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WO/1992/011280A1 |
By the method according to the invention condensation of 11beta,16alpha,17alpha,21-tetrahydroxy-1,4-pregnadiene-3,20-
dione 21-acetate with n-butyric aldehyde is carried out, in the known way, in the medium of hydrofluoric acid of concen...
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WO/1992/009619A1 |
The present invention is directed to 2beta,19-(methyleneamino)androst-4-ene-3,17-dione and the corresponding 17beta-ol which are useful as aromatase inhibitors. The compounds are prepared by the cyclization of an appropriate 19-N-protect...
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WO/1992/009618A1 |
Described are 8-ene-19, 11$g(b)-bridged steroids of general formula (I) which have a new structural feature in the form of a double bond between the 8 position and the 9 position. Also described is a method of preparing them. The substit...
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WO/1992/000992A1 |
The invention discloses [3,2-c]pyrazole and [3,2-d]triazole steroids of general formula (I), wherein X stands for the CH group or a nitrogen atom, R?1¿ stands for an alkylsulfonyl group R-SO¿2? and also, if X is the CH group, for an ac...
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WO/1991/019731A1 |
Novel angiostatic $g(D)?4,9(11)�-steroids (I), C�21?-oxygenated steroids (II) and other known steroidal compounds have been found to be useful in treating angiogenesis in mammals who have a need for the same. These steroids are usefu...
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WO/1991/012239A1 |
The invention provides new 24, 26, and/or 27 homologated vitamin D2 compounds, such as 26,27-dihomo-1alpha-hydroxyvitamin D2, 26,27-dihomo-1alpha-hydroxy-24-epi-vitamin D2 26,27-dihomo-1alpha,25-dihydroxy-24-epi-vitamin D2 and certain hy...
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WO/1991/012240A1 |
This invention relates to hydroxylated derivatives of vitamin D�2? and a process for preparing such compounds. In particular, a process for preparing the 24-epimer of 25-hydroxyvitamin D�2?, the 24-epimer of vitamin D�2? and the co...
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WO/1991/010743A1 |
The invention is directed to the control of cellular autophagy, cellular agglutination and the immobilization of motile cells. Such control is useful in, for example, the treatment of cancer, contraception, termination of pregnancy, remo...
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WO/1991/004984A1 |
The present invention relates to a novel process for the manufacture of (22 R,S)-16alpha, 17alpha-butylidenedioxy-11beta, 21-dihydroxypregna-1,4-diene-3,20-dione (I) by reacting 11beta, 16alpha, 17alpha, 21-tetrahydroxypregna-1,4-diene-3...
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WO/1991/003245A1 |
Pharmaceutical compositions useful in the treatment of ophthalmic inflammation and methods of treating ophthalmic inflammation with those compositions ar disclosed. The compositions contain a combination of a glucocorticoid and an angios...
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WO/1991/001991A1 |
Introduction of a C-12 substituent and especially a beta C-12 substituent into glucocorticoids improves their usefulness as topical anti-inflammatories by increasing their topical activity relative to their systemic activity, thus reduci...
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WO/1990/015608A1 |
The method of enhancing egg laying in the turkey which comprises administering to a turkey hen an amount of epostane sufficient to increase significantly the number of eggs laid during the egg laying cycle of said turkey hen is disclosed.
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WO/1990/015045A1 |
The present invention is an oxidative process for the conversion of 21-unsaturated progesterones (I) to the corresponding 3,5-secoandrost-5-one-3,17$g(b)-dioic acids (II) by use of either ozone or an oxidizing agent, which are useful int...
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WO/1990/014354A1 |
Steroids with a 9$g(a)-hydroxy-19,11$g(b) bridge, of general formula (I), in which A, B, R?1¿, R?2¿, G, Z, R?4¿-Y- and R?4'¿-Y'- have the meanings given in the description. The steroids of general formula (I) have an antigestagenic a...
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WO/1990/009394A2 |
The process of the present invention is a process for the preparation of an 11-oxygenated steroid of formula (II) which comprises (1) contacting a 9alpha-halo steroid of formula (I) with a metal selected from the group consisting of tin ...
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WO/1990/004968A1 |
Tannin derivatives are a new class of HIV reverse transcriptase inhibitor. Among these compounds are new galloylquinic acids having at least one depside galloyl group. These compounds inhibit the growth of HIV in cells with low cytotoxic...
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WO/1990/000560A1 |
Steroid compounds represented by general formulae (I), (II) or (III), wherein R1 and R2 each represents a hydrogen atom or a hydroxyprotecting group, R represents -CH2-X, a carboxyl group or a protected carboxyl group, X represents a sub...
