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WO/1992/008462A1 |
The invention relates to the novel use of compounds of formula (I) in which R¿1? is a hydrogen atom, a C¿1?-C¿6? alkyl radical or a phenyl radical optionally substituted by C¿1?-C¿6? alkyl; R¿2?-R¿4? are the same or different and ...
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WO/1992/007841A1 |
The invention relates to zinc- and phosphorus-free additives for lubricating compositions which are produced by a free radical reaction between a dimercaptothiadiazole and monomer oligomer or homologue of acrylates or methacrylate, which...
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WO/1992/007465A1 |
The present invention is directed to microbiocidal combinations and processes for inhibiting the growth of microorganisms. The novel combinations and processes of the present invention show unexpected activity against micoorganisms, incl...
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WO/1992/005164A1 |
Aminobenzosultam derivatives as inhibitors of lipoxygenase and useful in the treatment or alleviation of allergic and inflammatory diseases.
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WO/1992/004025A1 |
Novel unnatural dipeptoids useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer...
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WO/1992/002519A1 |
This invention relates to intermediate compounds of formula (VI), wherein: R1 is (L)a-(CH2)b-(T)c-B; a is 0 or 1; b is 3 to 14; c is 0 or 1; L and T are independently sulfur, oxygen, CH=CH, C=C, or CH2; B is H, C1-4alkyl, ethynyl, triflu...
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WO/1992/001667A1 |
Renal-selective prodrugs are described which are preferentially converted in the kidney to compounds capable of inhibiting synthesis of catecholamine-type neurotransmitters involved in renal sympathetic nerve activity. The prodrugs descr...
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WO/1992/001765A1 |
The subject application discloses a chiral nonracemic composition of the general formula: R1-Ar-O-CH2-C*HX-C*HY-CH2-O-R2, wherein R1 is a tail group of two to sixteen carbons; Ar is an achiral FLC core of at least two rings; * denotes a ...
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WO/1992/000743A1 |
The present invention relates to a method of treatment or prophylaxis of tumours in mammalian subjects wherein an effective dose of taurolidine and/or taurultam is administered to a mammalian subject suffering from or at risk to tumour g...
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WO/1992/000287A2 |
Analogs are prepared of the carbonic anhydrase inhibitors methazolamide, and dichlorphenamide. The analogs link a cleavable functional group to the pharmacologically active carbonic anhydrase inhibitor resulting in compounds of improved ...
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WO/1991/017978A2 |
Mono-acylated hydrazines are prepared in high yield by reaction of a hydrazine salt with an azole derivative of acyl halide in the presence of a strong base. Useful hydrazine salts include those of the formula RNHNH2.HX, where R is alkyl...
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WO/1991/014683A1 |
This invention relates to compounds of formula (I) useful as a carbonic anhydrase inhibitor. A compound of formula (I) and pharmaceutically acceptable salts thereof, wherein X is NR12; R1 is (II); R2 is (III); R3 is hydrogen or lower alk...
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WO/1991/014430A1 |
A compound of formula (I) or pharmaceutically acceptable salts thereof wherein R is hydrogen or lower alkyl; Y is (A'); X is O, S, NR6 or N; XY taken together is (B'); R2 is OR4, SR4, or NR4R5 represents a covalent bond connecting its ad...
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WO/1991/011441A1 |
Geminate dimethylalkyl compounds with general formula (I) can be used to good advantage in liquid crystalline mixtures. In the formula, R?1� is, for example, a straight or branched chain (with or without asymmetric C-atom) alkyl or alk...
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WO/1991/001724A1 |
Renal-selective prodrugs are described which are preferentially converted in the kidney to compounds capable of inhibiting synthesis of catecholamine-type neurotransmitters involved in renal sympathetic nerve activity. The prodrugs descr...
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WO/1990/014338A1 |
There are disclosed compounds of formula (I); in which R1 represents C(O)YZ or SO2R10, Y represents a single bond, O, NR11 or CO, Z represents hydrogen, alkyl or alkyl substituted by one or more substituents selected from hydroxy, alkoxy...
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WO/1990/013611A2 |
The invention relates to optically active compounds of formula (I) in which R denotes an alkyl or alkenyl residue with up to 15 carbon atoms which is unsubstituted or substituted once by -CN or substituted at least once with fluorine or ...
