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WO/2019/171625A1 |
The present invention is an apparatus for connecting a supercritical fluid extraction device and a liquid chromatograph mass spectrometer, the apparatus being provided with a dilution part, a six-port valve, and a trap column, the diluti...
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WO/2019/170634A1 |
The present invention relates to composite materials useful for purifying proteins obtained from biological feedstocks. The composite materials of the invention comprise a porous support having an average pore size of 5 to 500 nm, said p...
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WO/2019/171004A1 |
The invention relates to a method for chromatographic purification of an initial flow containing ammonium sulphate and 2-hydroxy-2-methylpropionic acid, comprising: - passing the initial flow over a stationary phase bed; - eluting a refi...
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WO/2019/167011A1 |
The invention relates to a liquid chromatography fluid supply device (150) for providing a mixture of several different fluids as a mobile phase for a liquid chromatography sample separation device (10), wherein the fluid supply device (...
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WO/2019/169040A1 |
Provided herein are compositions, methods and uses that relate to or result from providing separation media having at least one flocculant ligand covalently attached to a base surface or support, and the separation and/or purification of...
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WO/2019/168114A1 |
This chromatographic separation method employs chromatography to separate a plurality of components, contained in a liquid to be separated, by means of a chromatographic separation device 1 provided with a plurality of filling portions 1...
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WO/2019/167441A1 |
Provided is a toxin separator or the like that is to be used for a toxin bound to a protein and present in an organism-derived liquid and that is capable of selectively separating the toxin from between the toxin and the protein. The tox...
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WO/2019/169303A1 |
The disclosure features methods that include obtaining a vibrational spectrum (804) of a solution in a biological manufacturing system, analyzing the vibrational spectrum (806) using a first chemometrics model to determine a value of a f...
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WO/2019/168508A1 |
The method and materials of this invention make possible substantially faster techniques for organic-aqueous extractions and routine chemical reactions work- ups. The inventive material uses silicone elastomer-coated glass powders, magne...
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WO/2019/164918A1 |
A pump for high-pressure and/or nano-scale volumes permits identification of the internal pressure of the pump.
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WO/2019/164227A1 |
The present invention relates to a multi-column for isolating exosomes and an exosome isolation method, for isolating exosomes from a biological sample containing exosomes mixed with impurities such as lipoproteins and water-soluble prot...
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WO/2019/165148A1 |
Technologies are described related to determining conditions for the purification of proteins. In some implementations, models can be generated that predict yield and purity for various chromatographic techniques at a number of pH levels...
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WO/2019/163499A1 |
Provided is a method for producing a chelate resin, wherein a highly pure treatment liquid can be obtained by reducing the amount of metal impurities in a to-be-treated liquid containing metal impurities. The method for producing a chela...
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WO/2019/163245A1 |
This quinone analysis method comprises: a sample sealing step for sealing a sample including quinones in an extraction container; an extraction step for, after the sample sealing step and as a series of extraction operations, carrying ou...
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WO/2019/161252A1 |
Chromatographic processes are provided which utilize fiber conduit contactors to effect separation of chemical substances from a mixture. In particular, processes are provided which constrain a substance on the fibers and move a mixture ...
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WO/2019/160640A1 |
A method of purifying a rendered fat by contacting the rendered fat with at least one adsorbent material, such as magnesium silicate. The at least one adsorbent material may be used alone or in combination with other purifying materials,...
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WO/2019/155411A1 |
The invention relates to a method of purifying and/or separating lipopeptide surfactants of the natural origin using the Countercurrent Chromatography (CCC) characterised in that: the purification occurs within the system of two partiall...
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WO/2019/150137A1 |
This invention relates to a method of removing a chemical entity from a liquid using affinity chromatography. The method involves passing an elongate solid phase through a conduit through which the liquid also flows.
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WO/2019/152970A1 |
A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic ...
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WO/2019/152352A1 |
Methods for achieving complete sequence coverage of monoclonal antibodies by trypsin digestion and dual-column LC-MS system are provided. The disclosed method improves upon current techniques for standard peptide mapping.
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WO/2019/152411A1 |
A method for producing an ethanol product includes obtaining a condensed distillate including ethanol at a concentration greater than 30% by volume and contacting the condensed distillate with an adsorbent polymer resin. The adsorbent po...
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WO/2019/149878A1 |
The present invention relates to ligand that may be a peptide compound as well as peptoid or retro- inverso analogues thereof with binding affinity for the Fc region of immunoglobulins. The invention further relates to the application of...
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WO/2019/145117A1 |
The invention relates to a method for determining impurities in polyalkylene ethers or polyalkylene amines, comprising the following steps: i) introducing polyalkylene ethers or polyalkylene amines as the analyte into a chromatography co...
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WO/2019/145920A1 |
The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. T...
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WO/2019/147555A1 |
Disclosed is a method for the enrichment and purification of circulating, cell-free DNA (cfDNA) from a biological specimen. The method uses optimized mixtures and ratios of magnetic particles and reagents to efficiently enrich, purify, a...
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WO/2019/144228A1 |
The valve assembly (100) includes a main valve body (102) defining a first inner cylindrical cavity (180), a support plate (170) positioned above the main valve body (102), and an upper valve head (104) positioned above the support plate...
