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WO/2017/023487A1 |
Processes for synthesizing methoxy alkylether quaternary ammonium halides from methoxy alkyl tertiary amines and alkyl halides are provided.
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WO/2017/017156A1 |
The present invention relates to an aqueous dental composition having a pH of at most 7. Furthermore, the present invention relates to the use of a specific composition for the preparation of an aqueous dental composition.
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WO/2017/019540A2 |
The present invention includes novel compounds and methods for preventing or treating diseases associated with N-linked glycosylation in a subject in need thereof. The methods comprise administering to the subject an effective amount of ...
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WO/2017/016669A1 |
The present invention relates to substituted amide derivatives of formula (I) having dual pharmacological activity towards both the sigma (σ) receptor, and the p-opioid receptor, to processes of preparation of such compounds, to pharmac...
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WO/2017/011920A1 |
There are provided compounds, their preparation and their use in the treatment of medical conditions including cancers and immune disorders.
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WO/2017/012556A1 |
Disclosed are an aryl propionic acid compound and pharmaceutical use thereof. The present invention prepares a series of derivatives such as phosphate, sulfonate, carbonate, and amino acid esters by taking the most active alcohol metabol...
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WO/2017/012922A1 |
The invention relates to substituted cyclic aryl and heteroaryl carboxylic acid hydrazides of general formula (I) or salts thereof, wherein the groups of formula (I) have the definitions stated in the description, for increasing the stre...
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WO/2017/015474A1 |
This invention relates to deuterated forms of meclizine, and pharmaceutically acceptable salts or hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in met...
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WO/2017/013265A1 |
The present invention relates to compounds according to general formula (I) which are metabolically robust analogues of bioactive lipid mediators derived from omega-3 polyunsaturated fatty acids (n-3 PUFAs).The present invention further ...
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WO/2017/010399A1 |
Provided are compounds having RORγt inhibitory effects represented by formula (I). Compounds represented by formula (I) (wherein L represents -NR1ACO-, -SO2- or the like, A represents a substituted or unsubstituted aromatic carbocyclic ...
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WO/2017/011283A1 |
The present invention relates to an improved process for making hydroxyethyl piperazine compounds especially mono-hydroxyethyl piperazine. The improvement comprises reacting piperazine and an alkylene oxide, preferably ethylene oxide in ...
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WO/2017/006048A1 |
The invention relates to compounds of formula I (I) or the salts thereof, and to the use of same in the pharmaceutical, cosmetic or agrofood industry.
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WO/2017/005412A1 |
The invention relates to a solvent-free method for producing carboxylic acid amides of formula (1) R1-CONR3R4 (1) which are precipitated, at the given reaction temperatures, as a solid from the reaction mixture, in a mechanical device wi...
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WO/2017/004143A1 |
Compounds are provided having the following structure: Formula (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, G1, G2, G3, a, b, c a...
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WO/2012/025587A9 |
The present invention is directed to a process for the manufacture of 2,3,5-trimethyl-hydro-p-benzoquinone comprising the following steps: a) hydrogenating 2,6-dimethyl-p-benzoquinone with hydrogen in the presence of a hydrogenation cata...
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WO/2016/202254A1 |
Provided are a preparation method for synthesizing a pyrazolecarboxylic acid derivative of the following formula (I), which is suitable for industrial production, and an intermediate as shown by the following formula (II). The method is ...
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WO/2016/199906A1 |
The purpose of the present invention is to provide a novel low-molecular-weight compound which exhibits orexin receptor agonist activity and is expected to be useful as a prophylactic agent or therapeutic agent for narcolepsy and the lik...
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WO/2016/198374A1 |
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...
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WO/2016/197398A1 |
Disclosed are a sulfonic acid inner salt compound of amidine and a preparation method therefor. The product of a sulfonic acid inner salt of amidine is obtained and synthesized by adopting an o-aminobenzenesulfonyl chloride compound and ...
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WO/2016/193220A1 |
The present invention relates to a method for changing the pigmentation of a skin, a mucous membrane or hair with a compound of general formula (I), a cosmetic use of said compound of general formula (I), to cosmetic compositions compris...
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WO/2016/180870A1 |
The present invention provides vortioxetine pyroglutamate salt and pharmaceutical compositions comprising said salt.
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WO/2016/183097A1 |
Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
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WO/2016/176399A1 |
Methods and composition for treating or preventing pulmonary hypertension are provided. In certain aspects, compounds that inhibit TH17 cell maturation or activity, such as retinoic acid receptor-related orphan nuclear receptor (ROR) inh...
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WO/2016/173817A1 |
A personal care composition comprising N-aralkylcarbonyl-piperazine and/or - homopiperazines. When such compounds are used in personal care compositions, they have been unexpectedly to enhance cell proliferation and epidermal thickness, ...
