Title:
デプシペプチドおよびこれを有効成分とする医薬
Document Type and Number:
Japanese Patent JP3947229
Kind Code:
B2
Abstract:
Depsipeptides represented by the formula (1): (wherein: R1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R2 is -A-B, -A-B-W, -A-B-W-D or -A-B-W-D-E, R3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, -Z, -Z-G or -Z-G-J, the above A, B, D, E, G and J independently each other are a residue of an amino acid selected from alanine, valine, leucine, isoleucine, serine, threonine, lysine, hydroxylysine, arginine, cysteine, methionine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamic acid, glutamine and the like or an N-(C1-C4) alkyl derivative of these amino acid residues; the above W and Z independently each other are a residue of an amino acid selected from aspartic acid, asparagine, glutamic acid, glutamine, alanine, serine or lysine) or pharmacologically acceptable salts thereof. The depsipeptides have an activity of promoting the production of apolipoprotein E and are useful as a therapeutic agent for neurologic damages, especially for dementia, and further as a therapeutic agent for hyperlipemia.
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Inventors:
Makoto Taniuchi
Suzuki Masashi
Norio Oshida
Kawamura Koji
Shigeru Hiramoto
Orie Yasuda
Nobusuke Kinoshita
Akiko Makai
Masai Kanai
Suzuki Masashi
Norio Oshida
Kawamura Koji
Shigeru Hiramoto
Orie Yasuda
Nobusuke Kinoshita
Akiko Makai
Masai Kanai
Application Number:
JP50268998A
Publication Date:
July 18, 2007
Filing Date:
June 25, 1997
Export Citation:
Assignee:
Nisshin Flour Milling Group Inc.
International Classes:
C07K5/02; A61K38/00; A61P3/06; A61P25/00; A61P25/28; A61P43/00; C07K5/06; C07K5/072; C07K5/08; C07K5/10; C07K5/103; C07K5/113; C07K7/06; C07K11/00
Foreign References:
| WO1995032990A1 |
Other References:
OHNO M, ed. ”Peptide Chemistry 1994”,Protein Research Foundation, 1995, p.33-36
Tetrahedron Letters, 1976, no.21, p.1773-1776
J. Chem. Soc. Perkin Trans. I, 1974, no.7, p.802-808
Tetrahedron Letters, 1976, no.21, p.1773-1776
J. Chem. Soc. Perkin Trans. I, 1974, no.7, p.802-808
Attorney, Agent or Firm:
Chika Takagi
Kosuke Nishimura
Kosuke Nishimura