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Matches 1 - 50 out of 755

Document Document Title
WO/2022/160156A1
The present disclosure relates to the field of biotechnology. In particular, provided are a ligase fusion protein and an immobilized ligase comprising the same. Also provided is use of the ligase fusion protein or the immobilized ligase ...  
WO/2022/158977A1
The invention provides inter alia an engineered T cell, wherein said T cell is engineered to express a T cell receptor (TCR) or an antibody-based receptor that binds to a T cell epitope of human ropporin-1A (ROPN1) or human ropporin-1B (...  
WO/2022/136628A1
The present invention refers to the medical field. Particularly, it refers to a method for determining whether an immune response has occurred in subjects who have been infected with- or vaccinated against coronavirus.  
WO/2022/109058A1
The present disclosure provides systems, methods, and compositions for the delivery of one or more components of a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas (CRISPR associated protein) gene editing system.  
WO/2022/092295A1
The present disclosure provides a novel crosslinked peptide. The present disclosure provides a crosslinked peptide that contains a crosslinked portion and a peptide portion, wherein, when the carbon atom at which the crosslinked portion ...  
WO/2022/046941A1
Antibody-drug conjugates (ADCs) are described, comprising anti-TM4SF1 antibodies, antigen-binding fragments thereof, a linker and a drug. The drug is an antimitotic tetrapeptide. Methods of use of the ADCs are also  
WO/2022/037681A1
A bioinformatic method is used to analyze, discover and predict, from human intestinal metagenomics, peptides having microorganism inhibiting activity, that is, antimicrobial peptides, and the activity thereof is confirmed by means of ex...  
WO/2022/026867A1
The present invention provides for methods of treating solid tumors, particularly, KRas mutated solid tumors and KRas mutated pancreatic cancer. The method includes administering glutamine alone or in combination with an anti-cancer agen...  
WO/2022/005899A1
The present disclosure provides human 1L-23R (WL-23R) binding polypeptides, conditionally maximally active SilL~23R binding proteins, multimers thereof, and methods for using the polypeptides and binding proteins for therapeutic use.  
WO/2021/246392A1
A lactic acid bacteria growth promoter which has a growth promotion effect on lactic acid bacteria is provided. This lactic acid bacteria growth promoter contains at least one type of peptide selected from a first peptide, in which the t...  
WO/2021/138397A1
The present disclosure provides modified looped proteins comprising at least one looped region, wherein the at least one looped region comprises a cell penetrating peptide (CPP). In some embodiments, the present disclosure provides polyn...  
WO/2021/136475A1
A linker molecule for targeting molecule-drug conjugate, has the structure of formula (I): A1p-D1q-Y-Lk-W-A2q-D2p (I). A conjugate has the structure of formula (III): A-((compound of formula (I))-PL t) z (III). The conjugate can be used ...  
WO/2021/127294A1
A contraceptive device is provided which includes a (preferably elastomeric) surface; and a lubricant applied to the surface. The lubricant includes (a) a lubricious medium, and (b) a pharmaceutically effective amount of a peptoid dispos...  
WO/2021/069426A2
The treatment according to the invention provides the use of at least one peptide having the general Formula X-(Xaa)nK*TTK*X'aa-(Xaa)m-Z for a non-therapeutic cosmetic treatment of keratinous tissues of the skin and of its appendages. In...  
WO/2021/072392A1
Disclosed are agents and methods of using the agents to treat or prevent pain and/or induce anesthesia. The agents may be peptides, siRNAs, and/or shRNAs that target adaptin protein 2-clathrin mediated endocytosis (AP2-CME). Peptides of ...  
WO/2021/054448A1
Purposes of the present invention include: providing an efficient cell fusion method; and providing a method for killing cancer cells through cell fusion. The purposes are achieved by: (1) a polypeptide having an amino acid sequence se...  
