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JPWO2010122682A1 |
While controlling the pH of the solution within the range of 9 to 13 using a basic reagent, an N-alkoxycarbonylating agent of 0.90-fold molar or more and 1.00-fold molar or less was allowed to act on tert-leucine in the presence of water...
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JP2012197254A |
To provide a process for efficiently and simply producing benzyl 2-haloethylcarbamate.The process for producing a compound represented by formula (1) or its salt includes: a step (1) of causing a compound represented by formula (2) to re...
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JP5052420B2 |
PCT No. PCT/US97/12553 Sec. 371 Date Feb. 16, 1999 Sec. 102(e) Date Feb. 16, 1999 PCT Filed Jul. 22, 1997 PCT Pub. No. WO98/03519 PCT Pub. Date Jan. 29, 1999Bis-platinum(II) complexes with polyamine ligands, including spermidine and sper...
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JP5043191B2 |
The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compou...
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JPWO2010113458A1 |
Provided is an industrially advantageous method for producing a 1,5-benzodiazepine compound. Compound (5) is obtained by the following reaction formula, and this is used as an intermediate.
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JP5041219B2 |
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JP5040910B2 |
(PROBLEM) To provide a method for efficiently and industrially deuterating the benzyl position of a -O-benzyl group formed by introducing a benzyl group, a benzyloxymethyl group and the like as a protecting group. (SOLUTION) The deuterat...
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JP5036648B2 |
The invention provides compounds of formula I wherein n, A, R, R', R'', R0, X and Y are as defined in the description, and their preparation. The compounds of formula I are useful as pharmaceuticals.
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JP5005338B2 |
Tertiary non-vinylic carbamates of molecular weight less than 350 are useful as fragrance ingredients. A method of preparation is also described.
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JP5003324B2 |
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JP4993374B2 |
The present invention is directed to prodrugs of hydroxamic acid based histone deacetylase (HDAC) inhibitors, e.g., suberoylanilide hydroxamic acid (SAHA). The prodrugs are acylated derivatives having increased aqueous solubility and cel...
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JP4988118B2 |
Process for the preparation of aromatic urethanes consisting in reacting organic carbonates with aromatic amines in reactors operating in continuous, feeding a total quantity of aromatic amines in a percentage, with respect to the weight...
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JP4979889B2 |
R-Bambuterol, being the R-enantiomer of bambuterol of the following structure and is therapeutically acceptable salts.
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JP2012513966A |
A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drug substances. In particular, the process relates to the preparation of (S)-3-(1-Dimethylamino-ethyl)-phenol using asymmet...
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JP4954886B2 |
The present invention relates to a method for preparation of substituted phenyl carbamate and pharmaceutically acceptable salts thereof, which are of current pharmaceutical interest. The substituted phenyl carbamate and pharmaceutically ...
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JP4957067B2 |
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JP2012513391A |
The present invention provides novel and more efficient synthesis's for obtaining an intermediate in the synthesis of obtaining a protecting group aminoxy PEG linker.
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JP2012111717A |
To provide a method for obtaining a compound containing a dichloromethyl group from a compound containing a trichloromethyl group, capable of efficiently eliminating chlorine by cutting one carbon-chlorine bond in the trichloromethyl gro...
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JP2012512835A |
A continuous process for the production of an aromatic urethane from the reaction of an aromatic amine and an organic carbonate comprising the steps of passing the aromatic amine and the organic carbonate through a fixed bed reactor cont...
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JP4945823B2 |
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JP4941821B2 |
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JP4939010B2 |
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JP2012510958A |
The invention relates to the compounds suitable for radiolabeling with a chelator free radioisotope and radiolabeled compounds of the general Formula I. Said compounds are ornithine or lysine derivatives.
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JP4930951B2 |
The present invention provides a process comprising substitution of an acceptor molecule comprising a group -XC(O)- wherein X is O, S or NR 8 , where R 8 is C 1-6 alkyl, C 6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor m...
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JP4927258B2 |
The present invention has for its object to provide a practical method for the purification and isolation on a commercial scale of said compound (1) or compound (2) in good yield and with high quality. The present invention provides a pu...
