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JP4228450B2 |
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JP4228465B2 |
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JP2009029747A |
To provide an amidation method that permits the progress of a reaction even at room temperature and is satisfactory from the viewpoint of the yield because of a small amount of by-produced Boc derivatives of an amine.The amidation method...
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JP2009023941A |
To provide an asymmetric reduction catalyst useful for the production of an optically active alcohol compound and a method for the production of an optically active alcohol compound by using the asymmetric reduction catalyst.The organome...
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JP2009502792A |
A process for the preparation of aromatic carbamates comprising contacting one or more organic carbonates with an aromatic amine or urea in the presence of a catalyst and recovering the resulting aromatic carbamate product, characterized...
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JP2009503036A |
The invention relates to a method of obtaining phenyl carbamates (I), wherein R 1 is lower alkyl C 1 -C 5 or benzyl and R 2 is methyl, ethyl or propyl, consisting in reacting L-(S)-3-[(1-methylamino)ethyl]phenol, in the presence of a bas...
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JP4212466B2 |
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JP4208469B2 |
Intermediates (I) for the total synthesis of ecteinascidin compounds are new having the 10 membered ring structure of ecteinascidins with a 4-position thioether group and trichloroethoxycarbonyl (Troc) substituent as R 2in the 12-N posit...
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JP2009001545A |
To provide a method for producing alcohols from an ester or a lactone under a comparatively mild condition in high yield and in high catalytic efficiency.The method for producing the alcohols comprises reducing the ester or the lactone w...
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JP4202269B2 |
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JP4201881B2 |
A process is disclosed for the synthesis of aromatic urethanes which comprises: reacting an organic carbonate, in a stoichiometric quantity or higher than the stoichiometric value, with an aromatic amine having formula (I-III), in the pr...
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JP2008545724A |
The use of a metathesis catalyst in the preparation of a functionalized sphingolipid.
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JPWO2006115230A1 |
A main object of the present invention is to provide a compound having a structure in which a side chain having an amino acid or an oligopeptide is bound to the main chain. The compound represented by the following general formula (1) is...
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JP4193198B2 |
A process for producing alpha-aminohalomethyl ketones or N-protected alpha-aminohalomethyl ketones from specified 3-oxazolidin-5-one derivatives via 5-halomethyl-5-hydroxy-3-oxazolidine derivatives. By this process, alpha-aminohalomethyl...
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JP2008542415A |
The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a pr...
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JP2008540474A |
3-Haloalkoxy-phenyl-alkanone-O-substituted oxime derivatives (I) are new. 3-Haloalkoxy-phenyl-alkanone-O-substituted oxime derivatives of formula (I) are new. A 1CH 2CH=CCl 2, CH 2CH=CBr 2, CH 2CH=CClF, CH 2CF=CCl 2, CH 2CH 2CH=CF 2, CH ...
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JP4182271B2 |
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JP4181636B2 |
PCT No. PCT/US97/12553 Sec. 371 Date Feb. 16, 1999 Sec. 102(e) Date Feb. 16, 1999 PCT Filed Jul. 22, 1997 PCT Pub. No. WO98/03519 PCT Pub. Date Jan. 29, 1999Bis-platinum(II) complexes with polyamine ligands, including spermidine and sper...
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JP4181233B2 |
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JP2008538779A |
The invention provides compounds of formula (I), wherein the substituents are as defined in the specification, to processes for their preparation and their use as pharmaceuticals.
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JP4176020B2 |
The invention provides compounds of formula I wherein n, A, R, R', R'', R0, X and Y are as defined in the description, and their preparation. The compounds of formula I are useful as pharmaceuticals.
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JP4174580B2 |
To provide a polyester macromonomer which can industrially be used and whose polyester wastes can be recycled. This polyester macromonomer has a structure of formula (1) [(n) is an integer of 1 to 50; X is a polymerizable functional grou...
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JP4176153B2 |
This invention is directed to polymeric hydroxylamine resin compounds and to processes for the solid-phase synthesis of aldehydes, ketones, oximes, amines and hydroxamic acid compounds useful thereof.
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JP2008260755A |
To provide a method for retrieving, by a simple operation, an L-biphenylalanine salt formed by enzymohydrolysis of a biphenylalanine ester to utilize the thus retrieved salt.The method for retrieving an L-biphenylalanine compound salt co...
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JP2008538565A |
Disclosed is a method of making 2-substituted-2-halo-1,3-propanediols via reduction of corresponding malonate compounds. Also disclosed is a method of making 2-substituted-2-halo-1,3-dicarbamate compounds (such as halo derivatives of fel...
