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WO/1994/004143A1 |
Substituted hydrindanes, particularly of formula (I) in which X, Y, R4, R5, R6, R7 and R8 are as defined in the description, and their use in controlling angiogenesis dependent diseases in warm blooded animals, as well as a method for pr...
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WO/1994/004518A1 |
Compounds characterized generally as morpholino/thiomorpholino-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of f...
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WO/1994/004516A1 |
A biphenylmethane derivative represented by general formula (I), a salt thereof, and a remedy for circulatory system diseases containing the same, wherein A represents the group (II) or (III) wherein R1 represents hydrogen, lower alkyl, ...
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WO/1994/004517A1 |
Novel 1,2,4-dithiazolium iodides of formula (I) in which R1 and R2 have the significance given in the application, process for producing them and their use as pesticides and novel initial compounds. The novel compounds of formula (I) can...
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WO/1994/003167A1 |
A cataract remedy containing an active ingredient comprising the compound represented by formula (I), the intramolecular disulfide thereof, or a salt thereof.
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WO/1994/003174A1 |
The present invention provides a new means of combatting severe dentoalveolar infections such as dental gangrene, parodontitis and abscesses which involves the administration of the methylol-transfer agents taurolidine and/or taurultam. ...
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WO/1994/001115A1 |
Compositions containing S-(-)-3-morpholino-4-(3-text-butylamino-2-hydroxypropoxy)-1,
2,5-thiadiazole hemihydrate useful for administration to a subject, particularly for topical administration as a pharmaceutical agent for treating glauc...
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WO/1994/001421A1 |
The present invention relates to novel substituted benzothiazepines and benzoxazepines of formula (I), wherein R1, R2, R7, R8, R9 and X are as defined below, and to novel intermediates used in the synthesis of such compounds. Such compou...
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WO/1993/024474A1 |
The invention concerns thiadiazolines of general formula (I), in which n, R?1¿, R?2¿ and R?3¿ are as defined in the description. The invention also concerns a method for the preparation of such thiadiazolines and their use as herbicides.
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WO/1993/023394A1 |
The object of the present invention is a process for producing optically pure S-timolol or its derivatives wherein racemic R,S-timolol, or its racemic derivative, at elevated pressure and dissolved in carbon dioxide is periodically fed t...
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WO/1993/022260A1 |
Additives are proposed for compositions comprising radiolabelled organic compounds e.g. 32P-labelled nucleotides. Stabilisers are selected from tryptophan, para-aminobenzoate, indoleacetate and the azole group. Dyes are selected from Sul...
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WO/1993/021772A2 |
Herbicidal composition comprising N-[2-(3,3,3-trifluoropropyl)-phenylsulfonyl]-N'-(4-methoxy-6
-methyl-1,3,5-triazin-2-yl)-urea of formula (I) or agrochemically tolerated salts thereof, and a synergistic amount of one or more further her...
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WO/1993/021171A1 |
The use of 2H-1,2,4-benzothiadiazine-1,1-dioxide-3-carboxylic acid derivatives of formula (I), a salt thereof or a precursor thereof, for preparing NMDA and/or AMPA receptor antagonist drugs, the novel compounds of formula (I), preparati...
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WO/1993/021170A1 |
Compounds of formula (I), wherein R is (a) a hydrogen atom, (b) an alkyl radical, (c) an allyl radical, (d) a phenyl radical, (e) a 2-or-3-pyridyl alkyl radical, (f) a 2-quinolylalkyl radical, (g) a naphthylalkyl radical, (h) a cycloalky...
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WO/1993/019720A2 |
Novel compounds of Formulas (I) and (II) are described herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; these compounds a...
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WO/1993/019749A1 |
Novel compounds of formula (I) are described herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the presen...
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WO/1993/019054A1 |
Anilino heterocyclic compounds, e.g. 4-bromo-3-(4-fluorophenyl)-N-(2,4-dinitro-6-(trifluoromethyl
)-phenyl)isothiazol-5-amine and N-(4-bromo-4-chloro-3-methyl-5(4H)-isothiazolylidene)-2,4-di
nitro-6-(trifluoromethyl)benzenamine, exhibit ...