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WO/1990/013597A1 |
Disclosed are poly-methine compounds having formula (I), wherein R1 is an unsubstituted or substituted alkoxycarbonyl, cycloalkoxycarbonyl or aryloxycarbonyl radical; an unsubstituted or substituted carbamoyl radical; or an unsubstituted...
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WO/1990/012784A1 |
A method for control of plant disease, especially fungus, using compounds of formula (I) and novel compounds within the class (I), wherein: A is C(=O)R, C(=O)OR?1¿, C(=O)SR?1¿, P(=O)QR?2¿Q?1¿R?3¿; C(=O)NHR, SO¿2?R?5¿, SO¿2?NR?6¿...
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WO/1990/008128A1 |
Compounds of formula (I), wherein D represents the dehydrogenated residue of a hydroxyl group-containing drug or the dehydrogenated residue of an NH-acidic group-containing drug; the substituents in the phenyl ring alpha and beta are in ...
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WO/1990/007111A2 |
A molecular model of the interaction of various non beta-lactam antibiotics with the active site of a penicillin receptor has been developed so that it is now possible to predict the ''fit'' and ''reactivity'' of potential antibacterial ...
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WO/1990/004946A1 |
This invention is directed to obtain an ultrasonic diagnostic apparatus including a CFM system which can easily change algorithms for calculating a flow rate, and the like. The ultrasonic diagnostic apparatus of the present invention inc...
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WO/1990/004592A1 |
The novel crystalline S-(-)-3-morpholino-4-(3-tert-butyl-amino-2-hydroxypropoxy)-1
,2,5-thiadiazole hemihydrate (S-timolol hemihydrate) of formula (I) and a process for the preparation of the novel compound.
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WO/1990/004590A1 |
This invention provides benzothiadiazepine derivatives and pharmaceutically acceptable salts thereof represented by formula (I), wherein R1 is a lower alkyl group or (a) (wherein R3 is a hydrogen atom, a lower alkoxy group or a halogen a...
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WO/1989/010759A1 |
The invention relates to a method of preparing a diaminedithiol chelating agent by reacting a cyclic diamine disulfide with a thiol compound as a reducing agent, said thiol compound being selected from the group consisting of dithiothrei...
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WO/1989/009764A1 |
Chiral or achiral cyclic compounds of formula R1-(A1-Z1)m-A2-Q1-C*R°CF3-X, wherein R1 denotes alkyl or perfluoralkyl which can be interrupted by O- and/or -CO- and/or -CO-O- and/or -CH=CH- and/or -CH halogen- and/or -CHCN- and/or -O-CO-...
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WO/1989/008637A1 |
Derivatives of 2,3-difluorohydroquinone of formula (I) wherein R1 and R2, independently, denote an unsubstituted C1-C15 or C3-C15 alkyl or C3-C15 alkenyl or a C1-15 alkyl or C3-C15 alkenyl monosubstituted by cyanogen or at least monosubs...
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WO/1989/008639A1 |
Chiral derivatives of 1,2-difluorobenzene are suitable as components of chiral, oriented, smectic, liquid crystal phases.
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WO/1989/008649A1 |
Heterocyclic 1,2-difluorobenzene derivatives of formula (I), where R1 and R2 each denote, independently of each other, an alkyl group with 1 to 15 C atoms, in which one or more CH2 groups can also be replaced by a divalent residue chosen...
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WO/1989/008107A1 |
Diamines and bismaleinimides of general formula (I) in which R1 and R2 each denote H-atom or together denote the group -OC-CH-=CH-CO-, Y1 and Y2 denote independently of each other O or S, and Het denotes a 5-membered heterocycle with 2 o...
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WO/1989/007099A1 |
Novel 2,2-disubstituted glycerol compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor (''PAF''). Also disclosed are methods of synthesizing and usin...
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WO/1989/007100A1 |
Novel 2,2-disubstituted glycerol compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor (''PAF''). Also disclosed are methods of synthesizing and usin...
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WO/1989/001603A1 |
A scanning type tunnel microscope comprises a combination of an optical microscope with a tunnel scanning unit. The tunnel scanning unit is equipped with a probe held with a predetermined spacing from a sample placed on a sample mount in...
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WO/1989/000557A1 |
There are provided chelating agents particularly useful for the preparations of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents ...