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WO/2016/176330A1 |
The present invention relates to compositions and methods for inducing adaptive immune response in a subject. In certain embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule enc...
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WO/2016/176138A1 |
Disclosed are novel bis(aminophenylphenol) ligands and transition metal compounds derived therefrom. Also disclosed are methods of making the ligands and transition metal compounds.
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WO/2016/172425A1 |
Compounds of Formulas I-VI, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth. Formula I is exemplified below: Formula (i)
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WO/2016/171240A1 |
The present invention addresses the problem of providing an excellent method for producing an excellent therapeutic agent. The solution of the present invention is as shown in the following scheme. (In the formulae, R1 represents a C1-C6...
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WO/2016/172424A1 |
Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth: (I)
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WO/2016/168058A1 |
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...
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WO/2016/168462A1 |
The present invention relates to crystalline forms of modified triterpenoid hydrochloride salts with HIV maturation inhibitor activity. More specifically, the present invention relates to the H-4, TlF-1, and TlF-2 crystalline forms. The ...
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WO/2016/168447A1 |
A method for producing HIV maturation inhibitor compound is set forth using betulin Chemical Structure (I) as starting material, and utilizing Lossen rearrangement techniques.
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WO/2016/168056A1 |
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...
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WO/2016/161279A1 |
There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, suc...
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WO/2016/152831A1 |
The present invention provides: a pyrazole derivative which is useful as a intermediate of a pharmaceutical or agrochemical product; a method for producing this pyrazole derivative; and a novel intermediate compound which is useful in th...
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WO/2016/151484A1 |
This invention relates to new inhibitors of butyrylcholinesterase with general formulas I and II, where substituents are described in patent description. Compounds can be in the form of pure enantiomers or as racemic mixtures, or in the ...
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WO/2016/150208A1 |
Disclosed are a pharmaceutical composition and dosage form containing a glaucocalyxin A derivative as represented by the formula (I) or salt thereof, and a preparation method and use of said composition and dosage form; the anti-autoimmu...
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WO/2016/151085A1 |
The present invention relates to a compound or a pharmaceutically acceptable salt thereof or a solvate thereof or a pharmaceutical composition comprising said compound, a process for obtaining or screening for a toll-like receptor 9 (TLR...
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WO/2016/150207A1 |
Provided is a glaucocalyxin A derivative, or salt thereof, as represented by the formula (I), a method for preparation of said glaucocalyxin A derivative, and a use for said glaucocalyxin A derivative in preparing pharmaceuticals for fig...
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WO/2016/151328A1 |
The present invention relates to a process for preparing serotonin reuptake inhibitors of formula (I) and pharmaceutically acceptable salts thereof, (Formula (I)) wherein, R1, R2, R3, l, m, n and Z are as defined in the specification.
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WO/2016/143650A1 |
Provided is a compound that exhibits an excellent controlling effect against harmful arthropods. A 3-aminooxalylaminobenzamide compound represented by formula (1) has an excellent controlling effect against harmful arthropods.
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WO/2016/142819A2 |
The present invention relates to novel processes for the preparation of Ranolazine (I) and its acid addition salts and the novel process for the preparation of compound of formula (7).
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WO/2016/141499A1 |
The invention relates to blockers of hemichannels for the treatment of epilepsy. In particular, the invention relates to organic compounds that act as selective inhibitors of hemichannels formed by connexins and which are useful in the t...
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WO/2016/143652A1 |
Provided is a compound that exhibits an excellent controlling effect against harmful arthropods. A 3-aminooxalylaminobenzamide compound represented by formula (1) has an excellent controlling effect against harmful arthropods. [In the fo...
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WO/2016/139373A1 |
Molecular storage materials for incorporating small molecules in solid matrices may find applications in structure elucidation, decontamination, and slow release of active ingredients. The syntheses of 1,3,5,7-tetrakis(2,4-dimethoxypheny...
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WO/2016/135636A1 |
Disclosed herein a process for the isolation of intermediate of Vortioxetine in a solid state form and an improved, commercially viable and industrially advantageous process for the preparation of vortioxetine or a pharmaceutically accep...
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WO/2016/135070A1 |
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are as described herein, compositions including the compounds and methods of using the compounds.
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WO/2016/131371A1 |
Disclosed is a method for preparing a formamide compound, the method uses carbon dioxide, hydrogen and an amine compound as raw materials and a transition metal complex as a catalyst, and the reaction is carried out in an organic solvent...
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WO/2016/129490A1 |
Provided is a polar compound having high chemical stability, high ability to align liquid crystal molecules, and high solubility in a liquid crystal composition, and which has a large voltage holding ratio when used in a liquid crystal d...
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WO/2016/128325A1 |
The present invention relates to the preparation of sulfur containing ammonium and phosphonium borates KA wherein K is a compound of formula (I) A is an anion of formulae (IIa) or (IIb) by bringing into contact ammonium borates with sulf...
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