Title:
OSTEOBLASTS DIFFERENTIATED FROM MESENCHYMAL STEM CELLS AND COMPOSITION FOR TREATING BONE DISEASE COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2022/075809
Kind Code:
A1
Abstract:
The present invention relates to a method for differentiating mesenchymal stem cells into osteoblasts, and to a cell therapeutic agent for treatment of bone disease, comprising osteoblasts differentiated by the method, and a method for producing same. In addition, the present invention relates to a method for treating bone disease, comprising administering the osteoblasts obtained by the method to a patient with bone disease. The differentiation method according to the present invention can stably and rapidly differentiate mesenchymal stem cells into osteoblasts. The differentiated osteoblasts have excellent blood vessel-forming ability and excellent bone-forming ability. Accordingly, the method for differentiating stem cells into osteoblasts and the osteoblasts obtained by the method, according to the present invention, can be effectively used as a cell therapeutic agent or treatment method related to bone disease.
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Inventors:
PARK HYUN SOOK (KR)
LEE YEON KYUNG (KR)
GO EUN JIN (KR)
KIM HA JIN (KR)
LEE SUN RAY (KR)
KWON AH REUM (KR)
LEE YEON KYUNG (KR)
GO EUN JIN (KR)
KIM HA JIN (KR)
LEE SUN RAY (KR)
KWON AH REUM (KR)
Application Number:
PCT/KR2021/013900
Publication Date:
April 14, 2022
Filing Date:
October 08, 2021
Export Citation:
Assignee:
CEFO CO LTD (KR)
International Classes:
C12N5/077; A61K35/32; A61P19/00; C12M1/00; C12M1/12; C12N5/00; C12N11/08
Domestic Patent References:
| WO2020064791A1 | 2020-04-02 |
Foreign References:
| KR20170045023A | 2017-04-26 | |||
| KR20090076483A | 2009-07-13 | |||
| US20140206022A1 | 2014-07-24 | |||
| KR20130087952A | 2013-08-07 | |||
| KR20160034541A | 2016-03-30 | |||
| KR20180114307A | 2018-10-18 | |||
| US8580757B2 | 2013-11-12 |
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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