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JPH03503046A |
Bis-platinum complexes of formula I wherein A is a disubstituted 1,4-anthracenedione; X, X min are ligands selected from the group consisting of Cl, Br, OH, CH3 SOCH3.OH or CH3SOCH3.Hal or, taken together, form the anion of a dicarboxyli...
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JPH0339076B2 |
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JPH0339075B2 |
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JPH03127796A |
NEW MATERIAL:A L-xylopyranosideplatinum complex of formula I (R is H, alkyl, alkenyl, etc,: X is halogen, -SCN, -NO3, etc.). EXAMPLE: Dichloro-(benzyl 3,4-diamino-3,4-dideoxy-L-xylopyranoside)platinum. USE: Antineoplastic agents. High in...
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JPH0386893A |
PURPOSE: To obtain the subject analog useful for the preparation of nucleoside having tumor-disintegrative and antiviral properties by oxidizing a specific ribose, and stereoselectively reducing it with a hydride reducer. CONSTITUTION: P...
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JPH03501385A |
Derivatives of platinum (P) with polyanion of deoxyribonucleic acid have the following general formula (I): {[PtCl(NH3)]6(OH)x(H2O)y}n where DNA<-m> = ( C39H55-rO32N15P4 )n<-m>; n = 2000+/-200; when x = 0, y = 12, m = 6n, r = 6; when x =...
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JPH0368595A |
NEW MATERIAL:The compound containing a doxorubicin of formula I (n is cationic charge of platinum and is 2 or 4) and a platinum cation Pt(II) or Pt(IV) chelated with each other at a ratio of 1:1. USE: An antitumor antibiotic substance. P...
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JPH0312078B2 |
Novel O-alkylsilyl derivatives of macrolide antibiotics are disclosed. These compounds have markedly superior taste properties when compared to the corresponding parent compounds.
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JPH03500533A |
Compounds of the formula: wherein each of R1 and R2 is independently selected from the group consisting of halogen, hydroxy, or mono carboxylic acid or R1 and R2 together is a multifunctional carboxylic acid residue which forms a ring wi...
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JPH0327395A |
PURPOSE: To obtain an oligonucleotide by easy separation operation modifying a polymer by a coupling agent to bond the same to a nucleotide to form a nucleoside modified support and activating this support to bond nuleotide to isolate a ...
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JPH0259158B2 |
Modified inorganic polymers represented by the formula wherein P/ &cir& is an inorganic polymer linked to the 3 min or 5 min -0- of the nucleoside through a base hydrolyzable covalent bond; R is H or a blocking group; R1 is a hydrocarbyl...
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JPH02286093A |
PURPOSE: To afford the methane fermentation process with a new added value by a specific treatment of a liquid extract into which vitamin B12 derivatives have been extracted from the bacteria sludge produced by methane fermentation proce...
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JPH02264792A |
NEW MATERIAL:A compound expressed by formula I [R is H, acyl or (substituted) phosphoryl; T is thymin-1-yl; Y1 to Y3 are H, OH or lower alkyloxy, etc.; B is thymin-1-yl, adenin-9-yl or guanin-9-yl, etc.; n is 1-100]. USE: Carrier for iso...
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JPH0244836B2 |
The present invention relates to platinum (II) complexes showing antitumor activity and having the formulae and wherein the stereoisomerism of 1,2-diaminocyclohexane is cis-, trans(+) or trans(-) and R<1> and R<2> when taken together rep...
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JPH0244837B2 |
The present invention relates to platinum (II) complexes showing antitumor activity and having the formulae and wherein the stereoisomerism of 1,2-diaminocyclohexane is cis-, trans(+) or trans(-) and R<1> and R<2> when taken together rep...
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JPH0244838B2 |
The present invention relates to platinum (II) complexes showing antitumor activity and having the formulae and wherein the stereoisomerism of 1,2-diaminocyclohexane is cis-, trans(+) or trans(-) and R<1> and R<2> when taken together rep...
