Title:
エンジイン環構造の生合成に関与する遺伝子及びタンパク質
Document Type and Number:
Japanese Patent JP2005508140
Kind Code:
A
Abstract:
Five protein families cooperate to form the warhead structure that characterizes enediyne compounds, both chromoprotein enediynes and non-chromoprotein enediynes. The protein families include a polyketide synthase and thioesterase protein which form a polyketide synthase catalytic complex involved in warhead formation in enediynes. Genes encoding a member of each of the five protein families are found in all enediyne biosynthetic loci. The genes and proteins may be used in genetic engineering applications to design new enediyne compounds and in methods to identify new enediyne biosynthetic loci.
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Inventors:
Chris M. Furnet
Emanuel Zazopros
Alfredo Staffa
Emanuel Zazopros
Alfredo Staffa
Application Number:
JP2002592335A
Publication Date:
March 31, 2005
Filing Date:
May 21, 2002
Export Citation:
Assignee:
Ecopia Biosciences Inc.
International Classes:
C12N15/09; A61K31/27; A61K31/4748; A61K31/7048; A61P35/00; A61P35/02; C07D491/08; C07H17/04; C07H17/08; C07K14/36; C07K16/40; C12N9/00; C12N15/31; C12N15/52; C12P21/02; C12Q1/26; C12Q1/68; G06F17/30; (IPC1-7): C12N15/09; C07K16/40; C12N9/00; C12P21/02; C12Q1/26; C12Q1/68; G06F17/30
Attorney, Agent or Firm:
Masaki Hirota