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JPS6115880B2 |
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JPS6115878B2 |
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JPS6115879B2 |
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JPS6172798A |
A process for preparing a 17 alpha -hydroxy-20-keto steroid comprises contacting a DELTA <1><6>-20-keto steroid with a silylating agent in the presence of a catalyst, and contacting the resultant DELTA <17(20)>-20-silyl ether steroid (so...
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JPS615092A |
The 6 alpha -methyl-D-homo-corticoids have the general formula (I) in which the bond .... represents a single bond or a double bond and X is a hydrogen atom, a fluorine atom, a chlorine atom or a bromine atom, Z is a hydrogen atom or, to...
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JPS60260592A |
PURPOSE: To provide the titled antigen composed of the E-isomer of androgen, gestagen or corticoid having carboxyalkyloxyimino group at the 3-site, and capable of giving an antibody having high specificity and titer against the correspon...
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JPS60258197A |
NEW MATERIAL:Compounds of formula I (R1 is O, OH; when R1 is O, R2 is H, OH; when R1 is OH, R2 is also OH), formula II and formula III. USE: A food additive for giving foods bitter taste such as a substituent of hops for beer. PREPARATIO...
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JPS60237096A |
A novel process for the preparation of prednisone derivatives of the formula I wherein R1 is alkyl of 1 to 4 carbon atoms and R2 is selected from the group consisting of hydrogen and hydrocarbon of 1 to 8 carbon atoms comprising reacting...
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JPS60209599A |
The invention relates to a group of Δ4- and Δ5(10)-oestrene derivatives having an alkyl(1-4 C) substituent in position 6 or 7, an oxy substituent in position 17β and optionally an oxo- or oxy- substituent in position 3 and a hydrocarb...
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JPS6044318B2 |
1512400 16,17-Naphthopregnenes E R SQUIBB & SONS Inc 13 Nov 1975 [25 Nov 1974] 46902/75 Heading C2U The invention comprises #4 and #1'4 steroids of formula wherein R 1 is Cl, F or OH; R1 1 is H; or R 1 and R1 1 together are oxo; R 2 is H...
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JPS6043358B2 |
New 16-methyl-9 alpha -halo corticosteroid esters and ethers having high topical anti-inflammatory potency and low systemic activity and the manner in which they can be produced are described.
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JPS60188398A |
PURPOSE: To produce the titled fluorine-containing steroid compound useful as an anti-inflammatory agent, in high yield, by reacting an alkali metal salt of an organic acid with fluorine gas, reacting the product with Δ3.5-pregnadiene d...
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JPS6042799B2 |
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JPS60166627A |
Process for the formation of carbon-containing free radicals R., which optionally include functional groups, wherein thermal and/or photochemical energy is supplied to a thiocarbonyl-containing ester corresponding to the general formula ...
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JPS6034990A |
17-haloethynyl steroids of the partial formula wherein R1 is hydrogen or methyl, R2 is alkyl of 1-4 carbon atoms, acyl of 1-7 carbon atoms, trimethylsilyl, 2-tetrahydropyranyl, or nitrate, X is bromine or iodine, and V is methylene, ethy...
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JPS604198B2 |
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JPS60994B2 |
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JPS59205397A |
PROCESS FOR THE PRODUCTION OF 17-ESTERS OF CLOBETASOL This invention relates to an improved process for the preparation of 17-esters of Clobetasol having the formula II which consists in treatment of 9.beta.,11.beta.-epoxy-16.beta.-methy...
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JPS5938240B2 |
Topical and systemic anti-inflammatory activity is exhibited by steroids having the formula AND THE 1,2-DEHYDRO DERIVATIVES THEREOF, WHEREIN R1 is phenyl, naphthyl, or substituted phenyl or naphthyl.
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JPS59161400A |
Topical and systemic anti-inflammatory activity is exhibited by steroids having the formula AND THE 1,2-DEHYDRO DERIVATIVES THEREOF, WHEREIN R1 is phenyl, naphthyl, or substituted phenyl or naphthyl.
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JPS5933600B2 |
The invention relates to novel 11,11-alkylidene steroids of the estrane and (19-nor-)pregnane series having a double bond starting from carbon atom 5, the alkylidene group in 11-position having the formula R1 ANGLE C= , R2 wherein R1 and...
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JPS5922719B2 |
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JPS5922720B2 |
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JPS5919559B2 |
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JPS5976100A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS5912680B2 |
Pregnanoic acid derivatives of the following formula in which the substituents are defined in Claim 1, are prepared. These compounds are obtained by oxidising a corresponding pregnane derivative which has an aldehyde group in position 21...
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JPS5857440B2 |
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JPS5843399B2 |
Novel haptenes of the formula WHEREIN WHEN X is hydrogen, Y is =N-O-(CH2)a-COOH and a is a whole number of 1 to 12 and when H Y is ANGLE H X is hemiterephthaloyloxy in the alpha - or beta -position and antigens prepared therefrom by cond...