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JP4927563B2 |
Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acylo...
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JP4922082B2 |
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JP2012509351A |
Methods for fluorinating organic compounds are described herein.
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JP2012072171A |
To provide a method of producing rivastigmine, and the salts thereof which can be pharmaceutically permitted useful for treating diseases of Alzheimer's disease, Down syndrome, Huntington's chorea, Friedrich ataxia or the like.The method...
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JP2012508780A |
Provided is an enantioselective, palladium-catalyzed method for the preparation of γ-amino-α,β-unsaturated carboxylic acid derivatives having the formulas II, III, VII and VIII:
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JP4910148B2 |
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JP2012062262A |
To provide a method for producing an N-methylcarbamic ester derivative capable of becoming an important synthetic intermediate in producing a medicine, etc.; and to provide the synthetic intermediate.In the method for producing the N-met...
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JP2012506440A |
This disclosure relates to reagents and methods useful in the synthesis of aryl fluorides, for example, in the preparation of 18 F labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of comp...
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JP4896872B2 |
A process for preparing an amine of the structure which comprises a. treating an aqueous solution of a keto acid of the structure with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalani...
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JP2012046431A |
To provide a catalyst having the small number of processes for production without requiring much labor, for promoting a dehydration condensation reaction between a carboxyl group and an amino group, and to provide a method for producing ...
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JP4892195B2 |
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JP4889909B2 |
The present invention relates to a process for the preparation of alpha' chloroketones, such as 4-phenyl-3-t-butyloxy-carbonylamino)-2-keto-1-chlorobutane by reacting certain aryl amino acid esters, e.g. N-(2-t-butoxycarbonyl)-L-phenylal...
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JPWO2010038828A1 |
The present invention provides a novel photobase generator capable of generating a base with high sensitivity to h-rays, instead of the conventional 2-nitro-4,5-dimethoxybenzyloxycarbonylamine compound. I am aiming. The present invention...
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JP4876165B2 |
Hydride process for making acyclic diol intermediates from cyclic intermediates, useful in antibacterial quinolone synthesis.
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JP4859255B2 |
An object of the present invention is to provide a process that enables isocyanates to be stably produced over a long period of time at high yield without encountering various problems as found in the prior art when producing isocyanates...
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JP4861317B2 |
The invention relates to a method for producing enantiomers form of 2,3-diaminopropionic acid derivatives of formula (I) by asymmetric hydrogenation from compounds of formula (II).
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JP4857332B2 |
The invention relates to a compound of formula (I): Wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to methods of preparation of compounds of formula (I) as well as to their therapeutic application.
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JP2012006921A |
To provide a new high-yield and practical chemical synthetic method of oseltamivir phosphate, with which the oseltamivir phosphate is obtained from an easily available raw material compound with high optical purity.In the new chemical sy...
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JP2012500187A |
The resent invention rovides a novel rocess for re arin cinacalcet of formula I and pharmaceutically acceptable salts thereof and process of purification. The present invention also provides novel nitrogen protected synthetic intermediat...
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JP4845470B2 |
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JP4833479B2 |
Process for the synthesis of polyurethane derivatives from aromatic polyamine compounds. The method involves reaction of an aromatic polyamine compound with CO and O2 in the presence of a catalyst comprising a Group VIII or lanthanide me...
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JP4825947B2 |
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JP4827531B2 |
An asymmetric synthesis of amino acid compound that is useful as a starting material or synthetic intermediate for production of medicinal products, agrichemicals, perfumes, functional polymers, etc. There is provided a method of enanthi...
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JP4822351B2 |
Arylalkylcarbamate esters (I) are new. Arylalkylcarbamate esters of formula (I) and their acid addition salts, hydrates and solvates are new. [Image] n : 1-6; A : X, Y and/or Z; X : 1-2C alkylene optionally substituted with 1-12C alkyl, ...
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JP4822844B2 |
A method of an enantioselective nucleophilic addition reaction to carbonyl, which enables an asymmetric synthesis of an optically active ±-hydroxy-³-keto acid ester, an optically active ±-hydroxy-³-amino acid ester, hydroxydiketone c...
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