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Matches 151 - 200 out of 1,820

Document Document Title
WO/2013/030410A2
The present invention relates to processesfor obtaining abirateroneand derivatives thereof, such as abiraterone acetate, by means of a Suzuki coupling through a steroid borate of general formula (IV) or a C-C coupling through a steroid h...  
WO/2013/027073A1
The present invention relates to new histamine-3 (H3) receptor subtype preferring ligands of formula (I) (as defined in the claims) and/or geometric isomers and/or stereoisomers and/or diastereoisomers and/or salts and/or hydrates and/or...  
WO/2013/016725A1
Described herein are compounds which either act as pure antiprogestins or as antiprogestins with partial agonistic activity and methods of treating cancer using such compounds.  
WO/2013/013594A1
Disclosed are an amorphous substance of 17α-acetoxy-11β-(4-N,N-dimethylaminophenyl)-19-norpregna-4 ,9-diene-3,20- dione and a preparation method thereof. The said CDB-2914 amorphous substance generally has a powder X-ray diffraction pa...  
WO/2013/013595A1
Disclosed are a crystal of 17α-acetoxy-11β-(4-N,N-dimethylaminophenyl)-19-norpregna-4 ,9-dien-3,20- dione, and the preparation process thereof. The crystal substantially has the powder X-ray diffraction pattern shown in Fig. 1. The pre...  
WO/2012/110010A1
The presented invention applies to pregnanolone derivatives, substituted in 3 alpha-position with the cationic group, of general formula I, the method of the production of these compounds and their utilization for treatment of neuropsych...  
WO/2012/109275A1
Disclosed are methods and systems for the analysis of delta 5 steroid compounds in a sample using supported liquid extraction and liquid chromatography/mass spectrometry.  
WO/2012/047495A2
This invention relates generally to methods for preparing certain bile acids from non-mammalian sourced starting materials as well as to synthetic bile acids and compositions comprising such acids wherein the acids are characterized by a...  
WO/2012/035553A1
Provided is a process for preparing androstenone derivatives, specifically 3-oxo-4-aza-5α-androstene-17β-carboxylic acid of Formula I, a key intermediate for dutasteride.  
WO/2012/027957A1
Bufalin derivatives of formula I and the pharmaceutical compositions thereof are provided, wherein the radicals have the meanings as defined in the invention. The use of these derivatives is also provided.  
WO/2011/132045A2
The present invention provides novel process for preparation and purification of dienogest (I). The present invention provides dienogest (I) substantially free of impurities.  
WO/2011/119194A1
The subject matter of the instant invention is pertinent to the field of treatment of hormone-dependent conditions. New compounds and methods for treating these conditions are disclosed. Embodiments of the instant invention disclose meth...  
WO/2011/036557A1
Compositions, methods and compounds useful for enhancing the uptake of a lipid particle b\ a cell are described In particular embodiments, the methods of the invention include contacting a cell with a lipid particle and a compound that b...  
WO/2011/029639A2
The invention features compounds, pharmaceutical compositions and methods useful for the treatment of neoplasia. In particular embodiments, the compounds of the invention are useful for the treatment of multidrug resistant neoplasia.  
WO/2010/136940A1
This invention relates to novel glucocorticoid receptor agonists of formula (I) and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical compositions containing these compounds, to th...  
WO/2010/128472A1
Process for preparing glycocholic acid comprising the following steps: a) making a mixed anhydride of cholic acid through the suspension of cholic acid in acetone or in aqueous acetone in presence of a base, and subsequent reaction with ...  
WO/2010/126953A1
New chemical entities which comprise corticosteroids and phosphorylated β- agonists for use in therapy and compositions comprising and processes for preparing the same are provided.  
WO/2010/123545A2
Compounds of Structural Formula I or pharmaceutically acceptable salts thereof, are effective inhibitors of angiogenesis:  
WO/2010/118025A1
Described herein are compounds which exhibit progesterone antagonistic effects and methods of treating cancer using such compounds.  
WO/2010/118023A1
Described herein are methods of making drospirenone. Also described are intermediate compounds that may be used to synthesis drospirenone.  
WO/2010/106383A1
The present invention relates to novel crystalline Form A of 17α-acetoxy-21-methoxy- l lβ-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20- dione, (also known as CDB-4124) and methods for the preparation of it in excellent purity.  
WO/2010/102673A1
The present invention relates to new cardiotonic Steroid Compounds of Formula (I) or (II) wherein X1, X2, X3, L, R1, R2, R3, R4, and R5 have the same meaning as that defined in the Claims. The invention also relates to the use of said Co...  
WO/2010/092381A1
A process for the preparation of cholyl-L-lysine comprising the steps of:- (a) reacting N-ε-CBZ-cholyl-L-lysine with a hydrogen source in the presence of a catalyst in a solvent comprising one or more alkanols; (b) removing the catalyst...  
WO/2010/071772A2
The present invention relates to methods for synthesizing preferred membrane-binding elements, preferably cholesterylamine derivatives, including 3-amino-5-cholestene (3-cholesterylamine) and related 3-halides through i-steroid and retro...  
WO/2010/059853A1
The invention relates to compounds of Formula A: (A) or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory ...  
