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WO/1992/008706A1 |
An improved process for producing compounds of formula (I) in which R¿1? is a hydrogen atom or a straight-chained or branched alkyl radical with 1-6 carbon atoms, R¿2? is a hydrogen atom, a straight-chained or branched alkyl radical wi...
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WO/1992/007568A1 |
This invention relates to a method of inhibiting platelet aggregation, and compounds which are mimics of the peptide sequence Arg-Gly-Asp.
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WO/1992/006966A1 |
Thiol carboxylic acid derivatives, processes for their preparation and their use as collagenase inhibitors are described.
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WO/1992/004025A1 |
Novel unnatural dipeptoids useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer...
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WO/1992/004329A1 |
A process for producing a nitrogenous heterocycle represented by general formula (III) by the reaction of an N-nitroimidodithiocarbonate represented by general formula (I) with a diamine represented by general formula (II), wherein R1 an...
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WO/1992/004338A1 |
The present invention provides novel tropolone derivatives of formula (I), wherein R¿10? is a substituted or unsubstituted piperazinyl or benzothiazolidinyl group, and pharmaceutical compositions thereof. These compounds are useful for ...
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WO/1992/002487A1 |
Diamine compounds represented by general formula (I) and acid addition salts thereof, and a brain protecting agent containing the same, wherein R1 to R6 may be the same or different from one another and each represents hydrogen, halogen,...
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WO/1992/001474A1 |
A conjugate substance (A-B-A'), where A and A' are residues from organic compounds F and F'; at least one of which being a polymer (carrier) and said compounds having properties that are retained in the conjugate and -B- being a bridge t...
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WO/1992/001683A1 |
Benzodiazepine derivatives of formula (I), wherein R1 is heterocyclic group which may have one or more suitable substituent(s), or cyano, R2 is hydrogen or halogen, R3 is aryl which may have one or more suitable substituent(s), R4 is ary...
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WO/1992/000979A1 |
Novel tetrahydroimidazo[1,4]benzodiazepin-2-(thio)ones of formula (I), the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; R1 is a radical of formula (a-1); (a-2); (a-...
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WO/1991/018868A1 |
The invention relates to a method for the treatment or prophylaxis of psychosis, depression, hypertension, or anxiety in an animal by administering an effective amount of an N,N'-disubstituted guanidine or 2-imino-imidazolidine having a ...
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WO/1991/012237A1 |
A novel benzenesulfonamide derivative of formula (I) which has an action of inhibiting phospholipase A2 and therefore is effective in treating diseases for which this action is used to advantage.
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WO/1991/010661A1 |
Derivatives of 5-amino-8-chlorine-dibenzo[b,e][1,4]-diazepine of general formula (I) where R = H or -COR', where R' = CH�3?, C�2?H�5?, C�3?H�7?, C�4?H�9?, C�5?H�11? and CH(CH�3?)�2?. The claimed compounds have an an...
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WO/1991/010654A1 |
A muscarinic receptor antagonist of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is N or (a) where R4 is H, halo or C1-C4 alkyl; R1 is H or C1-C4 alkyl; R2 is H or C1-C4 alkyl; Y is a direct link, O or S; m is an ...
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WO/1991/008973A1 |
This invention relates to a container for carrying a fan-folded stack of plastic sheet assemblies (11) and for allowing the assemblies to be dispensed, one at a time, while preventing the assemblies from becoming jammed. The stack of she...
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WO/1991/008191A1 |
The invention provides compounds, several of which belong to a class having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound. The invention also concents a method of select...
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WO/1991/005473A1 |
Agricultural fungicidal compositions comprising compounds of formula (I-A), (I-B) or (I-C), wherein R1 and R7 are each independently hydrogen or C1-C3 alkyl, R2 is hydrogen or C1-C6 alkyl, R3 and R4 independently, and each R5 independent...
