Title:
SURFACTANT PROTEIN D FOR THE PREVENTION AND DIAGNOSIS OF PULMONARY EMPHYSEMA
Document Type and Number:
WIPO Patent Application WO2000023569
Kind Code:
A9
Abstract:
Surfactant protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene was targeted by homologous recombination in embryonic stem cells that were used to produce SP-D (-/-) mice. The SP-D (-/-) deficiency caused inflammation, increased oxidant production by isolated alveolar macrophages, abnormal surfactant structure and levels, and decreased SP-A expression. Therefore, disclosed is the SP-D (-/-) mouse as an excellent model for emphysema. Also included are models for testing emphysema therapies in the mouse model, methods for using SP-D protein or DNA as a treatment for emphysema and pulmonary infections, and diagnosis.
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Inventors:
WHITSETT JEFFREY A (US)
Application Number:
PCT/US1999/024675
Publication Date:
August 29, 2002
Filing Date:
October 20, 1999
Export Citation:
Assignee:
CHILDRENS HOSP MEDICAL CENTER (US)
WHITSETT JEFFREY A (US)
WHITSETT JEFFREY A (US)
International Classes:
A01K67/027; A61K9/12; A61K35/76; A61K48/00; A61P11/00; C07K14/47; C07K14/785; C07K16/18; C12N15/09; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566; (IPC1-7): C12N5/00; A01N61/00; A01N37/18; C07K1/00; C07K16/00; C12P21/06; C12N15/00
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