroxycholesterol and 25-hydroxycholecalciferol from animal bile starting materials in which hyodeoxycholic acid or an ester thereof is converted to the 3 beta -hydroxy-5-cholenic acid alkyl ester, and this is conver...
|
|
JPS5751383B2 |
Novel 1 alpha -hydroxy-24-dehydrovitamin D3 and its hydroxyl-protected derivatives; novel 1 alpha -hydroxy-24-dehydroprevitamin D3 and its hydroxyl-protected derivatives; and novel 1 alpha ,3 beta -dihydroxycholesta-5,7,24-triene or its ...
|
|
JPS5742080B2 |
|
|
JPS57131000A |
Compounds of the formula wherein Q is O or S; R2 is hydrogen or methyl; R6 is hydrogen, fluorine or methyl; either R9 is hydrogen, fluorine or chlorine, R11 is beta -chlorine, beta -hydroxyl or oxo, and the 9,11-bond is a single bond, or...
|
|
JPS57114599A |
Immunologic adjuvants are obtained by the synthesis of 6-(5-cholesten-3#-yloxy)hexyl 6-amino-6-deoxy-1-thio-β-D-galactopyranoside and its 6-deoxy-6-oleamido derivative.
|
|
JPS577640B2 |
|
|
JPS56152500A |
Steroids having the formula are useful intermediates for the preparation of novel antiinflammatory agents having the formula In the above formulas, X is S, R1 is alkyl, aryl, arylalkyl or acyloxyalkyl; R2 is fluoro, chloro, bromo or iodo...
|
|
JPS56152499A |
Topical antiinflammatory activity is exhibited by steroids having the formula wherein X is oxygen or sulfur; R1 is alkyl or aryl; R2 is alkyl or arylalkyl, or together the R2 groups are -(CH2)n- wherein n is 2 or 3; R3 is hydrogen, fluor...
|
|
JPS56142278A |
The invention relates to a process for preparing a spironolactone, having increased biological activity, by precipitation with water from a solution with preferably organic solvents at a temperature between 0 DEG and 30 DEG C. and under ...
|
|
JPS56122398A |
17 alpha -Acyloxy-5 alpha -pregnanes (I) and 17 alpha -acyloxy-5 alpha -pregnanes (IV) have an excellent activity split providing high topical anti-inflammatory activity with very low systemic side effects.
|
|
JPS5699500A |
Novel corticoid 17-thioacetals of the formula: wherein X is hydrogen, fluorine or methyl, R1 is hydrogen or C1-C6 alkyl, and R2 is hydrogen or the acyl group of a C1-16 - hydrocarbon carboxylic acid, have valuable medicinal properties, e...
|
|
JPS5617360B2 |
Pregnane steroids having the partial formula WHEREIN R1 is methyl or ethyl and R2 is hydrocarbon or acyl, are produced by reacting a steroid sulfite ester of the partial formula WHEREIN R1 has the values given above, with an alcohol or a...
|
|
JPS568399A |
A multi-step synthesis of chenodeoxycholic acid from 3-keto-bisnorcholenol, a compound readily obtained from the abundant plant sterol beta -sitosterol, is described. A key step in the synthesis is the stereoselective microbial introduct...
|
|
JPS565500A |
Improved yields of 25-hydroxycholesterol are obtained by employing 3 beta -hydroxy-5-cholenic acid as the starting material. This compound is an intermediate for 25-hydroxycholecalciferol.
|
|
JPS5530769B2 |
|
|
JPS5527884B2 |
A new use of dehydroepiandrosterone sulfate or its salt as a parturient canal conditioning agent is disclosed.
|
|
JPS5526157B2 |
Pharmaceutically active steroids of the formula (I) wherein X1 and X2 each is hydrogen, mercapto or acetylthio and X3 and X4 each is hydrogen or acetylthio or X3 and X4 form together a valence bond, with the proviso that at least one of ...
|
|
JPS5589298A |
Glycolipid compounds of the formulaewherein R isare useful immunologic adjuvants in vaccines.
|
|
JPS5517038B2 |
|
|
JPS5511680B1 |
17 beta -Hydroxy-17 alpha -ethynyl steroids are converted to 17-ethers and 17-esters of 17 alpha -hydroxy-20-keto-pregnane steroids by forming a 17-sulfite ester of the 17 beta -hydroxy group with thionyl chloride in the presence of base...
|
|
JPS5442970B2 |
A compound of the formula (I) (I) wherein X is a halogen, Z1 and Z2 are both hydrogen, or Z1 is hydroxy and Z2 is chlorine, or Z1 and Z2 together stand for an alpha -epoxy group.