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JPH02229194A |
NEW MATERIAL: A trisubstituted silyl-protected hydroxy derivative of formula I [wherein A is a single bond or a double bond; R1 is isopropyl or sec-butyl; R2 is (protected) OH, keto or a lower alkoxyl; R3 is H, OH, a halogen or keto; pro...
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JPH02223591A |
NEW MATERIAL:Dichloro-3,4-diamino-3,4-dideoxy-L-xylopyranose platinum and dichloro-2,4-diamino-2,4-dideoxy-L-arabinopyranose platinum expressed by formula I and II. USE: An antitumor agent. PREPARATION: The compound of formula I or II ca...
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JPH02134395A |
NEW MATERIAL:α-L-xylopyranoside platinum complex of formula I [X is halogen, -SCN or -NO3, or two X are combined to form a group of formula II-VI (R1 and R2 H, lower alkyl or -OM; M is H or an atom capable of giving a monovalent cation)...
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JPH02500745A |
The invention relates to a process for the treatment of tumors in animals with water soluble square-planar cis platinum(II) four-coordinate complexes comprising different nonovalent and divalent organic cations. Monovalent cations includ...
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JPH0211597A |
NEW MATERIAL: A compd. containing a DNA or RNA sequence bonded to a ruthenium composite represented by formula I [wherein L1 and L2 are each a charge transfer unit; L3 is a group A-X (wherein A is a group represented by formula II, SO or...
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JPH01230595A |
PURPOSE: To eliminate the title silicon group, by hydrolyzing a specific cyclic silicon derivative to cut several sites among siloxane bonds preferentially whereby local eliminating can be done highly selectively, thus the technique can ...
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JPH0133106B2 |
Process for the preparation of 7-acylamino-3-(thio--substituted)methyl-3-cephem-4-carboxyli
c acid 1-oxide derivatives by reacting a 7-acylamino-3-bromomethyl-3--cephem-4-carboxylic acid 1-oxide derivative with a silylated thiol of the g...
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JPH0132232B2 |
Procedure for the preparation of 1-N-substituted derivatives of aminocyclitols, specifically 4,6-di-0- (aminoglycosyl) -1,3-diaminocyclitols sisomycin, verdamicin, tobramycin, gentamicin C1, gentamicin Cla, gentamicin C2, gentamicin C2a,...
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JPH0130809B2 |
(A) Novel antigen derivs. (I) consist of an antigen to which at least one muramyl peptide is covalently bonded, opt. via a bridging gp. Prefd. cpds. are of formula (Ia): A-[(Z)m-MP]n (Ia) (A is an antigen residue; Z is a bridging gp.; MP...
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JPH01100187A |
NEW MATERIAL: A metal-contg. oligosaccharide-polysulfate compd., contg. the metal ions of the elements of atomic numbers 21 to 29, 42, 44 or 56 to 83. EXAMPLE: A sucrose-polysulfate-gadolinium compd. USE: A diagnostic agent for NMR- and ...
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JPH0193530A |
PURPOSE: To obtain a composition, comprising a specific platinum compound and a nontoxic insert carrier and having anticancer actions on malignant animal tumors. CONSTITUTION: This composition comprises a compound represented by formula ...
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JPS6427500A |
PURPOSE: To obtain a substrate for a β-galactosidase, related to a liposome immunoassay, increased in sensitivity and stable in an aqueous buffer by preparing the substrate for the β-galactosidase from a composition represented by a sp...
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JPS6362508B2 |
3-(Halogenovinyl- or propenyl-)-2,2-dimethyl cyclopropane-1-carboxylic acid esters, which are precursors of, or may themselves be, pyrethroid insecticides, are prepared by the reaction of certain halogenopentadienes with an alkyl diazoac...
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JPS6361955B2 |
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JPS63290893A |
Anthracycline glycosides of formula (I): wherein R1 and R2 are independently selected from hydrogen, methyl, ethyl or methoxy and pharmaceutically acceptable acid addition salts thereof, which are useful in treatment of human cancer, are...
