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JP2021528454A |
A compound of formula (I), or a pharmaceutically acceptable salt thereof. [Chemical 1]
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JP2021528416A |
The present invention relates to 1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R) -α-[N-((S) -1-carboxypropyl) carbamoyl). ] -4-Hydroxybenzyl} Carbamoylmethoxy) -2,3,4,5-tetrahydro-1,2,5-benzothia azepine (odebixibat) crystal trans...
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JP2021526545A |
Equation (I): [Chemical 1](In the formula, R1, R2, R3, R4a, R4b, And R5Is a compound of (described herein), or a stereoisomer, enantiomer, or tautomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt or solvate thereo...
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JP2021524867A |
To provide a 1,2,4-thiadiazole-based compound and a method and use thereof. As a light emitting layer material for an OLED device, a 1,2,4-thiadiazole compound significantly improves the performance in the areas such as light emission in...
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JP2021138718A |
To provide compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.The present disclosure provides a compound of Formula (I) or a pharmac...
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JP2021523942A |
In some embodiments of the invention, the compounds of the invention (eg, formulas (I), (IA), (II), and (III), and urolysin derivatives) are disclosed. Other embodiments include compositions containing the compounds of the invention (eg,...
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JP2021520342A |
The present invention relates to compounds of formula I, methods of using compounds as immunomodulators, and pharmaceutical compositions containing such compounds. Compounds are useful in the treatment, prevention or amelioration of dise...
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JP2021519312A |
Small molecule calpain modulator compounds can be included in pharmaceutical compositions, including their pharmaceutically acceptable salts. The compounds may be useful in inhibiting calpain or in competitive binding with calpastatins b...
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JP6915911B2 |
The present invention relates to medicine and is concerned with a compound of formula (a) below or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of the compound of formula (a) or a...
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JP6890454B2 |
A resist composition which generates acid upon exposure and exhibits changed solubility in a developing solution under action of acid, the resist composition including a base component (A) which exhibits changed solubility in a developin...
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JP2021042126A |
To provide a compound that has β2-adrenergic receptor antagonist activity and carbonic anhydrase-inhibitory activity and that exhibits excellent ocular antihypertensive activity.Provided is an aryloxy compound represented by formula (I)...
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JP2021507883A |
An oligomeric prodrug of etaclinic acid for the treatment of medical disorders such as glaucoma, disorders or abnormalities associated with increased intraocular pressure (IOP), disorders requiring neuroprotection, age-related macular de...
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JP2021017451A |
To provide an anticancer agent or a concomitant drug with radiation in chemoradiotherapy containing a gold complex with an amino acid derivative as a ligand, and a novel gold complex that can be used in the anticancer agent or the concom...
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JP2021501786A |
Provided herein are compounds, compositions, and methods useful for the regulation of integrated stress response (ISR) and the treatment of related diseases, disorders, and diseases. [Selection diagram] None
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JP6806770B2 |
agronomic compositions containing them and their use for the control of nematodes in agricultural crops, are described.
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JP6806981B2 |
Provided herein are a use of thioether compounds of formula I as nitrification inhibitors, and agricultural mixtures and compositions including the thioether compounds.
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JP2020196765A |
To provide compounds with a retinoid (vitamin A and its derivatives) activity.The invention relates to novel compounds, ligands that modulate RAR receptors.SELECTED DRAWING: None
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JP6797800B2 |
Novel compounds, synthesis methods and use of the same in medicine and in cosmetics are disclosed. Also disclosed, are novel compounds and ligands that modulate RARs.
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JP6790040B2 |
The present invention relates to a list of specific 2-hydroxy-1-{4-[(4-phenylphenyl)carbonyl]piperazin-1-yl}etha
n-1-one derivatives and related compounds as fatty acid synthase (FAS or FASN) inhibitors for treating cancer and pharmacuti...
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JP6789979B2 |
A method of producing an organopolysulfide or salt thereof is provided which includes a step of mixing an organomonosulfide or salt thereof and elemental sulfur, wherein the mixing is carried out at a temperature not greater than 95 C an...
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JP2020183405A |
To provide inhibitor compounds of cathepsin C, CELA1, CELA3A and/or enzymes structurally related to them, and compositions comprising the compounds for treatment of cell and/or tissue necrosis.The present invention provides compounds wit...
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JP6775010B2 |
Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of HIV; including the prevention of the p...
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JP2020158391A |
To provide a novel nitrocatechol derivative or a salt thereof that has catechol-O-methyltransferase inhibitory action and dopa decarboxylase inhibitory action and to provide a pharmaceutical composition containing the same derivative or ...
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JP2020158523A |
To provide novel histone deacetylase inhibitors.The present invention provides a compound represented by the following formula or a pharmaceutically acceptable salt thereof (each R' independently represent H or QR1; each Q independently ...
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JP6762124B2 |
To provide a new trifluoromethyl thiolation agent, a trifluoromethyl thiolation method, and an N-(substituted sulfonyl)-N-[(trifluoromethyl)thio]-substituted sulfonamide compound.Provided is a trifluoromethyl thiolation agent represented...