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WO/1990/000174A1 |
The invention concerns 13-Alkyl-11beta-phenylgonanes of general formula (I), wherein Z, R1, R2, R3 and R4 have the meaning given, a process for their preparation, pharmaceutical preparations containing these compounds, and their use for ...
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WO/1989/012448A1 |
An 11beta-aryl-19-norprogesterone steroid of formula (I): wherein (i) R1 is H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, OH, OC(O)CH3, or OC(O)R5, wherein R5 is C2-8 alkyl, C2-8 alkenyl, C2-8 alkynyl or aryl, R2 is H, R3 is H, C1-4 alkyl, ...
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WO/1989/011282A1 |
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase including using these compounds...
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WO/1989/008116A1 |
The invention relates to compounds having formula (I), wherein R1 is H or an acyl group having 1-12 carbon atoms, R2 and R3 are an alkyl or aralkyl group having 1-12 carbon atoms, or when taken together form with the nitrogen atom a hete...
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WO/1988/009336A1 |
Substantially pure saponins are disclosed. The saponins of the present invention are useful as immune adjuvants. Disclosed as well are immune response-provoking compositions comprising an antigen in admixture with the substantially pure ...
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WO/1988/007545A1 |
Pregnane derivatives represented by general formula (I) (wherein A1 represents a hydrogen atom or a hydroxy group, A2 represents a substituent such as a hydroxy group when A1 represents a hydrogen atom, or A2 represents a hydrogen atom w...
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WO/1988/007051A1 |
New 19, 11beta-bridged steroids having the general formula (I), in which R' signifies a methyl or ethyl residue; R2 signifies a hydrogen or chlorine atom or a C1-C4 alkyl residue; B and G, which are identical or different, signify respec...
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WO/1988/003419A1 |
An inhalation device, comprising an inhalation chamber (1) fitted with an inlet duct (2) and a mouthpiece (3), the former receiving a spray (6) containing a substance to be inhaled. Said inhalation chamber (1) is substantially in the sha...
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WO/1988/003534A1 |
17beta-Cyano-17alpha-hydroxy steroids (I) are transformed to 17alpha-halo silyl ethers (II) which are intermediates useful in the production of progesterones (V), 17-hydroxyprogesterones (VI), corticoids (VII) and 21-halo corticoids (III...
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WO/1987/007612A1 |
Process for the production of a DELTA17(20)-steroid of formula (II) which comprises starting with a 16-unsaturated corticoid of formula (I) and contacting the 16-unsaturated corticoid (I) with a methylating agent in the presence of a cop...
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WO/1987/005908A1 |
Products having the formula (I) wherein R1 is an aryl or aralkyl, R2 is a hydrocarbonated radical (1-18 carbon atoms), the dotted lines indicate an optional bond, the cycles A, B and C represent (II), (III), (IV), (V), (VI); R' and R'' a...
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WO/1987/005028A1 |
Compounds of formula (I), wherein one X is COOR, CH2COOR, CH(COOR)2, CONHR, CH2CONHR, or CN; remaining X's are H, F, CH3, OH, COOR, CH2COOR, CH(COOR)2, CONHR, CH2CONHR, or CN; Y is (i1), (i2), (i3), (i4), or (i5); R is H, alkyl of 1-5 ca...
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WO/1987/004168A1 |
Compounds of formula (I), ADR1 = H or C1-C3 alkyl, R2 = an (alkyl-substituted) aminodeoxy or aminodideoxy or aminotrideoxy sugar residue of the D and L series, the glycosidic linkage being alpha or beta BD and their pharmaceutically acce...
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WO1987004167A2 |
Compounds of formula (I) (either R1 = OH, C1-C4 alkoxy and R2 = H, C1-C4 alkyl, or R1 + R2 = a chemical bond; R3 = an aminodeoxy or aminodideoxy or aminotrideoxy sugar residue of the D and L series, the glycosidic linkage being alpha or ...
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WO/1987/004167A1 |
Compounds of formula (I) (either R1 = OH, C1-C4 alkoxy and R2 = H, C1-C4 alkyl, or R1 + R2 = a chemical bond; R3 = an aminodeoxy or aminodideoxy or aminotrideoxy sugar residue of the D and L series, the glycosidic linkage being alpha or ...
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WO/1987/002672A1 |
Novel tetrahydro steroids which are useful in inhibiting angiogenesis and have the following structure: A compound of formula (I), wherein R15 is = O or -OH; wherein R23 with R10 forms a cyclic phosphate of formula (II) or wherein R23 is...
