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Matches 1 - 50 out of 2,751

Document Document Title
WO/2024/033287A1
The present invention relates to a compound having general Formula (I) (e.g., hydroxycholest-5-ene glycoside or its derivatives; (e.g., Compounds 1-3 or their derivatives or analogues thereof or Compound 4 or its derivatives or analogues...  
WO/2024/025465A1
Disclosed herein are methods of obtaining ferulic acid. In one aspect, the present disclosure refers to a method of hydrolysing oryzanol to obtain ferulic acid, wherein the method comprises: i. hydrolysing an oryzanol-comprising material...  
WO/2024/012317A1
A composition for resisting aging, and a use thereof or a method therefor. The pharmaceutical composition comprises a therapeutic agent X or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipien...  
WO/2024/015201A1
The disclosure relates to a crystalline solid form of Compound 1. The disclosure also provides methods of preparing said crystalline solid form of Compound 1.  
WO/2023/247563A1
A compound of formula (I-A), R1 in each occurrence is selected from H, optionally substituted C1-12 alkyl and optionally substituted C6-20 aryl; R2 in each occurrence is selected from optionally substituted C1-12 alkyl and optionally sub...  
WO/2023/250185A1
The disclosure relates to Compound 1 and crystalline solid forms and solid dosage forms thereof. The disclosure also provides methods of preparing and methods of using said crystalline solid forms of Compound 1 and solid dosage forms the...  
WO/2023/233346A1
The present invention relates to compounds having general formula ( I ) and to their uses for simultaneously modulating the bile acid receptors, FXR and GPBAR1, and the orphan receptor ROR gamma (RORγ) and thus to their use in the treat...  
WO/2023/217237A1
Disclosed are a lipid compound having a general formula as shown, and a composition, preparation and use thereof. The lipid compound is a compound based on cholic acid or a derivative thereof, or a pharmaceutically acceptable salt thereo...  
WO/2023/216423A1
Disclosed in the present invention are a lipid compound as represented by a general formula and a composition, and the preparation and the use thereof. The lipid compound of the present invention is a compound based on cholic acid or a d...  
WO/2023/213540A1
The present invention relates to a process for the preparation of cholic acid derivatives, in particular of compounds of formula (V). The present invention also relates to compounds useful for the preparation of such derivatives.  
WO/2023/207268A1
Provided is a synthesis method for deoxycholic acid, which synthesizes deoxycholic acid from plant-derived 9-OH-BA as the starting material by means of steps of side chain oxidation reaction, Wittig or Wittig-Horner reaction, dehydration...  
WO/2023/192221A1
The present disclosure provides solid forms of sodium chenodeoxycholate (NaCDC), as well as compositions thereof and methods of using and preparing the same.  
WO/2023/179721A1
The present invention provides a synthesis method for a 7-ketolithocholic acid or an intermediate thereof, which is prepared from a new intermediate I-1. According to the method, phytosterol degradation product bisnoralchol is used as a ...  
WO/2023/181077A1
The present invention relates to a stable liquid pharmaceutical composition comprising Obeticholic acid or its salts and one or more pharmaceutically acceptable excipients and its process of preparation and its use for the treatment of a...  
WO/2023/179724A1
Provided in the present invention is a method for synthesizing a 7-ketolithocholic acid intermediate, the method comprising preparing compound OB-1 in an amide solvent to obtain a 7-ketolithocholic acid intermediate OB. The method of the...  
WO/2023/179062A1
The present invention relates to an extraction process for cholesterol. The extraction process comprises the following steps: adding a mixture to be extracted into n-hexane, and stirring same at a constant speed until the mixture is diss...  
WO/2023/176822A1
The purpose of the present invention is to provide: a sterol compound capable of achieving excellent nucleic acid delivery efficiency when used in lipid compositions; and a lipid composition which is capable of achieving excellent nuclei...  
WO/2023/173359A1
The present invention relates to a use of a compound and an extract derived from natural fungus Antrodia camphorata in the preparation of an FGF21 agonist and/or an RDH10 agonist.  
WO/2023/173846A1
A steroid compound and a pharmaceutically acceptable salt thereof, a preparation method therefor and the use thereof. The structural formula of the steroid compound is as shown in formula I', wherein R is dimethylamino or methylamino. Th...  
WO/2023/169372A1
A cucurbitacin B derivative, a preparation method therefor and a use thereof. The structure of the compound is shown in formula I. The cucurbitacin B derivative is easy to synthesize, has good anti-tumor and anti-inflammatory activity, a...  
WO/2023/168974A1
A cholic acid derivative, a preparation method therefor, and an application thereof as a TGR5 allosteric agonist. using CA as a lead compound, modification is performed at positions 7, 12, and 24 thereof by means of a series of reactions...  
WO/2023/081657A9
Methods of making cholic acid derivatives, particularly UDCA, from non-animal sources, having exceptional purity and therapeutic utility.  
WO/2023/147640A1
The invention generally refers to pharmaceutical uses of tetracyclic terpene 3-ols, as an example lanosta-8,24-dien-3-ol, bearing polar and/or charged moieties, as anti-inflammatory, anti-cancer and analgesic agents via the inhibition of...  
WO/2023/148764A1
The present invention is to design and develop novel synthetic cholic acid derivatives for treating autoimmune disorders/inflammatory conditions, process of synthesis of the compounds, compositions comprising the said compounds and use o...  
WO/2023/147141A1
The present disclosure relates to a combination of an FXR agonist and a fibrate. Also disclosed is use of the combination for the treatment, amelioration or prevention of an FXR mediated disease or condition, such as primary biliary chol...  