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JPS5842198B2 |
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JPS5840559B2 |
Pregnane-21-oic acids of the formula WHEREIN X is a hydrogen atom, a fluorine atom, or methyl; Y is a hydrogen atom, a fluorine atom, or a chlorine atom; Z is methylene, carbonyl, beta -hydroxymethylene, beta -acyloxymethylene or when Y ...
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JPS5837320B2 |
1387911 Anti-inflammatory medicines SCHERING AG 23 Feb 1972 [4 Oct 1971 27 Jan 1972 (3)] 8299/72 Heading A5B [Also in Division C2] Anti-inflammatory compositions comprise steroids of the formula: (wherein X is H, halogen or CH 3 ; Y is H...
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JPS5834480B2 |
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JPS58121300A |
PURPOSE: To prepare the titled clathrate compound free from toxicity and useful as a solution such as an antiphlogistic solution for oral administration or injection, etc., by including fluorometholone in cyclodextrin, thereby converting...
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JPS5830320B2 |
Steroids of the formula WHEREIN X is a hydrogen atom, a halogen atom or methyl; Y is a hydrogen atom or a halogen atom; Z is carbonyl, beta -acyloxymethylene or, when Y is a hydrogen atom, also methylene; R1 is a hydrogen atom or methyl;...
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JPS58103399A |
NEW MATERIAL:A compound of formulaI(R is isopropyl, isobutyl or phenyl). EXAMPLE: 6α-Methylpredonisolone 17-isobutyrate. USE: A local anti-inflammatory agent. PROCESS: A 6α-methylpredonisolone of formula II is reacted with an orthoeste...
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JPS58103400A |
NEW MATERIAL:A 6α-methylpredonisolone 17-ester, 21-chloride compound of the formula (R is lower alkyl or aryl). EXAMPLE: 6α-Methylpredonisolone 17-butyrate, 21-chloride. USE: An adrenocortical hormone, having the powerful anti-inflamma...
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JPS5826359B2 |
Novel DELTA 9,11-gonadiene-5 alpha -ols of the formula WHEREIN R is alkyl of 1 to 4 carbon atoms, K is a blocked ketone in the form of a ketal, thioketal or methyloxime, preferably a ketal, and X is the rest of a pentagonal ring optional...
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JPS5883699A |
The title complexes have 3-100 times the water-solubility of the uncomplexed steroids, e.g. spironolactone, nortestosterone, methyltestosterone, androst-4-ene- 3,17-dione, progesterone, Reichstein S, Reichstein S aceate, 16-methyl- Reich...
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JPS5879998A |
Novel dihalogenated steroids of the formula in which X represents methylene or an alpha -oriented methyl group together with a hydrogen atom and R represents an alkyl group having a maximum of 6 carbon atoms, and their 1,2-dehydro deriva...
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JPS5877898A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS5877900A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS5862200A |
PURPOSE: An essence mainly containing steroid saponine is extracted from KINGINNASUBI (Solanum aculeatissimum Jacq.) and the saponine is hydrolyzed to give isonuatigenin, then the isonuatigenin is used as a starting compound to subject t...
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JPS5817480B2 |
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JPS5811880B2 |
15 alpha , 16 alpha -METHYLENE-4-PREGNENES OF THE FORMULA WHEREIN R1 is a lower alkyl and R2 is alkanoyl of 1-18 carbon atoms have gestagenic activity.
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JPS5823645A |
This invention relates to processes for base catalyzed acylations using enol esters, for example, isopropenyl acetate. Particularly, the processes are useful for acylating acid sensitive alcohols including hydroxy steroids.
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JPS587612B2 |
Body function of a mammal is investigated using a gamma -emitting 75Se or 123mTe labelled derivative of a bile acid or bile salt. Thus bowel function may be investigated by oral administration of the labelled compound followed, after a s...
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JPS5821696A |
NEW MATERIAL:A compound of formulaI(the dotted line is single or double bond; X is acyloxy). EXAMPLE: 21-Bromo-17α-hydroxypregna-1,4-diene-3,20-dione 17-acetate. USE: An intermediate for preparing adrenocortical hormones, e.g. hydrocort...
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JPS5821697A |
NEW MATERIAL:A compound of formulaI(the dotted line is single or double bond; X is acyloxy). EXAMPLE: 21,21-Dibromo-17α-hydroxypregna-1,4-diene-3,20-dione 17-acetate. USE: An intermediate for preparing adrenocortical hormones, e.g. hydr...
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JPS5818400A |
PURPOSE: To prepare the titled compound useful as a synthetic intermediate of adrenocortical hormone, economically, by reacting a 17-halogenoacetyl-17-acyloxysteroid with a lower fatty acid salt in the presence of a crown ether. CONSTITU...
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JPS5816000A |
PURPOSE: To obtain the titled compound inexpensively useful as an intermediate for preparing adrenal cortical hormone, by reacting a 17-halogeneacetyl-17- acyloxysteroid with an alkali metal salt of a lower fatty acid in a polar aprotic ...
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