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WO/2002/014309A1 |
The invention relates to perfluoroalkyl-containing complexes comprising sugar residues of the general formula (I), wherein R represents a mono- or oligosaccharide residue bound in the 1-OH or 1-SH position, R¿f? represents a perfluorate...
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WO/2002/002588A1 |
Carbosilane dendrimer compounds containing sugar chains in the chemical structure and having verotoxin-neutralizing and antiviral activities. Also, carbosilane dendrimer compounds having terminal sialyl lactose to which viruses are speci...
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WO/2001/096356A1 |
Antisense molecules which act on both directions of the inhibition and restoration of the expression of a gene function and are capable of on/off switching appropriately depending on the external environment; and a method of reversibly c...
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WO/2001/092283A2 |
The invention provides cobalamin derivatives linked to a cardiovascular agent, as well as pharmaceutical compositions comprising the compounds and methods for using the compounds in treatment or diagnosis of a cardiovascular disease.
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WO/2001/092288A2 |
The invention provides cobalamin derivatives linked to an antibiotic and/or an imaging agent, as well as pharmaceutical compositions comprising the compounds and methods for using the compounds in treatment or diagnosis of a microbial in...
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WO/2001/091807A2 |
The invention provides, in a general sense, a new labeling strategy employing ?99m¿Tc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to ?99m¿Tc for use as an imaging agent for tissue-spec...
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WO/2001/070724A1 |
The present invention relates to a complex comprising one or more radioisotopes selected from the group consisting of ?99m¿Tc, ?188¿Re and ?186¿Re chelated to a glucose derivative having an intramolecular nitrogen or sulfur atom, whic...
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WO/2001/042271A1 |
A novel industrially excellent process for the production of methylcobalamin useful as drug or the like, characterized by methylating cyanocobalamin or hydroxocobalamin in the presence of a reducing agent and a water-soluble methylating ...
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WO/2001/035966A1 |
Inflammation is affected by topical application of a boron containing compound/complex in which a central tetrahedral boron atom is covalently bound to four ligands. At least one of the ligands preferably includes an oxygen, nitrogen, ca...
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WO/2001/028592A1 |
The invention provides cobalamin derivatives which are useful for medical treatment and diagnosis.
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WO/2001/014339A2 |
Heterocyclic aromatic amides (HAA) according to Formula (I) wherein X¿1?-X¿4?, M, Z, and A are herein defined. The invention also encompasses hydrates, salts and complexes thereof. These compounds are useful as antifungal agents.
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WO/2001/005769A2 |
Heterocyclic aromatic amides having a hydroxy group adjacent to the amide functionality of Formula (I) wherein (a) represents a 5- or 6- membered heterocyclic aromatic ring in which (i) each of X¿1?-X¿4? is O, S, NR', N, CR' or a bond;...
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WO2000020428A9 |
One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal precursors. In another aspect of the prese...
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WO/2000/057887A1 |
The present invention is directed to salt-free and essentially salt-free $i(p)-boronophenylalanine-carbohydrate or $i(p)-boronophenylalanine-polyol complexes, as well as methods for making such compounds. In addition, the present inventi...
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WO/2000/056740A1 |
The present invention provides arylboronic acid reagents useful for incorporation into modified oligonucleotides and polynucleotides. The modified oligonucleotides and polynucleotides thus produced are useful in bioconjugation reactions ...
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WO/2000/056734A1 |
The invention relates to compounds of formula (I), their tautomers, their salts and their water addition products, the radicals and symbols A, D, E, G and L having the meanings given in claim no. 1 and for example A = N, CR; D = C or N, ...
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WO/2000/050431A1 |
A compound which is a complex of formula (I) wherein each X, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, aralkyl, alkaryl, acyl, halogen, haloalkyl, haloaryl, hy...
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WO/2000/043013A1 |
The invention relates to products for complete nutrition of infants or diseased or elderly persons. The products are characterised by increased levels of folic acid, vitamin B6 and vitamin B12 or their functional equivalents. These produ...
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WO/2000/042868A1 |
The invention relates to products for complete nutrition of infants. The products are characterised by the type and amount of protein and carbohydrate and the increased levels of folic acid, vitamin B6 and vitamin B12 or their functional...
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WO/2000/042057A1 |
The invention provides collections of orthogonally-protected monosaccharides as universal building blocks for the synthesis of glycoconjugates of non-carbohydrate molecules, neo-glycoconjugates and oligosaccharides. This orthogonal prote...
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WO/2000/039142A1 |
The present invention relates to a new erythromycin A 9-oxime compound which can be effectively used as intermediates for the preparation of erythromycin A oxime compound, a process for preparing the same and a process for preparing 6-O-...
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WO/2000/004865A2 |
Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.
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WO/2000/002894A1 |
Provided is a method for characterising an analyte, which method comprises: (a) providing a compound in which the analyte is attached by a cleavable linker to a reporter group relatable to the analyte, the linker having formula (1): wher...
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WO/2000/002893A1 |
Provided is a method for characterising an analyte, which method comprises: a) providing a compound in which the analyte is attached by a cleavable linker to a mass marker relatable to the analyte; b) cleaving the mass marker from the an...
