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JP2004107230A |
To provide a carbosilane dendrimer which can highly be purified into the purified compound capable of being used as a medicine and has a strong vero toxin-neutralizing activity.This galabiose-bonded carbosilane dendrimer compound is repr...
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JP2004099575A |
To develop a saccharide derivative that functions as a saccharide donor and as a saccharide receptor and to simply synthesize mucin core 2 class by using the developed derivative.A D-galactosamine derivative bearing a free hydroxy group ...
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JP3512792B2 |
PCT No. PCT/NL91/00126 Sec. 371 Date Oct. 29, 1993 Sec. 102(e) Date Oct. 29, 1993 PCT Filed Jul. 16, 1991 PCT Pub. No. WO92/01699 PCT Pub. Date Jun. 2, 1992Pt-containing compound with the formula {PtII(w)(x)(y)(z)} or {PtIV(u)(v)(w)(x)(y...
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JP3507521B2 |
PURPOSE: To obtain a medicine for articular rheumatism, having an excellent anti-articular rheumatism effect, low in toxicity and capable of effectively exhibiting its effect by a small dose. CONSTITUTION: This medicine for articular rhe...
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JP2004506631A |
The invention relates to perfluoroalkyl-containing complexes comprising sugar residues of the general formula (I), wherein R represents a mono- or oligosaccharide residue bound in the 1-OH or 1-SH position, Rf represents a perfluorated c...
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JP3502855B2 |
To provide an improved process for detecting and determining a nucleic acid sequence. The process comprises the syntheses of a single-stranded RNA, a single-stranded DNA and a double-stranded DNA, and the subsequent detection of an objec...
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JP2003306496A |
To provide a method of efficiently purifying a 5-position protected 2'-deoxycytidine of which efficient purification is conventionally difficulty.The citidine compound is clathlated with an alcohol of 1-5 carbon atoms and the clathlation...
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JP2003300883A |
To provide film-coated tablets free of cracks even under high humidity, reduced in unpleasant odor and taste and stable with time.The film-coated tablets are characterized by being coated with a film layer formulated with hydroxypropylme...
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JP2003528806A |
The present invention relates to compounds of Formula I: wherein: a) represents a 6-membered heterocyclic aromatic ring in which X1 is N and X2, X3 and X4 are each independently CR''; R'' is independently H, halogen, cyano, hydroxy, C1-C...
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JP2003527324A |
Heterocyclic aromatic amides (HAA) according to Formula (I) wherein X1-X4, M, Z, and A are herein defined. The invention also encompasses hydrates, salts and complexes thereof. These compounds are useful as antifungal agents.
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JP2003526615A |
A compound which is a complex of formula (I) wherein each X, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, aralkyl, alkaryl, acyl, halogen, haloalkyl, haloaryl, hy...
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JP2003212893A |
To provide a sugar-containing carbosilane dendrimer having high biocompatibility, having properly designed molecular weight and shape, and having high disintoxication properties and antivirus properties.This amide-linked sugar chain-cont...
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JP2003514023A |
Inflammation is affected by topical application of a boron containing compound/complex in which a central tetrahedral boron atom is covalently bound to four ligands. At least one of the ligands preferably includes an oxygen, nitrogen, ca...
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JP2003512338A |
The invention provides cobalamin derivatives which are useful for medical treatment and diagnosis.
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JP2003073391A |
To provide a ligand that can trap the Vero toxin by changing the chemical structure of inexpensive trehalose.Trehalose, a disaccharide from tow glucoses, is used as a starting substance and the hydroxy group in the 4-position in one gluc...
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JP2003055394A |
To provide a synthetic compound which is useful for obtaining an oligo saccharide specifically bound to a target nucleic acid in the specific sequence of a gene, and to enable the enhancement in the effect of an anti-gene method. This di...
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JP2002538085A5 |
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JP2002538085A |
The invention provides collections of orthogonally-protected monosaccharides as universal building blocks for the synthesis of glycoconjugates of non-carbohydrate molecules, neo-glycoconjugates and oligosaccharides. This orthogonal prote...
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JP2002535277A |
The invention relates to products for complete nutrition of infants. The products are characterised by the type and amount of protein and carbohydrate and the increased levels of folic acid, vitamin B6 and vitamin B12 or their functional...
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JP2002533469A |
A new erythromycin A 9-oxime compound which can be effectively used as intermediates for the preparation of erythromycin A oxime compound, a process for preparing the same and a process for preparing 6-O-alkyl erythromycin A or its oxime...
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JP2002526549A |
One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal precursors. In another aspect of the prese...
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JP2002521317A |
Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.
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JP2002520330A |
A cleaveable linker of formula (I) attaches the analyte to the reporter groups associated with the analyte, (b) cleaves the reporter group from the analyte, and (c) the reporter. Provided is a method of characterizing an analyte, includi...
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JP2002520329A |
Provided is a method for characterising an analyte, which method comprises: a) providing a compound in which the analyte is attached by at cleavable linker to a mass marker relatable to the analyte; b) cleaving the mass marker from the a...
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JP2002515001A |
Porphyrins substituted with, for example, vinyl and acetylene groups are provided, along with polymers containing the same. In preferred embodiments, the substituted porphyrins are prepared by coupling halogenated porphyrins with anionic...
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JP3279502B2 |
To provide a novel modified nucleotide which contains a nucleotide prepared by introducing a detectable signaling zone into a naturally occurring nucleotide and enables stable, economical, prompt and reproducible detection of a nucleic a...