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WO/1993/016986A1 |
Azo oxime ethers of general formula (I), in which X is CH or N, R1 is hydrogen, C1-C3alkyl, trifluoromethyl or cylclopropyl and R2 is aryl or heteroaryl, have an activity against phytopathogenic fungi. They can be used in the form of for...
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WO/1993/016985A1 |
Cyano-oxime ethers of formula (I): R?1¿R?2¿CH-ON=C(CN)-R?3¿ in which R?1¿ is hydrogen or C¿1?-C¿4? alkyl, R?2¿ is a possibly substituted mono to tri-nuclear aliphatic or aromatic ring system which, besides carbon atoms, may contai...
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WO/1993/016075A1 |
Compounds of general formula (I); and their pharmaceutically and veterinarily acceptable acid addition salts and hydrates are antagonists of platelet activating factor (PAF) and as such are useful in the treatment or amelioration of vari...
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WO/1993/015046A1 |
Carbamate having the formula (I), its plant-compatible acid addition and basic addition products, and fungicides containing the same are disclosed.
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WO/1993/015047A1 |
Compounds of general formula (I), wherein: A represents: a) a group -Q-X wherein Q represents an -O-, -S- or -NR- group (wherein R is as defined below) or a bond; and X represents a 5- or 6-membered aromatic or heterocyclic ring, b) a gr...
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WO/1993/015041A1 |
This invention relates to new ethanolamine derivatives having gut selective sympathomimetic and anti-pollakiuria activities and represented by general formula (I) wherein R?1¿ is aryl or a heterocyclic group, each of which may be substi...
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WO/1993/014062A1 |
This invention encompasses compounds of formula (I), wherein X is either -NH- or -O-; R¿1? is =O, -OH, -OCH¿3? or -NH¿2?, R¿1? is =O when b is a double bond and when a is a single bond, when R¿1? is =O then R¿3? is -OH, -OCH¿3? or...
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WO/1993/012754A2 |
The present invention provides an amine compound of formula (I) or a pharmaceutically acceptable salt thereof which is an antagonist for alpha-2 adrenoreceptors and which inhibits serotonin (5-hydroxytryptamine, 5-HT) uptake.
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WO/1993/013085A1 |
Described is a method of producing tetrahydro-3,5-dimethyl-1,3,5-thiadiazin-2-thion powder (I) substantially free of dust fines by reacting methylamine (II) with carbon disulphide (III) and formaldehyde (IV) or by reacting the methylammo...
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WO/1993/012069A1 |
A compound represented by general formula (I), a pharmaceutical composition containing the same, and a process for producing the same, wherein R?1¿: hydrogen, lower alkyl, lower alkanoyl or aralkyl; R?2¿: optionally hydroxylated lower ...
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WO/1993/012119A1 |
The invention concerns thiadiazine carboxylic acid amide derivatives of general formula (I), methods of preparing them and drugs containing them.
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WO/1993/011117A1 |
Novel N-[2-(cyclic alkyl)phenyl]pyrazole-4-carboxamides useful as fungicides, methods of using said compounds, and fungicidal compositions containing them.
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WO/1993/010097A1 |
A few nitro compound of formula (I), wherein R?1¿ and R?2¿ are each lower alkyl or lower alkoxy(lower)-alkyl, or (a) is cyclized to form (b), X is -O-, -S- or -NH-, m is an integer 0 or 1, and R?3¿ is carbamoyl, lower alkylcarbamoyl, ...
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WO/1993/008805A1 |
The invention concerns drugs, containing 3,4-dihydro-1-phenyl-3-thio-1,2,4-benzothiadiazin-1-oxide, for lymphocyte protection, in particular for the treatment of AIDS.
