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JP6055771B2 |
Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R=C(0); -OC(O)- or -CH(OH)-; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B f...
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JP6024410B2 |
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JP2016164143A |
To prepare [(1R,2R)-4-oxo-1,2-cyclopentanedicarboxylic acid by the resolution of racemic 4-oxo-1,2-cyclopentanedicarboxylic acid.The process comprises: reacting 4-oxo-1,2-cyclopentanedicarboxylic acid with brucine or (1R,2S)-(-)-ephedrin...
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JP5960058B2 |
The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulati...
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JP2016520517A |
The present invention is formula (I) :A compound, its stereoisomeric form, or salt that can be permitted in medicine of (the inside of a formula and all the variable machines are as being specified on these specifications) is provided. T...
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JP5929555B2 |
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JP2016084315A |
To provide a method for easier manufacturing a hydroxy adamantane carboxylic acid at higher yield.There is provided a manufacturing method of 3-hydroxy adamantane-1-carboxylic acid represented by the formula (2) including Process 1: adam...
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JP2016510320A |
Equation (I):Compounds or pharmaceutically acceptable salts thereof are described herein. In equation (I), N, R1, R4a, R4b, R5, R7And R8Is as defined herein. The compounds of the present disclosure have activity as SHIP1 modulators and c...
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JP5899875B2 |
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JP2016040282A |
To provide methods for production of cyclopropyl ring-fused pyrrolidine compounds of dipeptidyl peptidase IV inhibitors.The present invention provides a method for production of a free base compound represented by formula M'.SELECTED DRA...
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JP5887065B2 |
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JP5860007B2 |
Methods and compounds for production of cycloproyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
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JP5846909B2 |
The present invention relates to compounds defined by formula (I) wherein the group R is defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase ...
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JP2016500368A |
The present invention has been substituted 1- (arylethynyl)-, 1- (heteroarylethynyl)-, 1- (to increase stress tolerance and / or increase plant yield in plants for abiotic stress. Heterocyclic ethynyl)-and 1- (cycloalkenylethynyl) cycloh...
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JP5764151B2 |
Preparing an optically pure (7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxyl
ic acid compound (I), comprises enantioselective enzymatically esterifying a racemic acid or 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxyl...
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JP5737751B2 |
To provide a novel method for acquiring shikimic acid, and to provide a process for producing shikimic acid.In the method for acquiring shikimic acid, a plant is added to a cellulose-soluble ionic liquid to carry out extraction from the ...
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JP5730341B2 |
Methods and compounds for production of cycloproyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
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JP5714267B2 |
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JP5685153B2 |
Phenyl-substituted cyclic keto-enol compounds (I) are new. Phenyl-substituted cyclic keto-enol compounds of formula (I) are new. [Image] W, Z' : H, alkyl, alkenyl or alkynyl; X : alkyl, alkenyl or alkynyl; Y : H, Me, Et, isopropyl, alken...
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JP2014527523A |
The present invention describes the use of compounds of formula 1 or 2 or compositions thereof for the treatment of leukemia and the use of compounds of formula 1 or compositions thereof for the treatment of infections caused by M. tuber...
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JP5593303B2 |
The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Dis...
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JP5580674B2 |
A salt represented by the formula (I-Pb): wherein Xpb represents a single bond or -O-, Rpb represents a single bond etc., Ypb represents a polymerizable group, Zpb represents an organic group, Xpc represents a single bond or a C1-C4 alky...
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JP2014519475A |
Disclosed are an amorphous asiatic tromethamine salt and the preparation method thereof. The method comprises the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salif...
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JP5551707B2 |
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I′A or I′B: where the definitions of the variables are provided herein. The ...
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JP5542058B2 |
Tricyclic compounds containing a cyclopropanecarboxylic acid fused to a bicyclic ring, including pharmaceutically acceptable salts, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particular...
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JP5511582B2 |
Methods and compounds for production of cycloproyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
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JP5464444B2 |
Disclosed is a process for producing carnosic acid (the major antioxidant active substance contained in a rosemary plant) with high efficiency by carrying out the ortho-position oxidation of a phenol with an oxidizing agent (e.g., 2-iodo...