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JP3279503B2 |
To obtain a new nucleotide derivative containing biotin, iminobiotin, lipoic acid, etc., bonded to pyrimidine ring or purine ring through covalent bond and useful as a substitute for radioactive isotope for the detection of nucleic acid....
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JP3268299B2 |
To provide a Gal-Gal disaccharide donor useful for the production of a sulfated and phosphorylated trisaccharide serine β-Gal(1→3)β-Gal(6-SO3 Na)(1→4)-β-Xyl(2-OPO3Na2)Ser(Gal is galactose; Xyl is xylose; and Ser is serine). (2,3,4...
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JP2002508386A |
The invention provides conductive polymers comprising metal-containing nucleic acid duplexes electrically coupled to an electron source. Methods for making conductive metal-containing nucleic acid duplexes are provided, comprising subjec...
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JP3265548B2 |
The present invention is directed toward a novel process of 2'-exocyclic vinylfluoride derivatives of cytidine analogues (I) for use as ribonucleotide reductase inhibitors, wherein V is oxy or methylene and Y is hydrogen, C1-C4 alkyl or ...
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JP2002069093A |
To provide a constructing block of thymine glycol, and to provide a method for synthesizing a long chain DNA having the thymine glycol in a high yield and in high purity by using the block.This thymine glycol constructing block of the ge...
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JP3258783B2 |
PURPOSE: To obtain a new oligosaccharide derivative useful as a separating agent, etc., for chromatography by oxidizing a reducing terminal of an optically active oligosaccharide, subjecting the oxidized terminal to chemical treatment wi...
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JP3256236B2 |
Nucleosides and linked nucleosides functionalized to include alkylthiol chemical functionality at ribofuranosyl positions, nucleosidic base positions, or on internucleoside linkages. In certain embodiments, the compounds of the invention...
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JP3246946B2 |
PURPOSE: To improve the brittleness of inorganic glass by homogeneously dispersing a saccharide derivative having a urethane bond, a urea bond and/or an amide bond in an inorganic compound matrix. CONSTITUTION: A saccharide such as sucro...
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JP2001524320A |
This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets ...
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JP2001328997A |
To provide a radioactive medicine enabling imaging of tumor part, determination of therapeutic effect thereof or treatment by radiation by being labeled with a nuclide having half life enough to supply to open markets and taken into a ce...
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JP3231765B2 |
Demethylepipodophyllotoxin- beta -glucosides are prepared by allowing demethylepipodophyllotoxin to react with a 2,3-di-O-ester of a 1-O-trialkylsilyl-4,6-O-alkylidene- beta -D-glucose derivative in the presence of a Lewis acid. The 4,6-...
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JP2001316270A |
To obtain a photosensitizer having excellent tumor selectivity, not requiring rays with short wavelength which causes photoexcitation essential for photosensitization.This photo-cleavage of RNA using texaphyrin comprises using photosensi...
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JP2001520679A |
Compositions and methods are disclosed which facilitate purification of oligomers and other compounds. The disclosed compositions are silyl compositions that can be directly coupled, or coupled through a linking group, to a compound of i...
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JP3224538B2 |
Marker components are provided which are compatible with aqueous solutions, exhibit favorable fluorescence properties and exhibit decreased non-specific binding to macromolecules in solution. These marker components are useful in applica...
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JP2001515466A |
Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.
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JP3172787B2 |
PURPOSE: To increase hydlophilicity, avoid coloration during aging, and improve biological safety by reacting a specific organohydrogensiloxane with a sugar deriv. in the presence of a catalyst. CONSTITUTION: 1 equivalent of an organohyd...
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JP3170241B2 |
To obtain a new nucleic acid monomer comprising a specific polyfunctional nucleic acid monomer, and useful for contamination of a selective cleaving site and an abasic site to an oligonucleotide chain, and determination of the oligonucle...
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JP3161730B2 |
PCT No. PCT/SE91/00797 Sec. 371 Date Jul. 24, 1992 Sec. 102(e) Date Jul. 24, 1992 PCT Filed Nov. 25, 1991 PCT Pub. No. WO92/09615 PCT Pub. Date Jun. 11, 1992Support system for the synthesis of oligonucleotides wherein the first nucleosid...
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JP2001505533A |
The present invention relates to Glutathione S-transferase (GST)/Reduced Glutathione (GSH) as a means for the in-vivo release of a drug that has been conjugated to specific electrophilic moieties via a sulfonamide bond. The drug may be a...
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JP2001505543A |
The present invention relates to a support system for solid phase synthesis of oligomers, such as oligonucleotides, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a me...
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JP2001097984A |
To provide a new near infrared-absorbing compound that scarcely absorbs the light in the visible ray wavelength range, but strongly absorbs the light in the near infrared ray wavelength range and has excellent solubility in water. The ob...
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JP2001064297A |
To obtain a new bicycle nucleoside compound having excellent anti- sense or anti-gene activity and useful as an intermediate for producing an artificial oligonucleotide analogue which is stable in organism. This new compound is represent...
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JP3138834B2 |
PURPOSE: To simply obtain the subject compound from a readily available raw material by reacting a D-arabinofuranoside derivative with a lower alkyl-metallic compound, then sulfonylating the reaction product, reacting the prepared sulfon...
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JP2001501596A |
The present invention relates to bioconjugates and the delivery of bioactive agents which are preferably targeted for site-specific release in cells, tissues or organs. More particularly, this invention relates to bioconjugates which com...
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