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JP5266056B2 |
The present invention relates to a new and useful process for preparing N,N-substituted carbamoyl halides from secondary amines, carbon dioxide, trialkylsilyl chloride and a halogenating agent.
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JP5260114B2 |
To find a method for efficiently and stably producing an N-alkoxycarbonyl-tert-leucine of high quality by a simple operation. The N-alkoxycarbonyl-tert-leucine is produced by causing an N-alkoxycarbonylation agent in an amount of at leas...
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JP5257785B2 |
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JP5249226B2 |
The invention relates to the compounds of formula (I) having antithrombotic activity which especially inhibit blood clotting factor IXa, to methods for producing the same and to the use thereof as drugs.
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JP5249572B2 |
To provide a novel (meth)acrylate excellent in flexibility and simultaneously satisfying both properties such as high refractive index and high heat resistance, and excellent flexibility.A urethane (meth)acrylate is obtained by using as ...
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JP5249571B2 |
To provide a novel urethane (meth)acrylate having a fluorene skeleton excellent in heat resistance and the like.The urethane (meth)acrylate is obtained using as reaction components a compound having a specific fluorene skeleton [for exam...
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JP5249570B2 |
To provide a new urethane (meth)acrylate having a fluorene skeleton excellent in hardness, heat resistance, etc.The urethane (meth)acrylate is obtained by using, as reaction constituents: a compound having at least three hydroxy groups a...
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JP5246903B2 |
An optically active ²-aminocarbonyl compound is obtained by a Mannich reaction between an aldimine in which nitrogen is protected and a malonic acid diester, in the presence of optically active BINOL and dialkyl magnesium (in which two ...
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JP5242678B2 |
An object of the present invention is to provide a process that enables isocyanate to be produced stably over a long period of time and at high yield without encountering problems of the prior art during production of isocyanate without ...
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JP5242422B2 |
Resorcinol-blocked isocyanate compositions are derived from the reaction between a resorcinol compound and at least two different isocyanate compounds. The resorcinol-blocked isocyanate compositions may have two or more unblocking temper...
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JP5238822B2 |
Described is a process for preparing docetaxel 1, including the following steps: a) hydroxyl acylation reaction of compound 2 and 3 to obtain compound 4; b) deprotection group R1 of the hydroxyl group of compound 4 obtained from step a t...
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JP2013528601A |
An improved process for the preparation of aryl substituted olefinic amines such as (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-
amine and (2S)-(4E)-N-methyl-5-[3-(5-methoxypyridin)yl]-4-penten-2-ami
ne and new intermedia...
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JP5230609B2 |
The compounds of the general Formula (I), wherein R1 is aryl or alkyl; R2 represents alkyl; R3 represents alkyl or aralkyl, are valuable pharmaceutical intermediates, which can be prepared by reacting a compound of the general Formula (I...
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JP2013523605A |
The invention relates to Sitagliptin intermediate compounds of formula (f), preparation methods and uses thereof. The compound of formula (f) are prepared by the following steps: compounds of formula (a) are subjected to electrophilic re...
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JP2013522277A |
The present invention relates to N-carbomethoxy-N-methoxy-(2-chloromethyl)-aniline compounds of the formula I, wherein: n is 0, 1, 2 or 3, each R1 is independently selected from halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C...
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JP2013518091A |
Herein described is a novel crystalline form of the hydrochloride of the (4-hydroxycarbamoyl-phenyl)-carbamic acid (6-diethylamino methyl-2-naphtalenyl) ester. In particular, herein described is a polymorph of the hydrochloride of the (4...
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JP5199865B2 |
The present invention is aimed at a process for the preparation of compounds of the general formula (I). The objective process is in this case based on the Michael reaction of compounds of the general formula (III) with compounds of the ...
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JP5198220B2 |
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JP2013082638A |
To provide a novel optically active aminonitrile compound and a method of producing the same.The novel optically active aminonitrile compound is represented by general formula (1). In the general formula (1): R1 and R2 may be the same or...
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JP5191385B2 |
The present invention provides with a process of preparing an optically active succinimide derivative, which is a key intermediate for production of ranirestat. A compound (3) is easily prepared by treating the derivative of succinic aci...
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JP5187922B2 |
The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compou...
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JP5189765B2 |
The present invention provides a compound having a formula: where R1 is selected from the group consisting of alkyl, CH2(OC2H4)OCH3, and —(OC2H4)OCH3; n is 0-4; Olig is an oligomer having a formula: -L-O-PAGR.R2]q where L is a optional...
