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JP2000516631A |
Texaphyrin metal complex-oligonucleotide and -oligonucleotide analog conjugates are provided where the texaphyrin is bound to an internal linkage of the oligonucleotide or oligonucleotide analog, the conjugates having catalytic activity ...
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JP3115386B2 |
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JP2000515546A |
Modified nucleotides and polynucleotides which are useful in hybridization assays for the detection of target genes are provided. The modified polynucleotides contain at least one boronic acid moiety which is attached to a nucleotide bas...
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JP2000514799A |
(57) [Summary] Provided is a technique for binding an oligonucleotide such as single-stranded DNA to another residue or a solid phase. With a binding functional group that can be defined by six adjacent histaminyl purines, which can coor...
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JP2000297041A |
To obtain a vitamin B12 preparation composition carried on a calcium carbonate carrier capable of exhibiting excellent fluidity even without adding an additive such as a fluidizing agent and excellent in handleability by compounding vita...
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JP2000511904A |
The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosp...
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JP3085320B2 |
A process for the production of hydroxocobalamin comprising the steps of: (1) putting a solution containing Co-enzyme type vitamin B12 contact with a divinylbenzene/styrene copolymer resin so that the Co-enzyme type vitamin B12 is adsorb...
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JP3064462B2 |
There is disclosed a process which comprises the steps of: (a) reacting a di(hydrocarbyl)tin oxide such as a dialkyltin oxide with a dihydric alcohol, alkanolamine, or an enolizable alpha -hydroxy ketone in an inert organic reaction vehi...
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JP3061062B2 |
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JP3054699B2 |
A process is provided which can easily produce a hydroxyl groups-containing cyclic ether compound in which at least one of the hydroxyl groups except a primary hydroxyl group thereof and its neighboring secondary hydroxyl group is protec...
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JP3032815B2 |
To obtain the subject new derivative useful as an intermediate for synthesizing and modifying ribonucleic acid compounds, etc., by cyclizing a nucleotide with a bifunctional silicon compound and subsequently silylating the 2-hydroxyl gro...
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JP3030064B2 |
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JP3016099B2 |
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JP3012355B2 |
Process which comprises reacting sucrose with a di(hydrocarbyl)tin oxide in an inert organic reaction vehicle with removal of water for a period of time and at a temperature sufficient to produce a 1,3-di-(6-O-sucrose)-1,1,3,3-tetra(hydr...
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JP2997768B2 |
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JPH11514642A |
PCT No. PCT/KR96/00189 Sec. 371 Date May 1, 1998 Sec. 102(e) Date May 1, 1998 PCT Filed Nov. 1, 1996 PCT Pub. No. WO97/16456 PCT Pub. Date May 9, 1997According to the present invention, provided are novel nucleoside derivatives having an...
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JPH11512100A |
The invention concerns metallocene-phosphoramidite conjugates comprising one or a plurality of metallocenes and one or a plurality of phosphoramidites. The invention further concerns a process for preparing the metallocene-phosphoramidit...
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JP2962755B2 |
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JP2951590B2 |
Novel reagents useful in a variety of biochemical and chemical contexts, including nucleic hybridization assays and chemical phosphorylation of hydroxyl-containing compounds. The reagents are particularly useful for introducing cleavable...
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JP2947580B2 |
Synthetic analogs of 2',5'-oligoadenylate wherein the aglycon, ribosyl moiety and/or terminal nucleoside have been modified are effective therapeutic agents, particularly against HIV infection. The analogs are utilized in compositions fo...
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JP2944117B2 |
Organic silicon compounds such as tetraloweralkylorthosilicates, silicon tetracarboxylates, and silicon-containing reaction products derived from carbohydrates, such as glucose, sucrose, and ascorbic acid are useful in treating, preventi...
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JP2916227B2 |
A vitamin B12 composition wherein vitamin B12 exists as dispersed in a mixture of starch and dextrin can keep vitamin B12 stable for a long time and can be easily manufactured by the ordinary convenient method without employing any speci...
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JPH11124392A |
To obtain the subject new tin compound comprising a C-glycosylated specific aryltin compound and useful as an intermediate or the like for synthesizing an aryl C-glycosyl compound useful for the production or the like of a saccharide cha...
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JPH11116594A |
To obtain a tin compound by reacting a specific aldohexose derivative with a di-substituted tin oxide, which is new and useful as a catalyst or the like capable of providing poly(3-hydroxyalkanoic acid) useful as a biodegradable polymer ...
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JPH11113529A |
To obtain the subject granular or pasty base agent useful for tablets, drinking agents, breads, noodles, pastas, snacks, jellies, and the like by extracting active ingredients containing vitamin B12 and a hypoglycemic peptide from a Porp...
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JPH1185348A |
To provide a data transfer system that can solve such a problem as the disconnection of serial data transfer, generated by the removal of a substrate by more inexpensive means, when data is transferred between substrates through a mother...
