To provide a non-human mammal model animal for cataract in order to develop the therapeutic method for cataract that is behind in development and open up a screening method for the therapeutic agent for cataract using a non-human mammal model.
A pathological non-human mammal model animal for cataract that has a functionally defected DLAD (DNase II like acid DNase) on its chromosome, for example, a DLAD knockout mouse or the like (the inherent gene of a non-human mammal encoding DLAD is inactivated by degradation, defection or substitution and the like) is prepared by using a targeting vector. A test substance is given to this pathological animal model and the pathogenic degree of cataract in this animal is evaluated whereby prophylactic and therapeutic agents for cataract are screened.
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