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JPS53141249A |
pg,1 Steroids having the formula wherein X is R1 is alkyl, aryl or acyloxyalkyl; R2 and R3 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, hydroxy, halogen, phenyl or cyano, with the proviso that when R2 a...
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JPS53141258A |
Compounds of the formula I (I), wherein R2 is hydrogen or an organic acid residue; R3 is methyl or ethyl; R4 is hydrogen or methyl; +TR wherein R1 is lower alkyl; and and when R2 is a dibasic acid residue, the physiologically acceptable ...
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JPS53111053A |
The present invention discloses a process for the production of -androsta-4,9(11)-diene-3,17-dione-type compounds from 9 alpha -hydroxyandrostenedione-type compounds by forming a sulfinate ester at C9 followed by desulfination.
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JPS5392753A |
PURPOSE: The title cpds. I [Z is oxo, β-OR1, etc.; R1 is II(R4 is H or alkyl; R2 and R3 are H, 1-8C alkyl, phenyl, etc.; R2 and R3 together form a ring); Q is oxo or III(R5 is H, -COOR4, etc.); the bond between C1 and C2 is single or do...
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JPS5320987B2 |
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JPS5320984B2 |
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JPS5318023B2 |
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JPS5346952A |
Novel 19-oxygenated steroids of the 20-spiroxane series of the formula in which R3 is a lower alkyl radical carrying an oxygen-containing functional group and R4 is two hydrogen atoms or an oxo group, and which carry a double bond or a m...
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JPS52111552A |
4-Androsten-3-ones of the formula wherein R1 is hydrogen or the acyl radical of an organic or inorganic acid, R2 is hydrogen, alkyl, or the acyl radical of an organic or inorganic acid, R3 is methyl or ethyl, R4 is hydrogen or methyl, +t...
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JPS5289662A |
Novel 6 alpha ,9 alpha ,21-trihalogeno-11 beta -hydroxy-16 alpha or 16 beta -methyl-17 alpha -propionyloxy-pregn-4-ene-3,20-dione compounds of the formula (I) in which X represents chlorine or flourine, R represents the group -CH2CH-, -C...
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JPS5285159A |
Pregnanes and androstanes are described which essentially possess a 3.alpha.-hydroxy group, a S.alpha.-hydrogen atom or a 4,5- or 5,6-double bond, a 17.alpha.-hydrogen atom and an 11.beta.-aminoester group. Other optional substituents or...
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JPS5271459A |
A method for treating arthritis which comprises administering to a subject in need of such treatment an effective amount of a fusidic acid derivative selected from compounds of the formula I: I in which R1 stands for a straight or branch...
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JPS5212777B2 |
1375357 Corticoid 21-sulphobenzoate ROUSSEL UCLAF 21 May 1973 [19 May 1972] 24013/73 Heading C2U The invention comprises 6α-methylprednisolone 21-(m-sulphobenzoate) and its alkali metal salts. The salts are prepared from the correspondi...
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JPS5210870B1 |
1,255,950. 18-Methylene steroids. CIBAGEIGY A.G. 20 Dec., 1968 [22 Dec., 1967; 25 Nov., 1968], No. 60763/68. Heading C2U. 18-Methylene steroids are prepared (1) by heating N-oxides of tertiary 18-aminomethyl steroids; or (2) by splitting...
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JPS5233663A |
Novel 2,2-dimethyl steroids of the formula I wherein R is selected from the group consisting of hydrogen, -OH and R1 is selected from the group consisting of hydrogen and hydrocarbon of 1 to 17 carbon atoms Z is selected from the group c...
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JPS5217401A |
The process for removing a secondary hydroxyl group from an organic compound having at least one secondary hydroxyl group and having any amino groups protected, comprises the reaction of a reactive ester of said secondary hydroxyl group ...
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JPS5212159A |
Therapeutically useful 16-dehydro-androstane derivatives of the general formula: processes for their preparation and pharmaceutical compositions for the treatment of dermatological disorders, which contain as active ingredient at least o...
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JPS51128959A |
Compounds of the general formula (I) wherein R1 represents a hydrogen atom or a lower alkyl group, which contain a double bond in 5-position and a methyl group in 10-position, or three double bonds in the position 1,3 and 5)10), and whic...
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JPS5136273B2 |
The present invention relates to new esters of the 21-thiol-steroids, having the general formula given at (I) below, and also to a method of preparation of these new esters: (I) in which:
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JPS5165747A |
1528796 7α-Hydroxy-cotradiols SCHERING AG 13 Oct 1975 [14 Oct 1974 8 Aug 1975] 41798/75 Heading C2U Novel steroids of the formula (wherein R 1 is H, acyl, optionally substituted alkyl, cycloalkyl or a saturated oxygen-containing heteroc...
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JPS5154542A |
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JPS5123251A |
Derivatives of 3,20-diketo-17 alpha -hydroxy-19-norpregnene-4 and their method of preparation is described. These compounds are useful as progestationals, pituitary-suppresants, contraceptives, anti-androgens, anti-estrogens, anti-seborr...
