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JP2662176B2 |
A process for the production of 3-vinylcephalosporin compounds of formula wherein R1 and R2 may be the same or different and are hydrogen or an organic radical using a Wittig reaction in which weak bases are used.
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JP2655790B2 |
Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum str...
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JP2655664B2 |
The invention relates to a method for preparing crystalline cefadroxil monohydrate. According to such a method a cefadroxil solvate is slurried with isopropyl alcohol containing less 6% to 18% W/W of water at a temperature between + 45 a...
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JPH09249643A |
To obtain an allenyl β-lactam compound and a 3-halocephem compound in a simple operation and in high purity by using a halogenated β-lactam compound as a starting material and solely changing reaction conditions. An allenyl β-lactam c...
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JPH09249983A |
To obtain a 3-alkoxymethylcephem of high purity in a simple process with high production yield by electrolyzing and oxidizing 3-alkoxymethylcephem compd. in the presence of a lower alcohol. A 3-thiomethylcephem compd. expressed by formul...
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JP2654076B2 |
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JP2650716B2 |
There is disclosed a process for the production of certain 3-hydrocarbyl-3-cephem derivatives wherein the hydrocarbyl group is selected from 1-alkenyl and conjugated and unconjugated 1-polyalkenyl, 1-alkynyl, carbocyclic and heterocyclic...
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JP2648862B2 |
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JP2647776B2 |
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JP2635078B2 |
Crystallized cephem-acid addition salts of the general formula +TR pharmaceutical preparations which contain such cephem derivatives and are active against bacterial infections, a process for the preparation of the cephem derivatives and...
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JP2633201B2 |
PURPOSE: To obtain the subject novel antibiotic which exhibits powerful anti- microbial activity against pathogenic bacteria including various gram-positive and gram-negative bacteria and is useful for the prophylaxis and treatment of di...
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JPH09506854A |
Derivatives of 2-spirocyclopropyl cephalosporin sulfone of the structural formula I I are provided which are useful as potent elastase inhibitors.
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JP2625937B2 |
A water-soluble antibiotic composition which comprises crystals of a cephem compound of the following formula: wherein R<1> is a residue of an aliphatic hydrocarbon which may have suitable substituent(s), and R<2> is a heteronio(lower)al...
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JP2625647B2 |
PURPOSE: To obtain a cephalosporine deriv. useful as antibiotics without isolating individual intermediate products through conversion of a specified aminocephalosporanic acid to an N,O-bissilylated deriv. CONSTITUTION: 7-Aminocephalospo...
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JP2620582B2 |
The invention relates to a novel crystalline cefadroxyl hemihydrate having a K.F. between about 3.5 and 2.0% : such compound is more stable than other cefadroxyl molecules. The novel cefadroxyl is obtained preparing and isolating a novel...
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JPH09506100A |
2-spiro (2'-spirocycloalkyl) cyclopropyl cephalosporin sulfone compounds, methods of treating patients for elastase inhibition, and processes for preparing such compounds.
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JPH09506112A |
Novel cephalosporin compounds of formula (I) exhibit potent and broad antibiotic activities against Gram-negative and Gram-positive bacteria and various resistant bacteria: (I)
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JP2618119B2 |
PURPOSE: To provide a new compound having excellent antibacterial action against Gram-positive and Gram-negative bacteria and useful for the treatment of various bacterial infectious diseases. CONSTITUTION: The compound of formula I (Acy...
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JP2619589B2 |
PURPOSE: To economically obtain 7-aminoacyl-cepharosporin without using a halogen-contg. solvent by allowing a N-substd. vinyl α-aminoacid to react with an acylating agent and then allowing the product to react with a cephem- carboxylic...
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JP2617618B2 |
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JP2614984B2 |
PURPOSE: To provide a novel carboxamide which inhibits thrombin-induced platelet aggregation and fibrinogen solidification in plasma and is useful for preventing and treating thrombosis, paroxysm, cardiac infarct, etc. CONSTITUTION: A co...
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JP2612493B2 |
A novel process is disclosed for preparing a 3-substituted methyl-3-cephem-4-carboxylic acid or pharmaceutically acceptable salt thereof. The process comprises reacting a 3-acetoxymethyl-3-cephem-4-carboxylic acid or pharmaceutically acc...
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JPH09132578A |
To obtain a new cephalosporin derivative having a strong and wide range antimicrobial activities, excellent in peroral absorption characteristics and useful as an antibiotic agent for preventing and curing infectious diseases. This new c...
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JP2609039B2 |
PURPOSE: To economically and easily obtain the subject compd. useful as a cephalosporin antibiotic by the reaction of 7-ACT and MAEM in the presence of a base. CONSTITUTION: A 7-ACT {7-amino-3-{[2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4...
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JP2607277B2 |
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JP2605096B2 |
NEW MATERIAL:The compound of formula I [R1 is lower alkyl; A is group of formula II-IV (R2 is lower alkyl; R3 is lower alkyl or hydroxy-lower alkyl; R4 is lower alkyl, hydroxy-lower alkyl or carbamoyl-lower alkyl; R5 is H or hydroxy-lowe...
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JPH09504306A |
A compound having the following general formula (I): where R is a hydrogen atom; a linear or branched C1-C4 alkyl group, unsubstituted or substituted by at least a phenyl group or at least a hydrogen atom; a benzyl group substituted by a...
