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JP2000515116A |
PCT No. PCT/KR96/00255 Sec. 371 Date Jun. 26, 1998 Sec. 102(e) Date Jun. 26, 1998 PCT Filed Dec. 27, 1996 PCT Pub. No. WO97/24359 PCT Pub. Date Jul. 10, 1997The invention provides novel cephalosporin derivatives of the formula (I) and sa...
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JP2000514090A |
Crystalline 2-(aminothiazol-4-yl)-2-(tert.butoxycarbonylmethoxyimino)ace
tic acid-S-mercapto-benzo-thiazolylester in form of an N,N-dimethylacetamide solvate; a crystalline salt of a 7-[2-(aminothiazol-4-yl)-2-(carboxymethoxyimino)acetam...
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JP2000514042A |
Catechol derivatives of general formula (I)in which R1 denotes O-acyl and R2 represents amino acid residues in the 3- and/or 4-position function as siderophores and/or as biological chelating agents for iron in gram-negative bacteria. Co...
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JP2000512297A |
A new crystalline form of potassium clavulanate is disclosed. Also disclosed are a process for producing the new crystalline form of potassium clavulanate, pharmaceutical compositions containing it and methods of treating bacterial infec...
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JP2000511893A |
The present invention relates to novel DNA alkylating agents and the prodrugs of these agents which are useful as antitumor agents and DNA labelling agents. The compounds are hydroxy dihydrobenzindole oligopeptides and prodrugs thereof w...
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JP2000511931A |
The present invention relates to the use of 7-alkylidene derivatives of cephalosporin esters, such as sulfides, sulfoxides, and sulfones, as inhibitors of human leukocyte elastase. These materials are therefore useful as anti-inflammator...
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JP3080692B2 |
The invention relates to the products of formula: in which: R1 =, in particular, or Rb and Rc = H or acyl A and A' =, in particular H, alkali metal equivalent, aminated organic base, readily cleavable ester group, or CO2A represents CO2<...
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JP2000229986A |
To efficiently obtain 6-aminoacyl-penicillin or the like useful as an antimicrobial agent or the like in high purity and high yield by acylating silylated 6-amino-penicillanic acid or the like obtained under a specified condition. 7-Amin...
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JP3072857B2 |
PCT No. PCT/EP95/04562 Sec. 371 Date Jul. 25, 1997 Sec. 102(e) Date Jul. 25, 1997 PCT Filed Nov. 2, 1995 PCT Pub. No. WO96/16067 PCT Pub. Date May 30, 1996A process for the silylation of 6-aminopenicillanic acid or 7-amino-desacetoxy-cep...
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JP3073437B2 |
To produce the subject compound without causing the isomerization reaction of the double bond in the cephem ring and the lactone formation and without emitting an unpleasant odor by oxidizing the corresponding 3- hydroxymethyl-cephem der...
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JP3068143B2 |
7 beta -[2-(2-Tritylaminothiazol-4-yl )-2-(t-butyloxycarbonylprop-2-yl )oxyiminoacetamido]-3-pyridiniummethyl-3-cephem-4-carboxylat
e 1 is obtained via a process comprising N-acylation of 7 beta -amino-3-pyridiniummethyl-3 -cephem-4-carb...
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JP3065289B2 |
The present invention relates to cephalosporin derivatives of the general formula where R<1> is halogen, lower alkyl, phenyl, benzyl, styryl, naphthyl or heterocyclyl; the lower alkyl, phenyl, benzyl, styryl, naphthyl and heterocyclyl be...
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JP3061642B2 |
A process for the removal of fluoride from spent liquors obtained in a process in the production of an organic compound in which boron trifluoride is used by conversion of fluoride into an isolatable salt of tetrafluoroborate.
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JP3061911B2 |
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JP3046068B2 |
Antimicrobial quinolone thiourea compounds of the general formula: wherein (1) A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial ...
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JP3044175B2 |
PURPOSE: To remove an allyl group, etc., in high selectivity and high yield without exercising bad influence on other functional group by reacting a specific compound containing an allyl group, etc., with a sulfinic acid compound in the ...
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JP3041309B2 |
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JP2000505432A |
PCT No. PCT/JP97/00280 Sec. 371 Date Aug. 12, 1998 Sec. 102(e) Date Aug. 12, 1998 PCT Filed Feb. 5, 1997 PCT Pub. No. WO97/29111 PCT Pub. Date Aug. 14, 1997This invention relates to new cephem compound represented by the following genera...
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JP3012986B2 |
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JP2000044573A |
To obtain the subject highly pure compound in a good yield in an industrial scale by dropwisely adding a specific N-substituted vinyl-amino acid to an acylating agent in the presence of a base in acetonitrile and subsequently reacting th...
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JP3009329B2 |
Cephalosporin(I), useful as an antibiotic, manufacturied by reacting iodomethylcephem(II) and amine or heterocyclic amine(III) at 20-25 deg.C in presence of solvent to give intermediate compound, which is reacted with compound(IV) contin...
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JP3005072B2 |
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JP3005279B2 |
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JP3004954B2 |
Compounds of formula I wherein R1 is hydrogen, lower alkyl, cycloalkyl or acetyl; x is CH or N; n is 0, 1 or 2; m is 0 or 1; R2 is hydrogen, lower alkyl, omega -hydroxy alkyl, benzyl or lower alkyl-heterocyclyl, the benzyl and the hetero...
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JP3001111B2 |
PCT No. PCT/EP90/02189 Sec. 371 Date Jun. 12, 1992 Sec. 102(e) Date Jun. 12, 1992 PCT Filed Dec. 14, 1990 PCT Pub. No. WO91/09036 PCT Pub. Date Jun. 27, 1991.Cephalosporins of the formula (I): (I) wherein m is one or two; n is zero, one ...
