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Patent Searching and Data


Matches 1 - 50 out of 3,763

Document Document Title
WO/2021/058648A1
A process for purification of phytosterols, said process comprising, a. providing a liquid mixture comprising a phytosterol, lower alcohol, wherein the lower alcohol is present in an amount of from 25 to 800% by weight, based on the amou...  
WO/2021/058646A1
The presently claimed invention relates to a process for the production and purification of sterols from oil distillates or oil distillation residues, in particular from the latter. Specifically, the presently claimed invention relates t...  
WO/2021/046678A1
A method for synthesising chenodeoxycholic acid and an application therefor, relating to the technical field of pharmaceutical and chemical product synthesis, and used for solving the technical problem of the high production costs of exi...  
WO/2021/043845A1
In its first aspect, the disclosure concerns a process for providing an extract of phytosterols and stanols from tall oil pitch with the steps of (b) saponifying tall oil pitch by addition of a basic compound; (c) extracting the saponifi...  
WO/2021/036998A1
Provided are a novel bile acid derivative for treating fatty liver disease, a pharmaceutical composition thereof, and a use in the preparation of a medicine for treating and improving diseases and symptoms mediated or caused by FXR or TG...  
WO/2021/033766A1
The purpose of the present invention is to provide a novel lithocholic acid derivative having sufficient vitamin D3 activity. A compound represented in general formula (I), a salt thereof, or a prodrug thereof is provided. (R1 and R2 ind...  
WO/2021/016954A1
Disclosed are a 3-acetyl-5-hydroxy-B-norcholesterol-6-(N-methyl)thiosemicarb azone, a preparation method therefor and the use thereof, and structural formula (I) of the 3-acetyl-5-hydroxy-B-norcholesterol-6-(N-methyl)thiosemicarb azone. ...  
WO/2021/005618A1
The present invention discloses novel method for synthesizing vegan cholesterol and vitamin D3 from inexpensive crude phytosterol.  
WO/2020/264512A1
Provided herein in part is a compound of Formula (I): or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of Formula I, and methods of using the compounds, e.g, in the treatment of CNS- relate...  
WO/2020/252713A1
The present invention relates to the preparation of a hydrophobic medicinal auxiliary material and a drug-loaded fat emulsion, and in particular to a hydrophobic auxiliary material with the structural formula as shown below, wherein R is...  
WO/2020/244483A1
Provided are novel chemical compounds in which a lipophilic moiety such as a lipid, fatty acid, polyethylene glycol or terpene is covalently attached to a non-acylated or desacylated triterpene saponin via a carboxyl group present on the...  
WO/2020/240483A1
The present invention relates to, in part, a combination therapy of a polyhydroxylated bile acid and a famesoid X receptor agonist. The present invention also provides, in part, a pharmaceutical composition comprising a famesoid X recept...  
WO/2020/243488A1
Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R7a, R7a, R11a, R11b, R12a, R12b, R16a, R16b, R19, R11a, R22, RX, RY and n are defined he...  
WO/2020/230159A1
The invention discloses an improved process for production of vitamin D3 from 7- dehydrocholesterol (7- DHC) and to a simple process for recovery unreacted 7-DHC for further reuse. The invention further describes a process for isolation ...  
WO/2020/221113A1
Provided by the present invention is a preparation method for momordin Ib, comprising: first, mixing a plant containing a triterpene saponin derivative having the structural unit shown in formula (I) or a plant extract containing a trite...  
WO/2020/218383A1
Development of a novel GLP-secretagogue for promoting secretion of GLP-1 is anticipated. The present invention provides a GLP-secretagogue characterized by containing 2 ppm or more of mogroside.  
WO/2020/214919A1
The present invention pertains to a method for inhibiting, reducing or reversing atherosclerosis or a composition or pharmaceutical composition for preventing or treating an atherosclerotic disease containing a preparation of Antrodia ca...  