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WO/1993/009095A1 |
Compounds of formula (I), wherein A represents C=C, S or O; Q represents a 5- or 6-membered unsaturated heterocycling ring having a nitrogen atom in the position adjacent to the point of attachment, 0-3 further heteroatoms selected from ...
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WO/1993/009101A1 |
This invention relates to new mercapto-amide derivatives having an inhibitory activity against the neutral endopeptidase and represented by general formula (I), wherein R1 is hydrogen or a mercapto-protective group, R2 is lower alkyl or ...
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WO/1993/009132A1 |
Compounds of formula (I) wherein R1 and A are amino terminal groups: Z is O or N-R2; M is a dipeptide isostere; and D1 and D2 are optionally absent or amino acids; and pharmaceutically acceptable salts thereof, are potent inhibitors of t...
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WO/1993/009075A1 |
A method for separating enantiomers of derivatives of aryloxipropanolamines is disclosed. In the method, the derivative is contacted with a chiral solid-phase chromatography material containing molecular imprints of an optically pure ena...
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WO/1993/006827A1 |
Topical ophthalmic compositions comprising certain thiadiazoles are useful in the treatment of glaucoma and ocular hypertension. The thiadiazoles are slightly less potent than timolol; however, they have greatly reduced systemic side eff...
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WO/1993/006832A1 |
Compounds capable of undergoing a mixed disulfide exchange with a disulfide bond are effective agents for the treatment of HIV infections.
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WO/1993/005029A1 |
High potency carbonic anhydrase inhibitors derived from methazolamide.
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WO/1993/004142A1 |
Decomposable complex ligands may be stabilized by derivating them with blocking secondary or tertiary carbonic or sulfonic acids. Orientation layers and liquid crystal mixtures may be added to these stabilized derivates that cause in FLC...
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WO/1993/003022A1 |
Treatment of Aids, inhibition of the replication of HIV and related viruses, and formulations using thiourea derivative compounds or salts thereof are disclosed. Also disclosed are novel thiourea compounds.
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WO/1993/001810A1 |
Chimeric analogs of calicheamicin that include an analog of calicheamicinone linked to an ester or glycoside, (-)-calicheamicinone, and intermediates useful in the synthesis of calicheamininone and its analogs are disclosed.
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WO/1992/022542A1 |
Described are aminoalkyl-substituted 2-amino-5-mercapto-1,3,4-thiadiazole derivatives of formula (I), in which A and n are as defined in the description, as well as their preparation. The compounds are suitable for use in the treatment o...
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WO/1992/022541A1 |
Described are aminoalkyl-substituted 2-amino-1,3,4-thiadiazoles of formula (I), in which n and A are as defined in the description, as well as their preparation. The compounds are suitable for use in the treatment of illnesses.
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WO/1992/020670A1 |
The invention relates, to the isomers (R) and (S) of sulphate of chloromethyl-1 ethylene, their preparation and their utilization particularly in the synthesis of adrenergic (S)-beta-blockers or the synthesis of L-carnitine or phospholip...
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WO/1992/020669A1 |
The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
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WO/1992/020682A1 |
Substituted anilides of formula (I), wherein Q is one of (Q-1), (Q-2) and (Q-3), and R?1� to R?5�, Y, Z and Z?1� are as defined in the text, arthropodicidal compositions containing such compounds; and a method for controlling arthr...
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WO/1992/020696A1 |
The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
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WO/1992/020662A1 |
Novel substituted triazolinone, triazolinethione, and triazolinimine compounds of formula (I) are useful as angiotensin II antagonists.
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WO/1992/020666A1 |
A benzothiadiazine derivative represented by general formula (I), a hydrate and acid addition salt thereof, and a remedy for peptic ulcer containing said derivative, said hydrate or said salt as an active ingredient. In formula (I) X rep...
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WO/1992/011249A1 |
Arthropodicidal carboxanilides of formulae (I) and (II) wherein Q, X, X?1¿, Y and G are as defined in the text, arthropodicidal compositions containing said compounds and a method for using the compounds to control arthropods.
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