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JP2014508111A |
Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists...
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JP5384485B2 |
The present invention relates to di(hetero)arylcyclohexane derivatives of the formula I, in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds ...
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JP5372258B2 |
The present invention relates to a preparation method of 1,4-disubstituted cyclohexane derivatives, and more specifically, to a preparation of 4-(hydroxymethyl)cyclohexanecarboxylic acid useful as a main raw material in fine chemistry su...
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JP5345986B2 |
Methods and compounds for production of cycloproyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
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JP5290272B2 |
Compounds of the Formula (I) wherein x is an integer from 1-4; p is an integer from 1-3; q is an integer from 0-3; Ar is phenyl, naphthyl, anthryl or phenanthryl each of which optionally is substituted by one or more Cl, CN, OR5, C3-C5al...
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JP5285656B2 |
The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogen...
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JP5271895B2 |
Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled recepto...
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JP5268657B2 |
Cyclic keto enol derivatives (I) are new. Cyclic keto enol derivatives of formula (I) are new. In (I): J = optionally substituted (OS) (hetero)cycloalkyl; X, Y' = H, alkyl, halo, haloalkyl, alkoxy or haloalkoxy; m = 1-3; CKE = a cyclic k...
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JP5236588B2 |
Preparing a bicyclo[4.2.0]octa-1(6),2,4-triene compound (IV) comprises: cyclization reaction of an ethyl-benzene compound (V) in the presence of a catalyst/ligand comprising a palladium catalyst and an organic phosphine (including tri-te...
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JP5230180B2 |
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JP2013522273A |
A process for preparing [(1 R ,2 R )-4-oxo-1,2-cyclopentanedicarboxylic acid II, by the resolution of racemic 4-oxo-1,2-cyclopentanedicarboxylic acid (V), said process comprising: (a) reacting 4-oxo-1,2-cyclopentanedicarboxylic acid (V) ...
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JP2013018874A |
To provide a porous film which has environmental suitability by utilizing a plant-origin compound and exhibits excellent heat resistance and high reflectance of visible light, and a reflection plate which uses the porous film.The porous ...
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JP2012241001A |
To provide side chain substituted alicyclic tetracarboxylic acid dianhydride and a method for producing the same having excellent solubility to organic solvents with low boiling point and serving as a monomer capable of giving a polyimid...
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JP5084503B2 |
A compound of the formula (I): wherein each symbol is as defined in the description, a salt thereof, and a prodrug thereof of the present invention unexpectedly have a superior GPR40 receptor agonist activity and superior properties as p...
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JP2012211162A |
To provide compounds useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, and thus useful in the treatment of various diseases.Analogous compounds using an acanthoic acid of formula (I) has as a prototype the therapeutic effect.
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JP5059996B2 |
A compound having the following chemical structure: its produg esters and acid-addition salts, useful as Interleukin-1 and Tumor Necrosis Factor-± modulators, wherein R groups are defined in the claims.
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JP5054532B2 |
The present invention relates to compounds having the general formula (I) with the definitions of R 1 -R 6 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds as a medicament, prefe...
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JP5013886B2 |
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JP4990501B2 |
Preparation of ether carboxylic acids involves alkylating a basic mixture of oxoalkylated alcohols and alkoxides with chlorocarboxylic acid in absence of solvent; without washing, reducing the residual water content in ether carboxylic a...
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JP4961689B2 |
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JP4947868B2 |
Phenyl-substituted cyclic keto-enol compounds (I) are new. Phenyl-substituted cyclic keto-enol compounds of formula (I) are new. [Image] W, Z' : H, alkyl, alkenyl or alkynyl; X : alkyl, alkenyl or alkynyl; Y : H, Me, Et, isopropyl, alken...
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JP4944344B2 |
The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; to the use of certain cyclopropyl carboxylic acid esters in a process for the p...
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JP4931349B2 |
The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Dis...
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