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JP4172717B2 |
Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selec...
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JP4167594B2 |
Provided is a method of preparing a hydroxyamino acid derivative, particularly in an optically active form thereof with high efficiency. Specifically, provided is a method of preparing hydroxyamino acid derivatives represented by Formula...
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JP4163254B2 |
PCT No. PCT/EP96/05874 Sec. 371 Date Dec. 4, 1998 Sec. 102(e) Date Dec. 4, 1998 PCT Filed Dec. 19, 1996 PCT Pub. No. WO97/25309 PCT Pub. Date Jul. 17, 1997Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and ...
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JP4161057B2 |
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JP4154143B2 |
A process for preparing N-[1- (S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride of the following formula (I), is to react N-[1-(S)-ethyoxy carbonyl-3-phenylpropyl]-L-alanine with XCOOR, wherein X is halogen atom, R is C1-C6...
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JP2008212815A |
To provide an organic synthesis reactor applied for organic synthesis reaction employing a carrier for crystallization separation, which requires no replacement of the reaction vessel in individual stages even in cases involving a multi-...
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JP4149668B2 |
Preparation of optically active N-protected S-phenylcysteine (III) using new process for preparing beta -halogeno-alpha -aminocarboxylic acid (I) starting materials. Preparation of beta -halogeno-alpha -aminocarboxylic acid (I) comprises...
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JP4147022B2 |
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JP4143787B2 |
Herein is disclosed a process for producing an alpha -aminohalomethyl ketone derivative which comprises subjecting to catalytic reduction the corresponding alpha -aminodihalomethyl ketone derivative, and which process is efficient and su...
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JP4138886B2 |
The invention relates to novel modifications of the compound 2-amino-4-(4-fluorobenzylamino)-1-ethoxy-carbonylaminobenzen
e of the formula I processes for their preparation and their use in pharmaceutical compositions.
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JP4134455B2 |
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JP2008531571A |
Disclosed is crystalline ladostigil tartrate of a specified density, compositions, including pharmaceutical compositions comprising such ladostigil tartrate, and a process for the manufacture thereof.
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JP2008531546A |
A process for manufacturing (R)-propynylaminoindans, and alternatively, a process for manufacturing (S)-propynylaminoindans. The chiral propynylaminoindans include alkoxy or alkylcarbamates derivatives. The process comprises transfer or ...
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JP4126512B2 |
A process for separation between dialkyl carbonate and alkyl carbamate which comprises adding an aromatic hydroxy compound to a liquid comprising alkyl carbamate having an alkyl group having 3 to 6 carbon atoms and dialkyl carbonate havi...
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JP4126673B2 |
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JP4124736B2 |
The present invention provides compounds of formula (I) wherein A1, A2, A3, A4, A5, A6, A7, A8, A9, A10, U, V, W, m, n and p are as indicated in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful f...
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JP2008163022A |
To provide a method for producing a chiral nonracemic amine by the catalytic asymmetric Mannich reaction suitable for the synthesis of a chiral alkylamine protected with an optically active carbamate.The highly enantiomerically selective...
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JP4120106B2 |
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JP4119503B2 |
Purification of diurethanes of formula (I) by distillation is carried out in the presence of low-boiling alcohols of formula (II). R<1>-(NHCOOR<2>)2 (I) R<3>OH (II) R<1> =4-10 carbon (C) aromatic, araliphatic, cycloaliphatic or aliphatic...
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JP4120709B2 |
Organic diurethanes and/or polyurethanes are prepared by reacting organic diamines and/or polyamines (a) with urea and/or alkyl cabamates (b) and alcohols (c) in the presence of soluble zirconium compounds, preferably zirconium alkoxides...
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JP2008150321A |
To provide a method by which a bethanechol halide can be produced by using a compound with little effects on the environments as a starting material or a reaction species and further through an isolable stable intermediate.The bethanecho...
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JP2008150292A |
To provide a carbonyl group-containing compound extremely high in storage stability, and to provide a polymer using the compound.The compound contains an (-oxoamidoalkoxy)carbonylamino group represented by formula (I) (wherein Y a 1 to 6...
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JP2008150322A |
To provide a new dimethylaminopropanol derivative useful as a raw material for producing a bethanechol halide.1-Dimethylamino-2-propanol is reacted with benzyl isocyanate to synthesize 2-dimethylamino-1-methyl-ethyl benzylcarbamate. Furt...
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JP4110642B2 |
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JP4107846B2 |
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