Title:
ALK-5阻害剤としてのピリミジン誘導体
Document Type and Number:
Japanese Patent JP4960450
Kind Code:
B2
Abstract:
Compounds of formula (I) in free or salt or solvate form, where T1, T2, Ra and Rb have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
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Inventors:
Catherine Leblanc
Maud Nadine Pierette Pipette
Robin Alec Fairhurst
Claire Adcock
Robert Alexander Pultz
Duncan Show
Nicolaus Johannes Steefle
Maud Nadine Pierette Pipette
Robin Alec Fairhurst
Claire Adcock
Robert Alexander Pultz
Duncan Show
Nicolaus Johannes Steefle
Application Number:
JP2009518795A
Publication Date:
June 27, 2012
Filing Date:
July 12, 2007
Export Citation:
Assignee:
Novartis Age
International Classes:
C07D401/14; A61K31/506; A61K31/5377; A61P1/04; A61P1/16; A61P3/10; A61P7/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P11/08; A61P13/12; A61P15/00; A61P17/02; A61P17/16; A61P19/02; A61P19/08; A61P19/10; A61P21/00; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P41/00; C07D405/14; C07D413/14
Domestic Patent References:
| JP2003524595A | ||||
| JP5501248A | ||||
| JP2003519143A | ||||
| JP2005528443A | ||||
| JP8502721A | ||||
| JP2005539026A | ||||
| JP2005539000A | ||||
| JP2004524302A |
Foreign References:
| WO2005058883A1 | ||||
| GB1345640A | ||||
| WO2005028467A1 | ||||
| WO2005007646A1 | ||||
| WO2007042810A1 | ||||
| WO2004065392A1 | ||||
| WO2004111036A1 |
Other References:
KATIYAR,S.B. et al,Syntheses of 2,4,6-trisubstituted pyrimidine derivatives as a new class of antifilarial topoisomerase II inhibitors,Bioorganic & Medicinal Chemistry Letters,2005年,Vol.15, No.1,p.47-50
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Masayuki Nakagawa
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Masayuki Nakagawa