Title:
【発明の名称】可逆的に不活性化された酸性化プラスミンの局所送達による血栓溶解の方法
Document Type and Number:
Japanese Patent JP2003514790
Kind Code:
A
Abstract:
The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.
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Inventors:
Valery Bee, Novocatoni
GSM Jay
Landscroner, Kyle A
Taylor, Kaslyn Kay
Zimmerman, Thomas Pea
GSM Jay
Landscroner, Kyle A
Taylor, Kaslyn Kay
Zimmerman, Thomas Pea
Application Number:
JP2001538488A
Publication Date:
April 22, 2003
Filing Date:
November 13, 2000
Export Citation:
Assignee:
BAYER CORPORATION
International Classes:
C12N9/99; A61B17/00; A61K9/19; A61K38/48; A61K47/02; A61K47/10; A61K47/12; A61K47/18; A61K47/22; A61K47/26; A61K47/36; A61K47/42; A61M25/00; A61P7/02; A61P9/10; C12N9/68; C12N9/96; A61K38/00; (IPC1-7): A61K38/48; A61B17/00; A61K47/10; A61K47/12; A61K47/18; A61K47/22; A61K47/26; A61M25/00; A61P7/02
Domestic Patent References:
| JPH0625011A | 1994-02-01 | |||
| JPH099997A | 1997-01-14 | |||
| JPH099998A | 1997-01-14 | |||
| JPH03502808A | 1991-06-27 |
Foreign References:
| US3950513A | 1976-04-13 | |||
| GB985498B |
Attorney, Agent or Firm:
Heiyoshi Odashima