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WO/2019/145552A1 |
The present specification discloses methods of purifying one or more cannabinoids from a plant material using unique biphasic solvent systems and liquid-liquid chromatography as centrifugation partitioning chromatography (CPC) or counter...
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WO/2019/142034A1 |
Exemplary embodiments are directed to methods and systems for managing fluid decompression. A fluid connector (703) is located downstream of a chromatography column and defines an interior bore (705) through which a fluid can pass. The i...
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WO/2019/143251A2 |
Continuous process in which a subset of a number of mutually identical columns, are connected in series. The process liquid, e.g. crude cell culture harvest, is supplied to the most upstream column of the subset, flows successively throu...
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WO/2019/138338A1 |
The present patent application discloses a new and innovative method for purification of glycerol derivatives, by simulated moving bed chromatography. The method of the present patent application allows the separation of at least one gly...
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WO/2019/137251A1 |
A novel porous framework material (such as a metal organic framework material or a covalent organic framework material) having a wide range of applications was designed and developed in an inventive manner to resolve issues with respect ...
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WO/2019/138784A1 |
A concentration device (100A) is for concentrating a solution containing biological substances, and comprises: a first chamber (5a) into which the solution is injected; a second chamber (5b) which is filled with a drawing agent (6); a fi...
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WO/2019/134418A1 |
A fully automatic chromatography column having a movable beam, which is provided with a door-type support (10); a detachable column tube (20) is provided within the door-type support (10), and the column tube (20) is internally provided ...
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WO/2019/126862A1 |
A process for recovery of lithium ions from a lithium-bearing brine includes contacting the lithium-bearing brine with a lithium ion sieve (where that LIS includes an oxide of titanium or niobium) in a first stirred reactor to form a lit...
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WO/2019/133677A1 |
Provided herein are methods of producing an adeno-associated virus (AAV) product and methods of purifying adeno-associated virus. AAV is loaded onto an affinity resin, wash steps are undertaken, and AAV is eluted from the affinity resin....
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WO/2019/131629A1 |
[Problem] To obtain a highly purified refined material composition by removing polyvalent metals, polyvalent metal ions and charged metal oxide colloid particles thereof from a composition in which a material to be refined is dissolved o...
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WO/2019/128838A1 |
Porous polymer microsphere having radial optical anisotropy and diverse swelling states when dispersed in different solvents, which have ability to well swell the porous microspheres. A method for preparing the porous polymer microsphere...
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WO/2019/127686A1 |
The present invention relates to a combined ligand, as well as a combined biomimetic chromatography medium, a preparation method therefor, and application thereof. Regarding the combined biomimetic chromatography medium, a hydrophilic po...
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WO/2019/133842A1 |
Disclosed is a method of purifying extracellular vesicles in a sample comprising extracellular vesicles and molecules that are not bound to the extracellular vesicles. The method includes (a) providing a mixed mode resin composition cont...
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WO/2019/125593A1 |
A filter includes an inlet side, an outlet side, and a body. The body includes a first substrate that includes an array of inlet holes passing through the first substrate, and a second substrate that includes an array of outlet holes pas...
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WO/2019/126752A1 |
In various aspects, the present disclosure pertains to methods of performing a sample enrichment procedure, which comprise: adding a sample fluid that comprises at least one phospholipid and at least one target analyte to a sorbent that ...
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WO/2019/122650A1 |
The present invention relates to zeolitic adsorbents based on agglomerated crystals of zeolite X comprising barium, potassium, sodium and strontium. These adsorbents are used in the separation of fractions of C8 aromatic isomers and in p...
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WO/2019/126259A1 |
The disclosure relates to methods, systems and kits for analyzing pesticides in samples, e.g., plant samples such as cannabis samples.
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WO/2019/126614A1 |
Disclosed herein are methods of producing a peptide map of peptide or protein compositions, final peptide or protein drug products produced by the disclosed methods, and articles of manufacture comprising the disclosed final peptide or p...
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WO/2019/122003A1 |
The present invention describes a method for isolating extracellular vesicles (EVs) from different biological fluids, said nickel-based isolation method (NBI) is fast, scalable and allows for the purification of dimensionally heterogeneo...
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WO/2019/123428A1 |
The invention provides methods and systems for washing adsorptive media with minimal water consumption. More specifically, the invention provides methods and systems for in situ regeneration and/or sanitization of adsorptive media, such ...
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WO/2019/126123A1 |
Systems and methods for characterizing low molecular weight (LMW) protein drug product impurities are provided. One embodiment uses hydrophilic interaction chromatography (HILIC) coupled to mass spectrometry analysis. After removal of th...
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WO/2019/119622A1 |
The present invention relates to a modified silica gel filler. The modified silica gel filler comprises particles having the following structure: silica gel microspheres grafted with functional groups, and a polymer coating layer at leas...
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WO/2019/118187A1 |
Embodiments of the present disclosure may assist in managing, storing, using, and re-using dedicated chromatography column bed supports. For example, devices and systems disclosed herein may include reusable cases for storing dedicated c...
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WO/2019/118426A1 |
The present invention provides a continuous upstream manufacturing process for the production of bispecific antibody products, which comprise at least two binding domains. The process comprises at least the steps of (i) providing in a pe...
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