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JPH09110877A |
To obtain a specific new cephem compound having 7- aminopyrazolo[1,5-a]pyridinium-4-ylmethyl group, etc., at the 3-site of cephem nucleus and exhibiting excellent antibacterial action even on a bacterial strain of the genus Pseudomonas. ...
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JP2602669B2 |
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JPH09104685A |
To obtain the subject new crystallin form having a specific X ray spectrum, having good biological utilization characteristic suitable for use for treatment and excellent in balance of physicochemical, biochemical characteristics and sta...
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JP2600883B2 |
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JP2600878B2 |
Procedure for preparing 7-[2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetamide]-3-cephe
m compounds with the formula:in which R<1> is an organic group, R<2> is a carboxy or a protected carboxy in which a reaction is produced with 7-amino-3-...
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JP2599105B2 |
PURPOSE: To obtain a new compound, useful as a synthetic intermediate for cephem compounds which are excellent antimicrobial agents and capable of industrially providing the cephem compounds in high yield and purity. CONSTITUTION: This d...
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JP2595679B2 |
A compound of the formula : wherein R<1> is amino or protected amino, R<2> is lower alkyl or lower alkenyl, R<3> is lower alkyl, hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R<4> is amino, protected amino, lower alkylamino, prot...
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JPH0987200A |
To obtain a therapeutic agent for bone resorption diseases using a compound selectively linking to human src SH2 domain. This is a medicinal composition to be utilized for treating bone resorption diseases because it contains a compound ...
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JP2594780B2 |
To obtain the subject derivative useful as raw materials for antibiotics in a simple way by ring opening of an ester group of a specific t-butyl ester of ceftazidime with an aqueous solution of hydrochloric acid, by adding acetone, ethan...
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JP2594720B2 |
Process for the preparation of crystalline TACA by reacting 7-ACA and MMTA in the presence of a base, followed by precipitation by adding a TACA solution to part of a given quantity of an acid which can also contain a precipitation auxil...
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JPH0959281A |
To obtain the subject compound comprising a specific cephalosporin containing a substituted benzyloxyimino group at the 7-position, having extremely excellent antibacterial activity against gram-positive bacterium, especially penicillin-...
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JPH0948785A |
To obtain a new cephem compound having wide antibacterial activity including that to MRSA by reacting 7-amino-4-pyridylthiovinyl-3-cephem-4- carboxylic acids with 1,2,4-thiadiazole-containing carboxylic acids. This new cephem compound (a...
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JPH0948784A |
To easily and stably obtain the subject compound having antibacterial effect in high purity with low by-products, by reaction of a specific organic acid with a specific condensation agent and a 1-hydroxybenzotriazole derivative followed ...
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JP2575590B2 |
PURPOSE: To obtain a pharmaceutically stable active ingredient of an antimicrobial agent. CONSTITUTION: The objective 7β-[(Z)-2-(2-amino-4-thiazolyl)-2 hydroxyiminoacetamido]-3-(1,2,3-triazolyl-4-yl)thiomethylthi
o-3-cephem-4-carboxylic...
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JPH0920783A |
To obtain the subject compound useful as a serine protease inhibitor (or its intermediate) by acylating a specific cephem carboxylic acid ester and oxidizing the acylated product to a sulfone followed by removing the ester moiety. A comp...
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JP2571815B2 |
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JP2572382B2 |
Trimethylsilyl 7-trimethylamino-3-iodomethylceph-3-em-4-carboxylate, its use as an intermediate for the preparation of cephalosporin derivatives, and a process for the preparation of cephalosporin derivatives using this intermediate.
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JP2572563B2 |
To obtain a new crystalline form (β-form) easily separable and good in stability and useful for a non-oral antibiotic drug having a high antibacterial activity by crystallizing a specific cephalosporin from an aqueous solution in a spec...
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JP2569455B2 |
PURPOSE: To efficiently obtain the subject derivative useful as a synthetic intermediate, etc., for antimicrobial agents according to simple operation by treating a specific azathiazabicycloalkane compound (salt) with a base in the prese...
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JPH092974A |
To obtain a medicine for promoting increase of blood corpuscle, using a compound capable of selectively binding to human hcpSH2 domain. The medicinal composition is used for promoting increase of blood corpuscle and comprises a compound ...
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JPH09500118A |
PCT No. PCT/EP94/02059 Sec. 371 Date Mar. 8, 1995 Sec. 102(e) Date Mar. 8, 1995 PCT Filed Jun. 24, 1994 PCT Pub. No. WO95/02603 PCT Pub. Date Jan. 26, 1995The present invention relates to the use of known cephem derivatives of the formul...
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JPH093074A |
PURPOSE: To obtain a new cephalosporin compound which is a specific one containing a difluoroalkyl group, capable of manifesting excellent antimicrobial activities, effective for both Gram-positive and Gram-negative bacteria and useful a...
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JP2568226B2 |
Amorphous solid formed by lyophilization or cosolvent precipitation of an aqueous solution of 7-[ alpha -(2-aminothiazol-4-yl)- alpha -(Z)-methoximinoacetamido]-3-[(1-methyl-1-pyrrolidinio)-meth
yl[-3-ceph em-4-carboxylate zwitterion and...
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