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WO/2024/154145A1 |
Nucleic acid molecules comprising a first sequence encoding a cyclic nucleotide gated potassium channel or a functional fragment thereof and a second sequence encoding a chemogenetically activatable cyclic adenosine monophosphate (cAMP) ...
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WO/2024/155907A2 |
Disclosed are immunogens for stimulating an immune response to coronaviruses. The immunogens can be non-receptor binding domain (RED) epitopes. The immunogens can be grafted into a scaffold polypeptide to produce an epitope scaffold. Ant...
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WO/2024/154138A1 |
The present invention relates to a chimeric polypeptide for use in in-vitro tissue engineering, the chimeric polypeptide comprising a cellulose binding domain (CBD); at least one extracellular matrix (ECM) module; and optionally at least...
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WO/2024/144269A1 |
The present invention relates to a bio-ink comprising a functional peptide and, more particularly, to a bio-ink comprising a modified functional peptide that can be easily loaded with a functional peptide and a bioprinting method using s...
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WO/2024/129493A1 |
Sulfonate-containing water-solubilizing peptides are provided. Such water-solubilizing peptides can be attached to, for example, a dye or a tandem dye to increase the solubility thereof. Also provided are methods of using the dyes that i...
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WO/2024/122553A1 |
Provided are, inter alia, a system for treating ulcerative colitis or primary sclerosing cholangitis including a means for removing anti-integrin αvβ6 antibodies or anti-integrin αvβ6 antibody-producing B-cells that produce the anti-...
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WO/2024/123807A1 |
This disclosure is directed to a method for sequencing protein and peptide. The method specifies the steps of providing a polypeptide that is immobilized on solid surfaces and binding a N-terminal amino acid (NTAA) of the polypeptide wit...
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WO/2024/117938A1 |
The invention relates to the field of biotechnology and medicine, and more particularly to the production of bioconjugates for liver-specific targeted proteome modulation, which can be used for treating a broad spectrum of diseases stemm...
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WO/2024/103860A1 |
Provided is a site-specific PEG-modified interleukin 2 (IL-2) mutant. Compared with a parent IL-2, the mutant has an improved preference for a Treg cell and a prolonged half-life period. Also provided are a composition comprising the IL-...
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WO/2024/103142A1 |
Disclosed are peptides having specific affinity to exfoliation syndrome (XFS) deposits in a mammalian eye, and magnetic particle-peptide conjugates. Also disclosed are methods and uses of such magnetic particle-peptide conjugates to disp...
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WO/2024/099975A1 |
The invention relates to nanoparticles for Cas protein/gRNA ribonucleoprotein (RNP) complex, siRNA or PMO delivery comprising one or more Cas protein/gRNA RNP complex(es), siRNA(s) or PMO(s) as cargo; and a carrier comprising a sequence-...
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WO/2024/094597A1 |
The invention relates to methods for the preparation of method of preparation of Tau aggregates, including fibrils, fibrillar species, soluble and insoluble oligomeric species, new Tau aggregates and uses thereof. The invention further r...
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WO/2024/091949A1 |
The disclosure provides methods and systems for sample screening which may involve screening samples in presence and/or absence of effectors (e.g., encoded effector/compound libraries) for their potential effects on the sample or a targe...
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WO/2024/077009A1 |
Disclosed herein are macromolecules, compositions thereof, and methods of making the same. In one aspect, the macromolecule are immobilized to a surface. In one aspect, provided herein are compositions, systems and kits comprising the ma...
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WO/2024/076928A1 |
The present disclosure relates to polymers that include a functional group configured to couple to a polypeptide or protein; a backbone; and an amino acid residue conjugated to a fluorophore. In some embodiments, the polymers may be used...
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WO/2024/071180A1 |
Provided is a novel carrier for introducing a protein such as a Cas protein into cells. A carrier for a protein according to the present invention is characterized by containing vesicles of the fruit of the Malpighiaceae plant, wherein...
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WO/2024/038721A1 |
A regrowth material for alveolar bone and periodontal ligaments, and a method for manufacturing the regrowth material for alveolar bone and periodontal ligaments, said regrowth material including a crosslinked product of gelatin.
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WO/2024/029242A1 |
Disclosed is a linear peptide or cyclic peptide having an amino acid sequence represented by formula (1): XN-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15 (1), or a pharmacologically acceptable salt thereof. Binding this peptide to LRP1 makes i...
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WO/2024/020690A1 |
A device or method for affinity binding on an aluminum oxide surface. A biomolecule provides for immobilizing on the aluminum oxide surface. The biomolecule includes a histidine rich domain, a metal binding domain, or a metal binding moi...
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WO/2024/024518A1 |
The present disclosure provides an enzyme electrode, etc., in which an enzyme is immobilized via a more appropriate bond. The enzyme electrode of the present disclosure comprises an electrode and a modified protein having an amino acid s...
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WO/2024/024517A1 |
The present disclosure provides, inter alia, an enzyme electrode obtained by immobilizing an enzyme by using more appropriate binding. The enzyme electrode according to the present disclosure comprises an electrode and a modified protein...
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WO/2024/014426A1 |
The present invention addresses the problem of clarifying the true cause of interstitial pneumonia that is associated with myositis/dermatomyositis to thereby enable a more accurate diagnosis of the onset risk of interstitial pneumonia a...
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WO/2024/003213A1 |
The present invention provides a molecular probe functionalized element comprising a solid base element, a first layer comprising a linker A, a second layer comprising a peptide compound, a third layer comprising a linker B, and a fourth...
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WO/2024/000262A1 |
Provided are a probe specifically binding to CD138, a kit and a microfluidic chip comprising the probe, and a method for diagnosing diffuse large B-cell lymphoma in a subject by using the probe, the kit or the microfluidic chip. Also pro...