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JPS50101358A |
1498132 Steroid [16α,17-b]dioxanes E R SQUIBB & SONS Inc 15 Jan 1975 [16 Jan 1974] 1776/75 Headings C2U and C2C The invention comprises 3,20-dioxo pregnenes having an 11#-hydroxy or 11-oxo group and having at position 16,17 a fused-on 1...
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JPS5095256A |
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JPS5069060A |
15 alpha -Sulfonyl-12 beta -hydroxypregnanes of the formula WHEREIN Ac is lower-acyl and R is alkyl, cycloalkyl, aralkyl or aryl, which are useful as intermediates for the production of digoxigenin, are produced by the selective sulfonic...
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JPS5040555A |
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JPS5036450A |
Pharmacologically valuable 3-keto-6-azido-4,6-bis-dehydro-steroids are prepared by treating a 3-keto-6 beta ,7-diacyloxy-4-dehydro-steroid, preferably a 3-keto-6 beta ,7 beta -diacyloxy-4-dehydrosteroid, wherein said acyloxy group is a g...
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JPS5024261A |
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JPS5019915A |
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JPS4940470B1 |
21-Mercapto-steroids of the pregnane series of the general formula WHEREIN R1 = H or an acyl radical R2 = H or free or esterified hydroxyl R3 = CH3 or alpha -hydroxy, free or esterified OR R2 + R3 = alkylidene or cycloalkylidene dihydrox...
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JPS4935619B1 |
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JPS4994659A |
Topical anti-inflamatory 11-oxygenated pregneno[17,16 alpha -d]-1', 3'-oxathiolanes of the formula I wherein R1 and R2, can be the same or different and are a hydrogen atom, an alkyl, a cycloalkyl, a cycloalkyl containing hetero atoms, a...
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JPS4972243A |
The present invention relates to an improved process for the manufacture of beta -(3-oxo-7 alpha -thioacyl-17 beta -hydroxy-4-androsten-17 alpha -yl)-propionic acid gamma -lactones, in which a beta -(3-oxo-17 beta -hydroxy-4,6-androstadi...
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JPS4970956A |
The present invention relates to an improved process for the manufacture of beta -(3-oxo-7 alpha -thioacyl-17 beta -hydroxy-4-androstene-17 alpha -yl)-propionic acid gamma -lactones in which a beta -(3-oxo-17 beta -hydroxy-4,6-androstadi...
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JPS4970957A |
1450425 Spironolactone and antecedents thereof HOECHST AG 4 Oct 1973 [5 Oct 1972] 46390/73 Heading C2U The invention comprises compound II and its preparation and conversion into spironolactone (V) as shown. The starting material I is pr...
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JPS4949951A |
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JPS4948652A |
1436324 21-Substituted 3α-hydroxy-pregnane compounds GLAXO LABORATORIES Ltd 11 May 1973 [12 May 1972] 22489/72 Heading C2U Novel steroids of the pregnane or 19- norpregnane series possess essentially a 3α-hydroxy group, a 5α-H atom or...
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JPS4947361A |
1432135 21-Substituted-pregnanes GLAXO LABORATORIES Ltd 4 May 1973 [5 May 1972] 21145/72 Headings C2U and C2C [Also in Division A5] Novel steroids are pregnanes or 19-norpregnanes possessing essentially a 3α-OH group, a 17α-H atom, a 2...
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JPS4943962A |
1444272 Spironolactone and precursors thereof HOECHST AG 27 July 1973 [28 July 1972] 35779/73 Heading C2U The invention comprises: (A) compounds of formula which contain either (i) #5 or #4'6-unsaturation, in which case R 1 is OH, alkoxy...
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JPS4911696B1 |
1,255,950. 18-Methylene steroids. CIBAGEIGY A.G. 20 Dec., 1968 [22 Dec., 1967; 25 Nov., 1968], No. 60763/68. Heading C2U. 18-Methylene steroids are prepared (1) by heating N-oxides of tertiary 18-aminomethyl steroids; or (2) by splitting...
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JPS4881847A |
1367025 Steroid sulphates MERCK PATENT GmbH 1 Jan 1973 [22 Jan 1972] 69/73 Heading C2U Novel steroids of the formula (wherein R1 is a cholestane or stigmastane side chain and R2 is H or R1 + R2 is a spirostane ring system, and R4 and R5 ...
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JPS4831106B1 |
1,255,950. 18-Methylene steroids. CIBAGEIGY A.G. 20 Dec., 1968 [22 Dec., 1967; 25 Nov., 1968], No. 60763/68. Heading C2U. 18-Methylene steroids are prepared (1) by heating N-oxides of tertiary 18-aminomethyl steroids; or (2) by splitting...
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JPS4830048B1 |
A method for the prepn. of ethers and thioethers of the androstane, estrane, pregnane, and 19-nor-pregnane series. 17-Cycloethylenedioxy-3-hydroxy-estra-1:3:5(10)-triene in T.H.F. (125 ml.), treated (5 h.) with BF3-B2H6. Excess B2H6 dec....
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JPS4840762A |
1356716 17 - Hydroxy - 7α - mercapto - 3- oxo - 17α - pregn - 4 - ene - 21 - carboxylic acid gamma lactone G D SEARLE & CO 29 Sept 1972 [30 Sept 1971] 45207/72 Heading C2U The novel title compound is prepared by alkaline hydrolysis of ...
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