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JP4406966B2 |
To obtain a new fluorine-containing polyfunctional (meth)acrylic acid ester exhibiting high surface hardness and low refractive index after crosslinking polymerization and useful as a raw material component of an antireflection film, a c...
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JP4406294B2 |
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JP4384315B2 |
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JP4384635B2 |
The present invention relates to a production method of asymmetric compound (IV) which includes conjugately adding nucleophilic reagent (III) to compound (II) in the presence of asymmetric urea compound (I). The present invention provide...
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JP2009543815A |
Disclosed is a method for producing aminocarbonyl compounds of the general formula (I) wherein R1 and R2 can be identical or different and represents hydrogen, alkyl, alkenyl, alkynyl, or aryl, X represents hydrogen, alkyl, alkenyl, alky...
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JP4374978B2 |
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JP4374658B2 |
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JP4371338B2 |
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JP4361094B2 |
The present invention is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallization with enantiomerically pure N-unprotected β-amino acid derivatives.
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JP4360660B2 |
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JP2009242319A |
To provide a polyfunctional fluorine-containing compound, a method of producing the same, a crosslinking agent comprising the same, a curable composition comprising the same, and a cured material obtained by curing the composition.Disclo...
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JP4349749B2 |
A process for producing a carboxylic acid derivative characterized by mixing a quaternary ammonium salt having a specific triazine ring in the molecule, a carboxylic acid compound, and a compound having a nucleophilic functional group to...
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JP4348126B2 |
Preparation of optically active cyclic amino alcohols or their salts involves reacting an optically active hydroxycarboxylate with hydrazine to form hydroxycarboxylic hydrazide followed by its Curtius reaction with an alcohol to form alk...
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JP4343260B2 |
A production method of a compound containing a primary, secondary, or tertiary aminomethyl aromatic ring of the present invention includes: using a fluoroboron compound or a dimer thereof, or solvates thereof, which are represented by a ...
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JP2009227685A |
To provide a new method for producing a racemic form or an optically active form of an amino alcohol expressed by formula I, a method for converting it to a corresponding acyl derivative and a method for further converting the above to (...
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JP2009533372A |
Method for preparing cyclic depsipeptides having the following formula (I) by intramolecular cyclization.
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JP2009533315A |
What is provided herein is an aromatic compound substitution agent that is a tRNA synthetase inhibitor and thus can be used as an antibacterial agent. The compounds described herein are Gram-positive, Gram-negative, anaerobic or fungal m...
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JP4326826B2 |
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JP4323032B2 |
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JP2009184933A |
To provide a simple, low cost, and industrially applicable method of producing N-methylcyclobutylamine.The method is accomplished, as a result of researching simple, low cost, and industrially applicable methods of producing N-methylcycl...
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JP4317343B2 |
The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases usin...
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JP4315145B2 |
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JP4311850B2 |
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JP4309251B2 |
Disclosed are novel nitrile compounds of formula (I) further defined herein, which compounds are useful as reversible inhibitors of cysteine proteases such as cathepsin K, S, F, L and B. These compounds are useful for treating diseases a...
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JP4310271B2 |
The present invention relates to crystalline 1-{[(±-isobutanoyloxyethoxy)carbonyl] aminomethyl}-1-cyclohexane acetic acid.
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JP4308263B2 |
A crystalline form of a γ-aminobutyric acid analog, and methods of preparing same, are provided.
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JP4299020B2 |
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JP4298995B2 |
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JP2009155276A |
To produce an organic carbamate in higher yield in a shorter time under milder conditions by using a green compound (safe raw material having less toxicity and effects on the environment) without depending on an organic isocyanate having...
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JPWO2007099843A1 |
The present invention provides a novel method for producing oseltamivir (trade name: Tamiflu), an antiviral drug, which does not use shikimic acid as a raw material, and a novel raw material or intermediate used in the production method....
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JP4292834B2 |
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JP2009524588A |
This invention provides compounds having the structural formula: wherein: R1 is an acyl or sulfonyl group, R2 is an acyl group selected from the group consisting of acyl groups derived from cycloaliphatic, aromatic or heterocyclic monoca...
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JP4277352B2 |
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JP2009521402A |
A process for isolating from a reaction mixture a salt of a mono-propargylated aminoindan, a process for isolating from a reaction mixture a crystalline diastereomeric salt of a mono-propargylated aminoindan, and a process for isolating ...
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JP2009108034A |
To provide fluorinated carbamates of high purity more efficiently in a high yield.The manufacturing method of fluorinated carbamates comprises causing an amine or a polyamine to react with a fluorinated carbonate in the presence of a cat...
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JP4261915B2 |
This invention relates to a process for the preparation of alkyl-N-(3-dimethylamino)alkylcarbamates by reacting an alkyl-chloroformate in an alcohol.
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JP4263200B2 |
A method for making a compound of Formula I which is racemic or enantiomerically enriched at chiral center* comprising hydrogenating a compound of Formula V in the presence of a compound of Formula VII wherein: R 1 is F, Cl, or C 1 -C 3 ...
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JP2009091331A |
To provide a method for efficiently preparing an optically active fluoromalonic ester.The method for preparing an optically active fluoromalonic ester comprises using a DBFOX-Ph/Lewis acid complex as a catalyst.
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JPWO2007049656A1 |
Provided are a novel fluoroadamantane derivative and a method for producing the same. A method for producing the following compound (2) in which the following compound (1) is reacted with an azide and then heat-treated, a method for prod...
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JPWO2007055180A1 |
The present invention has the general formula (1). [Chemical 1](In the formula, R1Indicates a group selected from a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxyl group, and a nitro group. Also, * me...
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JP2009514914A |
The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a pr...
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JP4249135B2 |
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JP4243183B2 |
The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.
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JP4244139B2 |
The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arterioscle...
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JP2009511578A |
The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
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JP4235732B2 |
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JP2009046452A |
To provide a method capable of producing a primary allylamine directly from an allyl alcohol without requiring the use of an activating agent of the allyl alcohol or the conversion to an active species.This method for producing the allyl...
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JP2009046467A |
To provide a method for preparing (S)(+)-3-(aminomethyl)-5-methylhexanoic acid.This method for preparing (S)(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or its salt comprises reacting a compound of formula (II) with an alcohol ...
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JP2009507793A |
This invention provides compounds of Formula I having the structure where R1, R2, R3 and A are defined in the specification or a pharmaceutically acceptable salt thereof useful as antibacterial agents. Compounds according to Formula (II)...
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JP2009040777A |
To provide a plasminogen activator inhibitor-1 (PAI-1) inhibiting agent and a novel compound acting as an active ingredient thereof and to provide a pharmaceutical composition having an action of inhibiting PAI-1 activity and being effec...
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