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JPH11514345A |
The present invention is to the novel compounds of Formula (I), their pharmaceutical compositions, and to the novel inhibition of ICE and ICE-like proteins for use in the treatment of apoptosis, and disease states caused by excessive or ...
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JPH11322757A |
To obtain a novel cephem compound showing strong antimicrobial effects against a wide range of bacteria, including methicillin resistant Staphylococcus aureus, and useful for prevention and/or treatment of infection diseases. This compou...
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JPH11513670A |
The present invention includes novel compounds of formula where R99 is selected from the group consisting of sulfur, SO, SO2, NH, N-alkyl, oxygen, C=C (cis or trans), and C 3BOND C, and R12 is The invention also includes the pharmacologi...
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JP2979235B2 |
beta -Lactam compounds of the formula (Ia) including pharmaceutically acceptable salts and in vivo hydrolysable esters, processes for their preparation and their use as antibiotics: wherein R<1> is hydrogen, methoxy or formamido; R<2> is...
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JP2977212B2 |
Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked, by a non-ester linking moiety, to the 3-carboxy group of a quinolone moiety. These compounds are of the formula: wherein (1) R<3>, R<4>, and R<5>, to...
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JP2975949B2 |
NEW MATERIAL:A compound shown by formula I [R<1> is H, amino-protecting group or acyl; R<2> is (protected) carboxyl or carboxylato; R<3> is H, formamido, lower alkylthio, etc,; A is (substituted) 1-6C hydrocarbon or bond valent; B is (su...
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JP2971534B2 |
An antibacteriai 3-optionally protected-vic-dihydroxyaroyl-lower alkyl-pyridiniothiomethyl cephalosporin derivative represented by the following formula (I): (wherein, R<1> is an amino group or acylamino; R2 is hydrogen or methoxy; R3 is...
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JPH11302176A |
To obtain an anti-Helicobacter agent having a strong antibacterial action against a bacterium belonging to genus Helicobacter and useful as a medicine such as an antiulcer agent by including oxacephem or a specific cephem as an active co...
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JPH11512737A |
PCT No. PCT/JP96/02797 Sec. 371 Date Mar. 26, 1998 Sec. 102(e) Date Mar. 26, 1998 PCT Filed Sep. 27, 1996 PCT Pub. No. WO97/12890 PCT Pub. Date Apr. 10, 1997A compound of the formula: wherein R1 is amino, R2 is hydrogen, R3 is carboxy, R...
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JP2969283B2 |
Antibacterial hydroxyarylpiperaziniocephalosporins of the formula : [wherein, R<1> is amino or acylamino; R<2> is H or methoxy; R<3> is alkyl; R<4> is -(P-C-Q)n- (where, P, Q each is H, alkyl, OH, or P + Q show oxo, and n is 0 to 4); R<5...
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JPH11512397A |
Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vi...
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JP2964423B2 |
3-Fluorosulfonyloxyceph-3-ems having a protected amino or acylamino group in the 7-position are subject to carbon-carbon bond formation at the 3-position by means of a palladium catalyzed coupling reaction with substituted organostannane...
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JP2960790B2 |
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JPH11279180A |
To obtain a new compound having strong antimicrobial activity to methicillin resistant Staphylococcus aureus and useful as a medicine, especially an antimicrobial agent to human and animals by binding a specific group to 3 position of ce...
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JP2959809B2 |
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JP2959821B2 |
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JP2957699B2 |
There is provided a process for preparing a compound of the formula (I): (I) wherein R1 is an organic residue, R2 is a hydrogen or a chlorine atom, a methoxy, ethoxy or an acetoxy group, and n represents 0, 1 or 2. The process comprises ...
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JP2960167B2 |
PCT No. PCT/GB93/00457 Sec. 371 Date Sep. 6, 1994 Sec. 102(e) Date Sep. 6, 1994 PCT Filed Mar. 4, 1993 PCT Pub. No. WO93/18044 PCT Pub. Date Sep. 16, 1993 (I) Compounds of formula (I) or salts thereof: wherein R1 is hydrogen, methoxy or ...
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JP2958567B2 |
A stable, amorphous, lyophilized dihydrochloride salt of 7-( alpha -(2-aminothiazol-4-yl)- alpha -(Z)-methoxyiminoacetamido]-3-[(1-methyl-1-pyrrolidi nium)methyl]-3-cephem-4-carboxylate is described. This lyophilized salt is more easily ...
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JPH11511463A |
The present invention is to the novel compounds of Formula (I), their pharmaceutical compositions, and to the novel inhibition of ICE and ICE-like proteins for use in the treatment of apoptosis, and disease states caused by excessive or ...
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JPH11255771A |
To obtain the subject new compounds useful for preventing, inhibiting or treating diseases caused by the uncontrolled release of a protease, especially emphysema or cystic fibrosis, as inhibitors against a protease, especially against hu...
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JP2951346B2 |
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JP2950795B2 |
The invention is concerned with a new process for the preparation of compounds of formula wherein R<1> is trityl, acetyl, tetrahydropyranyl or cyclopentyl; R<2> is hydrogen, hydroxy, lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, ...
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JP2951362B2 |
3-Exomethylenecepham sulfoxide esters are obtained in improved yields via cyclization of 3-methyl-2-(4-chlorosulfinyl-2-oxo-3-acylamino-1-azetidinyl)
-3-butenoic acid esters under anhydrous conditions with stannic chloride in the presenc...
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JP2948596B2 |
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