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WO/2015/191980A1 |
A method of mass spectrometry comprises ionising a sample eluting from a separation device in order to generate a plurality of parent ions. The method further comprises generating a target list of ions, which includes a predicted mass to...
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WO/2015/188283A1 |
The present disclosure describes a device for generating ionized molecules for analysis in a mass spectrometer. The device includes: a mesh substrate coated with an extraction phase, the extraction phase comprising a polymer that absorbs...
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WO/2015/189611A1 |
An apparatus for filtering ions is disclosed comprising a separation device for separating ions temporally according to a first physico-chemical property and a first quadrupole rod set for filtering ions according to their mass to charge...
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WO/2015/191683A1 |
An ion funnel device is disclosed. A first pair of electrodes is positioned in a first direction. A second pair of electrodes is positioned in a second direction. The device includes an RF voltage source and a DC voltage source. A RF vol...
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WO/2015/189539A1 |
An ion guide is disclosed comprising a first array of electrodes and a second array of electrodes and one or more apertures or ion exit regions. The first array of electrodes comprises a first plurality of arcuate electrodes arranged in ...
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WO/2015/189545A1 |
A method of analysing ions, comprising performing an initial multidimensional survey scan comprising separating parent ions according to a first physico-chemical property and separating said parent ions according to a second physico-chem...
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WO/2015/189538A1 |
A method of mass or ion mobility spectrometry is disclosed comprising: releasing ions from an ion trapping volume (4) into an ion separation region (2); separating the ions along a longitudinal direction according to a physicochemical pr...
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WO/2015/189749A1 |
A method and apparatus for analyzing samples using mass spectrometry are disclosed. The apparatus includes a reaction device configured to dissociate sample ions into fragments by reacting the sample ions with a charged species (e.g., el...
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WO/2015/189546A1 |
A method of mass spectrometry is disclosed comprising digitising at least one individual signal or transient, determining in relation to the digitised signal or transient an indication of overlap and/or coalescence of ion arrivals in the...
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WO/2015/189605A1 |
A mass spectrometer is disclosed comprising an ion mobility separation device (3) for separating ions according to their ion mobility, a first quadrupole mass filter (4) downstream of the ion mobility separation device (3), a control sys...
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WO/2015/185934A1 |
A mass spectrometer is disclosed comprising a first device, a second device and a switch arranged and adapted: (i) to direct ions at a first time T1 to the first device and to substantially prevent ions from entering the second device; a...
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WO/2015/185930A1 |
A method of mass spectrometry is disclosed comprising digitising a first signal output from an ion detector to produce a first digitised signal, detecting one or more peaks in the first digitised signal and determining a first area S0 or...
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WO/2015/181563A1 |
A method of analysing ions is disclosed comprising performing an initial multi- dimensional survey scan comprising separating parent ions according to a first physico- chemical property and separating the parent ions according to a secon...
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WO/2015/184048A1 |
A method, apparatus, and computer-readable storage medium for analyzing sample data from a component separation/mass spectrometer system. A profile plot is formed for each sample, each having retention time and intensity axes, the intens...
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WO/2015/183734A1 |
One embodiment relates to a dual Wien-filter monochromator. A first Wien filter focuses an electron beam in a first plane while leaving the electron beam to be parallel in a second plane. A slit opening allows electrons of the electron b...
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WO/2015/181564A1 |
An ion transfer apparatus for transferring ions from an ion source at a first pressure, which first pressure is >500 mbar, suitably atmospheric pressure, along a path towards a mass spectrometer at a lower second pressure, comprising a p...
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WO/2015/181562A1 |
A method of mass spectrometry is disclosed that comprises acquiring mass spectral data during a single experimental run or acquisition of a mass spectrometer and determining a first time T during the single experimental run or acquisitio...
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WO/2015/181566A1 |
A method of mass spectrometry is disclosed comprising separating ions temporally in a first device (5) and analysing the mass or mass to charge ratio of the ions or of product or fragment ions derived from the ions in a mass or mass to c...
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WO/2015/177886A1 |
The high-frequency voltage generator, whereby a high-frequency voltage is generated from a direct current voltage and applied to a load, comprises: a first direct current power source (11) for generating a first direct current voltage; a...
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WO/2015/176567A1 |
An atmospheric pressure interface device and mass spectrometer; the atmospheric pressure interface device comprises an interface end plate (1) and a sealing device (3); the interface end plate (1) is provided with a through hole (10) the...
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WO/2015/179709A1 |
Instruments are disclosed for analyzing ions from about 1000 to 10,000,000 Daltons by controlling a gaseous medium through which the ions travel under the influence of an electric field so that properties of the ions, such as diameter, e...
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WO/2015/173911A1 |
An off-axis ion transport optical system (20) including a front-stage quadrupole ion guide (21), a rear-stage quadrupole ion guide (22), and an ion deflection unit (23) is arranged inside an intermediate vacuum chamber (2) in the stage s...
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WO/2015/173577A1 |
A method of mass spectrometry is disclosed comprising separating first ions according to a first physico-chemical property in a first separator (2) wherein at least some of the first ions undergo a different number of cycles or passes wi...
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WO/2015/175988A1 |
Implementations of methods and apparatuses are disclosed for decoding multiplexed information in a chromatographic system. Implementations may include the method of pulsing ions from an ion source through an analyzer according to a prede...
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WO/2015/175685A1 |
A system and method for matrix assisted laser desorption time-of-flight (MALDI-TOF) mass spectrometry. A method for MALDI-TOF mass spectrometry includes initiating a spectral analysis of a sample on a MALDI-TOF spectrometer. The sample i...