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JP5179050B2 |
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JP2013060492A |
To produce an adamantane derivative which improves the moisture absorptivity and shrinkage percentage of the curable composition thereof.A production method of an adamantane derivative expressed by formula (1) is provided, which comprise...
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JP2013056894A |
To provide novel anthranilamide and 2-amino-heteroarene carboxamide derivatives useful as cholesteryl ester transfer protein (CETP) inhibitors; methods for producing the same; use thereof as pharmaceuticals; and pharmaceutical compositio...
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JP2013053166A |
To provide new crystallized diacetylenic compounds and to provide methods of preparing the compounds.This invention relates to: crystallized diacetylenic compounds having certain crystallographic and other characteristics; diacetylenic c...
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JP2013028573A |
To provide an amino acid derivative that can be manufactured in a high yield and at a high optical purity and a manufacturing method for the same, and a production intermediate of the amino acid derivative and a manufacturing method for ...
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JP2013028607A |
To provide a novel manufacturing process, novel process steps, and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors.The process for manufacturing a compound of formula (III) (w...
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JP5124753B2 |
The tube has a tubular unit (1) provided, where the tubular unit faces an inner surface of the tube and is made of a metal selected from a group of zirconium, tantalum, niobium, aluminium or metal alloy. The tubular unit extends evenly o...
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JP5124089B2 |
One or more organic isocyanate having Hazen color index of less than 100 APHA are partially carbodiimidized with a phospholine type catalyst. Carbodiimidization reaction is stopped with an alkylation agent. Organic isocyanate (A) having ...
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JP2013010740A |
To provide a new method for producing an isoxazoline compound and production intermediates thereof.The method for producing the isoxazoline compound represented by chemical formula includes: (1) producing a carbamic acid ester compound b...
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JP5105296B2 |
Functional group-selective hydrogenation catalyst for an organic compound containing at least a functional group of an aliphatic carbon carbon double or triple bond, an aromatic formyl group and an aromatic nitro group, comprises a carri...
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JP5108888B2 |
The present invention provides a method for producing an optically active N-(halopropyl)amino acid derivative, wherein the method comprises the steps of obtaining a compound represented by formula (III) by reacting an optically active al...
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JP2012250930A |
To provide a process for producing a carbamate which can directly produce a carbamate from raw materials without producing by-products such as a ketone and a hydrogen halide by using carbon dioxide, an alcohol, and an amine as the raw ma...
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JP5096653B2 |
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JP5093798B2 |
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JP2012236818A |
To provide a new method for producing amine compounds regardless of the presence of inorganic salts.The method for producing an amine compounds (5) includes the following steps. Step (1), a step in which R-Mg-X1 is reacted with X2-Zn-X2;...
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JP5089634B2 |
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JP5084498B2 |
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including these compounds a...
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JP5084068B2 |
The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compou...
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JP5085930B2 |
The Invention relates to novel ketones of formulae (I) and (II) wherein R1, R2, R3 and R4 are, for example, C1-C8alkyl, R5 is, for example, hydrogen, A is CI, Br, -0-R7, -NR8R9 or -S-R16, A' is -O-, -NH- or -NR8-, X and Y are each indepe...
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JP5077895B2 |
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JP5078005B2 |
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JP5076103B2 |
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JP5074400B2 |
The invention provides a multistage process for continuously preparing organic, distillable polyisocyanates, preferably diisocyanates, more preferably aliphatic or cycloaliphatic diisocyanates, by reacting the corresponding organic polya...
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JP5069222B2 |
The invention relates to a method for concentrating an aqueous ammonium carbamate stream, which has been formed in a process for the preparation of urea, has a pressure between 0.20 MPa and 0.9 MPa, a temperature between 35° C. and 95°...
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JP5067906B2 |
The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compou...
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JP5069883B2 |
To provide an industrial method for producing a diacyl oxazolone and a β-amino acid derivative in a mild condition in a short process without requiring a strong base or low temperature reaction. The diacyl oxazolone is expressed by gene...
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JP5064503B2 |
The present invention relates to compounds of formula I wherein R1, R2, R3, R4, R5, X, and n are as defined herein and the dotted line denotes an optional bond and pharmaceutically acceptable acid addition salts thereof. The compounds ar...
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JP5063860B2 |
Diamidine derivatives of formula (I) and their salts are new. Amidine derivatives of formula (I) and their salts are new. [Image] X : a group of formula (ii) or R 4; Z : -(CH 2) m-; m : 8 - 21; n : 0 or 1; Y : R 3 or a group of formula (...
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