WO/2020/201968A2
The present disclosure describes that high purity cholesterol is obtained by the processes of the invention without any further purification step, such as a crystallizing step from a solvent, but rather by distilling steps alone. The dis...  
WO/2020/201999A2
Described are various embodiments of a pupil tracking system and method, and digital display device and digital image rendering system and method using same. In one embodiment, a computer-implemented method for dynamically adjusting rend...  
WO/2020/187298A1
The present invention relates to a method for preparing a chenodeoxycholic acid derivative. Particularly, disclosed is a method for carrying out one-pot reduction on a compound represented by formula (Ⅵ), i.e., 3α-hydroxyl-ethidene-7-...  
WO/2020/189734A1
Provided is a compound or salt thereof represented by formula (I) below [In formula (I), R1 represents –COOH or –CY1Y2OH (where, Y1 and Y2 each represent a hydrogen atom or a detectable marker), A1 represents a sugar or an aglycone, ...  
WO/2020/177240A1
The present application relates to the field of drug synthesis and specifically relates to chenodeoxycholic acid and a preparation method therefor. The preparation method for the chenodeoxycholic acid comprises the following steps: formi...  
WO/2020/176436A1
The present invention pertains to a composition for preparing a medicament for preventing and/or treating a virus infection, especially a hepatitis B virus infection and/or a herpes simplex virus, and uses thereof.  
WO/2020/172313A1
The invention provides compounds as allosteric modulators that are useful as sweet flavor enhancers. The present invention also includes ingestible compositions comprising the present compounds and methods of enhancing the sweet taste of...  
WO/2020/169643A1
The present invention relates to the diethylamine salt of 3a- tetrahydropyranyloxy-6a-ethyl-7a-hydroxy-53-cholanic acid (I), which is a new intermediate in the synthesis of obeticholic acid, to the use of said diethylamine salt in the sy...  
WO/2020/163201A1
The present application relates to methods of treating or preventing an intestinal inflammatory disease or condition (e.g., intestinal ischemia reperfusion injury) in a subject in need thereof, comprising administering a therapeutically ...  
WO/2020/119836A8
A process for preparing obeticholic acid, wherein the 7-keto-litocholic acid amide of formula (II), where R1, R2 are a C1-C6 n-alkyl, or together a C5-C6 cycle and the protecting group on the hydroxyl in position 3 is a carbamoyl with th...  
WO/2020/117945A8
The compositions and methods provided herein are related, in part, to the discovery of cholic acid 7-sulfate as a treatment for diabetes. Provided herein is a method for treating a metabolic disorder (e.g., diabetes, obesity), or an infl...  
WO/2020/136292A1
The present invention relates to compounds that can be defined as compounds derived from lithocholic acid and the metabolites thereof. For this reason, the compounds of the invention are named using the steroid numbering system. More par...  
WO/2020/125825A1
The present technical solution relates to compounds of general formula (I), wherein X is independently H or OH, while at least one X is OH, for use as a medicament, particularly in the treatment or prevention of cellular growth and regen...  
WO/2020/068004A3
A new lanostane triterpenoid (24E)-3β-acetoxy-15α-propionyloxylanosta-7,9( 11 ),24-trien-26-oic acid (GA003), is synthesized by acylation reaction of a naturally occurring fungal metabolite, (24E)-3β-acetoxy-15α-hydroxylanosta-7,9( 1...  
WO/2020/128514A1
2-Fluorinated bile acid compounds of general formula (I) wherein at least one of R1 and R2 represents F and the other is chosen 3 from H and F and wherein R3 is as defined herein; are of use in the treatment and prevention of neurodegene...  
WO/2020/131058A1
Disclosed is a method for enhancing the activity of telomerase using a composition containing ecdysterone. The invention also discloses the use of a composition containing ecdysterone and/or an extract containing ecdysterone, isolated fr...  
WO/2020/121140A1
The present invention relates to fractionation of crude tall oil, which originates from the Kraft process black liquor. In the method,according to the present invention, simulated moving bed (SMB) chromatography is used to efficiently se...  
