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WO/1992/013952A1 |
This invention relates to novel biologically active molecules which bind to and inhibit thrombin. These molecules comprise a catalytic site directed moiety (CSDM) of formula (I), wherein X is hydrogen or is characterized by a backbone ch...
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WO/1992/013718A1 |
The lubricious hydrophilic coatings of the invention are significantly more lubricious when wet than when dry, are adherent to a variety of substrates, and are resistant to removal by wet abrasion. In one embodiment, the coatings include...
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WO/1992/011847A1 |
The invention relates to the use of a compound according to formula (I) in which x is an integer of from 2 to 5 and A signifies -NH-C(=NH)-NH2,-CH2-NH2 or -CO-NH2 or agmatin, for the preparation of a medicament for treatment of endotoxin...
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WO/1992/011877A1 |
Biocompatible polymeric coatings are provided which have excellent adhesion to a variety of substrate materials. The biocompatible coatings of the invention are comprised of a poly(alkylene oxide), a poly(carboxylic acid) or a poly(N-vin...
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WO/1992/011866A1 |
A laminin sequence of C-S-R-A-R-K-Q-A-A-S-I-K-V-A-V-S-A-D-R-NH2 or analogs thereof are provided for use in conjunction with tPA to greatly enhance plasminogen activation by the tPA. Formulations are provided combining the laminin fragmen...
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WO/1992/010532A1 |
Surfaces of polymers, particularly polyesters, can be fluorinated by deposition of a fluorocarbon from solution. The fluorocarbon may be an amorphous fluoropolymer, such as the copolymer of tetrafluoroethylene and bis-2,2-trifluoromethyl...
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WO/1992/009312A1 |
An implant material comprising a porous base material wherein the voids are filled with a denatured albumin or a biodegradable polyester and the blood-contacting surface contains an antithrombotic substance. This material is excellent in...
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WO/1992/007943A1 |
Retroviral vectors are disclosed which include an insertion site for genes of interest and are capable of expressing high levels of the protein derived from the genes of interest in a wide variety of transfected cell types. Also disclose...
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WO/1992/007573A1 |
Endothelial cells transduced with genetic material encoding a polypeptide or protein of interest and, optionally, a selectable marker, as well as methods for making and using the transduced endothelial cells are disclosed. Such endotheli...
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WO/1992/007858A1 |
A process for the preparation of compounds of formula (I) in which Z is hydrogen or -NHZ is an activated amine group capable of reacting with a surface, the groups R are the same or different and each is a straight or branched C1-C4 alky...
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WO/1992/007023A1 |
A hydrophilised solid surface having a biopolymer-repellent hydrophilic outer layer is produced by causing a solid surface with anionic groups capable of reacting with amino groups, to react with a polyethylene imine which is partly subs...
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WO/1992/006719A1 |
A process for coating a blood-contacting surface comprising applying a solution of a fatty acid diester of phosphatidyl choline in an organic solvent to the surface and removing the solvent, provides a non-thrombogenic coating of phospha...
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WO/1992/007005A1 |
The inhibitor is protein derived leech tissue or leech secretions (for example, from Hirudo medicinalis), which is capable of binding to native collagen, in such a way that substantially no cleavage breakdown products of collagen molecul...
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WO/1992/005695A1 |
Improved medical devices and instruments prepared by an improved method of producing hydrophilic, gamma-irradiation or electron beam-irradiation induced polymerized and chemically grafted coatings or plastic surfaces of articles adapted ...
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WO/1992/005748A1 |
Disclosed is a soluble, biocompatible, pharmacological agent for inhibiting thrombin generation and thrombus formation, and methods for producing the same. The pharmacological agent or conjugate includes a soluble, biocompatible carrier ...
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WO/1992/002238A1 |
Disclosed is a composition for bonding separated tissues together or for coating tissues or prosthetic materials including at least one natural or synthetic peptide and at least one support material which may be activated by energy and t...
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WO/1992/002114A1 |
The present invention is directed to a process for synthesizing hydroxylated plasma-polymerized films, as well as the hydroxylated plasma-polymerized films produced by the process of the invention. In addition, the present invention is d...
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WO/1992/000747A1 |
Anti-thrombogenic, and/or anti-microbial and/or pharmaceutical compositions containing heparin and/or antibiotics and/or other pharmaceutical agents which may be reacted with quaternary ammonium components or other ionic surfactants and ...
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WO/1991/019521A1 |
A method of modifying the properties of a surface of a substrate by covalent bonding of a compound to the surface, the compound comprising one or more functional groups which are all or partly activated by a reagent in a solvent-containi...
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WO/1991/018992A2 |
Disclosed herein are methods for using a proteinaceous material present in kinin-free high molecular weight kininogen to treat surfaces to prevent or minimize adhesion by blood components and/or animal cells. For example, in medical appl...
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WO/1991/017724A1 |
A medical device and a method for its manufacture. The function of the medical device requires exposure of the device to the tissue of a patient. The device has a tissue exposed surface portion (16) constructed to release an agent (26) t...
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WO/1991/016932A1 |
Polymers bearing heparin residues in bioactive form may be used in blood-contacting devices and as affinity chromatography agents. The polymers are produced by (a) polymerising heparin-bearing vinyl, acrylate, acrylamide or acrylonitrile...
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WO/1991/015952A1 |
The present invention is directed to thrombo-resistant coatings for use with gas permeable biomedical devices and implants. The coatings include a siloxane surface onto which a plurality of amine functional groups have been bonded. Coval...
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WO/1991/015252A1 |
New biocompatible glycosaminoglycan copolymers which are antithrombotic and antithrombogenic, are provided for demanding biomedical applications requiring long-term or permanent maintenance of anticoagulant properties. The novel copolyme...