WO/2010/043506A1
Method for preparing 2-alkoxy and 2-aryloxyestrogen compounds, and the intermediate compounds prepared during the use of this method, which intermediate compounds are useful intermediates in the preparation of certain physiologically act...  
WO/2010/015529A1
The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof. The compounds are useful in the treatment of illnesses wherein the known steroid, parent or precursor steroid, is g...  
WO/2010/015875A1
The present invention concerns a process for the preparation of lanosta-8-ene compounds having lanosta-8-ene-7-one or lanosta-8-ene-7-ol compounds as starting material.  
WO/2010/012904A2
The present invention relates to novel chemical compounds, in particular cholest-4-en-3-one oxime derivatives, and to the use thereof as medicaments, especially as cytoprotective medicaments, in particular as neuroprotective, cardioprote...  
WO/2010/012567A1
The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of usi...  
WO/2009/144738A1
Novel benzoic acid hydrazones of 5α-androstan-3, 17-dione have been prepared on the basis of steroidal tigogenin of the plant Yucca gloriosa. The hvdrazones of the General Formula (I), General Formula (II) and General Formula (III) as s...  
WO/2009/146218A2
This invention provides novel compounds comprising the following anti-inflammatory pharmacore Formula (I): wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprisin...  
WO/2009/122435A2
The present invention relates to preparation and biological evaluation of 3-acetoxy-17- acetamido-16-formyl-androst-5,17-diene (4) and 3-acetoxy2'-chloro-5-androsteno [17,16- b]pyridine (5) as gastric proton pump inhibitor and their comp...  
WO/2009/083268A2
The invention relates to 17-(1'-propenyl)-17-3'-oxidoestra-4-en-3-one derivatives with general chemical formula (1) wherein the radicals Z, R4, R6a, R6b, R7, R15, R16a, R16b and R18 have the designations given in claim 1, and to the solv...  
WO/2009/082818A1
The invention relates to 21 -keto triterpene compounds of formula (I): wherein R1, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, th...  
WO/2009/082819A1
The invention relates to 21-keto triterpene compounds of formula (I): wherein R1, X, and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, th...  
WO/2009/053439A2
The invention relates to the technical field of anti-inflammatory compounds, specifically those of a steroid nature, in particular to a new amorphous form of a nitrooxy derivative of a corticosteroid, its pharmaceutical formulations and ...  
WO/2009/054725A2
The invention provides means and methods for alleviating one or more symptom(s) of Duchenne Muscular Dystrophy and/or Becker Muscular Dystrophy. Therapies using compounds for providing patients with functional muscle proteins are combine...  
WO/2009/050483A1
This invention relates to cationic lipids. More particularly the invention relates to biodegradable cationic lipids having a plurality of cationic headgroups and one or more lipophilic tail groups. The lipids are of utility in various ap...  
WO/2009/047101A1
New aminooxime derivatives at position 3 of 2-and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as he...  
WO/2009/047006A2
An amphoteric liposome comprising neutral lipids wherein said neutral lipids are selected from the group comprising cholesterol or mixtures of cholesterol and at least one neutral or zwitterionic lipid and wherein K (neutral) of said mix...  
WO/2009/033505A1
The present invention relates to new cardiotonic steroids and their use in the treatment of cancer, in particular to compounds of Formula (I), stereoisomers, tautomers, racemates, prodrugs, metabolites, or a pharmaceutically acceptable s...  
WO/2009/027994A2
The present invention relates to steroidal esters of 17-oximino -5-androsten-3-ol,of compound of general formula (A) wherein R is selected form a group consisting of arylalkyl, aryl, substituted aryl. The ester derivatives are synthesize...  
WO/2009/027108A1
The present invention relates to a new process for preparing estrogen-antagonistic 11 β-fluoro-17α-alkylestra-1,3,5(10)-triene-3,17-diols of the general formula (I) having a 7α-(ξ-alkylamino-ω-perfluoroalkyl)alkyl side chain and to ...  
WO/2009/024022A1
Fatty acid bile acid conjugates of formula I, pharmaceutically acceptable salts, their preparation methods, pharmaceutical compositions containing the same, and the uses of the fatty acid bile acid conjugates or their pharmaceutically ac...  
WO/2009/001148A2
The present invention relates to a process for the synthesis of the known 17-acetoxy-11-β-[4-(dimethylamino)-phenyl]-21-methoxy-19-no rpregna-4,9-dien-3,20-dione (further on CDB-4124) of formula (I) from 3,3-[1,2-etandiyl-bis(oxy)]-oest...  
WO/2008/155141A2
A facultative cationic sterol derivate, said sterol derivate has a pka value of between 3.5 and 8 and the general formula Cation-Spacer 2-Y-Spacer 1-X-Sterol wherein X and Y are linking groups and wherein at least on of X and Y is -NH(C=...  
WO/2008/151745A1
The 17ß-cyano-18a-homo-19-nor-androst-4-ene derivatives of the present invention have gestagenic activity. They have the general chemical formula (1), in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO...  
WO/2008/151746A2
The 17ß-cyano-19-nor-androst-4-ene derivatives of the present invention have gestagenic activity. They have the general chemical formula (1), in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO2R, where...  
WO/2008/152112A2
The 17ß-cyano-19-androst-4-ene derivatives of the present invention have gestagenic activity. They have the general chemical formula (1), in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO2R, wherein R...  

Matches 151 - 200 out of 1,820