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JPH0739434B2 |
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JPH07503708A |
Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes are disclosed. A novel process for efficient synthesis of these glycosylated steroid derivatives, using activated glycosyl sul...
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JPH07503466A |
PCT No. PCT/US93/00211 Sec. 371 Date Jul. 25, 1994 Sec. 102(e) Date Jul. 25, 1994 PCT Filed Jan. 26, 1993 PCT Pub. No. WO93/15103 PCT Pub. Date Aug. 5, 1993.Novel steroids having a 9 alpha -hydroxy or a 9 alpha -carbonate substituent can...
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JPH07503008A |
Invented is an improved process for the preparation of benzo esters and benzo acids. Also invented are novel intermediates used in said process.
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JPH07503025A |
Pharmaceutical compositions are provided for lowering the activity of HMG-CoA reductase and/or lowering serum cholesterol, comprising an amount effective to lower the activity of HMG-CoA reductase and/or lower serum cholesterol of a side...
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JPH0733795A |
PURPOSE: To obtain the above-mentioned novel compound advantageous for treating cardiovascular disorders, such as heart failure, hypertension, or the like. CONSTITUTION: 14-Deoxy-14a-cardenolide 3β-thioderivative is represented by formu...
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JPH06510982A |
Compounds are provided which are highly selective inhibitors of the cytochrome P-450C17, commonly known as 17,20-lyase enzyme, responsible for androgen biosynthesis. These compounds can be administered to patients to inhibit the producti...
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JPH0699468B2 |
A 21-substituted thiosteroid represented by the general formulawhereinR1 represents an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 5 or 6 carbon atoms, a phenyl group, or a benzyl group which may have a substituent ...
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JPH0696592B2 |
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JPH0696491B2 |
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JPH06316557A |
PURPOSE: To provide a novel alkylthiofatty acid derivative having excellent properties as an agent for hepatic diseases kidney diseases, pancreatic diseases or cerebral diseases, etc. CONSTITUTION: A 4-alkylthio-2-oxybutanoic acid deriva...
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JPH06234788A |
PURPOSE: To obtain a new compound useful for treating and preventing human or animal viral infections, especially infection with human immunodeficiency virus, cat immunodeficiency virus or the like. CONSTITUTION: The objective compound i...
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JPH0660195B2 |
The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via ...
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JPH0659239B2 |
A cholesterol esterase substrate of the general formula I in which A is an alkylene or alkenylene group with 1 to 20 C atoms, Chol is the 3-cholesterol radical, X is the radical of an aromatic hydroxy or thiol compound and Y is -S- or -O...
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JPH06211893A |
PURPOSE: To provide the novel derivative exhibiting low toxicity and useful for remedy for diseases such as hear failure, hypertension or the like containing the derivative active on cardiovascular system. CONSTITUTION: By condensing a 1...
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JPH06192287A |
PURPOSE: To obtain new safe compounds having low toxicities and useful for treating cardiac and vascular diseases such as heart failure and hypertension. CONSTITUTION: There compounds of formula I [a wave line means that 17- positioned s...
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JPH06192286A |
PURPOSE: To obtain a new compound having an activity against the cardiovascular system and extremely low in toxicity and useful for treating cardiac and vascular diseases such as heart failure and hypertension. CONSTITUTION: This compoun...
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JPH06184187A |
PURPOSE: To provide a new compd. useful as a therapeutic agents for cardiovascular diseases such as heart failure and hypertension. CONSTITUTION: A compd. of formula I {Y is, when the double line of a solid line and a broken line is a si...
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JPH0649717B2 |
The intermediate products of formula (II): R' = especially H or optionally substituted alkyl, alkenyl, alkynyl, aryl or aralkyl, hydroxyl, tetrahydropyranyl, tert-butoxy, optionally esterified carboxyl, amino, mono- or dialkylamino, trit...
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JPH0633287B2 |
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JPH0665285A |
PURPOSE: To obtain a new compd. which is useful as a therapeutic drug for cardiovascular diseases such as heart failure and hypertension, is low toxic and which acts as a partial agonist for enzymic activity of Na+, K+-ATPase. CONSTITUTI...
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JPH0665284A |
PURPOSE: To obtain the subject low-toxic new compd. useful as a therapeutic drug for cardiovascular diseases such as heart failure and hypertension. CONSTITUTION: This invention provides a compd. expressed by formula I or its salts, and ...
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JPH0641187A |
PURPOSE: To produce a new compd. having excellent local antiinflammatory action, showing good local to systemic antiinflammatory activity and useful as agents for treating inflammatory and allergic dermatosis. CONSTITUTION: The compd. of...
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JPH061797A |
PURPOSE: To obtain an ethylenically unsatd. bile acid deriv. having an ethylenically unsatd. group bonded to a bile acid deriv. through a bridge group and used as starting material for the preparation of a polymeric bile acid deriv. whic...
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JPH05507912A |
Novel angiostatic DELTA <4,9(11)>-steroids (I), C21-oxygenated steroids (II) and other known steroidal compounds have been found to be useful in treating angiogenesis in mammals who have a need for the same. These steroids are useful in ...