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WO/1991/005549A1 |
Novel benzoheterocyclic compounds of formula (I), wherein R?1¿ is H, halogen, alkyl, optionally substituted amino, alkoxy; R?2¿ is H, halogen, alkoxy, phenylalkoxy, OH, alkyl, optionally substituted amino, carbamoyl-alkoxy, optionally ...
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WO/1991/004255A1 |
Tetrahydroimidazo[1,4]benzodiazepines of formula (I), wherein R1 is C1-6alkyl optionally substituted with aryl; C3-6alkynyl; C3-6cycloalkyl; or a radical of formula (a); (b); (c) or -Alk-S(O)m-R15; R2, R3 and R7 are hydrogen or C1-6alkyl...
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WO/1991/000257A1 |
The invention provides compounds, several of which belong to a class having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound. The invention also concerns a method of select...
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WO/1990/009092A2 |
The invention provides a class of compounds having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound. The invention also concerns a method of selectively inducing termini di...
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WO/1990/004917A1 |
A renin inhibiting compound of formula (I) wherein X is N, O or CH; R1 is absent or a functional group; A and L are independently selected from absent, C=O, SO2 and CH2; D is C=O, SO2 or CH2; Y is N or CH; R2 is hydrogen, loweralkyl or s...
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WO/1990/003371A1 |
2-hydroxy-3-phenoxy-propyl-substituted piperazines or homopiperazines of formula (I), in which R1 to R5, Y, m and n have the meaning given in the description, and their manufacture are described. The new compounds are useful for treating...
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WO/1990/002737A1 |
Nasal administration of benzodiazepines is described as providing improved therapeutic effects as compared to conventional delivery techniques. The compositions comprise a benzodiazepine hypnotic in a pharmaceutically acceptable nasal ca...
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WO/1986/004584A1 |
Novel compounds of formula (I), wherein R1 is selected from hydrogen, halogen; or trifluoromethyl; X is oxygen or sulfur; R2 and R3 are the same or different and selected from hydrogen or lower alkyl; m is 2 or 3; Y is oxygen or sulfur; ...
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WO/1986/001203A1 |
Compounds represented by general formula (I) (wherein A represents alkylene, Y-Z represents formula (II), -CH=CH-, -CH2CH2- or formula (III), R1 and R2 each represents a substituent, R3 represents hydrogen, alkyl or alkoxy, R4 represents...
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WO/1985/000810A1 |
Novel fused 7-membered ring compounds represented by the general formula (I), wherein R1 and R2 each represent hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy or, when taken together, R1 and R2 represent tri- or tetra-met...
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WO/1984/002704A1 |
Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: X is CH2, O, S, or NR where R is C1-4 alkyl; R1 and R2 are independently selected from hydrogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, halogen or CF3; R3 is C1-7...
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WO/1984/002702A1 |
Dihydropyridine derivatives represented by the formula (I), wherein R1, R2, and R3, which may be the same or different, each represents alkyl, cycloalkyl or alkoxyalkyl, R4 and R5, which may be the same or different, each represents hydr...
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WO1984002704A2 |
Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: X is CH2, O, S, or NR where R is C1-4 alkyl; R1 and R2 are independently selected from hydrogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, halogen or CF3; R3 is C1-7...
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WO/1983/004023A1 |
Dihydropyridine derivatives represented by the formula (I) wherein R1, R2, and R3 may be the same or different and each represents alkyl, cycloalkyl or alkoxyalkyl, R4 and R5 may be same or different and each represents hydrogen, halogen...
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WO/1983/000333A1 |
Compounds having the formula:$(6,)$wherein X is a halogen atom, a nitro, methoxy, thiomethyl, SOCH3, SO2CH3, acetamido or allyl group. R is a hydrogen atom, an alkyl radical particularly the terbutyl or isobutyl radical, a cyclo alkyl ra...