WO/2021/005019A1
The invention relates to isolated synthetic or recombinant peptides comprising an epitope of human tau 2N4R, wherein the tau peptide sequence comprising the epitope is not phosphorylated. The invention also relates to use of such peptide...  
WO/2020/232407A9
The invention features peptide antibiotic compositions and methods of using such compositions for the treatment of bacterial infections (e.g., vancomycin resistant infections).  
WO/2020/232440A1
Alzheimer's disease (AD) pathology is characterized by plaques of amyloid beta (Aβ) and neurofibrillary tangles of tau. Aβ aggregation is thought to occur at early stages of the disease, and ultimately gives way to the formation of tau...  
WO/2020/221145A1
Disclosed is a method for preparing a pearl shell whitening factor, comprising the following steps of: clam shell crushing and sieving; performing mixing with a weak acid aqueous solution, stirring for decomposition, and a solid being se...  
WO/2020/223581A1
A poly-N-substituted glycine compound of a formula A-(X-Y-Z)n-B is provided, wherein A is a terminal N-alkyl substituted glycine residue; n is an integer; B is selected from the group consisting of NH2, one and two N-substituted glycine ...  
WO/2020/158811A1
One purpose of the present invention is to provide a simple method for detecting H. pylori and simultaneously obtaining information related to the genotype of CagA protein of H. pylori. This method for detecting H. pylori includes: (i) a...  
WO/2019/183265A9
The presently disclosed subject matter relates to peptides and flavor compositions that include at least one, two, three, four, five or more peptide compounds, and screening methods for identifying the same. The flavor compositions can b...  
WO/2020/085219A1
Provided is a method for selecting a mineral containing arsenic. A peptide having the following amino acid sequence: (TSNQ)-(LIVFA)-(ED)-(RKNMDCPQSETGWHY)-(LIVFA)-(RKNMDCPQSETGW HY)-(LIVFA)-(LIVFA)-(LIVFA)-(RHK)-(TSNQ)-(TSNQ) [wherein an...  
WO/2020/077136A1
Charged polypeptides, their conjugates, and fusion proteins comprising such polypeptides are disclosed. Inclusion of such a polypeptide in a fusion protein increases the protein's properties such as stability and circulation half-life, w...  
WO/2020/065595A1
The present invention relates to synthetic leopeptides of formula Cn-X1-X2-X3-NH2 , wherein: Cn is a fatty acid selected from the group consisting of C12 to C16; X1 is at least one glycine molecule; X2 is at least two natural amino acids...  
WO/2020/067400A1
Provided are: an immune inducer that comprises, as an active ingredient, a polynucleotide/peptide conjugate wherein a CpG motif-containing single-stranded polynucleotide or polynucleotide derivative is bonded to a peptide having antigeni...  
WO/2020/023670A1
Provided are peptides, modified peptides, fragments thereof, conjugates thereof, and polymers thereof that have antibacterial activity against bacterial that include but are not limited to multidrug-resistant bacteria. In some embodiment...  
WO/2020/013265A1
The purpose of the present invention is to provide a technology which is for promoting the permeation of drugs through a membrane and which has high versatility and higher safety. Said purpose can be achieved by this polymer compound hav...  
WO/2020/008403A1
The present invention relates to an isolated peptide suitable as standard for the assaying of proAKAP4. Typically, said peptide is selected among the peptides having an N-terminus made of a region that is 100% identical to a region of th...  
WO/2020/005120A1
The invention is directed to new enzymes of fungal luciferin biosynthesis, the nucleic acids that encode them, and the use of proteins as enzymes catalyzing the stages of fungal luciferin biosynthesis. The invention also provides the use...  
WO/2019/245938A1
The present invention relates to, inter alia, compositions and methods, including therapeutic alkaline phosphatases that find use in the treatment of disease, such as microbiome-related diseases. In part, the invention provides, in vario...  
WO/2019/240288A1
The present invention provides art that enables modification of an antibody, particularly regioselective modification of an antibody. More specifically, the present invention provides a substance having affinity for an antibody, and a co...  
