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Patent Searching and Data


Matches 501 - 550 out of 7,108

Document Document Title
WO/2002/024200A1
The present invention relates to thiazoles, oxazoles, imidazoles and pharmaceutical compositions comprising said compounds antagonizing the corticotropin releasing factor receptor ('CRF receptor') and useful for the treatment of depressi...  
WO/2002/024679A1
Pyridine compounds of general formula (I) wherein -R?1¿ represents, or in which R?11¿ is hydrogen, C¿1-6? alkyl, halogen, hydroxy, C¿1-12? alkoxy, nitro, amino, C¿1-6? alkylsulfonylamino, C¿1-6? alkoxycarbonyl, C¿1-6? alkylamino, ...  
WO/2002/024651A1
This invention is to provide a process for producing 2-amino-4,6-disubstituted nicotinic acid ester analogs and salts thereof, comprising the reaction shown by the following scheme. The ester analogs can be prepared in one pot, and in go...  
WO/2002/024666A2
Quinazolines of the formula I, in which R, R?1¿, R?2¿, R?3¿, R?4¿ and Y have the meaning indicated in Patent Claim 1, and their salts or solvates as glycoprotein IbIX antagonists.  
WO/2002/024685A1
The invention concerns novel indole derivatives, their preparation method and their pharmacological activity as antimycotic and/or antiparasitic compounds.  
WO/2002/024687A1
This invention comprises the novel compounds of formula (I) wherein r, t, Y?1¿-Y?2¿, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ and R?7¿ have defined meanings, having farnesyl transferase inhibiting activity; their preparation, composit...  
WO/2002/022556A1
Amide derivatives represented by the following general formula (1) which have a C5$g(a) receptor antagonism, wherein each symbol has the meaning as defined in the description. These amide derivatives, optically active isomers thereof or ...  
WO/2002/022605A1
This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula VIII, wherein Z?1¿ is N or C-R?9¿, Z?2¿ is N or CH, and Z?3¿ is N or C-R?x¿, provided that one of Z?1¿ ...  
WO/2002/022603A1
This invention provides novel pyrazole compounds that are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3. The compounds may be used to treat abnormal physiological function leading to diseases such as...  
WO/2002/022604A1
This invention describes novel pyrazole compounds of formula III:wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R?x¿ and R?y¿ are taken toget...  
WO2001064826A3
The invention relates to catalytically bleaching substrates, especially laundry fabrics, with a bleaching composition and a peroxyl source.  
WO/2002/022608A1
This invention describes novel protein kinase inhibitors of formula (VII): wherein G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Rind C has ...  
WO/2002/022601A1
This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula (V) wherein Z?1¿ is N, CR?a¿, or CH, and Z?2¿ is N or CH, provided one of Z?1¿ and Z?2¿ is nitrogen; G i...  
WO2001014372A3
A neurotrophin production/secretion promoting agent which comprises an azole derivative of formula (I), wherein R<1> represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionall...  
WO/2002/022607A1
This invention describes novel pyrazole compounds of formula II:wherein Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1, 2, 4-triazinyl ring, and R?2¿, R?2¿, R?x¿, and R?y¿ are as described in t...  
WO/2002/022584A1
Compounds of the invention are useful in inhibiting thrombin and treating blood coagulation and cardiovascular disorders and have the following structure: where R?1¿ is hydrogen, or C¿1-4? alkyl, (CH¿2?)¿0-1?CN, C(O)R?14¿, (CH¿2?)...  
WO/2002/022606A1
This invention describes novel pyrazole compounds of formula (IV) wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R?x¿ and R?y¿ are independen...  
WO/2002/022550A2
The disclosed invention comprises a compound having the formula (I), in which R?1¿ and R?2¿ independently represent a hydrogen or an alkyl group of 4 carbon atoms or greater. Further disclosed is a process for the preparation of the di...  
WO2002006255A3
The invention provides compounds of Formula (I) having the structure wherein A, B, Z, R and R<1> are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders r...  
WO/2002/022602A2
This invention describes novel triazole compounds of formula (IX): wherein Z?1¿ is nitrogen or CR?9¿ and Z?2¿ is nitrogen or CH, provided that at least one of Z?1¿ and Z?2¿ is nitrogen; G is Ring C or Ring D; Ring C is selected from...  
WO/2002/020472A1
The invention relates to substituted phenylcyclohexane carboxylic acid amides of formula (I), a method for the production thereof and the use thereof in medicaments, especially in the prevention and/or treatment of cardiovascular diseases.  
WO2001047918A3
The invention relates to azolyl-alkyl oxazole and oxadiazole derivatives of the general formula (I), wherein the symbols and indices are defined as follows: R1 represents (C1-C4) haloalkyl; R2 represents hydrogen, halogen, (C1-C4)-alkyl,...  
WO/2002/020500A2
Compounds of Formula (I) that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods to inhibit the DNA-PK biological activity, methods to sensitize cells the agents that cause DNA lesions, and methods to po...  
WO/2002/018349A2