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JPS6357427B2 |
1 alpha ,25-Dihydroxy-26,27-dimethylcholecalciferol represented by formula: (I) This compound is prepared by irradiating 26,27-dimethylcholesta-5,7-diene-1 alpha ,3 beta ,25-triol with ultraviolet light, and is useful for the prevention ...
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JPS6354699B2 |
3-Halogenoethyl- or propyl-2,2-dimethylcyclopropane carboxylic acid esters, which are intermediates in the preparation of synthetic pyrethroids, are prepared by the reaction of certain halogenopentenes or hexenes with a diazoacetic ester...
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JPS6352014B2 |
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JPS6347720B2 |
The S-gold salt of 2,3,4,6-tetra-O-acetyl-1-thio- beta -D-glucopyranose reacts with triethylphosphine in an organic solvent to produce auranofin.
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JPS63229057A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS6345396B2 |
Cis-diammineplatinum(II) organophosphate complexes where the organophosphate moiety is a glycerophosphate or a monosaccharide phosphate moiety are prepared by reaction of cis-diaquodiammineplatinum(II) salts with alkali metal organophosp...
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JPS63152309A |
PURPOSE: To obtain an external preparation for skin useful as a skin cosmetic or a wound remedy, etc., having preventing effects on skin aging, containing a specific coenzyme selected from 5'-deoxyadenosylcobalamin, flavin-adenine dinucl...
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JPS6330316B2 |
Modified inorganic polymers represented by the formula wherein P/ &cir& is an inorganic polymer linked to the 3 min or 5 min -0- of the nucleoside through a base hydrolyzable covalent bond; R is H or a blocking group; R1 is a hydrocarbyl...
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JPS63135861A |
A method for detecting the presence of nucleic acid hybridization comprising (a) immobilizing onto a solid support a first nucleic acid, (b) contacting under hybridizing conditions the immobilized first nucleic acid of step (a) with a la...
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JPS63130599A |
NEW MATERIAL:The compound of formula I (P is phosphoric acid segment; S is sugar segment; B is nucleic acid base segment; Sig is chemical segment bonded to the nucleic acid base segment B through covalent bond; R is a spacer segment link...
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JPS6324519B2 |
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JPS6316390B2 |
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JPS6368546A |
Compounds of the general formula I I in which R1 represents a hydrogen atom or an alkyl group of the formula CH3(CH2)n-where n=0 to 5, R2 represents a hydrogen atom when X is a carbamoyl group, an alkyl group having 1 to 6 carbon atoms, ...
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JPS6344591A |
PURPOSE: To selectively obtain the titled compound useful as an antitumor agent, by reacting a specific platinum complex compound with uridine or thymidine in the presence of hydrogen peroxide, etc. CONSTITUTION: A compound expressed by ...
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JPS637557B2 |
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JPS6335593A |
Compounds of the forulae I and Ia (I) and (Ia) in which R1 is a group which can be transferred to carbonyl or imine compounds, for example alkyl, allyl, vinyl or the radical of an enol or enamine, R2 is, for example, cyclopentadienyl, R3...
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JPS637194B2 |
Platinum complexes of the following formula useful as antitumor agents with less nephro-toxicity and higher water solubility than cisplatin: wherein X and Y respectively or taken together represent a mono- or di-valent residue of hydroxy...
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JPS6317891A |
PURPOSE: To obtain the titled complex easily absorbable in plant body, utilizable for the culture of edible plant and useful for the prevention and remedy of cancer, diabetes, cardiac disease, etc., by reacting a monosaccharide with germ...
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JPS631319B2 |
PURPOSE:To obtain the title substance useful for preparing antibiotic amikacin, by forming a complex from an aminoglycoside antibiotic, e.g. kanamycin, gentamicin, or sisomicin, with zinc cations, and by acylating the complex. CONSTITUTI...
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