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WO/1986/003299A1 |
An immunoassay for cholesterol epoxide. To prepare the antibodies used in the immunoassay, novel immunogens, are prepared which comprise a 3,5(6)-transdiaxial-dihydroxycholestane-6(5)-yl-hapten adduct linked to a covalently bonded bridge...
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WO/1986/002078A1 |
New 24-homo-vitamin D compounds, methods for preparing the same and novel intermediate compounds. The compounds are characterized by vitamin D-like activity of the order of 1alpha,25-dihydroxyvitamin D3, the recognized circulating hormon...
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WO/1985/005622A1 |
New derivatives of vitamin D3 and specifically (22E,24R)-1,24-dihydroxy-DELTA22-vitamin D3 and (22E,24S)-1,24-dihydroxy-DELTA22-vitamin D3. The compounds exhibit vitamin D-like activity in their ability to stimulate intestinal calcium tr...
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WO/1985/003939A1 |
Novel vitamin D derivatives, analogs of vitamin D2 compounds which lack the 24-methyl substituent and are identified as 1alpha-hydroxy-28-norvitamin D2 and 1alpha,25-dihydroxy-28-norvitamin D2. The compounds of the invention are characte...
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WO/1985/003299A1 |
Novel 1-hydroxylated vitamin D compounds containing a 22, 23-cis double bond in the side chain. The compounds are characterized by an unexpectedly high binding affinity for the protein receptor forecasting their ready applicability as su...
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WO/1985/003300A1 |
Novel vitamin D derivative, 1alpha,25-dihydroxy-22Z-dehydrovitamin D2. The compound is characterized by unexpectedly high ability to raise serum calcium levels. The compound could therefore, find ready application as a substitute for vit...
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WO/1985/002189A1 |
Preparation of hydroxylated compounds of the vitamin D2 series and specifically to a process for synthesizing 1alpha,25-dihydroxy vitamin D2, 1beta,25-dihydroxyvitamin D2, their corresponding 5,6-trans isomers and the C-24 epimers of the...
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WO/1984/004527A1 |
Novel derivatives of vitamin D2 and more specifically 1alpha,25-dihydroxylated compounds of the vitamin D series. A process for the preparation of such derivatives is also provided as are certain intermediates in such process. The invent...
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WO/1984/001155A1 |
Hydroxylated derivatives of vitamin D2., processes for preparing such compounds, intermediates utilized in such processes and certain isotopically labelled vitamin D2 compounds. The vitamin D2 derivatives would find application in the tr...
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WO/1983/004256A1 |
The method permits the use of cholenic acid or an ester of cholenic acid as the starting material and the preparation of a compound which can be readily converted into a highly active derivative of vitamin D, 26,26,26,27,27,27-hexafluoro...
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WO/1983/003099A1 |
The invention relates to products having the general formula I, wherein R1 is thienyl or phenyl optionally substituted, furyl, cycloalkyl, naphtyl, phenyl-phenyl, alkyl or alkenyl; R2 is methyl or ethyl; R3 is H, OH, alkyl, alkenyl, opti...
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WO/1983/001065A1 |
Compounds represented by the general formula:$(10,)$wherein X represents$(15,)$a process for extracting them from plants belonging to genus Solanum, and a process for preparing 16-dehydropregnenolone therefrom. 16-Dehydropregnenolone is ...
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WO/1983/000335A1 |
New derivative of vitamin D, 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalcife
rol, a process for preparing the same, and novel intermediate compounds. The compound is characterized by vitamin D-like activity substantially gre...
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WO/1982/000294A1 |
5(Beta)-hydroxy-(Alpha)6-steroid derivatives having the general formula (FORMULA) wherein R1 represents a hydrogen atom, an acyl, lower alkyl or tetrahydropyranyl residue and R2, R3 each a hydrogen atom or in common a methylene residue a...
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WO/1981/002577A1 |
Novel cundurango glycosides represented by the following general formula (1), a process for preparing them from an extract of Marsdenia cundurango Reichenbach fil. of potato family, and the use of a compound or composition containing the...
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WO/1980/002502A1 |
New vitamin D derivatives as well as new intermediate compounds derived during the processes for preparing such new derivatives. The new derivatives have been identified as 1(Alpha)-hydroxy-25-keto-27-nor-vitamin D3 and its acylates. 1(A...
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WO/1980/002562A1 |
Isotopically labeled vitamin D compounds, including radiolabeled vitamin D compounds of high specific activity, methods for their preparation, and novel intermediates in their synthesis. The radiolabeled vitamin D compounds are character...
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