The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5- (2S-(1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6 -diphenylhexane and analogs...  
WO/2002/018368A1
The present invention discloses novel tricyclic compounds represented by the formula (1.0), a prodrug thereof, or a pharmaceutically acceptable salt or solvate of the compound or of said prodrug useful for inhibiting farnesyl protein tra...  
WO2001066551A3
The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared to known compounds such as fluconazole and itraconazole and the processes for the preparation t...  
WO/2002/016308A1
The invention relates to compounds of the general formula (1), wherein A, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and R?6¿ are defined as in the description and the claims. The invention further relates to a method for producing said compound...  
WO/2002/016324A1
The present invention relates to compounds of the general formula (I) wherein a.o. 5 R is hydrogen or halogen; R and R?2¿ or R?4¿ and R?4'¿ may be together -CH=CH-CH=CH-, optionally substituted by one or two substituents selected from...  
WO/2002/013824A1
The present invention is directed to compounds of the formula I (wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ and X are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are...  
WO2001019791A3
The invention relates to 3-vinylpryrrole derivatives of general formula (I), wherein M represents a substituted peptide, a substituted hydantoin or thiohydantoin, tetrazole, lactam or lactone group, Y and Z independently represent a hydr...  
WO/2002/014269A2
Disclosed are compounds of the formula (I) or pharmaceutically acceptable salts thereof wherein: (i) represents: (ii, iii, iv, v) and A, B, G, D, E, R¿a?, R¿b?, W, and Z are defined herein. These compounds are agonists, antagonists or ...  
WO/2002/014311A2
Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptabl...  
WO/2002/014276A1
Benzoylaminoisoindoline compounds of the general formula [I] useful as drugs, or pharmacologically acceptable salts thereof; processes for the preparation of the compounds or the salts; and intermediates for the synthesis thereof; [I] wh...  
WO/2002/012224A2
Substituted N-substituted alkoxyphenyl compounds, compositions containing them, and methods of making and using them.  
WO/2002/012190A2
Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.  
WO/2002/012214A2
Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.  
WO/2002/012197A1
The invention relates to 1H-pyrazol derivatives corresponding to general formula (I), wherein R?1¿ and R?3¿, independently of each other, represent H or a C¿1?-C¿4?-alkyl radical, R?2¿ represents H, halogen or a C¿1?-C¿4?-alkyl ra...  
WO/2002/010140A2
The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.  
WO/2002/010161A1
The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-arylacetylaminothiazole compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R?1¿, R?2¿, R?3¿, R?4¿...  
WO/2002/010163A1
The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-azacycloalkanoylaminothiazole compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R, R?1¿, R?2¿, R?3...  
WO/2002/008211A2
Compounds, pharmaceutical compositions, and methods for the treatment of a hyperlipidemic condition in a subject. The compounds of the present invention are apical sodium co-dependent bile acid transport inhibitors and are 1,4-benzothiaz...  
WO/2002/008213A1
The invention related to colchinol derivatives of the formula (I): Wherein: R?1¿, R?2¿ and R?3¿ are each independently hydroxy, phosphoryloxy (-OPO¿3?H¿2?), C¿1-4?alkoxy or an in vivo hydrolysable ester of hydroxy, with the proviso...  
WO/2002/008232A1
The invention relates to compounds of general formulas (IA) or (IB) wherein R?1¿ is (a), (b), (c), (d) or is -NH(CH¿2?)¿2?OH, -NR?3¿C(O)CH¿3? or -NR?3¿C(O)-cyclopropyl; R?2¿ is methyl or chloro; R?3¿ is hydrogen or methyl; R is h...  
WO/2002/008199A2
The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa...  
WO2001060814A3
The present invention relates to pyrrole substituted 2-indolinone compounds of formula (I): and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefor are expected to be useful in the preventi...  
WO2001053268B1
Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating , e.g., kinases-dependent...  
WO/2002/006255A2
The invention provides compounds of Formula (I) having the structure wherein A, B, Z, R and R?1¿ are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders ...  
WO/2002/006237A1
A 3,5-dicyanopyridine derivative or a salt thereof. The compound exhibits excellent activity of opening the maxi-K channel and bladder smooth muscle contracting activity based on the maxi-K opening activity, and thus can be used in the t...  
WO/2002/003912A2
Novel C-4 substituted all-trans retinoic acid analogs are synthesized and used to treat various cancers and dermatological diseases and conditions. These novel C-4 substituted all-trans retinoic acid analogs inhibit all-trans retinoic ac...  
WO/2002/002538A1
Amino acid-N-carboxy anhydrides having an N-acyl substituent at nitrogen which are represented by the following general formula (1); and a process for producing the same. These compounds easily react with free amino acids, alcohols or nu...  

Matches 501 - 550 out of 7,108