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WO/1981/002164A1 |
Seven-membered heterocyclic nucleosides used to inhibit the deamination enzyme responsible for the inactivation of arabinosylcytosine (ara-C). Preferred nucleosides containing a seven-member aglycone are as follows: (FORMULA) R = H, benz...
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WO/1980/002424A1 |
Anthracene-9,10-bis-carbonyl-hydrazones and derivatives thereof useful as antibacterial agents, for inhibiting the growth of transplanted mouse tumors, and for inducing the regression and/or palliation of leukemia and related cancers.
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WO/1980/002155A1 |
An antibacterial surfactant containing in an effective amount at least one of cyclic amides represented by the following general formula; (FORMULA) (wherein R represents an alkyl group, alkenyl group, alkylaryl group, alkylarylalkyl grou...
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WO/1980/000702A1 |
Improved process for the synthesis of 1,4-diaza-2-cycloalkanones and substituted derivatives thereof involving solid-liquid phase transfer phenomenon. More specifically, the subject compounds are prepared by combining a substituted diami...
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WO/1979/000166A1 |
Novel cyanocarboxamidines and a method for their preparation are disclosed. The use of these new cyanocarboxamidines as intermediates in the one step synthesis of antihypertensive 4-amino-2-(4-substituted-piperazine-1-yl)-quinozolines is...
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JP2024515619A |
Described herein are bifunctional compounds that find utility as modulators of B-cell lymphoma 6 protein (BCL6; a target protein). In particular, the bifunctional compounds of the present disclosure bind each E3 ubiquitin ligase on one e...
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JP2024513566A |
The present disclosure relates to bifunctional chemical conjugation molecules, which find utility as modifiers of target substrates. The present disclosure includes multifunctional compounds that include enzyme binding moieties, chemical...
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JP2024512428A |
The present invention relates to compounds that can be used to treat viral infections. The compound is a papain-like protease (PLpro) inhibitor.
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JP7431929B2 |
The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,where a compound represented by the formula (1):       â...
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JP2023550937A |
Deuterated 1,4-benzodiazepine-2,5-dione compounds and uses thereof are disclosed. A compound represented by formula I or a pharmaceutically acceptable salt thereof is provided. The disclosed 1,4-benzodiazepine-2,5-dione active compounds ...
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JP2023548947A |
The present invention discloses compounds and their uses as sodium channel modulators, and compounds of this type have pronounced inhibitory and blocking effects on the activity of voltage-gated sodium ion channel subtype Nav1.8 ion chan...
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JP2023165491A |
To provide a novel monomer of a degradable polymer that is stable even in the air, and a novel degradable polymer with superior degradability.The present invention provides a cyclic ketene aminal compound, and a degradable polymer prepar...
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JP2023548342A |
Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, in which X1,X2,Ry,Rz,R1,R2,R3, and R4is as defined herein. Also provided herein are pharm...
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JP2023547770A |
The present disclosure provides compounds, pharmaceutical compositions comprising such compounds, and methods or treatments for the treatment of inflammatory diseases and certain neurological disorders associated with inflammatory signal...
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JP2023543950A |
The present invention provides novel compounds of formula (I) and pharmaceutical compositions containing these compounds. Compounds of formula (I) can act as CXCR4 modulators that specifically target the minor pocket of CXCR4, and they h...
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JP2023540661A |
The present invention provides compounds of formula (I) as CCR8 inhibitors, which can be used to treat or prevent cancer using CCR8 inhibitors that target tumor-specific regulatory T cells. can be done. Formula (I): [Selection diagram] None
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JP2023540092A |
The present invention provides (2R,3S)-N-((3S)-5-(3-fluorophenyl)-9-methyl-2-oxo-2,3-dihydr
o- Provides crystalline forms of 1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)suc
cinimide, including the N-2 crystalline form, IPA2-...
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JP2023123614A |
To provide systems and methods for synthesizing chemical products, including active pharmaceutical ingredients.There are provided systems and methods for synthesizing chemical products, including active pharmaceutical ingredients. Certai...
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