WO/2019/219979A1
Described herein are a γ chain or a δ chain of a yδ5TCR or a yδ5TCR or a fragment thereof or a a nucleic acid molecule encoding them, a cell comprising preferably expressing them and their therapeutic uses for treating cancer in a su...  
WO/2019/204663A1
The present disclosure relates to compositions comprising a peptide with improved solubility and the methods of achieving the same. In one embodiment, the present composition comprises at least one peptide, a pH modifier present at a con...  
WO/2019/166347A1
The present invention relates to a family of peptides which are able to interfere in the formation of complex Munc18-Syntaxin-1 and, hence, are useful in the prevention and/or treatment of neuronal exocytosis and/or muscle contractility ...  
WO/2019/169145A1
This document provides materials and methods for treating cancer (e.g., PD-L1+ cancers). For example, methods and materials for using compositions (e.g., compositions containing a small bioactive S249/T252 phospho-mimicking polypeptide o...  
WO/2019/165048A1
Disclosed herein are computer implemented methods of distinguishing ischemic stroke, hemorrhagic stroke, and stroke mimic by detecting circulating biomarkers in a subject. Also provided herein are systems, kits, and methods for the detec...  
WO/2019/136531A1
Disclosed are proteinaceous molecules corresponding to an acetylation site and their use for inhibiting or reducing the nuclear localization of a nuclear localizable polypeptide, such as PD-1, PD-L1 and PD-L2. This invention also relates...  
WO/2019/126186A1
Disclosed herein relates to immunotherapeutic compositions comprising immunotherapeutic peptides comprising neoepitopes, polynucleotides encoding the immunotherapeutic peptides, antigen presenting cells comprising the immunotherapeutic p...  
WO/2019/096018A1
Provided herein are recombinant peptides useful for inhibiting the function of autophagy-related 8 (Atg8) proteins. The recombinant peptides can be used in the preparation of imaging agents for monitoring autophagy in a cell or subject a...  
WO/2019/094938A2
The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80...  
WO/2019/076856A1
The present invention relates to an adeno-associated virus (AAV), comprising an insertion of at least 6-8 amino acids between thepositions corresponding to position 87 and 588 of SEQ ID NO: 1. Also envisioned are AAVs of the present inve...  
WO/2019/074870A1
The present disclosure relates compositions and methods for combinatorial drug discovery in nanoliter droplets. More particularly, the disclosure relates to novel synergistic agents that increase efficacy of antibiotic agents to treat ba...  
WO/2019/055860A1
The invention relates to methods for treating cancers by targeting the elimination of selective activated immune cell populations in combination with checkpoint inhibitors. The cells may be targeted, for instance, using CLIP inhibitors a...  
WO/2019/039179A1
Provided is a means for conveniently isolating exosome from a sample containing exosome. The present invention relates to a method for isolating exosome, the method comprising: a complex formation step for binding a specific peptide cont...  
WO/2019/038789A1
The present disclosure provides a recombinant vector comprising BclB or BclA fused to a gene of interest encoding a fusion polypeptide for cell surface display of the fusion polypeptide. Also provided is a recombinant host cell comprisin...  
WO/2019/036761A1
A modified p145 peptide having enhanced mucosal immunogenicity for use in eliciting a mucosal immune response to group A streptococcal bacteria in a mammal such as a human. Intramuscular administration of the modified p145 5 peptide may ...  
WO/2018/213320A1
Disclosed herein are conjugates including a fatty acid, a self-assembly domain, and a polypeptide having phase transition behavior. Further disclosed are methods of using the conjugates to treat disease, methods of delivering an agent, a...  
WO/2018/208606A1
Disclosed herein is a CAR construct encoding an inhibitor of immunodeficiency virus fusion and human CD4 extracellular and transmembrane domains linked to a human CD3ζ signaling domain, and methods of making and using thereof to treat, ...  

Matches 1 - 50 out of 755