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WO/1999/065930A1 |
This invention relates to methods for preparing vitamin B¿12? (VB¿12?) derivatives suitable for linking to a polymer, nanoparticle or therapeutic agent, protein or peptide. The methods involve reacting the 5'OH group of VB¿12? or an a...
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WO/1999/057323A1 |
The invention relates to novel chemically modified nucleic acids with enhanced lability towards solid supports, such as glass. These modified nucleic acids can be readily affixed to solid supports, for instance, a glass surface, without ...
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WO/1999/032501A1 |
The present invention provides a compound having the following formula: N-L-M wherein N comprises one or more nucleic acid bases, L is either a direct bond between N and M or L comprises a linker moiety, and M comprises a mass marker com...
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WO/1999/031115A1 |
The invention provides conductive polymers comprising metal-containing nucleic acid duplexes electrically coupled to an electron source. Methods for making conductive metal-containing nucleic acid duplexes are provided, comprising subjec...
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WO/1999/027138A1 |
This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets ...
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WO/1999/009044A1 |
The ribonucleoside-derivatives serve for the synthesis of ribonucleic acids and comprise a triple substituted silyloxymethyl-group as a protection-group on the oxygen atom in 2'-position. The ribonucleoside-derivatives may be suitably pr...
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WO/1999/000402A1 |
Compositions and methods are disclosed which facilitate purification of oligomers and other compounds. The disclosed compositions are silyl compositions that can be directly coupled, or coupled through a linking group, to a compound of i...
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WO/1998/045304A1 |
The present invention is concerned with a trans-platinum based compound for use in a method for labelling a bio-organic molecule, having formula (I), wherein A represents a reactive moiety for attachment to a label, D represents a reacti...
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WO/1998/024429A1 |
Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.
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WO/1998/015564A1 |
The present invention provides improved methods for labeling nucleotides. The method of the invention for labeling nucleotides comprises the steps of: reacting a reactive moiety of a linker, which linker is a platinum compound having a s...
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WO/1998/008857A1 |
The present invention relates to a support system for solid phase synthesis of oligomers, such as oligonucleotides, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a me...
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WO/1998/008859A1 |
The present invention relates to bioconjugates and the delivery of bioactive agents which are preferably targeted for site-specific release in cells, tissues or organs. More particularly, this invention relates to bioconjugates which com...
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WO/1998/008522A1 |
Multivitamin products targeted to specific groups.
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WO/1998/007733A1 |
Texaphyrin metal complex-oligonucleotide and -oligonucleotide analog conjugates are provided where the texaphyrin is bound to an internal linkage of the oligonucleotide or oligonucleotide analog, the conjugates having catalytic activity ...
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WO/1998/005672A1 |
Modified nucleotides and polynucleotides which are useful in hybridization assays for the detection of target genes are provided. The modified polynucleotides contain at least one boronic acid moiety which is attached to a nucleotide bas...
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WO/1998/000173A2 |
The present invention relates to Glutathione S-transferase (GST)/Reduced Glutathione (GSH) as a means for the $i(in-vivo) release of a drug that has been conjugated to specific electrophilic moieties via a sulfonamide bond. The drug may ...
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WO/1998/000435A2 |
A technique is provided for linking an oligonucleotide, such as a single strand of DNA, to another moiety or solid phase. An oligonucleotide is provided with a linking functionality that can be defined by six neighboring hystaminyal puri...
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WO/1997/048722A1 |
The invention discloses a bisubstrate analogue effective at inhibiting pyridine nucleotide-dependent enzyme(s). Additionally, disclosed is a method for manufacture of said binding substrate analogue and a complex and drug relating to sam...
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WO/1997/046568A1 |
The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosp...
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WO/1997/027049A1 |
Substituted compounds having relatively large molecular first order hyperpolarizabilities are provided, along with devices and materials containing them. In general, the compounds bear electron-donating and electron-withdrawing chemical ...
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WO/1997/018231A1 |
A compound useful for in vivo imaging of organs and tumors is provided of formula (1) wherein (a) is cobalamin, (b) derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is a chelating group, optionall...
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WO/1997/016456A1 |
According to the present invention, provided are novel nucleoside derivatives having anti-viral activity, in particular, anti-HBV (anti-Hepatitis-B Virus) activity, represented by general formula (I), wherein R1 represents hydrogen, phos...
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WO/1997/014711A1 |
Vitamin B12 receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are disclosed. The vitamin B12 receptor modulating agents are comprised of a covalently bound ...
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WO/1997/009337A1 |
The invention concerns metallocene-phosphoramidite conjugates comprising one or a plurality of metallocenes and one or a plurality of phosphoramidites. The invention further concerns a process for preparing the metallocene-phosphoramidit...
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WO/1996/040712A1 |
The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosp...
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WO/1996/040253A2 |
Methods for photocleavage of a polymer of ribonucleic acid using a photosensitive texaphyrin are provided. A preferred method of use is the site-specific photocleavage of a polymer of ribonucleic acid and a preferred photosensitive texap...
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