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JPH0573759B2 |
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JPH0564158B2 |
6 alpha ,16 beta -Dimethyl corticoids of general Formula I (I) wherein the bond ----is a single bond or a double bond, and X is a hydrogen atom, a fluorine atom, a chlorine atom, or a bromine atom, Z is a hydrogen atom or, jointly with X...
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JPH0559919B2 |
6 alpha ,16 alpha -Dimethyl corticoids of general Formula I (I) wherein the bond is a single bond or a double bond, X is a hydrogen atom, a fluorine atom, a chlorine atom, or a bromine atom, R1 is a formyl group, an alkanoyl group or alk...
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JPH0559918B2 |
11 beta -Arylestradienes of general Formula I are disclosed (I) wherein R2 is a hydrogen atom, a methyl group, or an ethyl group, R3 is a hydrogen atom or an acyl group, R1 and A-B have various meanings, which possess antigestagen and an...
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JPH05202093A |
PURPOSE: To industrially advantageously obtain a thioketal compd. for an antiinflammatory agent, etc., by bringing a dione where one, but not the other, keto group of the dione is α,β-unsatd., into contact with a thiol in the presence ...
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JPH05194582A |
PURPOSE: To prepare a new compd. inhibiting testosterone 5α-reductase and useful for the treatment of benign prostatic hypertrophy or the like. CONSTITUTION: This is a new compd. of formula I [R is 1-6C alkyl, 1-4C alkoxy, (substituted)...
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JPH0535158B2 |
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JPH0533235B2 |
Novel corticoid 17 alpha -alkoxycarbonyl carboxylate derivatives are disclosed. These derivatives have strong topical anti-inflammatory activity and extremely weak systemic adverse reactions and are useful for the treatment of acute and ...
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JPH0533236B2 |
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JPH05502434A |
The use of fusidic acid or a derivative thereof for the manufacture of a composition for interfering with cytokines in a biological system, in particular for interfering with a cytokine such as a lymphokine, interleukine, monokine, inter...
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JPH0592989A |
PURPOSE: To obtain new 17β-acyl-3-carboxy-androsta-3,5-dienes useful to treat acne, seborrhea, female hirsutism and benign prostatic hypertrophy as testosterone 5α-reductase inhibitors. CONSTITUTION: The 17β-acyl-3-carboxy-androsta-3,...
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JPH0518837B2 |
11 beta -Arylspirolactones in the steroid series of the general formula I in which R1 is with R and R meaning in each case alkyl with 1 to 4 carbon atoms or R and R, with the inclusion of N, meaning a 5- or 6-membered saturated heterocyc...
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JPH059119A |
PURPOSE: To obtain an oral composition for hair tonic and hair growth capable of orally ingesting the composition as a medicine and a functional food, preventing and treating alopecia and simultaneously promoting hair production. CONSTIT...
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JPH059120A |
PURPOSE: To obtain an improver for drunken sickness, capable of suppressing toxicity caused by acetaldehyde produced in blood following ingestion of alcoholic beverages, removing intoxication due to the aforementioned toxicity, preventin...
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JPH054397B2 |
Novel 3-keto-19-nor- DELTA 4,9-steroids of the formula I
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JPH051094A |
PURPOSE: To obtain the subject new compound, having the substituted 21-position and powerful antiinflammatory and antiallergic actions with hardly any side effects and useful for preventing and treating, etc., various dermatopathies, chr...
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JPH051278B2 |
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JPH04331284A |
PURPOSE: To obtain lipid-selective antioxidants useful for the prophylaxis and treatment of coronary and circular diseases by reacting respectively specific antioxidative components and lipophilic components with bridging members. CONSTI...
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JPH0469638B2 |
The invention discloses 4-substituted androstendione derivatives of the following formula (I) (I) wherein R is amino or substituted amino or azido, one of R1 and R2 is hydrogen and the other is hydrogen, alkyl, alkenyl or alkynyl, and (x...
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JPH0466878B2 |
Novel 6-oxygenated corticoid 17 alpha -carbonates are disclosed. These compounds have strong topical anti-inflammatory activity which are accompanied by extremely weak systemic adverse reaction. The present compounds are useful for the t...
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JPH04506066A |
The invention is a method of treating angiogenesis in a warm blooded mammal who is in need of such treatment which comprises administration of an angiogenic inhibiting amount of a combination of a suramin-type compound and an angiostatic...
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JPH04297422A |
PURPOSE: To obtain an antirheumatic agent, containing a steroidal compound having the steroidal skeleton in which the 21-position is substituted with an acylthio group or amide group derived from an N-acylamino acid having a specific str...
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JPH04297420A |
PURPOSE: To obtain an anti-inflammatory agent, containing a steroidal compound having the steroidal skeleton in which the 21-position is substituted with an acylthio group or amide group derived from an N-acylamino acid having a specific...
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JPH04297423A |
PURPOSE: To obtain a therapeutic agent for ophthalmopathy, containing a steroidal compound having the steroidal skeleton in which the 21-position is substituted with an acylthio group or amide group derived from an N-acylamino acid havin...
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JPH04297421A |
PURPOSE: To obtain an antiallergic agent, containing a steroidal compound having the steroidal skeleton in which the 21-position is substituted with an acylthio group or amide group derived from an N-acylamino acid having a specific stru...
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