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WO/1991/014730A1 |
This invention concerns a process for modifying polymer surfaces by contacting the surface with a selected organic modifying agent while irradiating the surface with ultraviolet and/or visible light that can be absorbed by the modifier. ...
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WO/1991/013639A1 |
A process for treating suitable synthetic polymers comprising the steps of (a) where appropriate, activating the surface to be treated, and, if necessary, providing spacer groups thereon; and (b) treating the surface with a compound of f...
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WO/1991/012886A1 |
This invention pertains to a method for immobilizing polyethylene oxide (PEO) star molecules in the form of hydrogels. The PEO star molecules are biocompatible and demonstrate non-thrombogenic properties. As such, the PEO star molecules ...
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WO/1991/009877A1 |
The invention discloses a method of covalently bonding protein to a surface coated with a nonionic hydrophilic polymer having a cloud point which is at least 5 �C above the temperature of use of the final product. Immobilisation of the...
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WO/1991/008790A1 |
Method for rendering a preformed article (2) lubricious and antithrombogenic and a device being the same. On the surface of the article a thin coating (6) of a biologically compatible, lubricious, hydrophilic polymer including acid group...
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WO/1991/005817A1 |
Method for surface modifying substrates characterized in adsorbing on the surface of a solid substrate a polyamin of a high average molecular weight and cross-linking this with crotonaldehyde either simultaneously or by addition in separ...
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WO/1991/002750A1 |
This invention relates to novel biologically active molecules which bind to and inhibit thrombin. Specifically, these molecules are characterized by a thrombin anion-binding exosite association moiety (ABEAM); a linker portion of at leas...
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WO/1991/001767A1 |
A non thrombogenic quaternary ammonium-heparin complex coating for a medical article comprising an amount of at least 50% by weight of one or more cationic quaternary ammonium organic salts having formula (I), wherein R1 is an alkyl grou...
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WO/1991/001328A1 |
This invention relates to novel, biologically active peptide derivatives which inhibit the fibrinolytic, but not the amidolytic activity of thrombin. The peptide derivatives, which display partial homology to the carboxy terminal portion...
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WO/1991/000745A1 |
The invention relates to methods for producing biocompatible surfaces by coating them with phospholipid and binding the phospholipid to the surface by means of ultrasonication.
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WO/1990/012550A1 |
This invention describes self-reinforced, absorbable surgical materials and/or implants and/or their parts and/or components, which can be implanted into the living tissue or on its surface for the purpose of e.g. to repair tissue damage...
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WO/1990/012607A1 |
An antithrombotic blood treating system comprising a combination of a permselective hollow fiber membrane containing a copolymer having a polyethylene oxide unit; a header having a blood-contacting surface coated with either a heparinize...
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WO/1990/012060A1 |
This invention relates to the use of tetraalkylpyromellitates as plasticisers for PVC for use in articles for biomedical use. The pyromellitates are less toxic than the conventionally used phthalates and trimellitates and are extracted l...
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WO/1990/009384A1 |
A compound of formula (I), wherein each of A1 and A2 is, independently, hydrogen or a group (a), in which R1 is selected from (i) certain radicals containing (b), in which R3 is hydrogen or methyl, (ii) -CH2-CH2-COOH, (iii) -NH-CH2-CH2-N...
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WO/1990/008783A1 |
The present invention provides a membrane the conductivity of which is dependent on the presence or absence of an analyte. The membrane comprises a closely packed array of self-assembling amphiphilic molecules and two ionophore component...
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WO/1990/007950A1 |
A biocompatible prosthetic device is provided which comprises a solid polymeric body incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when the device is in contact with a ...
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WO/1990/007941A1 |
Surgical needle for middle ear and accident surgery, as well as for reconstruction of the rear wall of the auditory canal, on which a drop of an aqueous mixture of a vitreous ionomer material which hardens to form a vitreous ionomer ceme...
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WO/1990/004598A1 |
The invention provides glycoside derivatives represented by general formula (I) (wherein G-O- represents a sugar residue free of the protective group, r represents hydrogen or methyl, m represents 1 or 2, n represents an integer of 1 to ...
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WO/1990/001305A1 |
Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorporeal devices in contact with the vascular system, and methods for producing the same. The thromboresistant substance comprises a synthetic, bio...
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WO/1990/000887A1 |
Surfaces are provided with desired characteristics of a polymer by covalently bonding polymer molecules to the surface through external activation of latent reactive groups carried by the polymer molecules. The initial surfaces are free ...
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WO/1990/000343A2 |
The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been...
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WO/1989/011919A1 |
A method of making a biocompatible hollow artifact with perforated walls made from a substrate of electro-conductive material whose surface is exposed to a biological environment, such as living animal tissue or blood, to impart to said ...
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WO/1989/011836A1 |
An artifact for implantation into a living animal body, said artifact or part thereof having a thin surface coating which is biocompatible where implanted, characterized in that said coating is comprised of a carbonaceous material which ...
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WO/1989/011857A1 |
An improved method and composition for preventing adhesions during surgery. Tissue surfaces and surgical articles involved in the surgery are coated with a solution of a hydrophilic, polymeric material prior to manipulation of the tissue...
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WO/1989/010131A1 |
Antithrombogenic and antibiotic composition of matter and method of preparation thereof. A random copolymer of a component of garlic and a biocompatible polymer has been prepared and found to exhibit antithrombogenic and antibiotic prope...
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WO/1989/009627A1 |
An intravascular catheter comprising a cannula constructed and dimensioned for insertion into a vascular system of a patient, and a coating of an amount of polymyxing on said cannula surfaces effective to substantially prevent the growth...
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