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JP6754778B2 |
The present invention relates to compounds according to Formula I : or a pharmaceutically acceptable salt thereof wherein the variables have the meanings defined in the claims. The compounds can be used as inhibitors of ROR³ and are use...
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JP6754779B2 |
The present invention relates to compounds according to Formula I: or a pharmaceutically acceptable salt thereof wherein the variables are as defined in the claims. The compounds can be used as inhibitors of ROR³ and are useful for the ...
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JP2020525486A |
Provided are IDO inhibitor compounds of formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, methods of their preparation, and their use in the prevention and / or treatment of diseases. [Selection ...
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JP6746614B2 |
The present invention provides a urea compound or a pharmacologically acceptable salt thereof that has a formyl peptide receptor like 1 (hereinafter may be abbreviated as FPRL1) agonist effect, a pharmaceutical composition containing the...
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JP6732877B2 |
The present application relates to thiadiazole compounds, compositions containing such compounds, their use for controlling animal pests including arthropods, insects and nematodes, and to processes and intermediates for the preparation ...
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JP6730273B2 |
Wherein M1 and M2 are independently selected from Zn(II), Cr(II), Co(II), Cu(II), Mn(II), Ni(II), Mg(II), Fe(II), Ti(II), V(II), Cr(III)-X, Co(III)-X, Ni(III)-X, Mn(III)-X, Fe(III)-X, Ca(II), Ge(II), AI(III)-X, Ti(III)-X, V(III)-X, Ge(IV...
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JP6713928B2 |
Provided are a compound represented by the following Formula (III), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt or solvate thereof used as a therapeutic agent for gout or hyperuricemia. (In the Formu...
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JP2020512373A |
The present invention relates to a compound of formula (I): ABDE (I) or a pharmaceutically acceptable salt, solvate, or polymorphic form thereof, including all the tally mutants and stereoisomers thereof. In the formula: A is selected fr...
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JP2020511436A |
The present disclosure provides, in part, a cyclic sulfamide compound and a pharmaceutical composition thereof, which are useful as modulators of hepatitis B (HBV) core proteins, as well as methods of treating hepatitis B (HBV) infection...
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JP2020511450A |
The present invention is desmethylanethole trithione (AOX) and its derivatives for the prevention and treatment of diseases in which the initiation and / or alteration of the disease is associated with the production and action of mitoch...
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JP2020045326A |
To provide a novel compound, an agrochemical, especially a herbicide containing the compound.There is provided a ketone or oxime compound represented by the formula (1) and a herbicide containing them. [B is a substituent having a cyclop...
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JP6665196B2 |
Compounds of formula I wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in...
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JP6666263B2 |
The present disclosure provides compounds of formula (I) to (III) as glutaminase inhibitors, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of diseases or d...
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JP6663863B2 |
The invention describes compounds that inhibit both HDAC and GSK3β (i.e., HDAC/GSK3β dual inhibitors). The invention further describes compositions containing these HDAC/GSK3β dual inhibitors, as well as methods and kits using these H...
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JP6644067B2 |
The invention relates to benzylhydroxyde derivatives of formula (I): The invention also relates to the preparation and the therapeutic use of the compounds of formula (I).
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JP2020503363A |
Described herein are compounds capable of binding to tubulin and activating GEF-H1. Methods of using these compounds to treat cancer are also disclosed.
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JP2020502168A |
The present application is for a thiadiazole compound of formula (I). (In the formula, A, B, E and Q have the meanings provided herein), the composition containing the compound, its use for controlling animal pests including arthropods, ...
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JP2020502189A |
IDO inhibitor compounds of formula (I) and their pharmaceutically acceptable salts, their pharmaceutical compositions, their preparation methods, and chronic viral infections, chronic bacterial infections, cancer, sepsis or neurological ...
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JP2020500207A |
Small molecule calpain modulator compositions, pharmaceutical compositions, their use and preparation are disclosed herein.
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JP2019218387A |
To provide compounds active on protein kinases.The invention provides compounds represented by the formula I in the figure. (In the formula, Ar represents optionally substituted heteroaryl; Reach independently represent halogen, optional...
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JP6622353B2 |
The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap ...
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JP6615876B2 |
The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact with one or more enzymes in the sphingolipid biosynthesis pathway. The disclosur...
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JP6616785B2 |
Insecticidally active amide derivatives with sulfur-substituted phenyl- and pyridine groups of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomer...
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JP2019202997A |
To provide compounds that are useful as charge transport and emissive materials for fabrication of electronic devices such as diodes, transistors, and photovoltaic devices.The invention provides compounds of the formula D-S-A-S-B. (A rep...
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JP2019532077A |
In the present invention, it is a compound of the formula I, and the variables X and Y in the formula1-Y5, R1, R2, R3, R4, And Het have the meaning described herein, a compound, or a pharmaceutically acceptable salt thereof, and a compos...
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