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WO/2023/247468A2 |
The present invention relates to isolation and separation of kappa light chain-containing proteins. More specifically it relates to a separation matrix comprising kappa light chain-binding ligands covalently coupled to a porous support, ...
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WO/2023/183628A9 |
Disclosed herein are conjugate agents comprising a targeting moiety, directly or indirectly conjugated with a payload moiety, compositions comprising the same as well as methods of making and using the same.
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WO/2023/204043A1 |
Provided is a technique that enables isolation using few steps. Provided by this technique is a method for isolating biological particles, the method including: an immobilization step for immobilizing a sample containing biological parti...
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WO/2023/196306A1 |
Disclosed are methods for producing matrix-encapsulated proteins, including matrix-encapsulated hemoglobin. Also provided are pharmaceutical compositions comprising a matrix-encapsulated hemoglobin, as well as methods of using thereof to...
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WO/2023/181025A1 |
Provided herein are silica nanoparticles conjugated to a phosphate binding hexapeptide (PBH) via a linker amino acid residue and methods of making the same. Further provided are compositions including the nanoparticles and uses thereof i...
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WO/2023/180502A1 |
The present invention provides a compound for the sequestration of undesirable neutralizing antibodies against oncolytic viruses in a patient. The compound comprises an inert biopolymer scaffold and at least a first peptide n-mer of the ...
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WO/2023/170118A1 |
The present application discloses methods for characterising vesicles. The method involves (1) a sample preparation step, comprising providing a test specimen with vesicles attached to a substrate, wherein the vesicles are labelled with ...
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WO/2023/170216A1 |
A method for predicting the efficacy of an antibody drug conjugate (ADC) therapy involves determining the mean optical density (OD) of membrane and optionally cytoplasm staining of each cancer cell in a whole slide image. A diagnostic an...
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WO/2023/165529A1 |
Provided are a method for detecting migrasomes and a system. Provided is a method for detecting migrasomes, which comprises: (a) providing a sample to be tested; (b) mixing the sample to be tested with a solid-phase support to form a "mi...
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WO/2023/162903A1 |
The present invention addresses the problem of providing: a liquid that contains a group of exosome-like particles obtained by causing an arbitrarily defined membrane protein to be associated with lipid particles in which the particle si...
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WO/2023/157460A1 |
The present invention addresses the problem of specifying a factor involved in depression and aging and providing a method for the use thereof. This problem is solved by a method for acquisition of data for diagnosis or testing of SFPQ-r...
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WO/2023/142999A1 |
A nano vaccine used for delivering an mRNA antigen and derived from a bacterial outermembrane vesicle and the use thereof. Specifically provided is a technology for displaying nucleic acid on the outer surface of a vesicle.
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WO/2023/140197A1 |
The present invention addresses the problem of providing an improved adeno-associated virus (AAV)-binding protein having an enhanced binding ability to an AAV and a method for analyzing an AAV contained in a sample on the basis of differ...
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WO/2023/124207A1 |
The present application relates to the technical field of immunoglobulin separation and purification, and in particular, to an immunoglobulin-binding protein and an application thereof. The immunoglobulin-binding protein is obtained by s...
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WO/2023/127780A1 |
Provided is a cell culture scaffold material capable of maintaining cell culture stability over a long period. The cell culture scaffold material according to the present invention comprises a peptide-containing (meth)acrylic copolymer...
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WO/2023/127777A1 |
Provided is a scaffold material for cell culture with which it is possible to maintain the culture stability of cells over an extended period of time. A scaffold material for cell culture according to the present invention includes a p...
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WO/2023/127778A1 |
Provided is a scaffold material for cell culture, with which cell culture stability can be maintained over a long period of time. This scaffold material for cell culture contains a peptide-containing (meth)acrylic copolymer having: a (...
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WO/2023/127779A1 |
Provided is a coating solution for forming a cell scaffold that can easily form a thick cell scaffold and increase cell proliferation. This coating solution for forming a cell scaffold, according to the present invention, includes an a...
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WO/2023/122327A2 |
The present disclosure relates to the field of chromatography, and more specifically to novel affinity ligands and affinity agents which are suitable for use in isolation of antibody and antibody fragments that contain the heavy chain fi...
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WO/2023/106379A1 |
Provided are: cellulose porous particles which have large surface areas on which cells can be attached, and on which cells can be adhered easily, and which rarely undergo the detachment of cells when the cells are cultured at a high dens...
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WO/2023/100976A1 |
Disclosed is a peptide-immobilized bead library which, in comparison to well-known OPOB libraries, has a higher potential for an obtained peptide to become a useful substance candidate for a drug or the like, and makes it easier to analy...
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WO/2023/100974A1 |
The problem to be solved by the present invention is to provide a method which makes it possible to culture anchorage-dependent cells with a serum-free culture medium. The present invention provides a cell culture method including a step...
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WO/2023/095665A1 |
This antibody isolation method comprises: a step for adding a solution containing antibodies to a column filled with an antibody adsorption material containing an insoluble porous carrier and an Fc-binding protein immobilized on the carr...
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WO/2023/081924A1 |
Described in several embodiments herein are olfactory sensory neuron (OSN) derived extracellular vehicles (EVs), formulations thereof, and uses thereof. In some embodiments, the OSN derived extracellular vesicles are effective to increas...
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WO/2023/074642A1 |
[Problem] To provide a immunoglobulin-binding protein which has improved chemical stability, particularly stability with respect to alkalis, an immunoglobulin-binding protein which enables antibody elution in mild pH conditions, and an a...
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WO/2023/054636A1 |
The present invention relates to a compound having: (i) a photocleavable site; and (ii) at least one selected from the group consisting of a target substance binding site and an anchor binding site.
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