Title:
METHOD FOR IMPROVING ACTIVATION OF STING PATHWAY AND ANTI-TUMOR T CELL RESPONSE
Document Type and Number:
WIPO Patent Application WO/2023/178964
Kind Code:
A1
Abstract:
The present invention relates to a method for promoting a drug molecule to reach an action target in a tumor cell, a method for promoting delivery of an endogenous tumor antigen and tumor DNA to a DC, a method for activating a STING pathway in a DC, a method for promoting T cell response, use of active oxygen and a sound sensitizer, a complex and use thereof, a liposome-complex and a preparation method therefor, and a pharmaceutical composition and use thereof.
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Inventors:
KUAI RUI (CN)
WANG CHAOYU (CN)
ZHANG RUOSHI (CN)
HE JIA (CN)
WANG CHAOYU (CN)
ZHANG RUOSHI (CN)
HE JIA (CN)
Application Number:
PCT/CN2022/120608
Publication Date:
September 28, 2023
Filing Date:
September 22, 2022
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
A61K9/127; A61K45/06; A61K31/704; A61K41/00; A61K47/24; A61P35/00
Foreign References:
| CN114588268A | 2022-06-07 | |||
| CN114007649A | 2022-02-01 | |||
| CN106551904A | 2017-04-05 | |||
| CN108186569A | 2018-06-22 | |||
| CN108815521A | 2018-11-16 | |||
| CN114222591A | 2022-03-22 | |||
| CN105997877A | 2016-10-12 | |||
| CN112999153A | 2021-06-22 | |||
| CN102670512A | 2012-09-19 | |||
| US20190336604A1 | 2019-11-07 | |||
| US20220062417A1 | 2022-03-03 |
Other References:
XU HAOYUE, HAN YUHAN, ZHAO GANG, ZHANG LONG, ZHAO ZONGREN, WANG ZHEN, ZHAO LIANG, HUA LEI, NAVEENA KONDURU, LU JUN, YU RUTONG, LIU: "Hypoxia-Responsive Lipid–Polymer Nanoparticle-Combined Imaging-Guided Surgery and Multitherapy Strategies for Glioma", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 47, 25 November 2020 (2020-11-25), US , pages 52319 - 52328, XP093094417, ISSN: 1944-8244, DOI: 10.1021/acsami.0c12971
WENWEN YUE, LIANG CHEN, LUODAN YU, BANGGUO ZHOU, HAOHAO YIN, WEIWEI REN, CHANG LIU, LEHANG GUO, YIFENG ZHANG, LIPING SUN, KUN ZHAN: "Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice", NATURE COMMUNICATIONS, vol. 10, no. 1, 1 December 2019 (2019-12-01), XP055667402, DOI: 10.1038/s41467-019-09760-3
WENWEN YUE, LIANG CHEN, LUODAN YU, BANGGUO ZHOU, HAOHAO YIN, WEIWEI REN, CHANG LIU, LEHANG GUO, YIFENG ZHANG, LIPING SUN, KUN ZHAN: "Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice", NATURE COMMUNICATIONS, vol. 10, no. 1, 1 December 2019 (2019-12-01), XP055667402, DOI: 10.1038/s41467-019-09760-3
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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