WO/2020/119836A1
A process for preparing obeticholic acid, wherein the 7-keto-litocholic acid amide of formula (II), where R1, R2 are a C1-C6 n-alkyl, or together a C5-C6 cycle and the protecting group on the hydroxyl in position 3 is a carbamoyl with th...  
WO/2020/117945A1
The compositions and methods provided herein are related, in part, to the discovery of cholic acid 7-sulfate as a treatment for diabetes. Provided herein is a method for treating a metabolic disorder (e.g., diabetes, obesity), or an infl...  
WO/2020/104356A1
The present invention relates to 7-dehydrocholesterol-hemihydrate. It has been found that the formation of 7-dehydrocholesterol-hemihydrate offers an efficient method of increasing the storage stability of 7-dehydrocholesterol, respectiv...  
WO/2020/104353A1
The present invention relates to 7-dehydrocholesterol-hemimethanolate. It has been found that the formation of 7-dehydrocholesterol-hemimethanolate offers an efficient method of increasing the storage stability of 7-dehydrocholesterol, r...  
WO/2020/095888A1
Provided is a method for producing high-purity cholesterol which does not contain a substantial amount of desmosterol, said method comprising reacting cholesterol mixed with desmosterol with a halogenating reagent and water and then sepa...  
WO/2019/161211A3
Methods useful for reducing or preventing hepatic steatosis and NASH are provided herein. Such methods may comprise administering to a subject in need thereof an FXR agonist in combination with an amount of a branched amino acid in free ...  
WO/2019/228602A8
The invention relates to a process for recovering sterols and a fraction rich in fatty acids and resin acids from tall oil pitch, said process comprising a) saponifying the tall oil pitch with an alkali to hydrolyse esters included in th...  
WO/2020/076815A1
Steroid compounds are disclosed that have a formula represented by the following: (I) and wherein R1, R2, R3a, R3b, R4a, R4b, R5, R6a, R6b, R7, R8, and n are as described herein. The compounds may be prepared as pharmaceutical compositio...  
WO/2020/061317A1
The invention relates to sterol esters and methods for producing purified sterols that can be utilized in methods for producing a lipid nanoparticle.  
WO/2020/061332A1
The invention relates to compositions and methods for the preparation, manufacture, and therapeutic use of compositions comprising mRNA and a lipid nanoparticle comprising a compound of the invention and an ionizable lipid.  
WO/2020/045570A1
Provided are: a novel compound that forms a self-assembly; the self-assembly; production methods for the compound and the self-assembly; and pharmaceutical use of the compound and the self-assembly. The compound is represented by formula...  
WO/2020/039449A1
The present invention relates to an improved process for the preparation of Obeticholic acid and intermediates used in the process thereof. The invention also relates to a solid form of tertiary butylamine salt of Obeticholic acid and te...  
WO/2020/030737A1
The present invention relates to isolithocholic acid (3ß-hydroxy-5ß-cholan-24-oic acid, iso-LCA) and isoallolithocholic acid (3ß-hydroxy-5α-cholan-24-oic acid) and their deuterated analogs for preventing or treating Clostridium diffi...  
WO/2020/025942A1
Compounds of general formula (I): wherein R2a, R2b, R3a, R3b, R5, Y and R7 are as defined herein are selective agonists at the FXR receptor and are useful for the treatment or prevention of diseases and conditions including nonalcoholic ...  
WO/2020/020728A1
Disclosed are compounds of formula (I), wherein X, Y, Z are annular atoms comprised in a five-membered carbocyclic or heterocyclic ring, selected from the group consisting of CH, NH, N, O, S; saidcarbocyclic or heterocyclic ring being op...  
WO/2020/020306A1
The present invention relates to a crystal form of a compound of formula (I) and an application thereof in preparing a drug for treating an ophthalmic disease.  

Matches 1 - 50 out of 3,763