Title:
CORONAVIRUS VACCINES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/110099
Kind Code:
A1
Abstract:
This disclosure relates to coronavirus vaccines and uses thereof. In one aspect, the disclosure provides a nucleic acid vaccine, comprising a sequence encoding a spike protein or fragment thereof derived from a coronavirus.
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Inventors:
ZHANG BILL BILIANG (CN)
LI MAN (CN)
MA LIN (CN)
WEN JIAN (CN)
ZHANG HONG (CN)
ZHONG HUILING (CN)
LI MAN (CN)
MA LIN (CN)
WEN JIAN (CN)
ZHANG HONG (CN)
ZHONG HUILING (CN)
Application Number:
PCT/CN2020/132609
Publication Date:
June 02, 2022
Filing Date:
November 30, 2020
Export Citation:
Assignee:
GUANGZHOU ARGORNA BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
C07K19/00; C07K14/165; C12N15/50
Foreign References:
| CN110352071A | 2019-10-18 | |||
| US20200188475A1 | 2020-06-18 | |||
| US10392341B2 | 2019-08-27 | |||
| US8802644B2 | 2014-08-12 |
Other References:
ZHANG DONG YAN, WANG JIAN, DOKHOLYAN NIKOLAY V.: "Prefusion spike protein stabilization through computational mutagenesis", PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS, JOHN WILEY & SONS, INC., US, vol. 89, no. 4, 1 April 2021 (2021-04-01), US , pages 399 - 408, XP055936466, ISSN: 0887-3585, DOI: 10.1002/prot.26025
HSIEH CHING-LIN, GOLDSMITH JORY A, SCHAUB JEFFREY M, DIVENERE ANDREA M, KUO HUNG-CHE, JAVANMARDI KAMYAB, LE KEVIN C, WRAPP DANIEL,: "Structure-based design of prefusion-stabilized SARS-CoV-2 spikes", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 369, no. 6510, 18 September 2020 (2020-09-18), US , pages 1501 - 1505, XP055780339, ISSN: 0036-8075, DOI: 10.1126/science.abd0826
WRAPP DANIEL, WANG NIANSHUANG, CORBETT KIZZMEKIA S., GOLDSMITH JORY A., HSIEH CHING-LIN, ABIONA OLUBUKOLA, GRAHAM BARNEY S., MCLEL: "Cryo-EMstructure of the 2019-nCo Vspike in the prefusion conformation", SCIENCE, 19 February 2020 (2020-02-19), pages 1260 - 1263, XP055829067, Retrieved from the Internet [retrieved on 20210730], DOI: 10.1126/science.abb2507
MAO YAPING , BIAN DAWEI: "Bioinformatics Analysis of Mutations in the Spike Protein of SARS-CoV- 2 and Their Effects", CHINESE JOURNAL OF VIROLOGY, vol. 36, no. 6, 11 November 2020 (2020-11-11), pages 1020 - 1027, XP055936542, ISSN: 1000-8721, DOI: 10.13242/j.cnki.bingduxuebao.003822
XIN LI, GUANGYOU DUAN, WEI ZHANG, JINSONG SHI, JIAYUAN CHEN, SHUNMEI CHEN, SHAN GAO, JISHOU RUAN: "A furin cleavage site was discovered in the S protein of the 2019 novel coronavirus", CHINESE JOURNAL OF BIOINFORMATICS, vol. 18, no. 2, 30 June 2020 (2020-06-30), pages 103 - 108, XP055936473, DOI: https://doi.org/10.12113/202002001
OKBA NMAMULLER MALI W ET AL.: "Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease 2019 Patients", EMERG INFECT DIS, vol. 26, no. 7, 8 April 2020 (2020-04-08)
ZHOU PYANG XLWANG XG ET AL.: "A pneumonia outbreak associated with a new coronavirus of probable bat origin", NATURE, vol. 579, no. 7798, March 2020 (2020-03-01), pages 270 - 273, XP037296454, DOI: 10.1038/s41586-020-2012-7
HOFFMANN MKLEINE-WEBER HSCHROEDER S ET AL.: "SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor", CELL, 4 March 2020 (2020-03-04)
YAMAMOTO ET AL., J. EXP. MED., vol. 185, 1997, pages 1203 - 1210
DI TOMMASO ET AL., INFECT. IMMUNITY, vol. 64, 1996, pages 974 - 979
See also references of EP 4034548A4
HSIEH CHING-LIN, GOLDSMITH JORY A, SCHAUB JEFFREY M, DIVENERE ANDREA M, KUO HUNG-CHE, JAVANMARDI KAMYAB, LE KEVIN C, WRAPP DANIEL,: "Structure-based design of prefusion-stabilized SARS-CoV-2 spikes", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 369, no. 6510, 18 September 2020 (2020-09-18), US , pages 1501 - 1505, XP055780339, ISSN: 0036-8075, DOI: 10.1126/science.abd0826
WRAPP DANIEL, WANG NIANSHUANG, CORBETT KIZZMEKIA S., GOLDSMITH JORY A., HSIEH CHING-LIN, ABIONA OLUBUKOLA, GRAHAM BARNEY S., MCLEL: "Cryo-EMstructure of the 2019-nCo Vspike in the prefusion conformation", SCIENCE, 19 February 2020 (2020-02-19), pages 1260 - 1263, XP055829067, Retrieved from the Internet
MAO YAPING , BIAN DAWEI: "Bioinformatics Analysis of Mutations in the Spike Protein of SARS-CoV- 2 and Their Effects", CHINESE JOURNAL OF VIROLOGY, vol. 36, no. 6, 11 November 2020 (2020-11-11), pages 1020 - 1027, XP055936542, ISSN: 1000-8721, DOI: 10.13242/j.cnki.bingduxuebao.003822
XIN LI, GUANGYOU DUAN, WEI ZHANG, JINSONG SHI, JIAYUAN CHEN, SHUNMEI CHEN, SHAN GAO, JISHOU RUAN: "A furin cleavage site was discovered in the S protein of the 2019 novel coronavirus", CHINESE JOURNAL OF BIOINFORMATICS, vol. 18, no. 2, 30 June 2020 (2020-06-30), pages 103 - 108, XP055936473, DOI: https://doi.org/10.12113/202002001
OKBA NMAMULLER MALI W ET AL.: "Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease 2019 Patients", EMERG INFECT DIS, vol. 26, no. 7, 8 April 2020 (2020-04-08)
ZHOU PYANG XLWANG XG ET AL.: "A pneumonia outbreak associated with a new coronavirus of probable bat origin", NATURE, vol. 579, no. 7798, March 2020 (2020-03-01), pages 270 - 273, XP037296454, DOI: 10.1038/s41586-020-2012-7
HOFFMANN MKLEINE-WEBER HSCHROEDER S ET AL.: "SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor", CELL, 4 March 2020 (2020-03-04)
YAMAMOTO ET AL., J. EXP. MED., vol. 185, 1997, pages 1203 - 1210
DI TOMMASO ET AL., INFECT. IMMUNITY, vol. 64, 1996, pages 974 - 979
See also references of EP 4034548A4
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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