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JP2828642B2 |
A nucleoside derivative of formula (1), characterized in that: Y is H or OH or a protected hydroxy group; X is H, a phosphonate group or a phosphoramidite group of formula (II), where R1 and R2 are the same or different, and are selected...
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JP2823959B2 |
Linked nucleosides having at least one functionalized nucleoside that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a peptide, a protein, a water soluble vitam...
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JP2818650B2 |
To obtain the subject new compound having a base-stable, acid- sensitive blocking group and a phosphorus derivative selected to enable addition of the reagent to an oligonucleotide chain, exhibiting selectable cleavability into polynucle...
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JPH10510844A |
Methods for photocleavage of a polymer of ribonucleic acid using a texaphyrin or a texaphyrin metal complex are provided. A preferred method of use is the site-specific cleavage of a polymer of ribonucleic acid and a preferred texaphyrin...
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JPH10508603A |
Methods and compositions for treating urogenital tumors, and particular, cancer of the prostate, bladder, and kidney, with BCNT, are disclosed. Any boron-containing compound that is sufficiently lipophilic to pass through the appropriate...
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JP2782345B2 |
The present invention provides a process for selective production of a 2- alpha -O-glycoside compound of sialic acid which is useful as a starting material or intermediate for medicines and biochemical reagents. The process comprises rea...
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JPH10507751A |
According to the present invention, an antianemic agent for the treatment of anemia caused by iron-deficiency containing iron and difructose. Iron and difructose contained in the said antianemic agent may form a complex, and their approp...
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JP2771326B2 |
Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. Compounds having the formula (I) wherein n is 0 or 1 and when n is 1 R1 is H or...
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JPH10506621A |
PCT No. PCT/GB95/01955 Sec. 371 Date Apr. 14, 1997 Sec. 102(e) Date Apr. 14, 1997 PCT Filed Aug. 17, 1995 PCT Pub. No. WO96/08503 PCT Pub. Date Mar. 21, 1996A compound of formula (I) or salts thereof, where R0 is hydrogen or together wit...
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JP2770162B2 |
To obtain the subject compound useful for therapy against AIDS, etc., by reacting a specific compound with an acid halide, adding silane and then reacting the resultant product with such a reagent as ammonia. This compound is obtained by...
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JPH10506389A |
The present invention relates to derivatives of phosphorylated carbohydrates and pharmaceutical compositions comprising as a pharmaceutically active ingredient at least one of these compounds.
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JP2761439B2 |
Synthetic processes are provided wherein substituted silylalkyl phosphoramidites serve as coupling reagents for preparing phosphate, phosphorothioate, and other phosphorous-containing covalent linkages. Also provided are synthetic interm...
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JP2753748B2 |
The invention relates to a process for the preparation of a sol of a metallic or non-metallic element or compound, such as SiO₂, sulfur, selenium, tellurium, and copper, wherein the sol is formed in a medium which contains at least one...
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JP2751934B2 |
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JP2749092B2 |
Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. Platinum compounds of formula (I) and (II) and (III) are disclosed. Composition...
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JPH10504800A |
Electron-deficient porphyrins are provided, as well as processes and intermediates for their preparation. In preferred embodiments, the electron-deficient porphyrins are prepared by condensing pyrrole derivatives and removing water thus ...
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JP2731636B2 |
The invention relates to the use of complexes and chelates resp., of antibiotics, especially azithromycin, with bivalent and/or trivalent metals in the obtaining of antiulcer drugs, to new complexes and chelates resp., of antibiotics wit...
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JPH10503182A |
This invention relates to chemically modified oligonucleotide conjugates that contain a complexing agent or complex that is bound by a connecting component to the oligonucleotides. In this case, the oligonucleotides are modified in a way...
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JP2727127B2 |
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JP2727289B2 |
For determining 3-deoxyglucosone derivatives which are intermediate metabolites of the Maillard reaction in body fluids such as blood, urine, serum, plasma and the like in gas chromatography/mass spectrometry, <1><3>C-labelled compounds ...
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JP2725710B2 |
Sucrose is reacted with a 1,3-di(hydrocarbyloxy)-1,1,3,3-tetra(hydrocarbyl)distannoxan
e to produce a 1,3-di-(6-O-sucrose)-1,1,3,3-tetra(hydrocarbyl)distannoxane,
which can be acylated to produce a sucrose-6-ester.
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JPH1067683A |
To prevent and treat congestive heart failure(CHF) at a low medical payment by preventing and treating anaemia of a CHF patient by increasing erythrocyte cells by using a compound for treating for the anaemia. A compound for treating ana...
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JPH10502334A |
Vitamin B12 receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are disclosed. The vitamin B12 receptor modulating agents are comprised of a covalently bound ...
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JP2718887B2 |
PURPOSE: To obtain the new compound for surface active agent, wetting agent or the like having a foam stabilizing and foaming activities by reacting a mono- or oligosaccharide with unsaturated oxyalkylalcohols and then reacting the resul...
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