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WO/1988/008019A1 |
Chiral and/or achiral compounds containing at least one structural element from the group thiazol-2,4-diyl, thiazol-2,5-diyl, 1,2,4-thiadiazol-2,5-diyl, 1,2,4-thiadiazol-3,5-diyl, are used as components of media with a smectic liquid-cry...
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WO/1988/007044A1 |
Lipophilic, transient ester derivatives of timolol represented by general formula (I), wherein R1 represents a substituted or unsubstituted branched chain alkyl, straight or branched chain alkenyl, aryl, aralkyl or cycloalkyl group, a su...
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WO/1988/007036A1 |
Compound having beta-adrenergic blocking properties having formula (I), wherein X is -O-, -CH2- or -----; Y is =O or a derivatized keto group, each of which is hydrolyzable or enzymatically convertible to a ketonic group; R is alkyl havi...
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WO/1988/000183A1 |
S-trifluorobutenyl thiocarbonic acid esters of formula (I) and salts thereof, wherein X is R1N or S and Y is RS or R3R2N; wherein R is a metal or a radical selected from alkyl, cycloalkylalkyl, halocycloalkylalkyl, alkenyl, haloalkyl, ha...
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WO/1987/006576A1 |
Antidepressant agents having formula (I), wherein R1 is a polycycloalkyl group; R2 is methyl or ethyl, X is O or NH; and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens; or fused bicyclic heterocyclic rings h...
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WO/1987/006232A1 |
Compounds represented by general formula (I), [wherein R represents a hydrogen atom, a carboxyl protective group or an anionic charge, Q represents a hydrogen atom, a halogen atom, a hydroxy group, an acetoxy group, a carbamoyloxy group,...
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WO/1987/005898A2 |
Method for retarding plant growth by applying to the plant an effective amount of a malonic acid derivative compound. This invention also relates to novel malonic acid derivative compounds and processes for the preparation thereof.
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WO/1987/005897A2 |
Malonic acid derivative compounds, processes for their preparation and their use for increasing crop yield.
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WO/1987/003584A1 |
A process for preparing a racemic or chiral aryloxypropanolamine (1) or arylethanolamine (2) of formula (1) or (2), wherein Ar is aryl, substituted aryl, heteroaryl, or aralkyl and R is alkyl, substituted alkyl, aralkyl, or WB wherein W ...
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WO/1987/003588A1 |
Process for the preparation of 3-isopropyl-benzo-2-thia-1,3-diazinone-(4)-2,2-dioxide which comprises preparing isopropyl sulfamoyl chloride in one step by reacting N,N'-diisopropyl-urea with phosphorus trichloride and chlorine in the pr...
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WO/1987/003583A1 |
A process for preparing a racemic or chiral aryloxypropanolamine (1) or arylethanolamine (2) of the formula (1) or (2) wherein Ar is aryl, substituted aryl, heteroaryl, or aralkyl and R is alkyl, substituted alkyl, aralkyl or WB wherein ...
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WO/1987/002358A1 |
Novel thiadiazole compounds and lubricant compositions thereof prepared from the derivatives of dimercaptothiadiazole and maleic anhydride or a halosuccinate. Lubricating compositions containing the compound, or their metal salts, provid...
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WO/1987/001591A2 |
PCT No. PCT/EP86/00545 Sec. 371 Date May 19, 1987 Sec. 102(e) Date May 19, 1987 PCT Filed Sep. 19, 1986 PCT Pub. No. WO87/01591 PCT Pub. Date Mar. 26, 1987.Taurolin compounds are used as blood coagulation-inhibiting agents and as abacter...
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WO/1986/007590A1 |
Polyhaloalkene compounds of formula (I), wherein X is sulfur, oxygen, nitrogen or methylene, Y1 and Y2 independently are fluorine, chlorine or bromine, Z is hydrogen or the same as Y1 or Y2, and n is 1-4; provided that: (A) when X is sul...
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WO/1986/006368A1 |
The S-isomer of a compound of the formula (V), wherein Ar is an optionally substituted aryl, heteroaryl or heterocyclic group, and R1 is phenyl optionally substituted by C1-6alkoxy or C1-6alkyl and its use in a process for the preparatio...
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WO/1986/005779A1 |
Novel phenylene derivatives shown by general formula (I) wherein A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R1 represents a hydrogen atom or a lower alkoxy group, X1 represents -C...
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