|
|
JPS5442971B2 |
Pharmaceutically active steroids of the formula (I) wherein X1 and X2 each is hydrogen, mercapto or acetylthio and X3 and X4 each is hydrogen or acetylthio or X3 and X4 form together a valence bond, with the proviso that at least one of ...
|
|
JPS5442973B2 |
Pharmaceutically active steroids of the formula (I) wherein X1 and X2 each is hydrogen, mercapto or acetylthio and X3 and X4 each is hydrogen or acetylthio or X3 and X4 form together a valence bond, with the proviso that at least one of ...
|
|
JPS5442972B2 |
Pharmaceutically active steroids of the formula (I) wherein X1 and X2 each is hydrogen, mercapto or acetylthio and X3 and X4 each is hydrogen or acetylthio or X3 and X4 form together a valence bond, with the proviso that at least one of ...
|
|
JPS54154750A |
The present invention relates to a novel general process for synthesizing a alpha - or beta -oriented hydroxyacetyl side chain of steroids of the pregnane type, which comprises treating a corresponding steroid carbaldehyde in succession ...
|
|
JPS5439388B1 |
1306622 21 - (4 - Methyl - 1 - piperazinyl)- Steroid RICHTER GEDEON VEGYESZETI GYAR RT 30 April 1971 [13 May 1970] 12350/71 Heading C2U [Also in Division A5] In the preparation of 11#,17α-dihydroxy-21- (4 - methyl - 1 - piperazinyl) - p...
|
|
JPS5438098B2 |
Synthesis of 1 alpha -hydroxylated cholesterol derivatives, particularly 1 alpha -hydroxycholesterol and 1 alpha ,25-dihydroxycholesterol and intermediates therefor.
|
|
JPS54135761A |
17 beta -Thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes of the formula: wherein X<1> is fluoro, chloro or bromo; X<2> is fluoro, chloro or hydrogen; X<3> is fluoro, chloro, bromo or hydrogen; X<4> is =C=O or or may also be when...
|
|
JPS54132565A |
Diuretic pharmaceutically active steroid-spiro-oxazolidinone compounds of the formula (I), (I) wherein R1 is hydrogen or methyl, R2 is C1-4 alkyl, R3 is hydrogen, C1-4 alkyl or C2-4 alkenyl, Z1 and Z2 each are hydrogen or together form a...
|
|
JPS54125674A |
Steroids having the formula wherein X is -S-, R1 is alkyl, aryl or acyloxyalkyl; R2 is carbonyl or beta -hydroxymethylene; R3 is hydrogen or halogen; R4 is hydrogen, fluorine or methyl; R5 is hydrogen or alkyl; and R6 and R7 are the same...
|
|
JPS54122264A |
Steroids having the formula wherein X is -S-, R1 is alkyl or aryl; R2 is hydrogen or halogen; and R3 is hydrogen, fluorine or methyl; can be used as antiinflammatory agents.
|
|
JPS54122265A |
This invention relates to novel dermatologically active androstadienes of the formula wherein M is a benzyl, phenethyl, methylbenzyl, dimethylbenzyl, chlorobenzyl or dichlorobenzyl group or an alkyl group having from 1 to 8 carbon atoms,...
|
|
JPS5417733B1 |
|
|
JPS5473765A |
Disclosed are novel 6-oxygenated-3,20-dioxo-pregnane derivatives of the general formula I and specified 1,2-dihydroderivatives thereof. wherein Z represents specified acylgroups. The other substituents of formula I include those comm...
|
|
JPS5412464B2 |
5 alpha , 17B-Diacetoxy-6 -chloro-2 alpha , 3 alpha ; 16 alpha , 17 alpha -diepoxy-androstane; 5 alpha , 17B-Dicetoxy-6 -chloro-androsta-2,16-diene; 5 alpha -Hydroxy-6 -chloro-17-oxo-androst-2-ene or a like intermediate in the production...
|
|
JPS546553B1 |
1395820 Corticosteroid 21-inorganic esters I VILLAX 12 May 1972 [5 June 1971] 22412/72 Heading C2U The invention comprises (A) the 1 : 2 salt of N,N1-dibenzylethylenediamine with betamethasone 21-(hydrogen sulphate) or 21-(dihydrogen pho...
|
|
JPS53149964A |
19-Oxygenated steroid compounds of the pregnane series of the formula I (I) in which R1 represents a hydrogen atom, and R2 represents an alpha -oriented lower alkanoylthio group, or R1 and R2 together represent a carbon-carbon bond or an...
|
|
JPS53147057A |
A process for the preparation of a compound of the formula (A): (A) wherein: R3 is a C1-5 alkyl group, a C3-6 alkenyl group, a C3-6 cycloalkyl group or an alkylphenyl group in which the alkyl moiety contains 1 to 3 carbon atoms and the p...
|
|
JPS53141281A |
|