WO/2023/143402A1
Disclosed in the present invention are a steroid compound, a preparation method therefor, and an application thereof. The steroid compound can have a structure shown in formula I. The compound of the present invention has SREBP pathway i...  
WO/2023/142890A1
Disclosed in the present invention is a synthesis method for high-purity cholesterol. The cholesterol is synthesized by using plant-derived 21-hydroxy-20-methylpregn-4-en-3-one, which is also referred to as bisnoralcohol or BA, as a raw ...  
WO/2023/142888A1
Disclosed in the present invention is a method for synthesizing high-purity plant-derived cholesterol. By taking plant-derived 21-hydroxy-20-methylpregn-4-en-3-one, also called bisnoralcohol or BA, as a raw material, cholesterol is synth...  
WO/2023/143399A1
Disclosed in the present invention are a steroid compound, and a preparation method therefor and an application thereof. The steroid compound may have a structure as shown in formula XXI, etc. The compound of the present invention has SR...  
WO/2023/143400A1
Provided are a steroid compound, a preparation method therefor and a use thereof. The steroid compound may have a structure as shown in formula VI. The compound has SREBP pathway inhibitory activity, and can be used for preventing and/or...  
WO/2023/143398A1
Disclosed in the present invention are a steroid and a preparation method therefor and an application thereof. The steroid may have a structure as shown in formula II. The compound of the present invention has SREBP pathway inhibitory ac...  
WO/2023/137529A1
The present invention relates to compounds which are active against parasitic infections, such as protozoan parasite infections (including flagellate parasite infections, ciliate parasite infections, amoeba parasite infections and apicom...  
WO/2023/138493A1
Disclosed are a crystal form of a high-stability nor-ursodeoxycholic berberine salt and a preparation method therefor, which relate to the field of pharmaceutical chemistry. The crystal form has the following structural formula. In X-ray...  
WO/2023/118484A1
A drug on the basis of 7,19-epoxy steroids, containing a compound of the general formula (I) or a physiologically acceptable salt thereof, wherein R1 = H; methyl, aryl-CH2-, Rx-C(=O)- or Rx-O-C(=O)-; or R1O is dispensed with if there is ...  
WO/2023/115742A1
Disclosed in the present invention are a brassinosteroid analog, a new crystal form, a preparation method, and the use. The chemical formula of the brassinosteroid analog is C27H46O7, the chemical name thereof is (20R,22R)-2β,3β,14α-1...  
WO/2023/115741A1
Disclosed in the present invention are a novel brassinosteroid analogue, a novel crystalline form and a preparation method therefor and an application thereof. The chemical formula of the brassinosteroid analogue is C27H46O7, the chemica...  
WO/2023/088308A1
A class of steroid derivatives, and a preparation method therefor, a pharmaceutical composition and the use thereof. The steroid derivative is represented by formula (I 0), and also comprises a hydrate, a solvate, an isotope derivative, ...  
WO/2023/083343A1
Among other things, the present disclosure provides technologies, e.g., compounds, compositions, methods, use for preventing or treating various conditions, disorders or diseases. In some embodiments, a condition, disorder or disease is ...  
WO/2023/081166A1
Methods of making 5.beta-steroids by stereoselective hydrogenation of the corresponding 4(5)-unsaturated starting compounds, said method employing a solvent comprising at least 10% of pyridine or a substituted pyridine.  
WO/2023/081658A2
Methods of making cholic acid derivatives, particularly TUDCA, preferably from non- animal sources, having exceptional purity and therapeutic utility.  
WO/2023/068376A1
Provided is a pharmaceutical composition which is effective as an anti-cancer immunostimulating therapy. Said pharmaceutical composition has a compound set forth in general formula (I) or a salt thereof as an active ingredient {in the fo...  
WO/2023/049295A1
Deuterated compounds are provided according to Formula (I): Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. These compounds are contemplated as useful for the prevention and treatment o...  
WO/2023/040879A1
Disclosed herein are drug delivery systems and methods for locally delivering therapeutic agents, and methods for using such drug delivery systems for the treatment of diseases.  
WO/2023/030332A1
A steroidal compound, a preparation method therefor and an application thereof. On one hand, provided are a compound represented by formula I, a preparation method therefor, and an application thereof in a method for separating and purif...  
WO/2023/028278A2
Compounds are provided according to Formulae (A-I), (B-I), (C-I), (D-I), (E-I), (F-I), (G-I), and (H-I) : and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present disclosure are con...  
WO/2023/000135A1
Provided are new process and intermediates for preparing onapristone.  
WO/2023/288123A1
The present application relates to methods and novel intermediates useful in the preparation of a compound of formula 100 (Compound 100).  
WO/2023/281388A1
The subject matter of the invention is an imidazolium salt, being a derivative of lithocholic acid, with a structural formula (I), wherein X is selected from the group comprising: I, Br, Cl, and R is selected from the group comprising no...  
WO/2023/280313A1
Disclosed is a method for purifying ursodeoxycholic acid (UDCA), comprising the following steps: step A sets forth the preparation of 4-dimethylpyridine ammonium salt of UDCA; and step B sets forth the hydrolysis of the 4-dimethylpyridin...  
WO/2022/272103A1
25HC3S choline and crystalline 25HC3S choline are described herein. Pharmaceutical formulations of 25HC3S choline such as with crystalline 25HC3S choline and methods of treating or preventing disease with same such as hypercholesterolemi...  

Matches 1 - 50 out of 2,751