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WO/2015/173562A1 |
An sub-ambient gas pressure ion separation device is disclosed comprising: an ion entrance aperture (2) having an axis therethrough that extends in a first direction, and an ion exit aperture (30); wherein the entrance aperture (2) and e...
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WO/2015/173616A1 |
A mass analyser comprises a pair of electrode arrays. Each array has a set of focusing electrodes which are supplied, in use, with voltage to create an electrostatic field in a space between the electrode arrays causing ions to undergo p...
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WO/2015/168724A1 |
The present disclosure provides methods for detecting biological print(s) or biological fluid(s) or target low molecular weight analyte(s) therein comprising contacting the suspected print(s) or fluid(s) with porous semiconductor substra...
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WO/2015/169184A1 |
A mass calibrator ionization and introduction device for a mass spectrometer, comprising at least a first ion source for the mass calibrator ionization (1); at least a second ion source for the ionization analysis (2); independent vacuum...
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WO/2015/165589A1 |
The present invention relates to a microfluidic interface for the coupling of a bioaffinity sensor system to a mass spectrometry system, as well as to a respective method of using said interface.
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WO/2015/167586A1 |
The present disclosure provides methods and systems for improved detection and/or quantification of selenium (Se) and/or silicon (Si) in samples. In certain embodiment, the methods and systems feature the use of carbon dioxide (CO2) as a...
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WO/2015/166251A1 |
A method of mass spectrometry is disclosed comprising providing a first device and a second device disposed downstream of the first device. The method further comprises introducing a potential difference between the exit of the first dev...
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WO/2015/168337A1 |
Oxides of lanthanide metals are used to create stable surfaces for use in laser desorption ionization mass spectrometry. The disclosed lanthanide metal oxide surfaces are used to identify and characterize fatty acids from microorganism a...
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WO/2015/167216A1 |
The present invention relates to a photocleavable mass tag material and a use thereof. The photocleavable mass tag material of the present invention can be used for the detection and quantitative analysis of a biomarker, and can be used ...
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WO/2015/162426A1 |
A method of checking or adjusting the calibration of a mass spectrometer is disclosed. The method comprises fragmenting parent or precursor ions and generating fragment or product ion mass spectral data and recognising first neutral loss...
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WO/2015/162435A1 |
A method of mass spectrometry is disclosed comprising passing ions through a first stage and a second stage of a mass spectrometer and monitoring a first ion acquisition for a first dwell time extending from a time T1 to a time T1+ Tdwel...
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WO/2015/164221A1 |
A mass spectrometry substrate for performing adsorption and biological processing includes a porous silica-based material comprising a chemical adsorption material that captures analyte(s) of interest. A biologically active material inco...
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WO/2015/163266A1 |
Provided is a scanning electron microscope that has an electron spectroscopic system in which the energy resolution or the number of electrons that are incident on a spectrometer does not change even if the retarding voltage Vr is change...
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WO/2015/162415A1 |
A method of mass spectrometry is disclosed comprising mass analysing ions and obtaining mass spectral data and determining parent or precursor ions of interest. The method further comprises determining first adduct or chemical artefact i...
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WO/2015/162521A1 |
The present invention relates to a method and device for measuring m/z ratios of ions in ion cyclotron resonance (ICR) mass spectrometry. The described ion traps for ICR mass spectrometry are distinct from the previous configurations by ...
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WO/2015/159063A1 |
A method of mass spectrometry for analysing lipids and similar biological molecules is disclosed. The lipid molecules may be ionised to form a plurality of lipid parent ions and subjected to photon-induced fragmentation to form a plurali...
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WO/2015/159714A1 |
This mass spectrometer is equipped with: a cartridge (104B) into which a specimen is introduced and which can be attached to and detached from the main body; a lower heater (110) which thermally gasifies the specimen to generate a specim...
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WO/2015/159096A1 |
A method is disclosed wherein parent or precursor ions are fragmented or reacted according to a first fragmentation or reaction mode, and when an ion of interest is detected the method then temporarily switches to a second mode of fragme...
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WO/2015/160427A1 |
A device for separating non-ions from ions is disclosed. The device includes a plurality of electrodes positioned around a center axis of the device and having apertures therein through which the ions are transmitted. An inner diameter o...
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WO/2015/154719A1 |
Atmospheric pressure megavolt electrostatic field ionization desorption (APME-FID) method generates ions directly from the surface of sample (2) connected to a high electrical voltage generator (1) at megavolt conditions. Megavolt electr...
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WO/2015/156730A1 |
Methods and apparatus are provided that facilitate drug screening by using a multi-dimensional ligand multiplexing in combination with hydrogen deuterium exchange mass spectrometry (HDX MS). The present invention is based on ligand convo...
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WO/2015/157109A1 |
A test to identify whether a lung patient is likely to benefit from combination therapy in the form of an epidermal growth factor receptor inhibitor (EGFR-I) and a monoclonal antibody drug targeting hepatocyte growth factor (HGF) as comp...
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WO/2015/155551A1 |
A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) hasat least two arrays of electrodes (20,22). The device is operated in a first mode wherein DC potentials are succes...
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WO/2015/150808A1 |
A mass analyser is disclosed comprising an annular ion guide having a longitudinal axis and comprising a first annular ion guide section and a second annular ion guide section, wherein the annular ion guide comprises: (i) an inner cylind...
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WO/2015/153630A1 |
Apparatuses (41, 91, 111, 115, 121, 151) and methods (31) for time-of-flight mass spectrometry providing effective pulsed conversion of continuous ion beams into pulsed ion packets is disclosed. Bunching of energetic continuous ion beams...
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